TDMS Study 05217-04 Pathology Tables
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
Facility: Southern Research Institute
Chemical CAS #: 1948330
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70
Scheduled Sacrifice 10 10
Early Deaths
Moribund Sacrifice 39 32
Natural Death 3 4
Survivors
Terminal Sacrifice 18 24
Animals Examined Microscopically 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (68) (69)
Epithelium, Hyperplasia 1 (1%)
Intestine Large, Colon (69) (70)
Parasite Metazoan 5 (7%) 6 (9%)
Intestine Large, Rectum (70) (70)
Parasite Metazoan 5 (7%) 7 (10%)
Intestine Large, Cecum (70) (69)
Edema 1 (1%) 1 (1%)
Parasite Metazoan 1 (1%)
Intestine Small, Duodenum (69) (69)
Erosion 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Liver (70) (70)
Angiectasis 5 (7%)
Basophilic Focus 26 (37%) 23 (33%)
Clear Cell Focus 2 (3%) 2 (3%)
Cyst 1 (1%)
Eosinophilic Focus 7 (10%) 13 (19%)
Hematopoietic Cell Proliferation 2 (3%)
Hepatodiaphragmatic Nodule 2 (3%) 5 (7%)
Inflammation, Granulomatous 7 (10%) 3 (4%)
Inflammation, Subacute 1 (1%)
Mixed Cell Focus 8 (11%) 1 (1%)
Necrosis, Focal 7 (10%) 2 (3%)
Bile Duct, Hyperplasia 23 (33%) 24 (34%)
Centrilobular, Necrosis 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 7 (10%) 9 (13%)
Kupffer Cell, Pigmentation 14 (20%) 19 (27%)
Mesentery (8) (6)
Accessory Spleen 2 (25%)
Fat, Necrosis 5 (63%) 5 (83%)
Pancreas (70) (69)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 15 (21%) 11 (16%)
Acinus, Cytoplasmic Alteration 1 (1%) 1 (1%)
Stomach, Forestomach (69) (69)
Edema 1 (1%) 1 (1%)
Erosion 1 (1%) 2 (3%)
Ulcer 4 (6%)
Epithelium, Hyperplasia 5 (7%) 5 (7%)
Stomach, Glandular (69) (70)
Edema 1 (1%)
Erosion 1 (1%) 2 (3%)
Mineralization 1 (1%)
Ulcer 2 (3%)
Tongue (3)
Epithelium, Hyperplasia 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (70)
Cardiomyopathy 30 (43%) 30 (43%)
Mineralization 1 (1%)
Thrombosis 2 (3%) 2 (3%)
Endocardium, Hyperplasia 1 (1%)
Schwann Cell, Hyperplasia 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70)
Accessory Adrenal Cortical Nodule 10 (14%) 10 (14%)
Atrophy 2 (3%)
Degeneration, Fatty 11 (16%) 10 (14%)
Hemorrhage 1 (1%)
Hyperplasia, Diffuse 1 (1%)
Hyperplasia, Focal 7 (10%) 1 (1%)
Hypertrophy, Focal 5 (7%) 8 (11%)
Necrosis 1 (1%)
Adrenal Medulla (67) (70)
Hyperplasia 5 (7%) 15 (21%)
Islets, Pancreatic (70) (69)
Hyperplasia 1 (1%)
Parathyroid Gland (62) (64)
Hyperplasia 2 (3%)
Pituitary Gland (69) (70)
Pars Distalis, Angiectasis 2 (3%) 10 (14%)
Pars Distalis, Cyst 9 (13%) 11 (16%)
Pars Distalis, Hyperplasia, Focal 11 (16%) 13 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Intermedia, Angiectasis 2 (3%) 4 (6%)
Pars Intermedia, Cyst 4 (6%) 6 (9%)
Thyroid Gland (70) (69)
Ectopic Thymus 1 (1%)
Ultimobranchial Cyst 2 (3%) 4 (6%)
C-Cell, Hyperplasia 4 (6%) 3 (4%)
Follicle, Cyst 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (69) (69)
Cyst 5 (7%) 6 (9%)
Hyperplasia 5 (7%) 6 (9%)
Inflammation, Chronic 3 (4%) 2 (3%)
Inflammation, Suppurative 2 (3%)
Ovary (70) (70)
Angiectasis 2 (3%)
Cyst 6 (9%) 14 (20%)
Uterus (70) (70)
Hydrometra 5 (7%) 3 (4%)
Hyperplasia, Cystic 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70)
Hyperplasia 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%)
Inflammation, Granulomatous 1 (1%) 1 (1%)
Myelofibrosis 1 (1%) 5 (7%)
Stromal Cell, Hyperplasia 1 (1%)
Lymph Node (19) (23)
Iliac, Ectasia 1 (5%)
Iliac, Hemorrhage 1 (4%)
Iliac, Pigmentation 1 (4%)
Mediastinal, Hemorrhage 3 (13%)
Mediastinal, Hyperplasia, Lymphoid 1 (4%)
Mediastinal, Pigmentation 8 (42%) 11 (48%)
Pancreatic, Ectasia 1 (5%)
Pancreatic, Pigmentation 2 (11%) 4 (17%)
Renal, Pigmentation 6 (32%) 5 (22%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mandibular (70) (69)
Ectasia 3 (4%) 2 (3%)
Hemorrhage 5 (7%) 5 (7%)
Hyperplasia, Lymphoid 9 (13%) 3 (4%)
Hyperplasia, Plasma Cell 1 (1%) 1 (1%)
Pigmentation 22 (31%) 22 (32%)
Lymph Node, Mesenteric (69) (69)
Ectasia 1 (1%) 2 (3%)
Hemorrhage 2 (3%) 6 (9%)
Hyperplasia, Lymphoid 1 (1%)
Pigmentation 1 (1%)
Spleen (70) (70)
Fibrosis 4 (6%) 2 (3%)
Hematopoietic Cell Proliferation 9 (13%) 12 (17%)
Hyperplasia, Lymphoid 1 (1%)
Necrosis 1 (1%) 1 (1%)
Pigmentation, Hemosiderin 30 (43%) 38 (54%)
Lymphoid Follicle, Atrophy 2 (3%)
Red Pulp, Atrophy 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (70) (69)
Dilatation 51 (73%) 34 (49%)
Galactocele 1 (1%) 4 (6%)
Hyperplasia 3 (4%) 2 (3%)
Skin (70) (70)
Inflammation, Chronic 2 (3%)
Ulcer 1 (1%) 2 (3%)
Epidermis, Hyperplasia 1 (1%) 3 (4%)
Subcutaneous Tissue, Edema 1 (1%) 3 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70)
Fibrous Osteodystrophy 2 (3%)
Cranium, Osteopetrosis 3 (4%) 2 (3%)
Femur, Osteopetrosis 3 (4%) 7 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70)
Atrophy 17 (24%) 15 (21%)
Gliosis 1 (1%)
Hemorrhage 1 (1%)
Hydrocephalus 1 (1%) 3 (4%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70)
Edema 1 (1%) 3 (4%)
Fibrosis 1 (1%)
Foreign Body 1 (1%)
Hemorrhage 2 (3%) 3 (4%)
Infiltration Cellular, Histiocyte 33 (47%) 30 (43%)
Inflammation, Subacute 1 (1%)
Mineralization 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (4%) 4 (6%)
Nose (70) (70)
Foreign Body 1 (1%) 1 (1%)
Inflammation, Suppurative 3 (4%) 2 (3%)
Goblet Cell, Hyperplasia 7 (10%) 13 (19%)
Mucosa, Hyperplasia 4 (6%) 3 (4%)
Mucosa, Metaplasia, Squamous 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Inflammation, Chronic 1 (50%)
Eye (1)
Cataract 1 (100%)
Retina, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70)
Glomerulosclerosis 1 (1%)
Hydronephrosis 2 (3%)
Inflammation, Chronic 2 (3%)
Inflammation, Suppurative 1 (1%)
Mineralization 69 (99%) 66 (94%)
Nephropathy 38 (54%) 41 (59%)
Renal Tubule, Atrophy 1 (1%) 14 (20%)
Renal Tubule, Cytoplasmic Alteration 5 (7%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Dilatation 2 (3%) 7 (10%)
Renal Tubule, Necrosis 1 (1%)
Renal Tubule, Pigmentation 17 (24%) 17 (24%)
Transitional Epithelium, Hyperplasia 5 (7%) 5 (7%)
Urinary Bladder (70) (70)
Transitional Epithelium, Hyperplasia 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70
Scheduled Sacrifice 10 10
Early Deaths
Natural Death 7 5
Moribund Sacrifice 43 33
Survivors
Terminal Sacrifice 10 22
Animals Examined Microscopically 70 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (70) (70)
Parasite Metazoan 7 (10%) 8 (11%)
Intestine Large, Rectum (69) (70)
Erosion 1 (1%)
Parasite Metazoan 4 (6%) 7 (10%)
Intestine Large, Cecum (70) (70)
Edema 3 (4%) 2 (3%)
Parasite Metazoan 3 (4%)
Intestine Small, Duodenum (70) (70)
Ulcer 3 (4%)
Liver (70) (70)
Angiectasis 5 (7%) 6 (9%)
Basophilic Focus 5 (7%) 1 (1%)
Clear Cell Focus 3 (4%)
Cyst 1 (1%)
Degeneration, Cystic 6 (9%) 12 (17%)
Eosinophilic Focus 6 (9%) 9 (13%)
Hematopoietic Cell Proliferation 1 (1%)
Hepatodiaphragmatic Nodule 2 (3%) 5 (7%)
Inflammation, Subacute 1 (1%)
Mixed Cell Focus 3 (4%)
Necrosis, Focal 7 (10%) 6 (9%)
Thrombosis 2 (3%)
Bile Duct, Hyperplasia 45 (64%) 30 (43%)
Centrilobular, Necrosis 2 (3%)
Hepatocyte, Vacuolization Cytoplasmic 2 (3%) 2 (3%)
Kupffer Cell, Hyperplasia 1 (1%)
Kupffer Cell, Pigmentation 19 (27%) 14 (20%)
Mesentery (8) (5)
Accessory Spleen 2 (25%) 1 (20%)
Fat, Necrosis 4 (50%) 1 (20%)
Pancreas (68) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 21 (31%) 19 (27%)
Acinus, Cytoplasmic Alteration 1 (1%)
Salivary Glands (70) (70)
Atrophy 1 (1%) 1 (1%)
Stomach, Forestomach (70) (70)
Erosion 2 (3%)
Hyperplasia 5 (7%) 3 (4%)
Ulcer 1 (1%) 1 (1%)
Stomach, Glandular (70) (70)
Edema 1 (1%) 1 (1%)
Erosion 1 (1%) 2 (3%)
Mineralization 1 (1%)
Ulcer 1 (1%)
Tongue (1) (2)
Epithelium, Hyperplasia 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (69) (70)
Hypertrophy 1 (1%) 1 (1%)
Inflammation, Subacute 1 (1%) 1 (1%)
Thrombosis 1 (1%)
Heart (70) (70)
Cardiomyopathy 37 (53%) 45 (64%)
Thrombosis 5 (7%) 6 (9%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70)
Accessory Adrenal Cortical Nodule 15 (21%) 7 (10%)
Angiectasis 1 (1%) 1 (1%)
Degeneration, Fatty 13 (19%) 5 (7%)
Hematopoietic Cell Proliferation 1 (1%)
Hemorrhage 1 (1%)
Hyperplasia, Diffuse 1 (1%)
Hyperplasia, Focal 2 (3%) 2 (3%)
Hypertrophy, Focal 5 (7%) 5 (7%)
Necrosis 1 (1%)
Adrenal Medulla (69) (70)
Hyperplasia 18 (26%) 15 (21%)
Islets, Pancreatic (68) (70)
Hyperplasia 2 (3%) 1 (1%)
Parathyroid Gland (66) (66)
Hyperplasia 1 (2%)
Pituitary Gland (67) (66)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Angiectasis 3 (4%) 3 (5%)
Pars Distalis, Cyst 8 (12%) 8 (12%)
Pars Distalis, Hyperplasia, Focal 14 (21%) 7 (11%)
Pars Distalis, Hypertrophy 1 (2%)
Pars Intermedia, Cyst 3 (4%) 4 (6%)
Thyroid Gland (70) (69)
Ultimobranchial Cyst 2 (3%) 2 (3%)
C-Cell, Hyperplasia 5 (7%) 5 (7%)
Follicle, Cyst 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (70)
Atypia Cellular 25 (36%) 19 (27%)
Preputial Gland (70) (69)
Cyst 3 (4%) 1 (1%)
Hyperplasia 1 (1%) 2 (3%)
Inflammation, Chronic 9 (13%) 13 (19%)
Inflammation, Suppurative 1 (1%)
Prostate (70) (70)
Inflammation, Suppurative 30 (43%) 23 (33%)
Epithelium, Hyperplasia 3 (4%) 5 (7%)
Testes (70) (70)
Atrophy 2 (3%) 4 (6%)
Interstitial Cell, Hyperplasia 3 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70)
Hyperplasia 2 (3%) 2 (3%)
Myelofibrosis 8 (11%) 3 (4%)
Lymph Node (36) (23)
Iliac, Hyperplasia, Lymphoid 1 (4%)
Iliac, Pigmentation 2 (9%)
Mediastinal, Hemorrhage 2 (6%)
Mediastinal, Pigmentation 19 (53%) 11 (48%)
Pancreatic, Pigmentation 8 (22%) 4 (17%)
Renal, Hemorrhage 1 (3%)
Renal, Pigmentation 7 (19%) 3 (13%)
Lymph Node, Mandibular (70) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Ectasia 2 (3%) 2 (3%)
Hemorrhage 1 (1%) 3 (4%)
Hyperplasia, Lymphoid 5 (7%) 4 (6%)
Hyperplasia, Plasma Cell 1 (1%) 2 (3%)
Pigmentation 13 (19%) 14 (20%)
Lymph Node, Mesenteric (70) (70)
Ectasia 2 (3%) 4 (6%)
Hemorrhage 2 (3%)
Hyperplasia, Lymphoid 1 (1%) 2 (3%)
Spleen (70) (70)
Fibrosis 13 (19%) 16 (23%)
Hematopoietic Cell Proliferation 2 (3%) 7 (10%)
Necrosis 2 (3%) 2 (3%)
Pigmentation, Hemosiderin 3 (4%) 18 (26%)
Lymphoid Follicle, Atrophy 2 (3%) 1 (1%)
Thymus (64) (67)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (68) (68)
Dilatation 16 (24%) 14 (21%)
Galactocele 1 (1%)
Hyperplasia 7 (10%) 9 (13%)
Skin (70) (70)
Cyst Epithelial Inclusion 1 (1%)
Hyperkeratosis 1 (1%)
Hyperplasia 1 (1%)
Subcutaneous Tissue, Edema 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70)
Hyperostosis 1 (1%)
Cranium, Osteopetrosis 1 (1%)
Femur, Osteopetrosis 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70)
Atrophy 3 (4%) 8 (11%)
Hemorrhage 1 (1%)
Hydrocephalus 1 (1%) 2 (3%)
Necrosis 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70)
Congestion 1 (1%)
Edema 3 (4%)
Hemorrhage 4 (6%) 6 (9%)
Infiltration Cellular, Histiocyte 14 (20%) 21 (30%)
Inflammation, Subacute 2 (3%)
Alveolar Epithelium, Hyperplasia 6 (9%) 8 (11%)
Nose (70) (70)
Foreign Body 3 (4%) 2 (3%)
Inflammation 1 (1%)
Inflammation, Suppurative 5 (7%) 2 (3%)
Goblet Cell, Hyperplasia 8 (11%) 17 (24%)
Mucosa, Hyperplasia 8 (11%) 2 (3%)
Mucosa, Metaplasia, Squamous 7 (10%) 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (3)
Cataract 1 (100%) 3 (100%)
Hemorrhage 1 (33%)
Retina, Degeneration 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70)
Calculus Micro Observation Only 2 (3%)
Cyst 2 (3%)
Hydronephrosis 1 (1%)
Infiltration Cellular, Lipocyte 1 (1%)
Inflammation, Suppurative 3 (4%)
Mineralization 4 (6%)
Nephropathy 53 (76%) 60 (86%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (1%) 1 (1%)
Renal Tubule, Atrophy 1 (1%) 4 (6%)
Renal Tubule, Dilatation 1 (1%)
Renal Tubule, Necrosis 3 (4%)
Renal Tubule, Pigmentation 17 (24%) 18 (26%)
Transitional Epithelium, Hyperplasia 1 (1%) 5 (7%)
Urinary Bladder (70) (70)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05217-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:12:00
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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