TDMS Study 05217-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 04 TIME: 08:26:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948330
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 04 TIME: 08:26:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948330
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 04 TIME: 08:26:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948330
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF T-BUTYLHYDROQUINONE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma: Benign, Complex, Malignant, NOS
Skin Fibroma
Testes Adenoma
Thyroid Gland: C-Cell Carcinoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
====================================================================================================
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/69 (17%) 12/70 (17%) | 4/67 (6%) 4/70 (6%) |
|ADJUSTED (b) | 57.5% 42.5% | 17.1% 12.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/10 (30%) 7/22 (32%) | 2/18 (11%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | 707 732 | 677 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.066N | P=0.530N |
|INCIDENTAL TUMOR | P=0.255N | P=0.503N |
|LOGISTIC REGRESSION | P=0.163N | P=0.598N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.573N | P=0.616N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/69 (3%) 2/70 (3%) | 0/67 (0%) 1/70 (1%) |
|ADJUSTED (b) | 12.0% 5.3% | 0.0% 2.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 661 712 | --- 823 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.494N | P=0.538 |
|INCIDENTAL TUMOR | P=0.626N | P=0.488 |
|LOGISTIC REGRESSION | P=0.646N | P=0.517 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.685N | P=0.511 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/69 (22%) 14/70 (20%) | 4/67 (6%) 5/70 (7%) |
|ADJUSTED (b) | 65.0% 45.5% | 17.1% 15.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/10 (40%) 7/22 (32%) | 2/18 (11%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | 552 712 | 677 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.037N* | P=0.619 |
|INCIDENTAL TUMOR | P=0.217N | P=0.630 |
|LOGISTIC REGRESSION | P=0.157N | P=0.551 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.483N | P=0.528 |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 5.4% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 796 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.356 | (e) (e) |
|INCIDENTAL TUMOR | P=0.232 | (e) (e) |
|LOGISTIC REGRESSION | P=0.272 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248 | (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/69 (1%) | 3/69 (4%) 10/69 (14%) |
|ADJUSTED (b) | 3.8% 2.0% | 13.4% 27.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/21 (0%) | 1/18 (6%) 3/23 (13%) |
|FIRST INCIDENCE (DAYS) | 786 731 | 866 673 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.673N | P=0.093 |
|INCIDENTAL TUMOR | P=0.756 | P=0.040 * |
|LOGISTIC REGRESSION | P=0.750N | P=0.047 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.748 | P=0.039 * |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/69 (3%) | 2/69 (3%) 5/69 (7%) |
|ADJUSTED (b) | 3.8% 6.2% | 6.2% 21.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/21 (0%) | 0/18 (0%) 5/23 (22%) |
|FIRST INCIDENCE (DAYS) | 786 793 | 788 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.686 | P=0.310 |
|INCIDENTAL TUMOR | P=0.490 | P=0.279 |
|LOGISTIC REGRESSION | P=0.568 | P=0.279 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.495 | P=0.220 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 3/69 (4%) | 5/69 (7%) 15/69 (22%) |
|ADJUSTED (b) | 7.7% 8.0% | 18.8% 45.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/21 (0%) | 1/18 (6%) 8/23 (35%) |
|FIRST INCIDENCE (DAYS) | 786 731 | 788 673 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.647N | P=0.051 |
|INCIDENTAL TUMOR | P=0.487 | P=0.019 * |
|LOGISTIC REGRESSION | P=0.560 | P=0.019 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.493 | P=0.014 * |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/68 (3%) 6/70 (9%) | 1/70 (1%) 2/69 (3%) |
|ADJUSTED (b) | 8.3% 20.6% | 1.9% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 3/22 (14%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 707 778 | 677 780 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.394 | P=0.538 |
|INCIDENTAL TUMOR | P=0.241 | P=0.457 |
|LOGISTIC REGRESSION | P=0.244 | P=0.501 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.147 | P=0.495 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/70 (3%) | 2/70 (3%) 2/70 (3%) |
|ADJUSTED (b) | 10.0% 7.4% | 9.1% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 1/22 (5%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 911 (T) 820 | 870 841 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.724N | P=0.593N |
|INCIDENTAL TUMOR | P=0.674 | P=0.651 |
|LOGISTIC REGRESSION | P=0.688 | P=0.662N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.690N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 3/70 (4%) | 3/70 (4%) 2/70 (3%) |
|ADJUSTED (b) | 10.0% 11.8% | 11.0% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/22 (9%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 911 (T) 820 | 711 841 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.591 | P=0.402N |
|INCIDENTAL TUMOR | P=0.524 | P=0.556N |
|LOGISTIC REGRESSION | P=0.530 | P=0.478N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.310 | P=0.500N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 6/70 (9%) | 30/70 (43%) 17/70 (24%) |
|ADJUSTED (b) | 19.9% 19.6% | 86.8% 56.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 3/22 (14%) | 14/18 (78%) 12/24 (50%) |
|FIRST INCIDENCE (DAYS) | 745 745 | 688 780 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.565N | P<0.001N** |
|INCIDENTAL TUMOR | P=0.556 | P=0.002N** |
|LOGISTIC REGRESSION | P=0.530 | P=0.002N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.372 | P=0.016N* |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 5/70 (7%) 7/70 (10%) | 31/70 (44%) 17/70 (24%) |
|ADJUSTED (b) | 28.8% 23.0% | 87.5% 56.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/10 (20%) 3/22 (14%) | 14/18 (78%) 12/24 (50%) |
|FIRST INCIDENCE (DAYS) | 745 745 | 688 780 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.463N | P<0.001N** |
|INCIDENTAL TUMOR | P=0.596 | P=0.001N** |
|LOGISTIC REGRESSION | P=0.602 | P<0.001N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.382 | P=0.010N* |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 6.4% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/22 (5%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.371 | (e) (e) |
|INCIDENTAL TUMOR | P=0.320 | (e) (e) |
|LOGISTIC REGRESSION | P=0.285 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248 | (e) |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 4.3% 6.4% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/22 (5%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 796 730 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.685 | (e) (e) |
|INCIDENTAL TUMOR | P=0.582 | (e) (e) |
|LOGISTIC REGRESSION | P=0.572 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/70 (3%) 1/70 (1%) |
|ADJUSTED (b) | | 7.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/18 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | | 837 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.414N |
|INCIDENTAL TUMOR | | P=0.495N |
|LOGISTIC REGRESSION | | P=0.459N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.500N |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 3/70 (4%) 1/70 (1%) |
|ADJUSTED (b) | | 9.7% 4.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 0/18 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | | 820 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.234N |
|INCIDENTAL TUMOR | | P=0.313N |
|LOGISTIC REGRESSION | | P=0.274N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.310N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/67 (19%) 16/66 (24%) | 30/69 (43%) 18/70 (26%) |
|ADJUSTED (b) | 46.6% 47.2% | 81.1% 50.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/10 (20%) 6/20 (30%) | 11/17 (65%) 9/24 (38%) |
|FIRST INCIDENCE (DAYS) | 569 641 | 638 649 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.286N | P=0.004N** |
|INCIDENTAL TUMOR | P=0.342 | P=0.009N** |
|LOGISTIC REGRESSION | P=0.488 | P=0.007N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.321 | P=0.021N* |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/70 (1%) | 2/70 (3%) 0/70 (0%) |
|ADJUSTED (b) | 10.0% 1.9% | 7.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 911 (T) 712 | 777 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.633N | P=0.199N |
|INCIDENTAL TUMOR | P=0.680N | P=0.265N |
|LOGISTIC REGRESSION | P=0.722N | P=0.226N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.752N | P=0.248N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 2/70 (3%) | 2/70 (3%) 0/70 (0%) |
|ADJUSTED (b) | 18.2% 4.9% | 7.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 900 712 | 777 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.457N | P=0.199N |
|INCIDENTAL TUMOR | P=0.634N | P=0.265N |
|LOGISTIC REGRESSION | P=0.589N | P=0.226N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.690N | P=0.248N |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 3/70 (4%) | 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 33.6% 12.5% | 3.7% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/22 (9%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 730 866 | 856 837 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.043N* | P=0.708N |
|INCIDENTAL TUMOR | P=0.141N | P=0.735 |
|LOGISTIC REGRESSION | P=0.077N | P=0.748N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247N | P=0.752N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 4/70 (6%) | 1/70 (1%) 1/70 (1%) |
|ADJUSTED (b) | 33.6% 14.0% | 3.7% 2.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/22 (9%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 730 671 | 856 837 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.093N | P=0.708N |
|INCIDENTAL TUMOR | P=0.247N | P=0.735 |
|LOGISTIC REGRESSION | P=0.185N | P=0.748N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.372N | P=0.752N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 3/70 (4%) | 0/70 (0%) 2/70 (3%) |
|ADJUSTED (b) | 0.0% 9.7% | 0.0% 7.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 1/22 (5%) | 0/18 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | --- 743 | --- 855 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.235 | P=0.295 |
|INCIDENTAL TUMOR | P=0.163 | P=0.257 |
|LOGISTIC REGRESSION | P=0.167 | P=0.274 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.122 | P=0.248 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 59/70 (84%) 60/70 (86%) | |
|ADJUSTED (b) | 100.0% 100.0% | |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | |
|TERMINAL (d) | 10/10 (100%) 22/22 (100%) | |
|FIRST INCIDENCE (DAYS) | 484 600 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** | |
|INCIDENTAL TUMOR | P=0.506 | |
|LOGISTIC REGRESSION | P=0.758 | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/70 (10%) 6/69 (9%) | 3/70 (4%) 6/69 (9%) |
|ADJUSTED (b) | 30.0% 17.9% | 11.4% 16.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/22 (9%) | 1/18 (6%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | 604 730 | 677 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.191N | P=0.348 |
|INCIDENTAL TUMOR | P=0.616N | P=0.273 |
|LOGISTIC REGRESSION | P=0.409N | P=0.254 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.511N | P=0.239 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 5/69 (7%) | 0/70 (0%) 1/69 (1%) |
|ADJUSTED (b) | 0.0% 12.1% | 0.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/22 (0%) | 0/18 (0%) 1/24 (4%) |
|FIRST INCIDENCE (DAYS) | --- 641 | --- 911 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.082 | P=0.557 |
|INCIDENTAL TUMOR | P=0.012 * | P=0.557 |
|LOGISTIC REGRESSION | P=0.038 * | P=0.557 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.028 * | P=0.496 |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/70 (10%) 11/69 (16%) | 3/70 (4%) 7/69 (10%) |
|ADJUSTED (b) | 30.0% 27.8% | 11.4% 20.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 2/22 (9%) | 1/18 (6%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | 604 641 | 677 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595 | P=0.259 |
|INCIDENTAL TUMOR | P=0.103 | P=0.196 |
|LOGISTIC REGRESSION | P=0.293 | P=0.172 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.215 | P=0.157 |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/69 (0%) | 0/70 (0%) 0/69 (0%) |
|ADJUSTED (b) | 12.6% 0.0% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/10 (10%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 732 --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.127N | (e) (e) |
|INCIDENTAL TUMOR | P=0.162N | (e) (e) |
|LOGISTIC REGRESSION | P=0.184N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.252N | (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 8/70 (11%) 6/70 (9%) |
|ADJUSTED (b) | | 21.2% 18.5% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/18 (6%) 2/24 (8%) |
|FIRST INCIDENCE (DAYS) | | 562 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.281N |
|INCIDENTAL TUMOR | | P=0.463N |
|LOGISTIC REGRESSION | | P=0.369N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.390N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 8/70 (11%) 7/70 (10%) |
|ADJUSTED (b) | | 21.2% 22.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 1/18 (6%) 3/24 (13%) |
|FIRST INCIDENCE (DAYS) | | 562 672 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.368N |
|INCIDENTAL TUMOR | | P=0.559N |
|LOGISTIC REGRESSION | | P=0.476N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 46/70 (66%) 39/70 (56%) | 37/70 (53%) 34/70 (49%) |
|ADJUSTED (b) | 86.9% 78.2% | 74.3% 64.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/10 (40%) 12/22 (55%) | 8/18 (44%) 7/24 (29%) |
|FIRST INCIDENCE (DAYS) | 484 641 | 504 540 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** | P=0.178N |
|INCIDENTAL TUMOR | P=0.277N | P=0.528 |
|LOGISTIC REGRESSION | P=0.036N* | P=0.552 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.150N | P=0.368N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 4/70 (6%) | 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 6.0% 18.2% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 4/22 (18%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | 552 911 (T) | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545N | (e) (e) |
|INCIDENTAL TUMOR | P=0.541 | (e) (e) |
|LOGISTIC REGRESSION | P=0.575 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | (e) |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 5.4% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 796 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.356 | (e) (e) |
|INCIDENTAL TUMOR | P=0.232 | (e) (e) |
|LOGISTIC REGRESSION | P=0.272 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248 | (e) |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 2/70 (3%) | 0/70 (0%) 0/70 (0%) |
|ADJUSTED (b) | 0.0% 5.4% | 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/10 (0%) 0/22 (0%) | 0/18 (0%) 0/24 (0%) |
|FIRST INCIDENCE (DAYS) | --- 796 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.356 | (e) (e) |
|INCIDENTAL TUMOR | P=0.232 | (e) (e) |
|LOGISTIC REGRESSION | P=0.272 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248 | (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 59/70 (84%) 60/70 (86%) | 46/70 (66%) 42/70 (60%) |
|ADJUSTED (b) | 100.0% 100.0% | 95.6% 86.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 10/10 (100%) 22/22 (100%) | 16/18 (89%) 18/24 (75%) |
|FIRST INCIDENCE (DAYS) | 484 600 | 562 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** | P=0.061N |
|INCIDENTAL TUMOR | P=0.506 | P=0.172N |
|LOGISTIC REGRESSION | P=0.758 | P=0.179N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.300N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD 0.5% | UNTREATD 0.5% |
| | CONTROL | CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 52/70 (74%) 49/70 (70%) | 40/70 (57%) 41/70 (59%) |
|ADJUSTED (b) | 94.0% 86.8% | 76.7% 77.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/10 (70%) 15/22 (68%) | 8/18 (44%) 13/24 (54%) |
|FIRST INCIDENCE (DAYS) | 484 600 | 504 540 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** | P=0.293N |
|INCIDENTAL TUMOR | P=0.604 | P=0.267 |
|LOGISTIC REGRESSION | P=0.583N | P=0.271 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.353N | P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 59/70 (84%) 60/70 (86%) | 59/70 (84%) 57/70 (81%) |
|ADJUSTED (b) | 100.0% 100.0% | 98.3% 96.6% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 10/10 (100%) 22/22 (100%) | 17/18 (94%) 22/24 (92%) |
|FIRST INCIDENCE (DAYS) | 484 600 | 504 499 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** | P=0.098N |
|INCIDENTAL TUMOR | P=0.506 | P=0.485N |
|LOGISTIC REGRESSION | P=0.758 | P=0.353N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.411N |
|=================================================================================================================================|
DATE: 04/04/96 EXPERIMENT: 05217 TEST: 04 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
TERMINAL SACRIFICE AT 131 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 92
Female interim sacrifices(days): 92
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).