TDMS Study 05214-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason TRANS-DELTA-9-TETRAHYDROCANNABINOL DATE: 05/20/95
EXPERIMENT: 05214 TEST: 02 TIME: 13:11:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85212 ROUTE: GAVAGE NTP C#: 56371B
PATHOLOGIST: F. VOELKER M. GOAD CAS: 1972-08-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason TRANS-DELTA-9-TETRAHYDROCANNABINOL DATE: 05/20/95
EXPERIMENT: 05214 TEST: 02 TIME: 13:11:29
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85212 ROUTE: GAVAGE NTP C#: 56371B
PATHOLOGIST: F. VOELKER M. GOAD CAS: 1972-08-3
TRANS-DELTA-9-TETRAHYDROCANNABINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| ---------------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 12 CENSORED DEATHS 18 TERMINAL 50 |
| |
| UNCENSORED DEATHS |
| 146 538 554 585 591 672 672 678 678 705 |
| 707 723 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 461 461 461 461 |
| 463 463 463 463 463 463 463 463 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 53 |
| |
| UNCENSORED DEATHS |
| 563 566 591 598 638 709 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 MG/KG |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 14 CENSORED DEATHS 11 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 28 94 225 395 405 486 493 508 563 574 |
| 611 670 716 728 |
| CENSORED DEATHS |
| 246 450 461 461 461 461 461 461 461 461 |
| 461 |
| |
==================================================================================
TRANS-DELTA-9-TETRAHYDROCANNABINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 500 MG/KG |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 25 CENSORED DEATHS 11 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 6 85 86 191 206 251 256 267 275 418 |
| 444 454 454 456 468 503 554 561 563 587 |
| 599 600 611 625 629 |
| CENSORED DEATHS |
| 90 461 461 461 461 461 461 461 461 461 |
| 461 |
| |
==================================================================================
TRANS-DELTA-9-TETRAHYDROCANNABINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 98.8 98.8 98.8 98.8 98.8 97.1 92.3 92.3 80.9 |
|MG/KG | |
| | |
|125 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 91.7 88.3 |
|MG/KG | |
| | |
|250 | 98.6 97.1 95.7 95.7 92.8 92.8 87.7 84.2 82.5 77.3 |
|MG/KG | |
| | |
|500 | 95.7 95.7 88.5 87.0 85.6 78.0 76.2 65.6 60.3 60.3 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 125 250 500 |
| MG/KG MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.9% 88.3% 77.3% 60.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.363N P=0.561 P=0.002 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.1 627.1 464.0 406.0 |
|NATURAL DEATHS (C) | (45.4) (25.1) (58.1) (38.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 650.8 718.0 631.3 566.7 |
|(STANDARD ERROR) | (14.1) ( 5.1) (19.8) (23.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRANS-DELTA-9-TETRAHYDROCANNABINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 0 TERMINAL 47 |
| |
| UNCENSORED DEATHS |
| 30 337 456 518 623 659 677 677 686 695 |
| 706 710 732 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 125 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 50 |
| |
| UNCENSORED DEATHS |
| 247 392 590 661 681 694 699 701 706 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 250 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 5 255 260 308 374 535 543 548 632 644 |
| 651 670 674 694 709 732 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
TRANS-DELTA-9-TETRAHYDROCANNABINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 500 MG/KG |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 2 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 5 127 145 174 198 215 313 398 495 567 |
| 642 672 682 701 722 727 727 |
| CENSORED DEATHS |
| 84 210 |
| |
==================================================================================
TRANS-DELTA-9-TETRAHYDROCANNABINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 98.3 98.3 98.3 96.7 96.7 95.0 93.3 93.3 90.0 78.3 |
|MG/KG | |
| | |
|125 | 100.0 100.0 98.3 98.3 96.7 96.7 96.7 95.0 93.3 83.3 |
|MG/KG | |
| | |
|250 | 98.3 98.3 95.0 93.3 91.7 91.7 88.3 86.7 81.7 73.3 |
|MG/KG | |
| | |
|500 | 98.3 93.2 89.8 88.1 86.4 86.4 84.6 82.9 81.2 70.8 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 125 250 500 |
| MG/KG MG/KG MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.3% 83.3% 73.3% 70.8% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.162 P=0.610N P=0.583 P=0.392 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 577.4 608.5 514.6 441.8 |
|NATURAL DEATHS (C) | (55.9) (50.6) (52.9) (62.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 702.4 715.6 677.7 633.7 |
|(STANDARD ERROR) | (14.5) (10.2) (18.8) (27.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
TRANS-DELTA-9-TETRAHYDROCANNABINOL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
125 MG/KG = 2
250 MG/KG = 3
500 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 14 3 1 2
| 4 3 43 1 1
| 3 3 1 1
| 4 4 3 3 2 2
95 + 1 1 22
| 4 4 33 1 12 2
| 4 4 3 3 1 1
| 44 33 2 2
P 90 + 4 4 3 3 2 2
E | 44 11 2 2
R | 4 4 3 3
C | 33 1 1
E 85 + 4 4
N | 4 4 3 3
T | 3 3 1 1
| 44 3 31 1
S 80 + 44
U | 33
R | 4 4 3 3
V | 4 4
I 75 + 44
V |
A |
L | 4 4
70 +
| 4 4
|
|
65 + 4 4
| 4 4
|
|
60 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.
TRANS-DELTA-9-TETRAHYDROCANNABINOL
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
125 MG/KG = 2
250 MG/KG = 3
500 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 13 1 2
| 3 1 4 23 1 2
|
| 4 4 33 1 2 1 2
P 95 + 4 4 3 3 1 1 2 2
E | 4 4 3 3 1 1 2 2
R |
C | 4 4 3 3 1 1 2 2
E 90 + 4 4 33 1 1
N | 33 22
T | 4 4
| 4 4 3 3 11
S 85 + 4 4 33 1 122
U | 33 112 2
R | 4 4
V | 43 3 11
I 80 + 334 1 1
V | 3 3 11
A | 4 4
L | 343 4
75 + 3 3
| 33
|
| 4 4
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.