TDMS Study 05212-05 Pathology Tables
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
CORE STUDY
Facility: Battelle Columbus Laboratory
Chemical CAS #: 604-75-1
Lock Date: 05/12/94
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 PPM
Include 004 625 PPM
Include 008 2500 PPM
Include 010 5000 PPM
Include 012 10,000 PPM STOP
Include 001 0 PPM
Include 003 625 PPM
Include 007 2500 PPM
Include 009 5000 PPM
Include 011 10,000 PPM STOP
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Natural Death 6 6 12 3 6
Moribund Sacrifice 11 18 18 16 19
Accidently Killed 1
Survivors
Terminal Sacrifice 32 26 20 31 25
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (49) (1)
Periesophageal Tissue, Necrosis 1 (100%)
Intestine Large, Colon (50) (48) (49) (50)
Parasite Metazoan 2 (4%) 2 (4%) 2 (4%) 2 (4%)
Intestine Large, Rectum (50) (49) (49) (50)
Cyst 1 (2%)
Parasite Metazoan 2 (4%) 2 (4%) 1 (2%)
Intestine Small, Duodenum (50) (49) (47) (49)
Ulcer 2 (4%)
Intestine Small, Jejunum (46) (48) (47) (48) (1)
Parasite Metazoan 1 (2%)
Ulcer 1 (100%)
Liver (50) (50) (50) (50) (49)
Basophilic Focus 44 (88%) 41 (82%) 28 (56%) 26 (52%) 16 (33%)
Clear Cell Focus 6 (12%) 3 (6%) 11 (22%) 22 (44%)
Degeneration, Cystic 2 (4%)
Degeneration, Fatty 1 (2%) 2 (4%)
Eosinophilic Focus 17 (34%) 18 (36%) 4 (8%) 11 (22%) 11 (22%)
Hepatodiaphragmatic Nodule 12 (24%) 2 (4%) 4 (8%) 5 (10%) 6 (12%)
Inflammation, Granulomatous 1 (2%) 2 (4%) 3 (6%)
Mixed Cell Focus 5 (10%) 15 (30%) 7 (14%) 3 (6%) 2 (4%)
Necrosis, Focal 2 (4%) 1 (2%)
Centrilobular, Atrophy 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (4%) 1 (2%)
Hepatocyte, Centrilobular, Hypertrophy 10 (20%) 31 (62%)
Mesentery (10) (9) (4) (6) (13)
Accessory Spleen 1 (10%)
Fat, Necrosis 8 (80%) 9 (100%) 4 (100%) 6 (100%) 13 (100%)
Pancreas (50) (50) (49) (49)
Acinus, Atrophy 6 (12%) 6 (12%) 1 (2%) 8 (16%)
Stomach, Forestomach (50) (50) (50) (50) (3)
Abscess 1 (2%)
Foreign Body 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 4 (8%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 1 (2%)
Ulcer 1 (2%) 2 (4%) 8 (16%) 6 (12%) 2 (67%)
Epithelium, Hyperkeratosis 1 (33%)
Epithelium, Hyperplasia 1 (2%) 4 (8%) 8 (16%) 3 (6%)
Epithelium, Ulcer 1 (2%)
Stomach, Glandular (50) (50) (50) (50) (1)
Erosion 2 (4%) 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
Ulcer 2 (4%) 2 (4%) 6 (12%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (49)
Aorta, Mineralization 1 (2%)
Heart (50) (50) (49) (49)
Atrium, Thrombosis 1 (2%)
Myocardium, Degeneration 32 (64%) 34 (68%) 35 (71%) 32 (65%)
Myocardium, Fibrosis, Focal 2 (4%)
Myocardium, Mineralization 1 (2%)
Pericardium, Inflammation, Chronic 1 (2%)
Valve, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50) (1)
Degeneration 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 9 (18%) 8 (16%) 5 (10%) 4 (8%)
Hypertrophy, Focal 2 (4%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Degeneration 1 (2%)
Hyperplasia 8 (16%) 3 (6%) 1 (2%) 4 (8%)
Islets, Pancreatic (50) (50) (49) (49)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (50) (35)
Angiectasis 2 (4%)
Cyst 1 (2%) 2 (6%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 5 (10%) 2 (4%) 1 (2%) 3 (6%) 2 (6%)
Pars Distalis, Degeneration, Cystic 1 (2%) 3 (6%) 5 (14%)
Pars Distalis, Hyperplasia 4 (8%) 5 (10%) 3 (6%) 8 (16%) 1 (3%)
Pars Distalis, Vacuolization Cytoplasmic,
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Focal 1 (3%)
Thyroid Gland (50) (50) (48) (49) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 40 (80%) 43 (86%) 35 (73%) 42 (86%) 43 (86%)
Follicle, Cyst 1 (2%) 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Granulomatous 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (50) (11)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (9%)
Duct, Cyst 1 (2%) 4 (8%) 6 (12%) 2 (4%) 3 (27%)
Ovary (50) (50) (50) (50) (4)
Cyst 5 (10%) 6 (12%) 5 (10%) 6 (12%) 4 (100%)
Uterus (50) (50) (50) (50) (5)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (20%)
Cervix, Cyst 2 (4%) 1 (2%) 1 (2%) 1 (20%)
Cervix, Inflammation, Suppurative 1 (20%)
Cervix, Myometrium, Hyperplasia 2 (4%) 1 (20%)
Endometrium, Hyperplasia, Cystic 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Necrosis 1 (2%)
Lymph Node (4) (2) (9) (3) (4)
Lumbar, Ectasia 1 (11%)
Mediastinal, Pigmentation, Hemosiderin 1 (33%)
Pancreatic, Inflammation, Granulomatous 1 (11%)
Renal, Ectasia 1 (25%)
Lymph Node, Mandibular (50) (48) (48) (49) (3)
Ectasia 1 (2%)
Lymph Node, Mesenteric (50) (50) (50) (49) (2)
Ectasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inflammation, Acute 1 (2%)
Spleen (50) (50) (50) (49) (12)
Fibrosis 1 (2%) 2 (4%) 2 (4%) 2 (17%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%) 3 (6%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%) 1 (8%)
Pigmentation, Hemosiderin 25 (50%) 27 (54%) 13 (26%) 22 (45%)
Lymphoid Follicle, Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (49) (50) (23)
Hyperplasia, Cystic 2 (4%) 3 (6%) 1 (2%) 1 (2%) 1 (4%)
Metaplasia, Squamous 1 (2%)
Skin (50) (50) (50) (50) (6)
Hyperkeratosis 1 (17%)
Ulcer 2 (4%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (17%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (1)
Hyperostosis 1 (2%) 2 (4%)
Inflammation, Chronic 1 (100%)
Osteopetrosis 3 (6%)
Cranium, Hyperostosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hydrocephalus 7 (14%) 12 (24%) 3 (6%) 3 (6%)
Cerebellum, Mineralization 1 (2%)
Cerebrum, Degeneration, Focal 1 (2%)
Hypothalamus, Hemorrhage 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (49)
Congestion 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Granulomatous 2 (4%) 2 (4%) 5 (10%) 8 (16%)
Alveolar Epithelium, Hyperplasia 3 (6%) 4 (8%) 1 (2%) 3 (6%)
Interstitium, Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%)
Serosa, Inflammation, Chronic 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 5 (10%) 2 (4%) 6 (12%) 4 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (1) (2)
Choroid, Inflammation, Chronic 1 (100%)
Lens, Cataract 2 (100%) 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (1)
Inflammation, Chronic Active 1 (2%)
Nephropathy 32 (64%) 43 (86%) 41 (82%) 48 (96%) 1 (100%)
Pigmentation, Lipofuscin 2 (4%)
Renal Tubule, Cyst 1 (2%) 1 (2%) 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (48) (49) (49) (50)
Inflammation, Chronic Active 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50
Early Deaths
Moribund Sacrifice 25 27 33 43 39
Natural Death 8 12 11 7 11
Survivors
Terminal Sacrifice 17 11 6
Animals Examined Microscopically 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (47) (50) (50) (1)
Parasite Metazoan 4 (9%) 2 (4%)
Serosa, Inflammation, Chronic 1 (100%)
Intestine Large, Rectum (50) (48) (49) (50) (1)
Congestion 1 (2%)
Edema 1 (2%)
Parasite Metazoan 1 (2%) 2 (4%)
Serosa, Inflammation, Chronic 1 (100%)
Intestine Large, Cecum (50) (48) (49) (50) (1)
Congestion 1 (2%)
Edema 1 (2%)
Serosa, Inflammation, Chronic 1 (100%)
Intestine Small, Duodenum (50) (48) (49) (50)
Erosion 2 (4%) 6 (12%) 3 (6%)
Ulcer 3 (6%) 3 (6%) 5 (10%) 13 (26%)
Intestine Small, Ileum (50) (47) (46) (49)
Ulcer 1 (2%)
Liver (50) (50) (49) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 21 (42%) 11 (22%) 4 (8%) 2 (4%) 13 (26%)
Clear Cell Focus 2 (4%) 4 (8%)
Degeneration, Cystic 3 (6%) 1 (2%) 1 (2%)
Degeneration, Fatty 1 (2%) 1 (2%)
Eosinophilic Focus 8 (16%) 5 (10%) 5 (10%) 6 (12%) 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%) 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Mixed Cell Focus 2 (4%) 4 (8%) 2 (4%) 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%) 5 (10%) 4 (8%)
Bile Duct, Hyperplasia 1 (2%) 1 (2%)
Centrilobular, Congestion 1 (2%)
Centrilobular, Degeneration 1 (2%) 1 (2%) 1 (2%)
Centrilobular, Necrosis 3 (6%) 1 (2%) 4 (8%) 3 (6%) 2 (4%)
Hepatocyte, Centrilobular, Hypertrophy 1 (2%) 8 (16%) 14 (28%)
Serosa, Fibrosis 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (7) (6) (4) (4) (5)
Accessory Spleen 1 (14%) 1 (17%) 1 (20%)
Necrosis, Acute, Focal 1 (17%)
Fat, Necrosis 6 (86%) 3 (50%) 3 (75%) 4 (100%) 4 (80%)
Pancreas (50) (48) (49) (50)
Acinus, Atrophy 17 (34%) 10 (21%) 14 (29%) 1 (2%)
Acinus, Hyperplasia 1 (2%)
Artery, Inflammation, Granulomatous 1 (2%) 1 (2%)
Salivary Glands (50) (49) (50) (50)
Parotid Gland, Degeneration 1 (2%)
Parotid Gland, Hyperplasia, Focal 1 (2%)
Stomach, Forestomach (50) (48) (50) (50) (10)
Hyperplasia 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%) 4 (8%) 3 (6%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 5 (10%) 5 (10%) 1 (10%)
Mineralization 1 (2%)
Ulcer 9 (18%) 12 (25%) 17 (34%) 11 (22%) 7 (70%)
Epithelium, Hyperkeratosis 2 (20%)
Epithelium, Hyperplasia 1 (2%) 3 (6%) 11 (22%) 11 (22%)
Stomach, Glandular (50) (48) (50) (50) (4)
Erosion 2 (4%) 1 (2%) 4 (8%) 3 (6%)
Mineralization 3 (6%) 1 (2%) 4 (8%) 2 (50%)
Ulcer 2 (4%) 6 (13%) 13 (26%) 5 (10%) 2 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (49) (50) (50) (50)
Aorta, Mineralization 1 (2%) 3 (6%)
Aorta, Thrombosis 1 (2%)
Heart (50) (50) (50) (50) (7)
Atrium, Thrombosis 7 (14%) 1 (2%) 5 (71%)
Myocardium, Degeneration 46 (92%) 40 (80%) 43 (86%) 37 (74%) 1 (14%)
Myocardium, Mineralization 1 (2%) 2 (4%) 1 (2%) 4 (57%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Degeneration, Cystic 1 (2%)
Hyperplasia, Focal 5 (10%) 10 (20%) 8 (16%) 6 (12%)
Hypertrophy, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Adrenal Medulla (50) (50) (50) (50) (1)
Hyperplasia 9 (18%) 9 (18%) 15 (30%) 16 (32%)
Islets, Pancreatic (50) (48) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 3 (6%) 2 (4%) 1 (2%)
Parathyroid Gland (39) (41) (46) (40) (13)
Hyperplasia 3 (8%) 6 (15%) 9 (20%) 16 (40%) 13 (100%)
Pituitary Gland (49) (50) (50) (48) (5)
Cyst 1 (2%)
Degeneration, Cystic 1 (2%)
Pars Distalis, Cyst 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 5 (10%) 3 (6%) 1 (2%)
Pars Distalis, Thrombosis 1 (2%)
Pars Nervosa, Gliosis, Focal 1 (2%)
Thyroid Gland (50) (49) (50) (50) (50)
Mineralization 1 (2%)
C-Cell, Hyperplasia 33 (66%) 36 (73%) 38 (76%) 38 (76%) 41 (82%)
Follicle, Cyst 4 (8%) 2 (4%) 4 (8%) 6 (12%) 9 (18%)
Follicle, Hyperplasia 1 (2%)
Follicle, Ultimobranchial Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2) (1) (1) (2) (1)
Inflammation, Chronic 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (49) (50) (50) (1)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%)
Preputial Gland (48) (50) (50) (49) (14)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 4 (8%) 3 (21%)
Duct, Cyst 1 (2%) 4 (8%) 4 (8%) 3 (6%) 1 (7%)
Prostate (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (50) (50) (50) (50) (1)
Atrophy 1 (100%)
Cyst 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Testes (50) (50) (50) (50) (48)
Germinal Epithelium, Atrophy 2 (4%) 2 (4%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Lymph Node (5) (8) (8) (1) (9)
Renal, Ectasia 1 (13%)
Renal, Pigmentation 1 (11%)
Lymph Node, Mesenteric (49) (49) (50) (47) (4)
Congestion 1 (2%)
Inflammation, Chronic Active 1 (2%)
Spleen (50) (50) (50) (50) (33)
Fibrosis 7 (14%) 3 (6%) 3 (6%) 4 (8%) 8 (24%)
Hematopoietic Cell Proliferation 6 (12%) 1 (2%) 3 (6%) 5 (10%)
Necrosis 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 3 (6%) 2 (4%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%)
Red Pulp, Congestion 1 (2%) 1 (2%) 2 (4%)
Thymus (49) (47) (49) (47)
Ectopic Parathyroid Gland 2 (4%)
Ectopic Thyroid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (44) (48) (48) (2)
Hyperplasia, Cystic 3 (6%)
Inflammation, Suppurative 1 (2%)
Skin (50) (49) (49) (50) (8)
Ulcer 2 (4%)
Epidermis, Cyst 1 (2%)
Epidermis, Inflammation, Suppurative 1 (13%)
Hair Follicle, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (4)
Fibrosis 1 (25%)
Fibrous Osteodystrophy 1 (2%) 6 (12%) 8 (16%) 3 (75%)
Hyperostosis 3 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (2)
Hydrocephalus 6 (12%) 2 (4%) 1 (2%)
Necrosis, Focal 1 (2%)
Hypothalamus, Degeneration 1 (2%)
Medulla, Gliosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (3)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%) 2 (4%) 3 (6%)
Metaplasia, Squamous 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Interstitium, Inflammation, Acute 1 (2%)
Interstitium, Inflammation, Chronic 2 (4%) 3 (6%)
Interstitium, Inflammation, Chronic, Focal 1 (2%)
Interstitium, Mineralization 1 (2%) 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Vein, Thrombosis 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Suppurative 13 (26%) 14 (28%) 9 (18%) 7 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (3) (2) (1) (2)
Cataract 1 (33%)
Inflammation, Suppurative 1 (100%)
Anterior Chamber, Inflammation, Acute 1 (33%) 1 (50%)
Anterior Chamber, Inflammation, Suppurative 1 (50%)
Lens, Cataract 2 (100%) 1 (33%) 1 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50) (42)
Amyloid Deposition 1 (2%)
Fibrosis, Focal 1 (2%)
Infarct 1 (2%)
Nephropathy 49 (98%) 44 (88%) 49 (98%) 50 (100%) 42 (100%)
Renal Tubule, Cyst 1 (2%) 1 (2%) 6 (12%) 8 (16%) 3 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05212-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXAZEPAM Date: 07/19/96
Route: DOSED FEED Time: 15:50:37
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 625 PPM 2500 PPM 5000 PPM 10,000
PPM STOP
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Hyperplasia 1 (2%) 3 (6%) 1 (2%)
Renal Tubule, Pigmentation, Lipofuscin 1 (2%)
Urinary Bladder (50) (50) (50) (50) (1)
Hemorrhage 1 (2%)
Ulcer 1 (100%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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