TDMS Study 05214-01 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
TRANS-DELTA-9-TETRAHYDROCANNABINOL
NTP Experiment-Test: 05214-01 Report: PEIRPT09
Study Type: CHRONIC Date: 03/18/94
Route: GAVAGE Time: 18:28:14
2 YEAR CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 1972-08-3
Lock Date: 06/17/92
Cage Range: All
Reasons For Removal: 25008 Accident 25022 Accidently Killed
25018 Dosing Accident 25003 Moribund
25019 Moribund Sacrifice 25020 Natural Death
25006 Terminal Sacrifice 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 004 12.5 MG/KG
Include 006 25 MG/KG
Include 008 50 MG/KG
Include 001 0 MG/KG
Include 003 12.5 MG/KG
Include 005 25 MG/KG
Include 007 50 MG/KG
Page 1
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|
| 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/KG | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + A + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X |
Cyst | |
Eosinophilic Focus | X X |
Fatty Change | 2 3 2 |
Hepatodiaphragmatic Nodule | X X X X X X|
Hyperplasia | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 2 |
Mixed Cell Focus | X X X|
Necrosis | 1 |
Pigmentation | 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
Fat, Pigmentation | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 1 2 2 1 2 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Duct, Metaplasia, Squamous | 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Hyperplasia, Basal Cell | 2 2 2 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperplasia | 1 |
__________________________________________________________________________|
Tooth | |
Foreign Body | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|
| 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/KG | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 1 2 2 1 2 1 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hyperplasia | 3 3 3 2 3 |
Pars Intermedia, Atypia Cellular | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + M + + + + + + + + + + +|
Abscess | |
Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 1 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|
| 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/KG | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + M M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Edema | 2 |
Foreign Body | 1 1 2 2 1 1 1 1 1 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
Pleura, Bacterium | |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Foreign Body | |
Fungus | 2 |
Inflammation, Acute | 3 1 2 2 1 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 5| 5| 7| 7| 6| 5| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7|
DAY ON TEST | 3| 2| 9| 3| 3| 3| 6| 4| 3| 3| 3| 3| 3| 3| 7| 9| 3| 3| 1| 2| 4| 7| 3| 3| 3|
| 7| 4| 0| 4| 6| 6| 1| 6| 8| 2| 6| 6| 6| 6| 6| 0| 6| 6| 6| 4| 7| 6| 2| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/KG | 6| 7| 8| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 3 2 |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 1|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|
| 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Rectum | A + + A + + + + + + + + + + + + + + + A + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Cecum | A + + A + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + + + + + + + A + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X |
Cyst | X |
Eosinophilic Focus | X |
Fatty Change | 2 3 2 2 |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 2 |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Mixed Cell Focus | |
Necrosis | 2 |
Pigmentation | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 2 3 |
Fat, Pigmentation | 2 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 3 2 1 1 1 1 1 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 1 |
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | 1 3 |
Inflammation, Acute | |
Inflammation, Chronic | |
Ulcer | 3 1 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Foreign Body | 4 |
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|
| 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 2 1 2 2 1 1 2 2 2 2 2 1 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Focal Cellular Change | 2 1 |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 2|
Pars Distalis, Cyst | X X X X X X X X X |
Pars Distalis, Hyperplasia | 4 2 3 3 3 1 2 3 2 2 2 2 3|
Pars Intermedia, Atypia Cellular | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Abscess | 3 |
Dilatation | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 |
__________________________________________________________________________|
Vagina | M M M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 3 |
Ectasia | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|
| 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 1 |
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 |
Necrosis | 4 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 |
Cyst Epithelial Inclusion | X |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hyperostosis | X |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | 1 1 |
Foreign Body | 1 1 1 1 1 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | 2 1 1 2 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 3 |
Pleura, Bacterium | 2 |
Pleura, Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Foreign Body | 1 |
Fungus | |
Inflammation, Acute | 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 6| 7| 7| 7| 7| 7| 3| 3| 6| 7| 7| 4| 7| 6| 7| 6| 6| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 7| 6| 9| 3| 3| 3| 3| 4| 3| 2| 2| 3| 3| 2| 3|
| 5| 6| 6| 5| 1| 6| 6| 6| 6| 6| 4| 5| 4| 6| 6| 5| 6| 5| 6| 0| 6| 3| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 3| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 2 1 2 1 1 1 1 1 1 2 1 1 1 1 1|
Cortex, Mineralization | 1 1 1 1 1 1 1 |
Renal Tubule, Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0 | 5| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 49 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 46 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 45 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Basophilic Focus | X | 43 |
Clear Cell Focus | | 16 |
Cyst | | 1 |
Eosinophilic Focus | | 3 |
Fatty Change | | 7 2.3|
Hepatodiaphragmatic Nodule | X | 11 |
Hyperplasia | | 2 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
Mixed Cell Focus | | 3 |
Necrosis | | 2 1.5|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Fat, Necrosis | | 5 2.6|
Fat, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Acinus, Atrophy | 2 | 24 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Degeneration | | 1 1.0|
Duct, Metaplasia, Squamous | | 4 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Hyperkeratosis | | 2 2.0|
Hyperplasia, Basal Cell | | 5 2.0|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Erosion | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0 | 5| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Foreign Body | | 1 4.0|
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | 2 | 39 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Angiectasis | | 1 2.0|
Focal Cellular Change | | 2 1.5|
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hemorrhage | | 1 3.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Pars Distalis, Angiectasis | | 3 2.0|
Pars Distalis, Cyst | | 18 |
Pars Distalis, Hyperplasia | 2 | 19 2.5|
Pars Intermedia, Atypia Cellular | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Hyperplasia | 2 | 17 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 48 |
Abscess | | 1 3.0|
Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + | 51 |
Cyst | | 6 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Dilatation | | 4 1.8|
__________________________________________________________________________|____________|
Vagina | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0 | 5| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Mediastinal, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 50 |
Angiectasis | | 1 3.0|
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Depletion Lymphoid | | 1 1.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Necrosis | | 1 4.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Acanthosis | | 1 1.0|
Cyst Epithelial Inclusion | | 2 |
Hyperkeratosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Developmental Malformation | | 1 |
Hyperostosis | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 51 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 51 |
__________________________________________________________________________|____________|
Spinal Cord | + | 51 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| | |
DAY ON TEST | 2| | |
| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 3| | A |
0 | 5| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | | 3 1.3|
Foreign Body | | 15 1.1|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 4 1.0|
Inflammation, Chronic Active | | 25 1.1|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Pleura, Bacterium | | 1 2.0|
Pleura, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Bacterium | | 2 1.5|
Foreign Body | | 1 1.0|
Fungus | | 1 2.0|
Inflammation, Acute | 1 | 13 1.7|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 2 2.5|
Retina, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Nephropathy | 1 | 38 1.2|
Cortex, Mineralization | 1 | 16 1.0|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|
| 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12.5 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Dilatation | 2 |
Mineralization | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X|
Congestion | |
Cyst | |
Developmental Malformation | |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 2 2|
Mixed Cell Focus | X X |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 2 |
Acinus, Atrophy | 1 1 1 1 2 1 1 2|
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia, Basal Cell | 1 |
Hyperplasia, Focal, Squamous | |
Inflammation, Acute | |
Ulcer | 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 1 1 1 1 2 1 1 2 2 1 1 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|
| 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12.5 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | X X X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 2 1 2 3 2 4 2 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
C-Cell, Hyperplasia | 1 3 1 2 1 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Granuloma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + M + + + M + + + +|
Cyst | |
Hyperplasia | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|
| 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12.5 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Neuron, Necrosis | |
Hippocampus, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Foreign Body | 1 1 1 1 1 1 |
Hemorrhage | 1 |
Inflammation, Chronic Active | 2 2 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1 1 2 2 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | |
Lens, Cataract | 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3 1|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| 5| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 0| 3| 3| 8| 3| 5| 5| 6| 3| 2| 3| 9| 3| 3|
| 7| 7| 1| 7| 1| 6| 7| 1| 4| 1| 7| 1| 7| 6| 4| 7| 9| 8| 5| 6| 8| 1| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12.5 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8|
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|
| 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
MG/KG | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Mineralization | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X |
Congestion | 2 2 |
Cyst | X |
Developmental Malformation | X |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X X X X X X X |
Hyperplasia | 3 2 2 3 |
Mixed Cell Focus | X X X |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
Acinus, Atrophy | 1 1 1 1 2 1 2 1 1 1 1 1 1 2|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 1 |
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Basal Cell | 2 2 |
Hyperplasia, Focal, Squamous | 2 |
Inflammation, Acute | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|
| 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
MG/KG | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 1 |
Pars Distalis, Cyst | X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 3 1 2 3 2 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 2 1 2 1 1 1 2 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Granuloma | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + M + + + + + + + + + + +|
Cyst | X X |
Hyperplasia | 2 3 |
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cyst | X X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 |
__________________________________________________________________________|
Vagina | M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 |
__________________________________________________________________________|
Lymph Node | + |
Mediastinal, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|
| 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
MG/KG | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Neuron, Necrosis | 2 |
Hippocampus, Neuron, Necrosis | 4 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Foreign Body | 1 2 1 1 1 2 1 |
Hemorrhage | 3 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 2 1 2 2 1 1 1 1 1 1 2 2 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Phthisis Bulbi | 4 |
Lens, Cataract | 3 |
Retina, Atrophy | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 2 2 2 1 1 1 3 1 1 1 1 2 1 2 1 1 1|
Cortex, Mineralization | 1 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 1| 2| 2| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 2| 2| 3| 3| 5|
| 5| 1| 1| 1| 9| 5| 6| 1| 7| 7| 7| 7| 1| 7| 1| 6| 6| 1| 1| 1| 6| 5| 1| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
MG/KG | 3| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
12.5 | 1| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 50 |
Dilatation | | 1 2.0|
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 50 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 44 |
Clear Cell Focus | X | 21 |
Congestion | | 2 2.0|
Cyst | | 1 |
Developmental Malformation | | 1 |
Eosinophilic Focus | | 6 |
Hepatodiaphragmatic Nodule | | 12 |
Hyperplasia | | 6 2.3|
Mixed Cell Focus | | 5 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Metaplasia | | 1 2.0|
Acinus, Atrophy | | 22 1.2|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Focal Cellular Change | | 3 1.0|
Duct, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Dilatation | | 1 2.0|
Hyperplasia, Basal Cell | | 3 1.7|
Hyperplasia, Focal, Squamous | | 1 2.0|
Inflammation, Acute | | 1 2.0|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Erosion | | 1 2.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
12.5 | 1| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | 2 | 41 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Focal Cellular Change | | 1 1.0|
Hyperplasia | | 5 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Pars Distalis, Angiectasis | | 5 1.6|
Pars Distalis, Cyst | | 25 |
Pars Distalis, Hyperplasia | 2 | 15 2.2|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Cyst | | 1 |
C-Cell, Hyperplasia | | 19 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Mediastinum, Granuloma | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 46 |
Cyst | | 2 |
Hyperplasia | | 3 2.3|
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + | 50 |
Cyst | | 10 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Dilatation | | 3 2.7|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
12.5 | 1| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Myelofibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Mediastinal, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 51 |
Infiltration Cellular, Plasma Cell | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | M | 47 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 49 |
Galactocele | | 4 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Erosion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 51 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Cerebrum, Neuron, Necrosis | | 1 2.0|
Hippocampus, Neuron, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 51 |
__________________________________________________________________________|____________|
Spinal Cord | + | 51 |
Inflammation, Acute | | 1 1.0|
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Edema | | 1 2.0|
Foreign Body | | 13 1.2|
Hemorrhage | | 3 1.7|
Inflammation, Chronic Active | 1 | 48 1.3|
__________________________________________________________________________|____________|
Nose | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
12.5 | 1| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | | 1 2.0|
Inflammation, Acute | | 5 1.6|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Phthisis Bulbi | | 1 4.0|
Lens, Cataract | | 2 2.5|
Retina, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Nephropathy | | 37 1.3|
Cortex, Mineralization | | 11 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|
| 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Ulcer | 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X |
Eosinophilic Focus | X |
Fatty Change | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Hyperplasia | 3 2 3 |
Mixed Cell Focus | X |
Serosa, Fibrosis | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Ectopic Tissue | |
Inflammation, Chronic | |
Acinus, Atrophy | 2 1 1 1 1 4 1 1 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | 1 |
Hyperkeratosis | 1 |
Hyperplasia, Basal Cell | 1 2 2 3 3 |
Inflammation, Acute | 2 |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Perforation | X |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Ulcer | 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|
| 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 1 1 2 2 2 2 2 2 1 2 1 2 1 1 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 3 2 3 |
Pars Distalis, Cyst | X X X X X X X X X X X X X|
Pars Distalis, Hyperplasia | 2 1 3 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hemorrhage | 4 |
Hyperplasia, Glandular | |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Vagina | M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|
| 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
Pigmentation | 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Thyroid | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X X |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Chronic | |
Inflammation, Chronic Active | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Foreign Body | 1 1 1 2 1 1 1 1 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic Active | 1 2 2 2 2 2 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 |
Mediastinum, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Foreign Body | 1 1 2 1 |
Fungus | X |
Inflammation, Acute | 2 1 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 7| 6| 5| 7| 7| 6| 7| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 2| 2| 4| 3| 0| 9| 3| 3| 1| 4| 6| 3| 5| 6| 3| 3| 9| 3| 3|
| 8| 1| 7| 7| 1| 1| 6| 1| 4| 1| 9| 6| 1| 1| 5| 7| 1| 1| 6| 2| 6| 1| 4| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/KG | 6| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + |
Phthisis Bulbi | 4 |
Synechia | 2 |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1|
Pigmentation | |
Cortex, Mineralization | 1 1 1 1 1 1 1 1 |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|
| 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + A + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X|
Eosinophilic Focus | X X X |
Fatty Change | 2 |
Hematopoietic Cell Proliferation | 3 |
Hepatodiaphragmatic Nodule | X X X X X X X |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia | 2 2 2|
Mixed Cell Focus | |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Tissue | X X |
Inflammation, Chronic | 1 |
Acinus, Atrophy | 1 1 2 1 3 1 1 2 1 1 1|
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Hyperkeratosis | 2 |
Hyperplasia, Basal Cell | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 1 |
Inflammation, Chronic Active | |
Perforation | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|
| 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 2 2 2 1 1 1 1 1 2 1 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | X X X X X X X X X X |
Pars Distalis, Hyperplasia | 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + |
Dilatation | 2 2 3 |
Hemorrhage | |
Hyperplasia, Glandular | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Vagina | M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Pancreatic, Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|
| 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | 3 |
Pigmentation | |
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
Ectopic Thyroid | X |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 1 |
Foreign Body | 1 1 1 2 1 1 1 1 1 1 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Chronic Active | 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1|
Mediastinum, Inflammation, Acute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Foreign Body | 1 |
Fungus | |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 7| 7| 1| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 5| 3| 2| 2| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 2| 3| 2| 3| 2| 3|
| 3| 7| 0| 7| 6| 5| 6| 5| 1| 6| 9| 1| 7| 1| 7| 5| 1| 7| 5| 6| 7| 6| 1| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
25 | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/KG | 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 3| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
Synechia | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 3 1 1 1 1|
Pigmentation | 2 |
Cortex, Mineralization | 1 1 1 1 1 1 1|
Renal Tubule, Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
25 | 7| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
Hemorrhage | | 1 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 48 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 1 1.0|
Basophilic Focus | X | 42 |
Clear Cell Focus | X | 20 |
Eosinophilic Focus | | 4 |
Fatty Change | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hepatodiaphragmatic Nodule | | 9 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Hyperplasia | 2 | 7 2.3|
Mixed Cell Focus | | 1 |
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Cyst | | 1 |
Ectopic Tissue | | 2 |
Inflammation, Chronic | | 1 1.0|
Acinus, Atrophy | | 21 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + | 50 |
Focal Cellular Change | | 4 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Edema | | 1 2.0|
Hemorrhage | | 1 1.0|
Hyperkeratosis | | 2 1.5|
Hyperplasia, Basal Cell | | 6 2.2|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Inflammation, Chronic Active | | 1 4.0|
Perforation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
25 | 7| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Erosion | | 1 1.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Cardiomyopathy | 1 | 42 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Clear Cell Focus | | 3 |
Hyperplasia | 1 | 4 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 48 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Pars Distalis, Angiectasis | 2 | 7 2.3|
Pars Distalis, Cyst | | 23 |
Pars Distalis, Hyperplasia | | 9 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
C-Cell, Hyperplasia | 1 | 13 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
Cyst | | 5 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + | 50 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + | 50 |
Dilatation | 2 | 5 2.2|
Hemorrhage | | 1 4.0|
Hyperplasia, Glandular | | 1 2.0|
Inflammation, Acute | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
25 | 7| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 6 |
Pancreatic, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 50 |
Infiltration Cellular, Plasma Cell | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hyperplasia, Re Cell | | 1 3.0|
Pigmentation | | 1 2.0|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + | 50 |
Ectopic Thyroid | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Galactocele | | 7 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + | 51 |
Cyst Epithelial Inclusion | | 1 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 51 |
__________________________________________________________________________|____________|
Spinal Cord | + | 51 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS FEMALE | 0| | T |
ANIMAL ID | 4| | A |
25 | 7| | L |
MG/KG | 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Edema | | 2 1.5|
Foreign Body | | 19 1.1|
Hemorrhage | | 3 1.7|
Infiltration Cellular, Histiocyte | | 2 2.5|
Inflammation, Chronic Active | 1 | 43 1.3|
Mediastinum, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Bacterium | | 1 1.0|
Foreign Body | | 5 1.2|
Fungus | | 1 |
Inflammation, Acute | | 7 1.3|
__________________________________________________________________________|____________|
Trachea | + | 51 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Phthisis Bulbi | | 1 4.0|
Synechia | | 1 2.0|
Retina, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Nephropathy | 1 | 39 1.2|
Pigmentation | | 1 2.0|
Cortex, Mineralization | 1 | 16 1.0|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|
| 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
50 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X |
Eosinophilic Focus | X X X X X |
Fatty Change, Focal | 2 1 |
Fatty Change | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | 3 3 |
Mixed Cell Focus | X X X |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Fibrosis | 1 |
Fat, Hemorrhage | 3 |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 1 |
Acinus, Atrophy | 2 1 2 2 1 2 3 2 2 1 2|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Inflammation, Acute | 2 |
Duct, Metaplasia, Squamous | 1 1 |
Duct, Mineralization | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Hyperplasia, Cystic | 4 |
Inflammation, Chronic | |
Ulcer | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 1 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 2 2 2 1 1 1 2 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|
| 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
50 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + M + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X X X X|
Pars Distalis, Hyperplasia | 1 2 2 2 2 1 3 2 2 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
C-Cell, Hyperplasia | 1 2 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Vagina | M + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Lumbar, Necrosis | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
Necrosis | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Necrosis | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|
| 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
50 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + M + A + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + M + + + + + + M + +|
Galactocele | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Foreign Body | 1 1 1 1 1 1 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | 2 1 1 2 2 1 2 2 2 1 1 3 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 2 2 2 |
Respiratory Epithelium, Metaplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 0| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 5| 1| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 2| 5| 9| 2| 2| 3| 3| 4|
| 1| 9| 2| 4| 4| 5| 1| 1| 8| 7| 7| 1| 6| 1| 5| 9| 1| 5| 1| 0| 6| 6| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
50 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Nephropathy | 2 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 2 |
Cortex, Mineralization | 1 1 |
Renal Tubule, Hyperplasia | |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
50 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| L |
MG/KG | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Ectopic Tissue | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + A + + + +| 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X | 12 |
Eosinophilic Focus | X X X X | 9 |
Fatty Change, Focal | | 2 1.5|
Fatty Change | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | X X X X | 7 |
Hyperplasia | 2 2 2 | 5 2.4|
Mixed Cell Focus | X X X X | 7 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Fibrosis | | 1 1.0|
Fat, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia | | 1 1.0|
Acinus, Atrophy | 1 3 2 1 1 1 2 1 1 1 2 2 1 1 1| 26 1.6|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Duct, Inflammation, Acute | | 1 2.0|
Duct, Metaplasia, Squamous | 1 | 3 1.0|
Duct, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 2 | 1 2.0|
Hyperplasia, Basal Cell | 3 1 2 | 3 2.0|
Hyperplasia, Cystic | | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Ulcer | 1 | 3 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Erosion | 1 | 4 1.5|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
50 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| L |
MG/KG | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 2 2 2 1 1 1 1 1 1 2 1 1 2 2 1 2 2 2 2| 41 1.6|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + + + + + + + + + + + + M + + + +| 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 1 2 | 3 1.7|
Pars Distalis, Cyst | X X X X X X X X X| 18 |
Pars Distalis, Hyperplasia | 2 3 4 2 2 1 3 3 2 | 20 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
C-Cell, Hyperplasia | 2 1 1 1 1 1 1 | 11 1.3|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | X | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Vagina | M | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Re Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
50 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| L |
MG/KG | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Necrosis | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 1 2.0|
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 46 |
Galactocele | X | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 2 1.5|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 3 2.3|
Foreign Body | 1 2 1 1 1 1| 12 1.1|
Hemorrhage | | 2 2.0|
Infiltration Cellular, Histiocyte | 3 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 0| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 2| 2| 5| 1| 2| 3| 3| 3| 8| 2| 3| 3| 5| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| |
| 7| 2| 6| 9| 9| 6| 8| 1| 1| 1| 8| 5| 6| 1| 6| 1| 7| 1| 1| 1| 9| 6| 1| 7| 7| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
50 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| L |
MG/KG | 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | 3 1 2 2 1 2 1 1 1 1 1 1 1 2 1 1 2 3 1 1 1 2| 42 1.4|
Alveolar Epithelium, Hyperplasia | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | | 1 2.0|
Inflammation, Acute | 1 2 2 1 | 7 1.7|
Respiratory Epithelium, Metaplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Retina, Atrophy | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2| 34 1.2|
Cortex, Mineralization | 1 1 1 1 1 1 1 1 | 10 1.0|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|
| 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + A + + A + + + + + + + + + + + + + + + + A A +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + + A + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X|
Eosinophilic Focus | X X X X |
Fatty Change, Focal | 1 2 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 2 2 1 2 2 3 1|
Acinus, Hyperplasia | 1 3 3 1 3 3 2 1 3|
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | 3 |
Hyperplasia, Diffuse, Squamous | 2 2 2 2 2 2 |
Hyperplasia, Focal, Squamous | |
Ulcer | 2 2 1 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 3 1 1 |
Hyperplasia, Lymphoid | |
Mineralization | 1 1 |
Ulcer | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cardiomyopathy | 3 1 3 2 2 2 2 1 2 2 2 1 2 2 1 2 2 2 3 2 1 2 2 2 1|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|
| 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 2 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 1 1 2 1 2 1 3 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 1 2 1 3 2 2 2 4 1 2 |
Pars Intermedia, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1|
Concretion | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Interstitial Cell, Hyperplasia | 3 2 2 |
Seminiferous Tubule, Atrophy | 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + |
Mediastinal, Angiectasis | |
Mediastinal, Ectasia | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|
| 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M + + M + + M + + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization | 2 |
Hippocampus, Neuron, Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Congestion | |
Edema | 1 |
Foreign Body | 2 1 |
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | 1 1 2 2 2 3 2 1 2 1 2 2 2 2 1 1 1 2|
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | 2 2 2 |
Inflammation, Acute | 2 2 1 2 2 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 5| 4| 6| 5| 7| 6| 5| 7| 7| 7| 6| 7| 6| 7| 7| 5| 7| 6| 7| 7|
DAY ON TEST | 1| 0| 5| 2| 3| 0| 3| 1| 6| 3| 8| 8| 3| 3| 3| 3| 3| 2| 3| 3| 0| 3| 7| 1| 3|
| 6| 0| 9| 1| 1| 0| 8| 6| 6| 1| 3| 5| 1| 1| 1| 7| 1| 7| 1| 1| 5| 1| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4|
MG/KG | 2| 5| 6| 7| 8| 2| 3| 4| 7| 8| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 7| 8| 9| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + +|
Lens, Cataract | 2 2 1 2 2 2 2 2|
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Nephropathy | 2 2 3 3 2 1 2 2 2 3 3 1 2 3 2 2 2 3 2 3 2 3 2 3 3|
Cortex, Mineralization | 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|
| 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
MG/KG | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + A A + + + + + + + + + +|
Dilatation | 2|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + A + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X|
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 2 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 1 2 2 2 1 1 1 2 2 2 |
Acinus, Hyperplasia | 2 2 2 1 2 1 2 2 2 2|
Artery, Inflammation, Chronic Active | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperkeratosis | |
Hyperplasia, Diffuse, Squamous | 2 2 2 2 2 |
Hyperplasia, Focal, Squamous | 3|
Ulcer | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 3 1 1 2 2 |
Hyperplasia, Lymphoid | 2 |
Mineralization | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 3 |
Cardiomyopathy | 3 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 3 2 2 3|
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|
| 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
MG/KG | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 2 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 1 2 1 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 |
Concretion | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Interstitial Cell, Hyperplasia | 1 2 1 1 1 1|
Seminiferous Tubule, Atrophy | 3 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Ectasia | 1|
Mediastinal, Infiltration Cellular, | |
Histiocyte | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|
| 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
MG/KG | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Ectasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M + + + M + M + + M + M + + + + + +|
Galactocele | X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | |
Hippocampus, Neuron, Necrosis | 1 2 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Congestion | 2 |
Edema | |
Foreign Body | 1 1 1 2 1 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | 2 2 3 2 1 2 2 2 1 1 1 1 2 2 1 1 2 2|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 2 2 1 3 2 3 3 |
Inflammation, Acute | 2 3 2 2 1 2 2 2 1 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 5| 5| 5| 4| 7| 6| 6| 7| 7| 7| 7| 7| 5| 6|
DAY ON TEST | 3| 3| 1| 1| 2| 3| 7| 3| 3| 3| 3| 5| 4| 1| 9| 3| 8| 6| 3| 3| 3| 0| 3| 0| 4|
| 1| 1| 7| 7| 4| 1| 8| 1| 1| 1| 1| 6| 0| 6| 9| 1| 3| 2| 1| 1| 1| 9| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
MG/KG | 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 8| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + + |
Lens, Cataract | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Nephropathy | 3 3 2 1 2 3 2 2 3 3 3 2 2 2 1 3 3 2 2 2 2 3 2 2 3|
Cortex, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 1| | |
DAY ON TEST | 1| 1| | |
| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 0| 0| | A |
0 | 7| 7| | L |
MG/KG | 6| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 52 |
Perforation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 45 |
Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 48 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + | 52 |
Basophilic Focus | X | 23 |
Clear Cell Focus | | 25 |
Eosinophilic Focus | | 6 |
Fatty Change, Focal | | 13 1.2|
Hepatodiaphragmatic Nodule | | 3 |
Mixed Cell Focus | | 1 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | 1 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + | 52 |
Acinus, Atrophy | 2 1 | 25 1.6|
Acinus, Hyperplasia | 3 | 20 2.1|
Artery, Inflammation, Chronic Active | | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 52 |
Duct, Metaplasia, Squamous | | 7 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 52 |
Erosion | | 1 1.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia, Diffuse, Squamous | | 11 2.0|
Hyperplasia, Focal, Squamous | | 1 3.0|
Ulcer | | 9 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 52 |
Erosion | | 10 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
Mineralization | | 2 1.0|
Ulcer | | 3 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 1| | |
DAY ON TEST | 1| 1| | |
| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 0| 0| | A |
0 | 7| 7| | L |
MG/KG | 6| 7| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 52 |
Bacterium | | 1 3.0|
Cardiomyopathy | 2 1 | 51 1.9|
Inflammation, Acute | | 1 2.0|
Mineralization | | 2 1.5|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 52 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 52 |
Hyperplasia | | 21 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 52 |
Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | M + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 52 |
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | 2 | 14 1.9|
Pars Intermedia, Cyst | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 52 |
C-Cell, Hyperplasia | | 11 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 52 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 52 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + | 52 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 52 |
Atrophy | | 5 1.2|
Concretion | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + | 52 |
Inflammation | | 2 2.0|
Interstitial Cell, Hyperplasia | | 9 1.6|
Seminiferous Tubule, Atrophy | | 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 1| | |
DAY ON TEST | 1| 1| | |
| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 0| 0| | A |
0 | 7| 7| | L |
MG/KG | 6| 7| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 52 |
__________________________________________________________________________|____________|
Lymph Node | + + | 13 |
Mediastinal, Angiectasis | 1 | 1 1.0|
Mediastinal, Ectasia | | 1 1.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 52 |
Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 52 |
Infiltration Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + | 52 |
Depletion Lymphoid | 1 | 1 1.0|
Fibrosis | | 2 2.5|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + | 51 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 36 |
Galactocele | | 3 |
__________________________________________________________________________|____________|
Skin | + + | 52 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 52 |
Fracture | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 52 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 52 |
Hemorrhage | 1 | 2 1.0|
Mineralization | | 1 2.0|
Hippocampus, Neuron, Necrosis | | 4 1.5|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 51 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 52 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 1| | |
DAY ON TEST | 1| 1| | |
| 5| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 0| 0| | A |
0 | 7| 7| | L |
MG/KG | 6| 7| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 52 |
Bacterium | 2 | 1 2.0|
Congestion | | 1 2.0|
Edema | | 1 1.0|
Foreign Body | 1 | 8 1.3|
Hemorrhage | 3 | 2 2.0|
Infiltration Cellular, Histiocyte | | 2 1.0|
Inflammation, Chronic Active | 2 | 37 1.7|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 52 |
Foreign Body | | 1 1.0|
Fungus | | 11 2.2|
Inflammation, Acute | 1 | 24 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 18 |
Lens, Cataract | | 18 1.9|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 52 |
Cyst | | 6 |
Nephropathy | 2 | 51 2.3|
Cortex, Mineralization | | 4 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Calculus Gross Observation | | 2 |
Calculus Micro Observation Only | | 2 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|
| 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X X X|
Congestion | 2 |
Developmental Malformation | X |
Eosinophilic Focus | X X X X |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 1 1 1 1 1 1 1 1|
Hepatodiaphragmatic Nodule | X X X|
Hyperplasia | |
Mixed Cell Focus | X |
Necrosis | 2 |
Vein, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Acinus, Atrophy | 1 2 1 1 2 2 2 2 2 2 2 2|
Acinus, Hyperplasia | 1 2 2 2 2 |
Artery, Inflammation, Chronic Active | 2 |
Artery, Pigmentation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Diffuse, Squamous | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Erosion | 2 1 2 1 |
Hyperplasia | 1 |
Inflammation, Chronic Active | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|
| 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Cardiomyopathy | 1 2 2 2 3 3 2 2 2 2 2 1 2 2 2 3 2 1 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Hyperplasia | 3 2 2 1 1 2 1 |
Necrosis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hyperplasia | 2 1 2 2 3 2 2 2 1 2 1 |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 2 1 1 2 1 1|
Seminiferous Tubule, Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|
| 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Depletion Lymphoid | 2 |
Necrosis | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + M + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Mineralization | 1 |
Necrosis | 3 |
Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hippocampus, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1 |
Congestion | 3 |
Edema | 2 |
Fibrosis | 1 |
Foreign Body | 1 1 1 1 1 1 1 1 1 1 1|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Chronic Active | 2 3 2 1 2 1 1 2 2 2 1 2 1 2 1 2 1 1 1|
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 7| 7| 4| 6| 7|
DAY ON TEST | 8| 3| 3| 2| 2| 3| 2| 2| 3| 2| 2| 2| 2| 2| 3| 2| 3| 0| 7| 2| 3| 3| 5| 6| 2|
| 2| 0| 0| 8| 5| 0| 7| 5| 0| 5| 5| 6| 5| 5| 0| 5| 0| 0| 5| 7| 0| 0| 6| 2| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bacterium | 2 |
Foreign Body | 2 |
Fungus | 2 |
Inflammation, Acute | 1 2 2 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + + +|
Lens, Cataract | 2 2 2 2 2 2 2 2 2 2|
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Necrosis | |
Nephropathy | 2 2 2 2 2 3 1 1 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2|
Cortex, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|
| 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/KG | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + A + + + +|
Bacterium | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + A + + + A|
Bacterium | |
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Basophilic Focus | X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X |
Congestion | |
Developmental Malformation | |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | 3 |
Fatty Change, Focal | 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 |
Mixed Cell Focus | X |
Necrosis | 2 |
Vein, Dilatation | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1|
Acinus, Atrophy | 2 2 2 1 2 1 2 2 1 2 2 1 1|
Acinus, Hyperplasia | 1 2 1 |
Artery, Inflammation, Chronic Active | |
Artery, Pigmentation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 |
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Squamous | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Erosion | 1 2 2 |
Hyperplasia | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|
| 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/KG | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cardiomyopathy | 2 1 2 2 2 1 2 3 1 2 2 2 2 2 1 1 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1|
Hyperplasia | 1 2 1 1 1 1 1 |
Necrosis | 3|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M M + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 3 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 1 3 1 3 2 3 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
C-Cell, Hyperplasia | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 1 1 2 2 2 2 1 1 1 |
Seminiferous Tubule, Atrophy | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|
| 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/KG | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2|
Depletion Lymphoid | |
Necrosis | 3|
Pigmentation | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + M + + M + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Mineralization | |
Necrosis | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hippocampus, Neuron, Necrosis | 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Congestion | 3 |
Edema | |
Fibrosis | |
Foreign Body | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 |
Hemorrhage | 3 2 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Chronic Active | 1 1 2 1 2 1 1 2 2 1 1 1 3 2 1 1 2 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 3| 3| 7| 2| 2| 7| 1| 7| 2| 2| 2| 2| 2| 3| 2| 6| 2| 3| 9| 4|
| 8| 6| 8| 5| 7| 0| 0| 6| 5| 5| 9| 0| 4| 7| 5| 6| 7| 5| 7| 5| 8| 5| 0| 0| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
12.5 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
MG/KG | 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bacterium | |
Foreign Body | 2 |
Fungus | 3 2 |
Inflammation, Acute | 2 2 1 1 2 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + + + + + |
Lens, Cataract | 2 2 2 2 2 2 2 2 2 2 |
Retina, Atrophy | 3 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 1|
Necrosis | |
Nephropathy | 1 2 2 2 2 2 2 2 1 1 1 1 1 2 2 2 3 2 2 2 1 1 1 2|
Cortex, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 1| | A |
12.5 | 4| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 49 |
Bacterium | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 48 |
Bacterium | | 1 1.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 49 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Bacterium | | 1 2.0|
Basophilic Focus | | 20 |
Clear Cell Focus | | 28 |
Congestion | | 1 2.0|
Developmental Malformation | | 1 |
Eosinophilic Focus | | 7 |
Fatty Change, Diffuse | | 1 3.0|
Fatty Change, Focal | | 17 1.0|
Hepatodiaphragmatic Nodule | | 5 |
Hyperplasia | | 1 2.0|
Mixed Cell Focus | | 2 |
Necrosis | | 2 2.0|
Vein, Dilatation | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Bacterium | | 1 1.0|
Acinus, Atrophy | 2 | 26 1.7|
Acinus, Hyperplasia | | 8 1.6|
Artery, Inflammation, Chronic Active | | 1 2.0|
Artery, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Acinus, Atrophy | | 1 1.0|
Duct, Metaplasia, Squamous | | 5 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 50 |
Hyperplasia, Diffuse, Squamous | 2 | 3 2.3|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 1| | A |
12.5 | 4| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Bacterium | | 1 2.0|
Erosion | | 7 1.6|
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 51 |
Bacterium | | 1 1.0|
Cardiomyopathy | 2 | 48 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Bacterium | | 1 1.0|
Hyperplasia | | 14 1.4|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + | 51 |
Pars Distalis, Angiectasis | | 4 2.3|
Pars Distalis, Cyst | | 7 |
Pars Distalis, Hyperplasia | | 18 1.9|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
C-Cell, Hyperplasia | | 9 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 51 |
__________________________________________________________________________|____________|
Preputial Gland | + | 51 |
__________________________________________________________________________|____________|
Prostate | + | 51 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 51 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 1| | A |
12.5 | 4| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 1 | 20 1.3|
Seminiferous Tubule, Atrophy | | 4 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 50 |
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 51 |
Artery, Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Bacterium | | 1 2.0|
Depletion Lymphoid | | 1 2.0|
Necrosis | | 2 2.5|
Pigmentation | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | M | 48 |
Fibrosis | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M | 44 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + | 51 |
Abscess | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
Hyperostosis | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 51 |
Atrophy | | 1 2.0|
Mineralization | | 1 1.0|
Necrosis | | 1 3.0|
Pigmentation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 50 |
Hippocampus, Neuron, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 6| | |
DAY ON TEST | 8| | |
| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
FISCHER 344 RATS MALE | 0| | T |
ANIMAL ID | 1| | A |
12.5 | 4| | L |
MG/KG | 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 48 |
__________________________________________________________________________|____________|
Spinal Cord | + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Bacterium | | 1 1.0|
Congestion | | 2 3.0|
Edema | | 1 2.0|
Fibrosis | | 1 1.0|
Foreign Body | | 26 1.1|
Hemorrhage | | 2 2.5|
Infiltration Cellular, Histiocyte | | 3 1.0|
Inflammation, Chronic Active | 1 | 40 1.5|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Bacterium | | 1 2.0|
Foreign Body | | 2 2.0|
Fungus | | 3 2.3|
Inflammation, Acute | | 13 1.5|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 22 |
Lens, Cataract | 2 | 21 2.0|
Retina, Atrophy | | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Bacterium | | 1 1.0|
Necrosis | 2 | 1 2.0|
Nephropathy | 2 | 49 1.8|
Cortex, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|
| 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Perforation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X X X|
Cyst | |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 1 2 1 2 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | X X X X X |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Mineralization | 1 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 2 |
Acinus, Atrophy | 2 2 2 1 1 2 2 2 1 2 1 2 3 1 4 1 2|
Acinus, Hyperplasia | 3 1 |
Artery, Hyperplasia | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Hyperkeratosis | |
Hyperplasia, Cystic | 3 |
Hyperplasia, Diffuse, Squamous | 2 3 2 3 |
Hyperplasia, Focal, Squamous | 1 |
Ulcer | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
Abscess | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|
| 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 3 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 1 2 1 1 1 3 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X X X 2 |
Pars Distalis, Hyperplasia | 2 3 3 2 2 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Degeneration | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Interstitial Cell, Hyperplasia | 2 2 2 1 1 1 3|
Seminiferous Tubule, Atrophy | 3 3 3 3 |
Seminiferous Tubule, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Degeneration | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|
| 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + + + + + + + + + + + + M|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | |
Hyperkeratosis | |
Thrombosis | |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | 1 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Neuron, Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + M + + + +|
Inflammation, Acute | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Edema | |
Foreign Body | 2 1 1 1 1 1 1 2 1 1 1 1|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 2 1 1 2 2 1 1 3 1 1 1 1 2 2 2 1 1 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 1| 2| 2| 0| 3| 2| 2| 2| 0| 6| 3| 3| 2| 5| 0| 2| 5| 2| 3| 3| 3| 2|
| 6| 5| 5| 1| 7| 5| 9| 0| 5| 7| 7| 9| 8| 0| 0| 6| 9| 9| 5| 0| 8| 0| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
MG/KG | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 5| 7| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 |
Pleura, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 |
Fungus | 3 |
Inflammation, Acute | 2 2 1 1 2 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Erosion | |
Hemorrhage | |
Perforation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + |
Hemorrhage | |
Inflammation, Chronic Active | 2 |
Lens, Cataract | 2 2 2 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | 3 |
Nephropathy | 2 2 2 1 2 2 1 2 2 3 2 1 2 2 2 2 3 3 2 2 2 2 1 2 1|
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|
DAY ON TEST | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|
| 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
25 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Perforation | 2 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X |
Cyst | X |
Eosinophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 1 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Fat, Mineralization | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
Acinus, Atrophy | 2 2 2 1 1 2 1 1 2 |
Acinus, Hyperplasia | 2 |
Artery, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperkeratosis | 1 |
Hyperplasia, Cystic | |
Hyperplasia, Diffuse, Squamous | 2 |
Hyperplasia, Focal, Squamous | 2 |
Ulcer | 3 2 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 1 1|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|
DAY ON TEST | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|
| 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
25 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 2 2 2 2 1 2 1 2 2 2 2 1 2 2 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + M + + + + + + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 1 1 2 2 3 1 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 |
Degeneration | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Interstitial Cell, Hyperplasia | 1 1 1 1 1 1 2 2|
Seminiferous Tubule, Atrophy | 2 3 2 3 |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Degeneration | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|
DAY ON TEST | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|
| 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
25 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + M + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + M + M M M + + + + + M + + + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | 4 |
Hyperkeratosis | 2 |
Thrombosis | 3 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + M + + + + + + + + + + + +|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Edema | 1 2 1 |
Foreign Body | 2 1 1 1 1 2 1 1 2 1 2 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 4 2 |
Inflammation, Chronic Active | 2 1 2 1 1 1 2 1 2 1 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 3| 3| 6| 6| 6| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 7| 7| 0| 7| 4|
DAY ON TEST | 7| 9| 2| 2| 3| 7| 2| 5| 5| 4| 2| 2| 2| 2| 2| 2| 2| 2| 3| 8| 3| 2| 8| 2| 5|
| 4| 5| 5| 5| 0| 8| 4| 3| 1| 0| 5| 8| 5| 5| 5| 5| 8| 5| 0| 9| 0| 5| 8| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
25 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
MG/KG | 7| 8| 9| 1| 2| 3| 5| 6| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 2 3 1 |
Pleura, Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 3 |
Inflammation, Acute | 2 3 1 2 2 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Erosion | 1 |
Hemorrhage | 1 |
Perforation | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + |
Hemorrhage | 2 |
Inflammation, Chronic Active | |
Lens, Cataract | 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Acute | |
Nephropathy | 1 2 2 1 2 1 2 2 1 2 2 1 2 2 1 2 2 2 2 2 2 1|
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| 7| | |
DAY ON TEST | 9| 2| | |
| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
25 | 0| 1| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 52 |
Abscess | | 1 3.0|
Perforation | | 2 2.5|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 50 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 51 |
__________________________________________________________________________|____________|
Liver | + + | 52 |
Basophilic Focus | X | 26 |
Clear Cell Focus | X X | 32 |
Cyst | | 1 |
Eosinophilic Focus | | 2 |
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | 1 | 18 1.1|
Hepatodiaphragmatic Nodule | X | 8 |
Mixed Cell Focus | | 5 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Mineralization | | 1 1.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + | 52 |
Metaplasia | | 1 2.0|
Acinus, Atrophy | 1 | 27 1.7|
Acinus, Hyperplasia | | 3 2.0|
Artery, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 52 |
Hemorrhage | | 1 1.0|
Duct, Metaplasia, Squamous | | 4 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 52 |
Erosion | | 1 3.0|
Hyperkeratosis | | 1 1.0|
Hyperplasia, Cystic | | 1 3.0|
Hyperplasia, Diffuse, Squamous | 2 | 6 2.3|
Hyperplasia, Focal, Squamous | | 2 1.5|
Ulcer | 1 | 7 1.9|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| 7| | |
DAY ON TEST | 9| 2| | |
| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
25 | 0| 1| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 4 1.5|
Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Abscess | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 52 |
Cardiomyopathy | 2 1 | 47 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 52 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 52 |
Hyperplasia | | 17 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 52 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 51 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | X | 12 2.0|
Pars Distalis, Hyperplasia | 2 | 17 2.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 51 |
C-Cell, Hyperplasia | | 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 52 |
Atypia Cellular | | 1 2.0|
Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 52 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + | 52 |
Abscess | | 1 4.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 52 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + | 52 |
Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| 7| | |
DAY ON TEST | 9| 2| | |
| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
25 | 0| 1| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Interstitial Cell, Hyperplasia | 2 | 16 1.5|
Seminiferous Tubule, Atrophy | | 8 2.8|
Seminiferous Tubule, Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 52 |
Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Pancreatic, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 52 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 52 |
__________________________________________________________________________|____________|
Spleen | + + | 52 |
Depletion Lymphoid | | 1 3.0|
Fibrosis | | 4 2.5|
Hematopoietic Cell Proliferation | | 2 2.0|
Necrosis | | 1 2.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + | 47 |
Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 45 |
Galactocele | | 2 |
__________________________________________________________________________|____________|
Skin | + + | 52 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage | | 1 4.0|
Hyperkeratosis | | 1 2.0|
Thrombosis | | 1 3.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 52 |
Fracture | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 51 |
Atrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| 7| | |
DAY ON TEST | 9| 2| | |
| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
25 | 0| 1| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 52 |
Cerebellum, Neuron, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 51 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 49 |
Inflammation, Acute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 52 |
Bacterium | | 1 2.0|
Edema | | 3 1.3|
Foreign Body | 1 2 | 26 1.3|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 2 1.5|
Inflammation, Acute | | 3 2.7|
Inflammation, Chronic Active | 1 2 | 40 1.5|
Alveolar Epithelium, Hyperplasia | | 4 2.0|
Pleura, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 52 |
Foreign Body | | 3 1.7|
Fungus | | 2 3.0|
Inflammation, Acute | | 14 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + | 52 |
Abscess | | 1 4.0|
Erosion | | 1 1.0|
Hemorrhage | | 1 1.0|
Perforation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 17 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Lens, Cataract | | 16 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 52 |
Cyst | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 5| 7| | |
DAY ON TEST | 9| 2| | |
| 2| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
25 | 0| 1| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy | 1 2 | 49 1.8|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 52 |
Calculus Gross Observation | | 2 |
Calculus Micro Observation Only | | 3 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|
| 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + A + + +|
Dilatation | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + A + + + + + + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X|
Cyst | |
Eosinophilic Focus | |
Fatty Change, Focal | 1 1 1 2 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia | 2 |
Mixed Cell Focus | X X X |
__________________________________________________________________________|
Mesentery | + |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 2 |
Acinus, Atrophy | 2 2 1 1 1 2 2 2 1 2 1 3 |
Acinus, Hyperplasia | 2 |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Diffuse, Squamous | 2 |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + A + + +|
Erosion | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 1 |
Inflammation, Chronic | 1 |
Ulcer | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 3 3 2 2 2 3 2 2 3 2 1 2 2 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|
| 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 2 1 2 2 3 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hemorrhage | 3 |
Pars Distalis, Hyperplasia | 3 2 2 1 2 2 2 2 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Congestion | |
C-Cell, Hyperplasia | 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Concretion | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Interstitial Cell, Hyperplasia | 3 2 1 2 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Pigmentation | 2 |
Capsule, Necrosis | 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + M + + + + + M + + + + M|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|
| 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M M + + M + M + M + + M + + + M + + + + M +|
Fibrosis | 2 |
Galactocele | |
Hemorrhage | 2 |
Inflammation, Chronic Active | 1|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Gliosis, Focal | |
Hemorrhage | |
Mineralization | 2 |
Cerebellum, Neuron, Necrosis | 1 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | 2 |
Fibrosis | |
Foreign Body | 1 1 2 2 1 1 |
Granuloma | 2 |
Hemorrhage | 2 2 2 3 |
Infiltration Cellular, Histiocyte | 2 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 2 1 2 1 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Mediastinum, Bacterium | |
Mediastinum, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 1 |
Fungus | 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 7| 6| 7| 6| 7| 6| 7| 7| 6| 6| 5| 7| 7| 5| 5| 7| 7| 3| 7| 5| 7|
DAY ON TEST | 3| 2| 2| 2| 2| 1| 3| 8| 2| 9| 2| 3| 1| 8| 9| 2| 3| 7| 3| 2| 2| 0| 2| 6| 2|
| 0| 5| 1| 8| 5| 1| 0| 7| 7| 0| 5| 0| 0| 8| 2| 5| 0| 8| 1| 6| 5| 1| 7| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/KG | 3| 4| 5| 8| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 1 2 1 3 2 2 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + + + + + + + |
Lens, Cataract | 2 2 3 2 2 2 2 2 2 2 2 2 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Hydronephrosis | |
Nephropathy | 2 2 3 2 3 2 2 3 2 3 2 1 2 1 2 2 2 1 2 2 2 2 2|
Cortex, Mineralization | 1 |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|
| 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/KG | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + A + + + A A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + A A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X X|
Cyst | X |
Eosinophilic Focus | X X X X X|
Fatty Change, Focal | 1 1 1 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | + + |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
Acinus, Atrophy | 1 2 1 3 2 1 2 1 1 2 1 1 2 1|
Acinus, Hyperplasia | 2 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | |
Hyperplasia, Diffuse, Squamous | |
Hyperplasia, Focal, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
Erosion | 1 1 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | 2 |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 3 2 1 1 2 2 2 3 2 1 2 2 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|
| 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/KG | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 2 1 1 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | X X X X |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia | 2 2 1 2 2 1 2 2 1 3 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Congestion | 1 |
C-Cell, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Concretion | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Interstitial Cell, Hyperplasia | 1 2 2 1 1 2 2 1 1 1 2 2 2|
Seminiferous Tubule, Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Angiectasis | 3 |
Congestion | |
Pigmentation | 2 |
Capsule, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|
| 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/KG | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + M M + + M + + + + + + + M + M|
Fibrosis | 2 |
Galactocele | X |
Hemorrhage | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Gliosis, Focal | 1 |
Hemorrhage | 2 |
Mineralization | |
Cerebellum, Neuron, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + M + M + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Edema | |
Fibrosis | 2|
Foreign Body | 1 1 1 1 1 1 2 1 |
Granuloma | |
Hemorrhage | 3 3 |
Infiltration Cellular, Histiocyte | 1 2 1|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 2 1 1 1 2 1 2 2 1 2 1 2 1 2 2 2 1|
Alveolar Epithelium, Hyperplasia | 3 |
Mediastinum, Bacterium | 2 |
Mediastinum, Inflammation, Chronic | |
Active | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 1 1 |
Fungus | 2 2 |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 3| 7| 7| 6| 6| 6| 3| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 1| 3| 2| 3| 2| 8| 6| 2| 3| 5| 6| 8| 9| 2| 1| 9| 6| 2| 2| 2| 2|
| 5| 8| 5| 5| 5| 0| 6| 0| 8| 9| 9| 5| 1| 9| 2| 4| 6| 5| 0| 7| 8| 5| 5| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/KG | 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + + + +|
Lens, Cataract | 2 3 3 2 2 2 2|
Retina, Atrophy | 1 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hydronephrosis | 2 |
Nephropathy | 2 2 2 2 1 2 2 2 3 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2|
Cortex, Mineralization | |
Renal Tubule, Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 7| | |
DAY ON TEST | 2| 2| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
50 | 7| 8| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 50 |
Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 45 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 46 |
__________________________________________________________________________|____________|
Liver | + + | 52 |
Basophilic Focus | X | 22 |
Clear Cell Focus | X X | 29 |
Cyst | | 1 |
Eosinophilic Focus | | 5 |
Fatty Change, Focal | 1 | 13 1.2|
Hepatodiaphragmatic Nodule | | 2 |
Hyperplasia | | 1 2.0|
Mixed Cell Focus | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + | 52 |
Metaplasia | | 1 2.0|
Acinus, Atrophy | 2 1 | 28 1.6|
Acinus, Hyperplasia | | 3 2.0|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 52 |
Duct, Metaplasia, Squamous | | 7 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 52 |
Hyperplasia, Basal Cell | | 1 2.0|
Hyperplasia, Diffuse, Squamous | | 1 2.0|
Hyperplasia, Focal, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 49 |
Erosion | | 4 1.5|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 2 1.5|
Inflammation, Chronic | | 1 1.0|
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 7| | |
DAY ON TEST | 2| 2| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
50 | 7| 8| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 | 47 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 52 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 52 |
Hyperplasia | 3 | 15 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 52 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 52 |
Pars Distalis, Angiectasis | | 1 1.0|
Pars Distalis, Cyst | | 9 |
Pars Distalis, Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia | | 20 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 50 |
Congestion | | 1 1.0|
C-Cell, Hyperplasia | 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 52 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 50 |
Dilatation | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + | 52 |
Abscess | | 1 4.0|
Concretion | | 1 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 52 |
Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + | 52 |
Inflammation | | 1 2.0|
Interstitial Cell, Hyperplasia | | 22 1.7|
Seminiferous Tubule, Atrophy | | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 52 |
__________________________________________________________________________|____________|
Lymph Node | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 7| | |
DAY ON TEST | 2| 2| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
50 | 7| 8| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 52 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 52 |
Congestion | | 1 1.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + | 51 |
Angiectasis | | 1 3.0|
Congestion | | 1 2.0|
Pigmentation | | 2 2.0|
Capsule, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 38 |
Fibrosis | | 2 2.0|
Galactocele | | 1 |
Hemorrhage | | 2 2.0|
Inflammation, Chronic Active | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + | 52 |
Acanthosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 52 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 52 |
Atrophy | | 2 1.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 52 |
Congestion | | 1 1.0|
Gliosis, Focal | | 1 1.0|
Hemorrhage | | 1 2.0|
Mineralization | | 1 2.0|
Cerebellum, Neuron, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + | 52 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 52 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05214-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TRANS-DELTA-9-TETRAHYDROCANNABINOL Date: 03/18/94
Route: GAVAGE Time: 18:28:14
__________________________________________________________________________________________________________________________________
| 7| 7| | |
DAY ON TEST | 2| 2| | |
| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| | T |
ANIMAL ID | 2| 2| | A |
50 | 7| 8| | L |
MG/KG | 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
Fibrosis | | 1 2.0|
Foreign Body | 2 | 15 1.3|
Granuloma | | 1 2.0|
Hemorrhage | | 6 2.5|
Infiltration Cellular, Histiocyte | | 6 1.3|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 2 | 36 1.7|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Mediastinum, Bacterium | | 1 2.0|
Mediastinum, Inflammation, Chronic | | |
Active | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 52 |
Foreign Body | | 5 1.2|
Fungus | | 5 1.8|
Inflammation, Acute | | 14 1.6|
__________________________________________________________________________|____________|
Trachea | + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 21 |
Lens, Cataract | | 20 2.2|
Retina, Atrophy | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 52 |
Degeneration | | 1 2.0|
Hydronephrosis | | 1 2.0|
Nephropathy | 2 2 | 49 2.0|
Cortex, Mineralization | | 1 1.0|
Renal Tubule, Degeneration, Hyaline | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 52 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 2 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
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