TDMS Study 05212-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/18/94
EXP: 05212 OXAZEPAM TIME: 12:07:47
TEST: 04 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 062453
CONT: NO1ES85213 CAS: 604-75-1
PATHOLOGIST: M. RYAN HAILEY, JAMESR.
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REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/18/94
EXP: 05212 OXAZEPAM TIME: 12:07:47
TEST: 04 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 062453
CONT: NO1ES85213 CAS: 604-75-1
PATHOLOGIST: M. RYAN HAILEY, JAMESR.
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 397 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 161 244 257 279 281 281 293 295 327 327 |
| 331 338 344 358 371 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 41 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 14 107 145 159 183 206 225 268 295 296 |
| 296 297 305 312 317 327 328 329 331 336 |
| 339 340 341 341 350 351 356 359 360 361 |
| 362 365 369 375 376 379 382 383 385 387 |
| 393 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 57 165 225 231 237 271 271 272 273 281 |
| 285 286 292 296 302 302 305 306 310 311 |
| 314 328 328 334 341 341 344 345 351 355 |
| 358 361 362 363 364 365 368 369 370 370 |
| 371 371 373 374 375 379 383 385 385 395 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 397 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 397 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 98.3 95.0 76.7 75.0 75.0 75.0 75.0 75.0 75.0 |
| | |
| | |
|2500 PPM | 98.3 93.3 86.7 46.7 31.7 31.7 31.7 31.7 31.7 31.7 |
| | |
| | |
|5000 PPM | 98.3 96.7 91.7 40.0 16.7 16.7 16.7 16.7 16.7 16.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.0% 31.7% 16.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P