TDMS Study 05212-04 Pathology Tables
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
Facility: Battelle Columbus Laboratory
Chemical CAS #: 604-75-1
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9|
| 7| 7| 2| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 2| 7| 7| 6| 2| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 1 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 1 1 1 2 2 4 1 3 2 1 2 1 2 4 4 3 1 2 2 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 1 3 4 2 3 2 4 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Amyloid Deposition | 4 2 4 4 3 3 3 3 2 3 3 3 3 3 4 3 3 4 3 3 2|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 1 3 2 1 2 1 2 1 1 1 |
Hematopoietic Cell Proliferation | 2 3 2 |
Inflammation, Chronic | |
Inflammation, Subacute | 2 |
Necrosis | 1 2 1 2 2|
Centrilobular, Hypertrophy | 1 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Granulomatous | |
Inflammation, Subacute | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 1 2 3 4 3 4 3 2 3 2 4 2 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 3 1 2 3 4 1 1 1 1 1 1 1 1 3 2 1 1 2 |
Degeneration | |
Atrium, Thrombosis | X X |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9|
| 7| 7| 2| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 2| 7| 7| 6| 2| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 2 2 2 2 2 2 1 |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 2 4 2 1 1 2 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 4 3 3 2 2 3 3 2 3 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + M + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 1 2 2 3 2 1 2|
Angiectasis | |
Cyst | X |
Arteriole, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 2 2 2 2 3 2 2 3 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Inflammation, Suppurative | 2 |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 1 1 1 |
Cyst | X |
Hyperplasia, Lymphoid | 3 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9|
| 7| 7| 2| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 2| 7| 7| 6| 2| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 1 1 1 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 2 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + |
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 3 |
Inflammation, Subacute | 2 1 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulus, Amyloid Deposition | 3 3 3 2 2 2 4 2 2 3 3 3 3 3 3 3 3 2 3 2|
Interstitium, Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 9| 7| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9|
| 7| 7| 2| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7| 2| 7| 7| 6| 2| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 2| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | 1 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + M + + + + + + + +|
Amyloid Deposition | 1 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | 3 1 2 2 3 1 1 2 1 1 1 2 1 4 3 2 2 1 3|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | 1 4 2 3 4 3 2 1 2 2 3 3 1 2|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 4 3 3 4 3 4 4 3 3 4 2 3 2 3 2 3 3 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 1 3 2 1 2 2 1 1 1 1|
Hematopoietic Cell Proliferation | 2 1 |
Inflammation, Chronic | 1 |
Inflammation, Subacute | |
Necrosis | 2 1 1 |
Centrilobular, Hypertrophy | 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Granulomatous | 2 |
Inflammation, Subacute | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 2 2 3 3 2 2 4 4 4 3 3|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 2 2 1 1 1 1 1 1 2 1 2 1 1 2 1 3 2 1 1|
Degeneration | 2 |
Atrium, Thrombosis | |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 2| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 1 2 2 2 2 1 1 2|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M + + + + + + + M + + +|
Amyloid Deposition | 1 2 3 1 2 4 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 4 2 2 4 3 3 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 1 3 2 4 2 2 2 3 4|
Angiectasis | 3 |
Cyst | X X X X X |
Arteriole, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 1 1 2 2 2 2 2 3 1|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Suppurative | |
Thrombosis | |
Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 2 1 2 2 1|
Cyst | |
Hyperplasia, Lymphoid | 2 4 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 2| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 3 |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 3 3 2 2 2 2 3 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic | 1 |
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glomerulus, Amyloid Deposition | 3 2 3 3 2 1 2 4 3 4 3 2 2 3 4 2 3 3 4 3 3|
Interstitium, Amyloid Deposition | 2 1 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3|
DAY ON TEST | 9| 9| 9| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9|
| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 3| 7| 7| 7| 5| 7| 7| 7| 7| 2| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | |
| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 | 6 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
Amyloid Deposition | | 6 1.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 2 2 1 4 1 | 46 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 1 2 3 3 | 28 2.4|
Ulcer | 4 | 3 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Amyloid Deposition | 4 4 3 4 4 4 4 3 3 3 | 52 3.2|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 1 2 1 | 28 1.4|
Hematopoietic Cell Proliferation | | 5 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Subacute | 1 1 1 | 4 1.3|
Necrosis | 2 2 | 10 1.6|
Centrilobular, Hypertrophy | | 3 1.3|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Inflammation, Granulomatous | | 1 2.0|
Inflammation, Subacute | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 3 3 | 35 2.7|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Amyloid Deposition | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | |
| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Amyloid Deposition | 1 1 1 1 2 2 1 1 1 | 50 1.5|
Degeneration | | 1 2.0|
Atrium, Thrombosis | | 2 |
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 1 | 24 1.8|
Hematopoietic Cell Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
Amyloid Deposition | 2 2 2 3 1 | 24 2.2|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 4 | 22 2.8|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 2 2 2 | 24 2.3|
Angiectasis | | 1 3.0|
Cyst | X | 7 |
Arteriole, Inflammation, Chronic | 4 | 3 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 3 3 3 1 | 26 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia, Cystic | 2 | 13 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | |
| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | | 8 |
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + | 58 |
Amyloid Deposition | 2 | 3 1.7|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 1 2 1 | 16 1.5|
Cyst | | 1 |
Hyperplasia, Lymphoid | 4 | 5 3.4|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 2 1 | 12 2.0|
Hematopoietic Cell Proliferation | 2 | 5 2.8|
Hyperplasia, Lymphoid | 1 3 1 | 14 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 56 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 4.0|
Ulcer | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Inflammation, Chronic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 4 |
Axon, Degeneration | 1 | 2 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | |
| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 1 | 3 1.7|
Inflammation, Subacute | | 4 1.5|
Alveolar Epithelium, Hyperplasia | 2 2 | 6 1.5|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Glomerulus, Amyloid Deposition | 4 2 3 3 4 3 2 | 48 2.8|
Interstitium, Amyloid Deposition | 3 2 | 5 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 6| 9| 9| 9| 2| 6| 9| 7| 9| 2| 5| 9| 9| 8| 9| 2| 9| 9| 9| 9| 9| 0| 6| 9|
| 7| 3| 7| 7| 7| 6| 0| 4| 2| 7| 8| 6| 7| 7| 1| 7| 0| 7| 2| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 2 2 1 2 1 1 2 2 3|
Hemorrhage | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + A +|
Amyloid Deposition | 1 2 2 2 2 1 1 2 3 2|
Hemorrhage | 4 |
Ulcer | 4 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 3 4 2 4 4 3 1 4 4 2 3 1 3 4 3 3|
Ulcer | 3 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 4 4 4 4 3 4 1 4 2 4 2 4 4 3 4|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + M + + + A + + + + + + + +|
Amyloid Deposition | 2 4 4 4 3 4 3 4 4 4 3 2 3 4 4 2 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 1 2 3 2 3 2 2 3 3 4|
Eosinophilic Focus | X X X X X X X X |
Hematopoietic Cell Proliferation | 4 |
Hepatodiaphragmatic Nodule | |
Inflammation, Granulomatous | 3 |
Inflammation, Subacute | 1 1 |
Necrosis | 2 1 1 1 2 |
Centrilobular, Hypertrophy | 2 1 2 2 1 2 2 1 2 2 1 2 1 1 2 2 1 2 1 2 2 2 2|
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1|
Ectopic Tissue | X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 4 3 2 4 3 2 4 3 4 3 4 4|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 |
Hemorrhage | 1 |
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 3 1 2|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 6| 9| 9| 9| 2| 6| 9| 7| 9| 2| 5| 9| 9| 8| 9| 2| 9| 9| 9| 9| 9| 0| 6| 9|
| 7| 3| 7| 7| 7| 6| 0| 4| 2| 7| 8| 6| 7| 7| 1| 7| 0| 7| 2| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 4 3 2 3 3 1 3 1 4 2 2 3 2 3 3 3|
Atrium, Thrombosis | X X X X X X X X X X|
Coronary Artery, Inflammation, | |
Chronic | 1 |
Valve, Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 3 2 2 3 2 3 2 2 4|
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Mononuclear | |
Cell | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + M + +|
Amyloid Deposition | 3 2 3 1 3 2 3 2 3 2 2 3 3 2 3|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 4 2 2 3 3 3 3 3 3 2 3 3 4 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 2 4 2 2 2|
Cyst | X X |
Arteriole, Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 3 3 2 2 2 3 3 2 2|
Endometrium, Hyperplasia, Cystic | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
Axillary, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 6| 9| 9| 9| 2| 6| 9| 7| 9| 2| 5| 9| 9| 8| 9| 2| 9| 9| 9| 9| 9| 0| 6| 9|
| 7| 3| 7| 7| 7| 6| 0| 4| 2| 7| 8| 6| 7| 7| 1| 7| 0| 7| 2| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 1 2 1 1 3 1 1 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 2 2 1 2 1 3 2 3 3 |
Cyst | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 2 4 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 3 |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 2 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + M + + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + M + + + + + + + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 3 1 1 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Subacute | 1 1 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 3 3 2 2 2 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 6| 9| 9| 9| 2| 6| 9| 7| 9| 2| 5| 9| 9| 8| 9| 2| 9| 9| 9| 9| 9| 0| 6| 9|
| 7| 3| 7| 7| 7| 6| 0| 4| 2| 7| 8| 6| 7| 7| 1| 7| 0| 7| 2| 7| 7| 7| 9| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infarct | |
Glomerulus, Amyloid Deposition | 4 3 4 4 2 3 2 4 3 4 3 4 4 4 4 4|
Interstitium, Amyloid Deposition | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 4| 9| 3| 2| 7| 9| 8| 7| 9| 9| 9| 9| 9| 1| 9| 2| 3| 2| 9| 9| 5| 9| 9| 1|
| 4| 9| 7| 6| 2| 4| 7| 9| 6| 7| 4| 7| 7| 7| 7| 7| 0| 0| 1| 7| 7| 0| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 1 1 2 1 1 3 2 1 3|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 1|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + +|
Amyloid Deposition | 3 1 1 2 3 1 2 2 2 2 |
Hemorrhage | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M A + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 3 4 3 4 3 3 4 2 3 4 3 4 4 4 4 4|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 3 3 3 2 4 3 4 4 4 1 4 3 4 4 4 4 4 4|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 3 3 2 4 2 3 4 4 4 4 4 3 3 4 4 4 3 4 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 1 3 3 3 3 2 3 3 2 3 3 3|
Eosinophilic Focus | X X X X X X X X X|
Hematopoietic Cell Proliferation | 2 2 3|
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous | |
Inflammation, Subacute | 1 |
Necrosis | 2 1 1|
Centrilobular, Hypertrophy | 1 1 2 1 1 2 2 2 2 1 2 2 2 1 1 1 2 2 2 1|
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2|
Ectopic Tissue | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 3 2 3 3 4 2 3 3 3 3 3 3 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hemorrhage | |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 1 2 1 3 2 3 4|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 4| 9| 3| 2| 7| 9| 8| 7| 9| 9| 9| 9| 9| 1| 9| 2| 3| 2| 9| 9| 5| 9| 9| 1|
| 4| 9| 7| 6| 2| 4| 7| 9| 6| 7| 4| 7| 7| 7| 7| 7| 0| 0| 1| 7| 7| 0| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 3 2 3 3 3 2 2 4 3 2 2 1 2 4 4 4 3 3 2 4|
Atrium, Thrombosis | X X X X X X X X X|
Coronary Artery, Inflammation, | |
Chronic | |
Valve, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 3 2 3 2 2 3 1 3 4 2 3 2 2 4|
Hematopoietic Cell Proliferation | 4 |
Infiltration Cellular, Mononuclear | |
Cell | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M + + + + + + M M M + + + M + M|
Amyloid Deposition | 2 2 2 4 2 2 3 3 1 3 3 3 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 4 2 1 3 4 4 2 1 3 4 2 3 1 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 3 1 2 1|
Cyst | |
Arteriole, Inflammation, Chronic | 3 3 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 2 2 2 3 3 2 3 3 2 3|
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + +|
Axillary, Hematopoietic Cell | |
Proliferation | 4|
Mediastinal, Hematopoietic Cell | |
Proliferation | 4|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 4| 9| 3| 2| 7| 9| 8| 7| 9| 9| 9| 9| 9| 1| 9| 2| 3| 2| 9| 9| 5| 9| 9| 1|
| 4| 9| 7| 6| 2| 4| 7| 9| 6| 7| 4| 7| 7| 7| 7| 7| 0| 0| 1| 7| 7| 0| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hematopoietic Cell | |
Proliferation | 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 1 2 1 1 2 1 1 |
Hematopoietic Cell Proliferation | 4|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 1 3 3 1 2 2 2 2 1 2 1 1 |
Cyst | |
Hematopoietic Cell Proliferation | 4|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 1 1 3 4 1 1 1 4 4 4 2 |
Hematopoietic Cell Proliferation | 4|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M + + + + + + + + M + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + +|
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 1 2 2 3 1|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Inflammation, Subacute | 2|
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 1 4 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 2 3 3 3 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 4| 9| 3| 2| 7| 9| 8| 7| 9| 9| 9| 9| 9| 1| 9| 2| 3| 2| 9| 9| 5| 9| 9| 1|
| 4| 9| 7| 6| 2| 4| 7| 9| 6| 7| 4| 7| 7| 7| 7| 7| 0| 0| 1| 7| 7| 0| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 3 |
Glomerulus, Amyloid Deposition | 3 4 4 4 3 4 4 4 4 4 4 4 3 3 3 4 4 3|
Interstitium, Amyloid Deposition | 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 2| 3| 2| 3| 3| | |
DAY ON TEST | 2| 0| 9| 9| 4| 3| 9| 9| 9| 9| | |
| 6| 6| 7| 7| 4| 9| 3| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 58 |
Amyloid Deposition | 1 1 | 24 1.6|
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + | 56 |
Amyloid Deposition | | 4 1.8|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + | 56 |
Amyloid Deposition | 3 3 2 | 23 2.0|
Hemorrhage | | 1 4.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + | 56 |
Amyloid Deposition | 4 4 1 | 40 3.2|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Amyloid Deposition | 4 3 4 3 4 | 42 3.5|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + | 56 |
Amyloid Deposition | 4 4 2 2 | 43 3.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Amyloid Deposition | 2 3 3 | 31 2.5|
Eosinophilic Focus | X X X | 20 |
Hematopoietic Cell Proliferation | | 4 2.8|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Granulomatous | | 1 3.0|
Inflammation, Subacute | 1 | 4 1.0|
Necrosis | | 8 1.4|
Centrilobular, Hypertrophy | 2 2 1 2 1 2 2 2 | 51 1.6|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Granulomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Amyloid Deposition | | 3 1.7|
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 3 2 3 4 2 | 36 3.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 1.0|
Hemorrhage | | 1 1.0|
Hyperkeratosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 2| 3| 2| 3| 3| | |
DAY ON TEST | 2| 0| 9| 9| 4| 3| 9| 9| 9| 9| | |
| 6| 6| 7| 7| 4| 9| 3| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 | 17 2.0|
Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 2 2 4 4 | 44 2.7|
Atrium, Thrombosis | X X X X | 23 |
Coronary Artery, Inflammation, | | |
Chronic | | 1 1.0|
Valve, Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 3 3 | 32 2.5|
Hematopoietic Cell Proliferation | | 2 3.0|
Infiltration Cellular, Mononuclear | | |
Cell | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 50 |
Amyloid Deposition | 3 2 3 3 | 32 2.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 58 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 2 3 4 | 38 2.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Ovary | + + + + M + + + + + | 58 |
Amyloid Deposition | 1 | 13 1.8|
Cyst | X X X | 5 |
Arteriole, Inflammation, Chronic | 2 | 4 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 2| 3| 2| 3| 3| | |
DAY ON TEST | 2| 0| 9| 9| 4| 3| 9| 9| 9| 9| | |
| 6| 6| 7| 7| 4| 9| 3| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Amyloid Deposition | 3 4 1 3 2 | 28 2.6|
Endometrium, Hyperplasia, Cystic | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 10 |
Axillary, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Amyloid Deposition | 2 1 3 3 2 | 23 1.6|
Hematopoietic Cell Proliferation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M | 57 |
Amyloid Deposition | 3 2 3 2 | 30 2.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia, Lymphoid | 1 | 6 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 1 | 20 2.4|
Hematopoietic Cell Proliferation | | 4 3.3|
Hyperplasia, Lymphoid | 2 2 | 5 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Amyloid Deposition | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + M + + + + | 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 2| 3| 2| 3| 3| | |
DAY ON TEST | 2| 0| 9| 9| 4| 3| 9| 9| 9| 9| | |
| 6| 6| 7| 7| 4| 9| 3| 1| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Axon, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Fibrosis | 2 | 14 1.9|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Chronic | 3 1 | 2 2.0|
Inflammation, Subacute | | 4 1.3|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 3 3.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 2 3 | 16 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Cyst | | 1 |
Infarct | | 1 3.0|
Glomerulus, Amyloid Deposition | 4 4 2 4 4 | 39 3.6|
Interstitium, Amyloid Deposition | 2 1 | 5 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 0| 6| 2| 9| 7| 9| 5| 3| 7| 3| 8| 8| 9| 5| 9| 9| 2| 9| 9| 7| 2| 2| 9| 1| 0|
| 6| 0| 5| 7| 5| 7| 0| 7| 9| 9| 1| 4| 7| 0| 0| 7| 1| 7| 7| 6| 5| 1| 7| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + M + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + A + + + + + + + + + A + + +|
Amyloid Deposition | 3 3 2 3 3 1 2 2 2 3 3 3 2 1 3|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + A + + + + + + + + + A + + +|
Amyloid Deposition | 2 2 3 2 3 3|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + M A + + + + + + + + + A + + M|
Amyloid Deposition | 2 1 2 2 3 2 2 1 2 1 2 2 3 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + A + + + + + + + + + A + + +|
Amyloid Deposition | 4 3 4 4 4 3 2 2 2 3 3 4 3 3 4 3 3 2 4|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + A + + +|
Amyloid Deposition | 2 4 2 4 4 4 4 4 3 3 3 4 3 3 3 4 4 3 4 2 4|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + A + + + + + + + + + A M + +|
Amyloid Deposition | 3 4 3 4 4 4 4 3 3 3 3 4 4 3 4 4 3 4 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 3 3 3 2 3 3 3 2 1 2 2 3 2|
Eosinophilic Focus | X X X |
Hematopoietic Cell Proliferation | 1 |
Infarct | 3 |
Inflammation, Chronic | 1 |
Necrosis | 1 3 1 |
Centrilobular, Hypertrophy | 1 1 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 4 3 3 3 3 4 4 3 4 2 3 3 2 4 3 4|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | 3 2 |
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | 2 2 2 2 2 2 2 |
Mineralization | 3 3|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 3 4 4 4 3 3 3 3 3 3 1 4 4 4 2 3 4 4 3 3 3 3|
Atrium, Thrombosis | X X X X X X X X X X X 2 X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 0| 6| 2| 9| 7| 9| 5| 3| 7| 3| 8| 8| 9| 5| 9| 9| 2| 9| 9| 7| 2| 2| 9| 1| 0|
| 6| 0| 5| 7| 5| 7| 0| 7| 9| 9| 1| 4| 7| 0| 0| 7| 1| 7| 7| 6| 5| 1| 7| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 3 4 4 2 2 2 1 2 3 4 3 3 3 3 2|
Hematopoietic Cell Proliferation | 2 3 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + M + + + + + M + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + M M + M + + + M + + + M + + + + + + +|
Amyloid Deposition | 4 3 3 4 3 2 2 3 4 2 3 3 3 2 4|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 3 4 3 4 3 3 2 3 3 2 3 2 3 3 3 3 2 3 4|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 1 1 1 2 1 2|
Angiectasis | 3 |
Cyst | X |
Arteriole, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 3 2 4 3 2 4 4 4 3 2 2 3 3 2 2 1 2|
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 3 3 2 1 1 2 4 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 2 1 3 3 4 3 2 1 4 2 3 2 2 2 |
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 2 2 2 1 2 3 2 3 2 1 3 3 1 4|
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 0| 6| 2| 9| 7| 9| 5| 3| 7| 3| 8| 8| 9| 5| 9| 9| 2| 9| 9| 7| 2| 2| 9| 1| 0|
| 6| 0| 5| 7| 5| 7| 0| 7| 9| 9| 1| 4| 7| 0| 0| 7| 1| 7| 7| 6| 5| 1| 7| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + M + + M + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 3 3 |
Inflammation, Chronic | 2 |
Inflammation, Granulomatous | |
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 2 3 4 4 2 2 4 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Glomerulus, Amyloid Deposition | 4 4 4 4 4 4 4 3 4 4 4 4 4 4 3 4 4 4|
Interstitium, Amyloid Deposition | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
DAY ON TEST | 1| 6| 5| 9| 9| 7| 2| 1| 7| 9| 1| 5| 9| 6| 3| 2| 4| 9| 6| 3| 8| 8| 9| 9| 9|
| 8| 6| 5| 7| 7| 6| 8| 4| 6| 5| 1| 7| 7| 3| 6| 7| 9| 7| 5| 7| 5| 1| 7| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 4 2 2 3 2 2 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 1 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + M + +|
Amyloid Deposition | 2 2 1 3 3 2 2 1 3 1 2 3 4 1 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 4 4 3 3 4 4 2 2 4 4 4 3 4 3 4 4 4 3 4|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | 3 3 4 4 4 3 3 3 4 3 3 4 4 4 3 4 2 4 4 3 4|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 4 3 2 2 4 3 4 4 4 4 2 4 2 3 3 4 3 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 3 2 3 3 3 4 2 2 4 3 3 2 4|
Eosinophilic Focus | X X X X X X X X|
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Inflammation, Chronic | |
Necrosis | 2 2 1 1 |
Centrilobular, Hypertrophy | 1 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Mesentery | |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 3 3 3 4 4 4 4 4 3 3 4 3 4 4 3|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hyperkeratosis | 3 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 3 2 2 4 1 3 2|
Mineralization | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 4 3 3 3 3 1 4 4 1 4 4 4 3 4 3 3 4 3 3 3|
Atrium, Thrombosis | X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
DAY ON TEST | 1| 6| 5| 9| 9| 7| 2| 1| 7| 9| 1| 5| 9| 6| 3| 2| 4| 9| 6| 3| 8| 8| 9| 9| 9|
| 8| 6| 5| 7| 7| 6| 8| 4| 6| 5| 1| 7| 7| 3| 6| 7| 9| 7| 5| 7| 5| 1| 7| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 3 4 4 1 4 3 3 4 4 2 3 4 3 2 3 1 4|
Hematopoietic Cell Proliferation | 4 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M M + + + + + M + + + + + + + + + +|
Amyloid Deposition | 3 2 2 3 3 4 3 2 4 3 4 1 4 2|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 2 4 4 3 4 3 3 3 4 4 4 3 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + M M + + + +|
Amyloid Deposition | 3 2 1 2 1 1 |
Angiectasis | |
Cyst | |
Arteriole, Inflammation, Chronic | 3 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + M + + + + +|
Amyloid Deposition | 1 3 2 2 3 2 1 2 3 2 3 3 2 2 2 2 2 2 3 |
Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 2 4 2 3 3 4 2 3 2 3 2 3 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M|
Amyloid Deposition | 2 2 3 2 2 4 2 2 2 2 3 2 3 3 2 2 |
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 3 2 4 1 1 1 2 4 3 4 3 4 1 3 3|
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + M M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3|
DAY ON TEST | 1| 6| 5| 9| 9| 7| 2| 1| 7| 9| 1| 5| 9| 6| 3| 2| 4| 9| 6| 3| 8| 8| 9| 9| 9|
| 8| 6| 5| 7| 7| 6| 8| 4| 6| 5| 1| 7| 7| 3| 6| 7| 9| 7| 5| 7| 5| 1| 7| 4| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + M + M + M M M M + M + + + + + + + M M + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 |
Inflammation, Chronic | 3 2 2|
Inflammation, Granulomatous | |
Inflammation, Subacute | 1 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 2 3 2 2 3 2 2 3 2 2 2 3 2 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Glomerulus, Amyloid Deposition | 4 4 3 4 4 4 4 4 4 4 4 4 4 4 3 4 3 4|
Interstitium, Amyloid Deposition | 2 2 3 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 4| 9| 6| 9| 4| 9| 9| 9| 2| 9| | |
| 0| 5| 4| 7| 2| 7| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + | 55 |
Amyloid Deposition | 3 1 2 2 1 | 30 2.4|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 56 |
Amyloid Deposition | 1 | 12 2.3|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 51 |
Amyloid Deposition | 3 2 1 1 1 | 34 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Amyloid Deposition | 4 3 4 4 4 4 | 47 3.4|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Amyloid Deposition | 2 4 3 3 4 4 2 | 49 3.4|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 54 |
Amyloid Deposition | 4 3 3 4 4 4 | 46 3.5|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 3 1 | 35 2.7|
Eosinophilic Focus | X X X | 14 |
Hematopoietic Cell Proliferation | | 2 1.5|
Infarct | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Necrosis | | 7 1.6|
Centrilobular, Hypertrophy | 2 1 2 2 2 2 2 2 2 | 53 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Inflammation, Granulomatous | 2 | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 4 3 | 40 3.4|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 57 |
Amyloid Deposition | | 3 2.7|
Hyperkeratosis | 1 | 5 2.6|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Amyloid Deposition | 2 | 19 2.3|
Mineralization | | 3 2.3|
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 4| 9| 6| 9| 4| 9| 9| 9| 2| 9| | |
| 0| 5| 4| 7| 2| 7| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 4 3 3 2 3 | 53 3.2|
Atrium, Thrombosis | X X | 31 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 3 1 | 41 2.9|
Hematopoietic Cell Proliferation | | 3 3.0|
Capsule, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + + + + M | 45 |
Amyloid Deposition | 2 3 2 3 | 33 2.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Amyloid Deposition | 2 4 3 3 3 2 3 | 46 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + + + + + + + | 57 |
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | M + + + M + + + + + | 55 |
Amyloid Deposition | 2 | 15 1.6|
Angiectasis | | 1 3.0|
Cyst | | 1 |
Arteriole, Inflammation, Chronic | | 4 2.3|
__________________________________________________________________________|____________|
Uterus | M + + + + + + + + + | 57 |
Amyloid Deposition | 4 | 40 2.5|
Dilatation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Amyloid Deposition | 2 3 2 3 1 2 | 35 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 4| 9| 6| 9| 4| 9| 9| 9| 2| 9| | |
| 0| 5| 4| 7| 2| 7| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + M | 56 |
Amyloid Deposition | 3 3 2 | 35 2.4|
Cyst | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 3 2 1 3 | 39 2.3|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 1 | 2 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 59 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 5 |
__________________________________________________________________________|____________|
Spinal Cord | + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Fibrosis | | 8 2.3|
Inflammation, Chronic | 3 3 | 6 2.5|
Inflammation, Granulomatous | 1 | 1 1.0|
Inflammation, Subacute | | 3 1.3|
Alveolar Epithelium, Hyperplasia | 1 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 2 1 | 26 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| | |
DAY ON TEST | 4| 9| 6| 9| 4| 9| 9| 9| 2| 9| | |
| 0| 5| 4| 7| 2| 7| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Necrosis | | 1 3.0|
Glomerulus, Amyloid Deposition | 4 4 4 | 39 3.9|
Interstitium, Amyloid Deposition | 1 | 7 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 2| 9| 9| 9| 9| 5| 9| 9| 8| 4| 5| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 3| 7| 7| 8| 7| 7| 1| 4| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 4 3 1 1 1 2 1 1 1 2 1 3 1 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 3 3 4 1 2 3 1 3 1 3 3 1 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 2 3 3 3 3 3 3 3 4 2 3 4 4 4 3 3|
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 1 1 1 2 1 2 |
Basophilic Focus | X |
Hematopoietic Cell Proliferation | |
Inflammation, Subacute | |
Necrosis | 1 2 3 1 1 |
Centrilobular, Hypertrophy | 2 2 1 1 1 1 1 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 3 3 4 3 4 2 2 3 2 4 3 3 3 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 1 3 1 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1 1 1|
Degeneration | |
Inflammation, Subacute | 2 |
Atrium, Thrombosis | |
Valve, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 2| 9| 9| 9| 9| 5| 9| 9| 8| 4| 5| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 3| 7| 7| 8| 7| 7| 1| 4| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 1 2 |
Capsule, Hyperplasia | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 1 1 1 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Germinal Epithelium, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Amyloid Deposition | 1 1 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 2 1 1 2 2 1 |
Cyst | X |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 4 1 3 2 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 1 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 2| 9| 9| 9| 9| 5| 9| 9| 8| 4| 5| 7| 9| 9| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9|
| 7| 7| 7| 3| 7| 7| 8| 7| 7| 1| 4| 7| 1| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
0 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + M M + M M + M M M + M M M M + M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hyperkeratosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + |
Axon, Degeneration | 1 |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 |
Inflammation, Granulomatous | 2 |
Inflammation, Subacute | 2 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 2 |
Alveolus, Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
External Ear, Ulcer | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Infarct | |
Inflammation, Granulomatous | |
Glomerulus, Amyloid Deposition | 3 2 3 3 3 3 4 3 2 3 2 2 2 2 3 3 3 2 4 4 2|
Interstitium, Amyloid Deposition | 1 |
__________________________________________________________________________|
Urethra | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 3| 9| 4| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
| 8| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 4 3 3 4 2 3 1 2 1 2 3 1 1 3|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 2 3 1 2 2 3 1 1 2|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 4 2 3 4 1 2 4 4 3 4 4 3 3 3 3 4|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 3 3 1 2 1 2 1 1|
Basophilic Focus | |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Subacute | 1 |
Necrosis | 2 3 2 |
Centrilobular, Hypertrophy | 1 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 2 3 3 3 4 3 2 4 2 2 3|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 1 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 1 1 3 1 1 2 2 1 2 1 1 2 2 1|
Degeneration | 2 |
Inflammation, Subacute | |
Atrium, Thrombosis | X |
Valve, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 3| 9| 4| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
| 8| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 |
Capsule, Hyperplasia | 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M M + + + + + + M + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Germinal Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Renal, Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 1 1 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Amyloid Deposition | 1 1 2 1 2 3 2 3 2 1 1 1 2 |
Cyst | X |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 3 2 2 1 1 |
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Lymphoid | 2 4 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 3| 9| 4| 9| 9| 9| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9|
| 8| 7| 4| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M M M M + M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperkeratosis | 2 |
Ulcer | 3 3 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + |
Axon, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
Inflammation, Granulomatous | |
Inflammation, Subacute | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | |
Alveolus, Metaplasia, Osseous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
External Ear, Ulcer | 3 |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infarct | 2 2 |
Inflammation, Granulomatous | 2 1|
Glomerulus, Amyloid Deposition | 4 3 3 3 2 2 3 4 3 3 3 2 3 4|
Interstitium, Amyloid Deposition | 1 2 |
__________________________________________________________________________|
Urethra | + |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 3| 9| 7| 9| 9| | |
| 7| 7| 7| 7| 7| 1| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + M M + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + M + + + + + + | 59 |
Amyloid Deposition | | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 | 6 1.8|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 1 3 1 3 2 1 3 | 40 2.1|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + M + + | 59 |
Amyloid Deposition | 4 1 1 2 1 | 32 2.1|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Amyloid Deposition | 4 4 4 3 3 4 3 4 3 | 46 3.3|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 1 1 1 | 22 1.5|
Basophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Inflammation, Subacute | | 1 1.0|
Necrosis | 1 1 | 10 1.7|
Centrilobular, Hypertrophy | 1 | 12 1.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 3 | 32 2.9|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Amyloid Deposition | | 8 1.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 2 1 1 2 2 2 1 1 | 43 1.5|
Degeneration | 1 | 2 1.5|
Inflammation, Subacute | | 1 2.0|
Atrium, Thrombosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 3| 9| 7| 9| 9| | |
| 7| 7| 7| 7| 7| 1| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Valve, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 2 2 1 | 17 1.8|
Hyperplasia | | 4 1.3|
Capsule, Hyperplasia | | 3 3.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 4 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 54 |
Amyloid Deposition | | 10 1.6|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M M | 58 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 1 2 2 | 19 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 3 2 | 5 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Edema | | 1 4.0|
Germinal Epithelium, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Renal, Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + M + | 57 |
Amyloid Deposition | | 8 1.5|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 3| 9| 7| 9| 9| | |
| 7| 7| 7| 7| 7| 1| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Amyloid Deposition | 2 1 1 1 | 25 1.6|
Cyst | | 2 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 1 | 16 1.9|
Hematopoietic Cell Proliferation | | 3 2.7|
Hyperplasia, Lymphoid | | 7 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M + M M M M M | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Hyperkeratosis | 2 | 2 2.0|
Ulcer | | 3 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 7 |
Axon, Degeneration | | 2 1.5|
__________________________________________________________________________|____________|
Spinal Cord | | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 2 | 6 1.3|
Inflammation, Granulomatous | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | | 1 2.0|
Alveolus, Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | |
DAY ON TEST | 9| 9| 9| 9| 9| 3| 9| 7| 9| 9| | |
| 7| 7| 7| 7| 7| 1| 7| 9| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Ear | + | 4 |
External Ear, Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Eye | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 3.0|
Infarct | | 2 2.0|
Inflammation, Granulomatous | | 2 1.5|
Glomerulus, Amyloid Deposition | 4 4 3 3 3 2 3 | 42 2.9|
Interstitium, Amyloid Deposition | | 3 1.3|
__________________________________________________________________________|____________|
Urethra | | 1 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 2| 3| 3| 3| 2| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
DAY ON TEST | 9| 8| 2| 9| 5| 4| 9| 8| 9| 7| 9| 6| 3| 0| 9| 0| 3| 9| 6| 9| 7| 5| 9| 5| 9|
| 6| 5| 5| 7| 9| 1| 6| 3| 7| 6| 5| 2| 9| 6| 7| 5| 6| 7| 5| 7| 5| 1| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 2 2 3 2 2 1 1 1 3|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 1 2 2 1 3 2 2 2 1 2|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 3 4 3 4 3 3 4 3 3 3 3 4 3 2 2 2 4 2|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 3 3 4 4 3 4 2 3 4 3 4 4 1 2 4 2 4|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Amyloid Deposition | 3 3 3 3 3 4 4 3 4 3 2 3 4 4 3 4 2 3 4 4|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 1 3 2 3 1 1 1 1 2 3 2 2 3 |
Eosinophilic Focus | X X X X X X X X|
Infarct | 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | |
Necrosis | 1 2 2 2 2 1 1 2 2 |
Centrilobular, Hypertrophy | 1 2 1 2 1 2 2 2 2 1 2 1 2 2 2 2 1 2 2|
Oval Cell, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 2 3 3 2 3 2 3 3 3 4 3 4 3 3 3 3 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 3 2 2 2 2 1 2|
Mineralization | |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 2 4 3 4 3 4 4 3 2 4 2 2 3 1 3 2 3 3|
Atrium, Thrombosis | X X X X X X X X X X X X X |
Valve, Thrombosis | X |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 2| 3| 3| 3| 2| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
DAY ON TEST | 9| 8| 2| 9| 5| 4| 9| 8| 9| 7| 9| 6| 3| 0| 9| 0| 3| 9| 6| 9| 7| 5| 9| 5| 9|
| 6| 5| 5| 7| 9| 1| 6| 3| 7| 6| 5| 2| 9| 6| 7| 5| 6| 7| 5| 7| 5| 1| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 4 2 3 3 3 3 2 3 4 4 2 3 3 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + M + + + + M + +|
Amyloid Deposition | 2 4 2 4 3 3 3 2 3 3 1 4 3 1|
__________________________________________________________________________|
Pituitary Gland | + M + + + M + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 4 3 4 2 3 2 3 4 3 3 3 3 3 4 3 3 4 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation, | |
Granulomatous | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + M + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 3 2 2 2 1 2 2|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + M + + + + + M + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 3 2 2 3 2 1 2 2 3 2 3 2 2|
Hyperplasia, Lymphoid | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 2 3 1 3 1 2 1 1 1|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 2| 3| 2| 3| 3| 3| 2| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3|
DAY ON TEST | 9| 8| 2| 9| 5| 4| 9| 8| 9| 7| 9| 6| 3| 0| 9| 0| 3| 9| 6| 9| 7| 5| 9| 5| 9|
| 6| 5| 5| 7| 9| 1| 6| 3| 7| 6| 5| 2| 9| 6| 7| 5| 6| 7| 5| 7| 5| 1| 7| 9| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M + M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + |
Axon, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 4 3 1 2 3 2 3 |
Inflammation, Chronic | 3 2 |
Inflammation, Subacute | 2 2 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 3 1 4 3 2 3 3 3 3 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Inflammation, Suppurative | 4 |
Artery, Thrombosis | X |
Glomerulus, Amyloid Deposition | 3 4 4 3 4 4 3 3 3 4 4 3 3 4 |
Interstitium, Amyloid Deposition | 2 1 1 1 1 2 |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
DAY ON TEST | 8| 9| 5| 4| 0| 9| 9| 6| 9| 8| 2| 9| 1| 9| 8| 6| 9| 6| 9| 7| 4| 2| 9| 1| 4|
| 2| 7| 0| 1| 7| 7| 7| 8| 7| 7| 7| 7| 2| 7| 3| 9| 7| 0| 7| 9| 0| 8| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 2 2 2 2 2 1 1 2 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 1 2 1 2 1 3 2 2 3 |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + M + + + A + + + + + + + + +|
Amyloid Deposition | 4 4 3 4 4 4 3 3 3 3 3 4 4 3 2 3 3 3 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 4 4 3 4 2 4 2 3 4 3 2 2 4 3 3 4 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 3 3 4 4 3 4 2 3 4 3 4 2 2 2 4 3 4 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 2 4 1 2 3 4 2 3 4 |
Eosinophilic Focus | X X X X X X X X |
Infarct | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 2 |
Necrosis | 1 1 1 1 |
Centrilobular, Hypertrophy | 1 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 |
Oval Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 3 3 2 3 2 3 2 4 2 3 4 3 3 4 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 2 3 1 2 2 1 1 2 1 2 2 |
Mineralization | 3 2 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 4 4 4 4 4 3 4 3 2 3 4 4 4 4 3 4 4 4 2 4 |
Atrium, Thrombosis | X X X X X X X X X X X X X X X X |
Valve, Thrombosis | X |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
DAY ON TEST | 8| 9| 5| 4| 0| 9| 9| 6| 9| 8| 2| 9| 1| 9| 8| 6| 9| 6| 9| 7| 4| 2| 9| 1| 4|
| 2| 7| 0| 1| 7| 7| 7| 8| 7| 7| 7| 7| 2| 7| 3| 9| 7| 0| 7| 9| 0| 8| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 1 3 4 3 4 2 3 2 4 4 2 4 3 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + + + + + + M + + + + + + +|
Amyloid Deposition | 4 3 4 4 4 3 3 1 1 3 4 4 2 3 3 2 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 4 3 4 4 3 3 2 4 4 3 3 3 4 3 2 4 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Inflammation, | |
Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 2 4 1 2 1 1 2 3 2 2 2|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + + +|
Amyloid Deposition | 1 2 2 2 2 2 2 2 3 2 1 2 2 2 2 |
Hyperplasia, Lymphoid | |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 1 4 3 1 1 4 3 1 2 2 1 3 3 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|
DAY ON TEST | 8| 9| 5| 4| 0| 9| 9| 6| 9| 8| 2| 9| 1| 9| 8| 6| 9| 6| 9| 7| 4| 2| 9| 1| 4|
| 2| 7| 0| 1| 7| 7| 7| 8| 7| 7| 7| 7| 2| 7| 3| 9| 7| 0| 7| 9| 0| 8| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
2500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M + + M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
Axon, Degeneration | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 2 2 3 2 1 2 3 3 2 3 2 3 1 |
Inflammation, Chronic | 2 |
Inflammation, Subacute | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 3 3 3 3 3 1 3 3 3 4 3 2 3 2 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Inflammation, Suppurative | |
Artery, Thrombosis | |
Glomerulus, Amyloid Deposition | 4 4 4 4 4 3 3 3 3 4 3 3 3 2 |
Interstitium, Amyloid Deposition | 2 1 4 1 2 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 9| 9| 9| 1| 6| 9| 3| 2| 9| | |
| 6| 7| 3| 7| 4| 1| 7| 1| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 1 1 2 3 | 29 1.9|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Amyloid Deposition | | 5 2.2|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 | 24 1.8|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Amyloid Deposition | 4 2 3 3 4 3 3 3 3 | 49 3.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Amyloid Deposition | 3 2 2 4 4 4 3 4 | 49 3.1|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Amyloid Deposition | 3 4 3 2 4 2 3 4 | 48 3.2|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 3 3 | 31 2.5|
Eosinophilic Focus | X X X X X X | 22 |
Infarct | | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation, Chronic | | 2 2.0|
Necrosis | | 13 1.5|
Centrilobular, Hypertrophy | 2 2 2 2 2 2 2 2 | 46 1.8|
Oval Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 3 3 1 2 1 | 44 2.9|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 2 1 2 | 29 1.9|
Mineralization | 1 | 3 2.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 9| 9| 9| 1| 6| 9| 3| 2| 9| | |
| 6| 7| 3| 7| 4| 1| 7| 1| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Amyloid Deposition | 4 3 3 3 3 3 4 2 4 | 52 3.3|
Atrium, Thrombosis | X X X X X | 34 |
Valve, Thrombosis | | 2 |
Ventricle, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 3 3 3 3 | 37 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + M + | 52 |
Amyloid Deposition | 3 3 3 3 4 3 | 39 2.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M + + + + | 53 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 3 3 3 3 4 4 3 | 48 3.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Penis | + + + + | 23 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + M + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Inguinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Inflammation, | | |
Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 56 |
Amyloid Deposition | 2 1 3 2 | 29 2.1|
Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 9| 9| 9| 1| 6| 9| 3| 2| 9| | |
| 6| 7| 3| 7| 4| 1| 7| 1| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Amyloid Deposition | 2 3 3 3 3 | 36 2.2|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 1 4 2 2 2 | 32 2.1|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 2 | 4 2.5|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M M M M | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 7 |
Axon, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Fibrosis | 2 3 2 | 27 2.3|
Inflammation, Chronic | | 3 2.3|
Inflammation, Subacute | | 2 2.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 1.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 3 3 3 | 31 2.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 0| 3| 3| 3| 3| 3| | |
DAY ON TEST | 5| 9| 9| 9| 1| 6| 9| 3| 2| 9| | |
| 6| 7| 3| 7| 4| 1| 7| 1| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
2500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Infarct | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Artery, Thrombosis | | 1 |
Glomerulus, Amyloid Deposition | 2 3 4 3 3 3 4 | 35 3.4|
Interstitium, Amyloid Deposition | 1 2 2 | 14 1.6|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Hemorrhage | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3|
DAY ON TEST | 4| 5| 6| 9| 7| 6| 6| 7| 7| 8| 9| 7| 7| 4| 9| 4| 7| 6| 5| 2| 0| 8| 9| 7| 4|
| 1| 1| 3| 7| 5| 9| 1| 3| 1| 1| 7| 0| 1| 1| 7| 5| 3| 5| 7| 5| 2| 3| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + M +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
Amyloid Deposition | 3 2 2 3 1 1 2 2 3 1|
Lumen, Hemorrhage | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
Amyloid Deposition | 3 1 1 4 2 3|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + M + + + + + + + + + + + + + + + A + M|
Amyloid Deposition | 2 2 3 2 2 4 4 2 3 |
Ulcer | 4 |
Lumen, Hemorrhage | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + A + +|
Amyloid Deposition | 4 4 3 4 4 2 2 3 4 3 3 3 4 4 4 3 3 4|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + + + A + +|
Amyloid Deposition | 3 4 4 4 4 2 4 2 4 4 3 4 4 3 3 3|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + A + +|
Amyloid Deposition | 4 4 4 4 4 3 2 2 4 3 1 4 4 3 4 4 3 3|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 3 3 3 4 3 3 4 |
Basophilic Focus | |
Eosinophilic Focus | X X X X X X X X X|
Fatty Change | |
Hematopoietic Cell Proliferation | |
Inflammation, Chronic | |
Inflammation, Subacute | |
Necrosis | 1 1 1 1 |
Centrilobular, Hypertrophy | 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2 1 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 3 3 3 3 4 3 4 3 2 2 4 3 4 3 3|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 3 2 2|
Mineralization | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 4 4 4 4 1 4 3 4 3 4 4 4 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3|
DAY ON TEST | 4| 5| 6| 9| 7| 6| 6| 7| 7| 8| 9| 7| 7| 4| 9| 4| 7| 6| 5| 2| 0| 8| 9| 7| 4|
| 1| 1| 3| 7| 5| 9| 1| 3| 1| 1| 7| 0| 1| 1| 7| 5| 3| 5| 7| 5| 2| 3| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 4 2 3 4 2 4 3 3 2 3 3 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + M + + + + + + + M + M + + M|
Amyloid Deposition | 3 3 2 4 2 4 2 3 2 2 2 3 2 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 2 3 2 4 2 3 4 3 3 4 4 3 4 3 4 2|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Amyloid Deposition | 2 2 4 2 2 3 2 4 3 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + M + +|
Amyloid Deposition | 2 3 1 1 2 3 3 3 3|
Cyst | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 4 2 1 3 2 1 4 3 2 3 4 3 4 |
Hyperplasia, Lymphoid | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M M + + + + + + + + + M + + + +|
Amyloid Deposition | |
Vein, Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 0| 2| 3| 3| 2| 3| 3|
DAY ON TEST | 4| 5| 6| 9| 7| 6| 6| 7| 7| 8| 9| 7| 7| 4| 9| 4| 7| 6| 5| 2| 0| 8| 9| 7| 4|
| 1| 1| 3| 7| 5| 9| 1| 3| 1| 1| 7| 0| 1| 1| 7| 5| 3| 5| 7| 5| 2| 3| 2| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M + M M M M + M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 1 2 2 2 3 3 1 1 2|
Inflammation, Chronic | 3 |
Inflammation, Subacute | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 2 3 3 3 3 3 2 2 3 4 3 3 3|
Alveolus, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
__________________________________________________________________________|
Eye | |
Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Inflammation, Suppurative | 4 |
Glomerulus, Amyloid Deposition | 4 3 2 4 3 3 4 4 2 3 2 4 3 3|
Interstitium, Amyloid Deposition | 2 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Inflammation, Suppurative | 3 |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
DAY ON TEST | 9| 1| 1| 0| 3| 9| 0| 9| 1| 7| 8| 5| 7| 8| 9| 8| 6| 2| 7| 9| 5| 7| 3| 8| 2|
| 7| 4| 0| 2| 4| 7| 6| 7| 1| 1| 6| 5| 1| 5| 7| 5| 2| 8| 9| 7| 8| 0| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 1 1 3 2 3 2 1 2 |
Lumen, Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 1 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + A + + + +|
Amyloid Deposition | 1 3 2 1 2 3 1 3 3 2 2 2 2 |
Ulcer | |
Lumen, Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 3 3 4 3 4 4 1 4 3 3 4 4 3 4 4 3 2 3 4 2 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +|
Amyloid Deposition | 4 3 4 4 4 4 3 4 3 3 3 3 4 4 3 3 3 3 3 2 4 4|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + A + + + + + A + + + + + + +|
Amyloid Deposition | 4 3 3 4 4 2 4 3 2 4 3 4 3 3 3 4 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 2 2 2 1 3 3 2 1 |
Basophilic Focus | X |
Eosinophilic Focus | X X X X X X X X X X|
Fatty Change | 3 |
Hematopoietic Cell Proliferation | 2 3 |
Inflammation, Chronic | 2 |
Inflammation, Subacute | |
Necrosis | 2 3 1 1 |
Centrilobular, Hypertrophy | 2 1 1 2 2 2 1 2 1 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 4 3 4 3 4 4 4 4 4 4 3 4 4 3 4 4 3 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 1 |
Hyperkeratosis | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 1 2 3 1 1 1 |
Mineralization | 2 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 4 4 3 4 1 3 4 3 4 4 2 4 4 2 4 4 3 3 4 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
DAY ON TEST | 9| 1| 1| 0| 3| 9| 0| 9| 1| 7| 8| 5| 7| 8| 9| 8| 6| 2| 7| 9| 5| 7| 3| 8| 2|
| 7| 4| 0| 2| 4| 7| 6| 7| 1| 1| 6| 5| 1| 5| 7| 5| 2| 8| 9| 7| 8| 0| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | X X 2 X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 3 4 4 3 4 3 2 2 3 3 3 4 4 3 3 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + M + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 4 2 4 4 4 4 4 4 3 3 4 2 4 3 3 4 |
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 4 2 3 3 4 4 4 3 4 2 4 3 3 3 4 4 3 2 3 3 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | X |
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + + + + + M + + + + + + + +|
Amyloid Deposition | 1 2 3 2 3 3 1 2 3 1 2 2 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 1 1 3 1 4 2 2 2 3 2 3 3 3 2 3 |
Cyst | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 2 3 4 3 2 1 2 |
Hyperplasia, Lymphoid | 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + M M + + + + + + M M + + M + + + + + + + + + + +|
Amyloid Deposition | 3 |
Vein, Thrombosis | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|
DAY ON TEST | 9| 1| 1| 0| 3| 9| 0| 9| 1| 7| 8| 5| 7| 8| 9| 8| 6| 2| 7| 9| 5| 7| 3| 8| 2|
| 7| 4| 0| 2| 4| 7| 6| 7| 1| 1| 6| 5| 1| 5| 7| 5| 2| 8| 9| 7| 8| 0| 7| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 2 3 2 3 3 2 2 3 |
Inflammation, Chronic | |
Inflammation, Subacute | 1 1 2 2 1 1 1 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Mononuclear Cell | 3 1 2 3 3 4 2 3 2 4 2 3 3 3 2 3 3 |
Alveolus, Metaplasia, Squamous | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 2|
Inflammation, Suppurative | |
Glomerulus, Amyloid Deposition | 3 3 4 3 4 3 3 3 3 3 4 4 3 4 3 4 3 3 3 3 |
Interstitium, Amyloid Deposition | 2 1 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Inflammation, Suppurative | 1|
Transitional Epithelium, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 2| 2| 3| 3| 2| | |
DAY ON TEST | 6| 9| 0| 9| 9| 7| 3| 6| 6| 9| | |
| 5| 5| 5| 7| 7| 2| 1| 4| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + M + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Amyloid Deposition | 1 3 2 2 2 3 | 29 2.0|
Lumen, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Amyloid Deposition | | 9 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 55 |
Amyloid Deposition | 2 2 1 3 2 3 2 | 29 2.3|
Ulcer | | 1 4.0|
Lumen, Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Amyloid Deposition | 3 4 3 4 4 4 1 3 3 4 | 50 3.3|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Amyloid Deposition | 4 4 3 4 4 3 4 3 3 4 | 49 3.4|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 54 |
Amyloid Deposition | 3 4 4 3 4 3 3 4 | 45 3.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Amyloid Deposition | 3 4 2 1 3 2 | 28 2.5|
Basophilic Focus | | 1 |
Eosinophilic Focus | X X X | 22 |
Fatty Change | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Inflammation, Subacute | 1 | 1 1.0|
Necrosis | | 8 1.4|
Centrilobular, Hypertrophy | 1 1 2 2 2 2 2 2 1 | 47 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Duct, Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Amyloid Deposition | 4 4 3 3 4 3 2 | 44 3.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Amyloid Deposition | | 4 1.8|
Hyperkeratosis | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 2 2 2 | 22 2.0|
Mineralization | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 2| 2| 3| 3| 2| | |
DAY ON TEST | 6| 9| 0| 9| 9| 7| 3| 6| 6| 9| | |
| 5| 5| 5| 7| 7| 2| 1| 4| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 4 4 4 3 4 3 4 4 4 | 52 3.6|
Atrium, Thrombosis | X X X X X X X | 35 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Amyloid Deposition | 4 4 4 3 2 4 3 | 41 3.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + M + + + + + + + | 56 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 52 |
Amyloid Deposition | 2 3 4 3 4 4 3 3 3 | 42 3.1|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 3 4 2 3 4 4 3 4 | 48 3.2|
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | + | 24 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Cyst | | 1 |
Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + M + + | 55 |
Amyloid Deposition | 2 2 3 1 3 | 29 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
Amyloid Deposition | 2 3 2 3 1 2 2 1 | 35 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 2| 2| 3| 3| 2| | |
DAY ON TEST | 6| 9| 0| 9| 9| 7| 3| 6| 6| 9| | |
| 5| 5| 5| 7| 7| 2| 1| 4| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | X | 1 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Amyloid Deposition | 2 1 2 4 3 | 30 2.5|
Hyperplasia, Lymphoid | | 3 2.3|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + | 51 |
Amyloid Deposition | | 1 3.0|
Vein, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 9 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Fibrosis | 2 2 2 2 | 25 2.2|
Inflammation, Chronic | 1 | 2 2.0|
Inflammation, Subacute | 1 1 2 | 11 1.3|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.0|
Alveolus, Infiltration Cellular, | | |
Mononuclear Cell | 2 3 2 1 2 3 2 | 37 2.6|
Alveolus, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05212-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC OXAZEPAM Date: 04/18/97
Route: DOSED FEED Time: 14:29:17
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 2| 2| 3| 3| 2| | |
DAY ON TEST | 6| 9| 0| 9| 9| 7| 3| 6| 6| 9| | |
| 5| 5| 5| 7| 7| 2| 1| 4| 8| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS WEBSTER MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Infarct | | 1 2.0|
Inflammation, Suppurative | | 1 4.0|
Glomerulus, Amyloid Deposition | 2 3 3 4 3 3 3 3 | 42 3.2|
Interstitium, Amyloid Deposition | 2 2 | 10 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Inflammation, Suppurative | | 2 2.0|
Transitional Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
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