TDMS Study 05212-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/18/94
EXP: 05212 OXAZEPAM TIME: 12:07:47
TEST: 04 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 062453
CONT: NO1ES85213 CAS: 604-75-1
PATHOLOGIST: M. RYAN HAILEY, JAMESR.
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/18/94
EXP: 05212 OXAZEPAM TIME: 12:07:47
TEST: 04 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 062453
CONT: NO1ES85213 CAS: 604-75-1
PATHOLOGIST: M. RYAN HAILEY, JAMESR.
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 397 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 161 244 257 279 281 281 293 295 327 327 |
| 331 338 344 358 371 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 41 CENSORED DEATHS 0 TERMINAL 19 |
| |
| UNCENSORED DEATHS |
| 14 107 145 159 183 206 225 268 295 296 |
| 296 297 305 312 317 327 328 329 331 336 |
| 339 340 341 341 350 351 356 359 360 361 |
| 362 365 369 375 376 379 382 383 385 387 |
| 393 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 50 CENSORED DEATHS 0 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 57 165 225 231 237 271 271 272 273 281 |
| 285 286 292 296 302 302 305 306 310 311 |
| 314 328 328 334 341 341 344 345 351 355 |
| 358 361 362 363 364 365 368 369 370 370 |
| 371 371 373 374 375 379 383 385 385 395 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 397 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 397 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 98.3 95.0 76.7 75.0 75.0 75.0 75.0 75.0 75.0 |
| | |
| | |
|2500 PPM | 98.3 93.3 86.7 46.7 31.7 31.7 31.7 31.7 31.7 31.7 |
| | |
| | |
|5000 PPM | 98.3 96.7 91.7 40.0 16.7 16.7 16.7 16.7 16.7 16.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 75.0% 31.7% 16.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 299.1 310.5 322.0 |
|NATURAL DEATHS (C) | (13.8) (13.2) ( 8.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 372.5 337.9 334.5 |
|(STANDARD ERROR) | ( 6.5) (10.4) ( 8.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 397 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 184 193 272 306 322 358 361 362 372 372 |
| 375 392 396 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2500 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 31 CENSORED DEATHS 1 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 106 160 239 256 281 291 294 294 309 315 |
| 320 320 321 322 326 326 328 330 336 344 |
| 349 350 363 367 372 374 376 389 392 393 |
| 394 |
| CENSORED DEATHS |
| 17 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 5000 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 42 CENSORED DEATHS 1 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 197 284 294 295 305 306 314 316 318 320 |
| 321 321 325 325 327 328 336 337 337 339 |
| 340 342 349 350 350 355 357 360 363 364 |
| 365 366 375 376 376 376 379 381 381 385 |
| 390 395 |
| CENSORED DEATHS |
| 111 |
| |
==================================================================================
OXAZEPAM
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 397 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 397 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 96.7 86.7 78.3 78.3 78.3 78.3 78.3 78.3 |
| | |
| | |
|2500 PPM | 100.0 96.6 93.2 61.0 47.5 47.5 47.5 47.5 47.5 47.5 |
| | |
| | |
|5000 PPM | 100.0 100.0 98.3 47.5 28.8 28.8 28.8 28.8 28.8 28.8 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 2500 PPM 5000 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 47.5% 28.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 328.1 320.5 341.0 |
|NATURAL DEATHS (C) | (19.7) (11.5) ( 5.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 382.1 351.2 353.0 |
|(STANDARD ERROR) | ( 5.5) ( 9.5) ( 6.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
OXAZEPAM
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
2500 PPM = 2
5000 PPM = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1
| 2 3 2 2 1 3 3 1 1
| 2 2 1 1
| 2 2 2 3 3 3 1 1
90 + 2 2 1 1
| 2 2 1 1 1
| 3 3
| 1 1 1
80 + 3 3 2 2 1 1
| 3 3 2 2 2 1 1 1
P | 2 2 1 1
E |
R 70 + 3 3 2 2
C | 2 2
E | 3 3
N | 3 3
T 60 + 3 2 2
| 3 2 2
S | 2 2
U | 3 3
R 50 + 3 3
V | 2 2
I | 2 2
V | 3 3 2 2
A 40 +
L |
| 2 2
| 2 2
30 + 3 3
|
| 3 3
|
20 +
| 3 3
|
|
10 +
|
---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
0 5 10 15 20 25 30 35 40 45 50 55 60
WEEK
NOTE: 19 obs hidden.
OXAZEPAM
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
2500 PPM = 2
5000 PPM = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 3
| 2 2 1 1 3 2 1 3 3
| 2 2 1 3 3 1
| 2 2 2 3 1 1 1
90 + 3 3
| 2 2 3 1 1
|
| 2 2 1 1
P 80 + 3 3 1 1
E | 2 2 1
R |
C | 3 3
E 70 + 2 2 3
N | 2 2
T |
| 3 2 2
S 60 + 2 2 2
U | 3 3
R | 3 3 2 2
V |
I 50 + 3 3 2 2
V | 2
A | 3 3
L |
40 + 3 3
|
|
| 3 3
30 + 3 3
|
|
|
20 +
|
---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
0 5 10 15 20 25 30 35 40 45 50 55 60
WEEK
NOTE: 13 obs hidden.