https://ntp.niehs.nih.gov/go/4715

TDMS Study 05214-01 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL
NTP Experiment-Test: 05214-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: GAVAGE                                                                                                     Time: 12:11:43
       Facility:  TSI Mason Research
       Chemical CAS #:  1972-08-3
       Lock Date:  06/17/92
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                             Page   1
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                  9            9            9           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18            9            9           10                                     
    Natural Death                                      8            2            6            5                                     
    Dosing Accident                                    2                         3            1                                     
    Accidently Killed                                                                         2                                     
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                        1                                     
    Natural Death                                                   1                         1                                     
    Terminal Sacrifice                                23           39           33           30                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (54)         (59)         (58)         (57)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Adenoma                                                     3 (5%)                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (6)          (5)          (2)          (1)                                    
   Oral Mucosa                                        (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
   Pancreas                                           (60)         (60)         (60)         (59)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Carcinoma                                        1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (60)         (60)         (58)                                   
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant                                    1 (2%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          2 (3%)       2 (3%)       2 (3%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (59)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Adenoma                          26 (43%)     28 (47%)     32 (53%)     19 (32%)                               
      Pars Distalis, Carcinoma                                                                1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      C-Cell, Adenoma                                  3 (5%)                    2 (3%)       1 (2%)                                
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (57)         (55)         (60)         (59)                                   
      Adenoma                                          3 (5%)       4 (7%)       2 (3%)       3 (5%)                                
      Bilateral, Adenoma                               1 (2%)                                 2 (3%)                                
   Ovary                                              (60)         (59)         (59)         (60)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Uterus                                             (60)         (60)         (59)         (60)                                   
      Polyp Stromal                                    9 (15%)      4 (7%)       3 (5%)       3 (5%)                                
      Polyp Stromal, Multiple                                       1 (2%)                                                          
      Sarcoma Stromal                                  1 (2%)                                                                       
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (6)          (6)          (10)         (7)                                    
      Mediastinal, Histiocytic Sarcoma                 1 (17%)                                                                      
   Lymph Node, Mandibular                             (60)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Salivary Glands           1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (55)         (56)         (59)         (57)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (60)         (58)         (59)         (56)                                   
      Adenocarcinoma                                   1 (2%)       1 (2%)                                                          
      Adenoma                                                       1 (2%)                                                          
      Adenoma, Multiple                                             1 (2%)                                                          
      Fibroadenoma                                    16 (27%)      8 (14%)     10 (17%)      6 (11%)                               
      Fibroadenoma, Multiple                                        3 (5%)       1 (2%)       2 (4%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                               1 (2%)                                                                       
      Keratoacanthoma                                               1 (2%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Histiocytic Sarcoma         1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                    (60)         (60)         (59)         (60)                                   
      Rhabdomyosarcoma                                              1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                            1 (2%)                                 1 (2%)                                
      Carcinoma, Metastatic, Pituitary Gland                                                  1 (2%)                                
      Meningioma Malignant                                          1 (2%)                                                          
      Oligodendroglioma NOS                            1 (2%)                                                                       
   Spinal Cord                                        (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Salivary Glands           1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Alveolar Epithelium, Alveolar/Bronchiolar                                                                                     
          Adenoma                                                   1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
   Trachea                                            (60)         (60)         (60)         (60)                                   
      Carcinoma, Metastatic, Salivary Glands           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Urinary Bladder                                    (60)         (60)         (60)         (59)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                             9 (15%)     17 (28%)     20 (33%)     13 (22%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            47          43          45          36                                       
     Total Primary Neoplasms                           85          79          76          55                                       
   Total Animals with Benign Neoplasms                 43          38          37          27                                       
     Total Benign Neoplasms                            65          55          55          40                                       
   Total Animals with Malignant Neoplasms              18          23          20          15                                       
     Total Malignant Neoplasms                         19          24          21          15                                       
   Total Animals with Metastatic Neoplasms              2                                   1                                       
     Total Metastatic Neoplasm                          4                                   1                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          80           60           70           70                                     
  Scheduled Sacrifice                                 10            9            9            9                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19            8           11           10                                     
    Natural Death                                     10            8            6           10                                     
    Dosing Accident                                    1                         2                                                  
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Natural Death                                                                             1                                     
    Terminal Sacrifice                                22           35           33           30                                     
  Special Study                                       18                         9            9                                     
  Animals Examined Microscopically                    62           60           61           61                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (62)         (58)         (59)         (58)                                   
      Carcinoma                                                                               1 (2%)                                
   Intestine Large, Cecum                             (55)         (57)         (59)         (56)                                   
   Intestine Small, Duodenum                          (61)         (59)         (60)         (58)                                   
      Sarcoma                                                                                 1 (2%)                                
   Intestine Small, Ileum                             (58)         (58)         (60)         (55)                                   
   Liver                                              (62)         (60)         (61)         (61)                                   
      Cholangioma                                      1 (2%)                                                                       
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Hepatocellular Carcinoma                         2 (3%)                                                                       
      Hepatocellular Adenoma                           3 (5%)       1 (2%)       1 (2%)       2 (3%)                                
   Mesentery                                          (6)          (5)          (3)          (4)                                    
      Sarcoma                                                                    1 (33%)                                            
   Pancreas                                           (62)         (60)         (61)         (61)                                   
      Mixed Tumor Benign                               1 (2%)                                                                       
      Acinus, Adenoma                                  7 (11%)                   2 (3%)                                             
      Acinus, Adenoma, Multiple                        1 (2%)                                                                       
   Salivary Glands                                    (62)         (60)         (61)         (61)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (62)         (59)         (61)         (61)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                    1 (2%)                                
   Stomach, Glandular                                 (62)         (60)         (61)         (58)                                   
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (62)         (60)         (61)         (61)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (62)         (60)         (61)         (61)                                   
      Adenoma                                                                                 1 (2%)                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
   Adrenal Medulla                                    (62)         (60)         (61)         (61)                                   
      Pheochromocytoma Malignant                       1 (2%)       3 (5%)                    1 (2%)                                
      Pheochromocytoma Benign                          9 (15%)      6 (10%)      4 (7%)       6 (10%)                               
   Islets, Pancreatic                                 (62)         (60)         (61)         (61)                                   
      Adenoma                                          5 (8%)       3 (5%)       4 (7%)       3 (5%)                                
   Parathyroid Gland                                  (58)         (55)         (53)         (56)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (62)         (60)         (60)         (61)                                   
      Pars Distalis, Adenoma                          22 (35%)     21 (35%)     16 (27%)      9 (15%)                               
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (62)         (59)         (60)         (59)                                   
      C-Cell, Adenoma                                  3 (5%)       7 (12%)      2 (3%)       4 (7%)                                
      Follicular Cell, Adenoma                         1 (2%)                    1 (2%)       2 (3%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (62)         (60)         (61)         (61)                                   
   Preputial Gland                                    (62)         (60)         (61)         (59)                                   
      Adenoma                                          2 (3%)       2 (3%)       1 (2%)                                             
      Bilateral, Adenoma                                                                      1 (2%)                                
   Prostate                                           (62)         (60)         (61)         (61)                                   
   Seminal Vesicle                                    (62)         (60)         (61)         (61)                                   
   Testes                                             (62)         (60)         (61)         (61)                                   
      Bilateral, Interstitial Cell, Adenoma           48 (77%)     27 (45%)     29 (48%)     21 (34%)                               
      Interstitial Cell, Adenoma                       7 (11%)     14 (23%)      7 (11%)     22 (36%)                               
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (62)         (60)         (61)         (61)                                   
   Lymph Node                                         (14)         (5)          (5)          (3)                                    
   Lymph Node, Mandibular                             (62)         (59)         (61)         (61)                                   
   Lymph Node, Mesenteric                             (62)         (60)         (61)         (61)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
   Spleen                                             (62)         (60)         (61)         (60)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (59)         (57)         (55)         (57)                                   
      Thymoma Benign                                                1 (2%)                                                          
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (43)         (52)         (52)         (46)                                   
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Fibroadenoma                                     3 (7%)                                                                       
   Skin                                               (62)         (60)         (61)         (61)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Keratoacanthoma                                  3 (5%)       1 (2%)       3 (5%)       1 (2%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Trichoepithelioma                                                                       1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                                               1 (2%)                                
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (62)         (60)         (61)         (61)                                   
      Osteosarcoma                                                                            1 (2%)                                
   Skeletal Muscle                                    (62)         (60)         (60)         (61)                                   
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (62)         (59)         (61)         (61)                                   
      Astrocytoma Malignant                                         1 (2%)       1 (2%)                                             
      Reticulosis Malignant                                                      1 (2%)                                             
      Cranial Nerve, Schwannoma Malignant                                        1 (2%)                                             
   Spinal Cord                                        (62)         (59)         (58)         (59)                                   
      Glioma NOS                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   9                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (62)         (60)         (61)         (61)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)                                                          
      Fibrous Histiocytoma                                                                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                                          1 (2%)                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
   Nose                                               (62)         (60)         (61)         (61)                                   
      Squamous Cell Carcinoma                          1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Zymbal's Gland                                     (1)                                    (2)                                    
      Carcinoma                                        1 (100%)                               1 (50%)                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (62)         (60)         (61)         (61)                                   
      Thymoma Malignant, Metastatic, Thymus                                      1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (61)         (60)         (61)         (61)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(62)        *(60)        *(61)        *(61)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            14 (23%)      9 (15%)     10 (16%)      8 (13%)                               
      Mesothelioma Malignant                           2 (3%)       2 (3%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05214-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 TRANS-DELTA-9-TETRAHYDROCANNABINOL                            Date: 05/20/95  
Route: GAVAGE                                                                                                     Time: 12:11:43  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0            12.5         25           50                                        
                                                   MG/KG        MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            61          53          52          48                                       
     Total Primary Neoplasms                          145         105          90          96                                       
   Total Animals with Benign Neoplasms                 60          50          49          48                                       
     Total Benign Neoplasms                           118          88          70          76                                       
   Total Animals with Malignant Neoplasms              22          17          17          14                                       
     Total Malignant Neoplasms                         27          17          19          20                                       
   Total Animals with Metastatic Neoplasms              1           1           1           1                                       
     Total Metastatic Neoplasm                          1           2           5           1                                       
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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