TDMS Study 05214-01 Pathology Tables
NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 66 WEEK SCHEDULED SACRIFICE Facility: TSI Mason Research Chemical CAS #: 1972-08-3 Lock Date: 06/17/92 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 03/14/90 - 03/16/90 Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| | | | 8| 7| 7| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| | A | 0 | 0| 2| 2| 3| 4| | L | MG/KG | 3| 0| 5| 1| 3| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 5 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | Pars Distalis, Adenoma | X X | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 5 | __________________________________________________________________________|____________| Ovary | + + + + + | 5 | __________________________________________________________________________|____________| Uterus | + + + + + | 5 | Polyp Stromal | X | 1 | __________________________________________________________________________|____________| Vagina | + + + + + | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| | | | 8| 7| 7| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| | A | 0 | 0| 2| 2| 3| 4| | L | MG/KG | 3| 0| 5| 1| 3| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + | 5 | __________________________________________________________________________|____________| Spinal Cord | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| | | | 6| 8| 6| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| | A | 12.5 | 6| 7| 8| 8| 0| | L | MG/KG | 4| 8| 4| 8| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | __________________________________________________________________________|____________| Mesentery | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 5 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | Pars Distalis, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 5 | __________________________________________________________________________|____________| Ovary | + + + + + | 5 | __________________________________________________________________________|____________| Uterus | + + + + + | 5 | __________________________________________________________________________|____________| Vagina | + + + + + | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| | | | 6| 8| 6| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 4| | A | 12.5 | 6| 7| 8| 8| 0| | L | MG/KG | 4| 8| 4| 8| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + | 5 | __________________________________________________________________________|____________| Spinal Cord | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| | | | 6| 6| 7| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| | A | 25 | 2| 3| 4| 6| 7| | L | MG/KG | 0| 3| 1| 7| 2| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + | 5 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 5 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | Pars Distalis, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 5 | __________________________________________________________________________|____________| Ovary | + + + + + | 5 | __________________________________________________________________________|____________| Uterus | + + + + + | 5 | Polyp Stromal | X | 1 | __________________________________________________________________________|____________| Vagina | + + + + + | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node | + + + | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| | | | 6| 6| 7| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| | A | 25 | 2| 3| 4| 6| 7| | L | MG/KG | 0| 3| 1| 7| 2| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + | 5 | __________________________________________________________________________|____________| Spinal Cord | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| | | | 6| 8| 6| 8| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 5| 5| 5| | A | 50 | 7| 8| 9| 0| 1| 2| | L | MG/KG | 6| 7| 2| 8| 3| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + | 6 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + | 6 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + | 6 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + | 6 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + | 6 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + | 6 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + | 6 | __________________________________________________________________________|____________| Liver | + + + + + + | 6 | __________________________________________________________________________|____________| Pancreas | + + + + + + | 6 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 6 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + | 6 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + | 6 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + | 6 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + | 6 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + | 6 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + | 6 | __________________________________________________________________________|____________| Ovary | + + + + + + | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + | 6 | __________________________________________________________________________|____________| Vagina | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + | 6 | __________________________________________________________________________|____________| Thymus | + + + + + + | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05214-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/19/97 Route: GAVAGE Time: 19:52:25 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| | | | 6| 8| 6| 8| 7| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 5| 5| 5| | A | 50 | 7| 8| 9| 0| 1| 2| | L | MG/KG | 6| 7| 2| 8| 3| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + | 6 | __________________________________________________________________________|____________| Skin | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + | 6 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + | 6 | __________________________________________________________________________|____________| Peripheral Nerve | + + + + + + | 6 | __________________________________________________________________________|____________| Spinal Cord | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + | 6 | __________________________________________________________________________|____________| Nose | + + + + + + | 6 | __________________________________________________________________________|____________| Trachea | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + | 6 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------