TDMS Study 05217-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 04 TIME: 08:26:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948330
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 04 TIME: 08:26:30
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948330
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 911 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 484 552 569 578 590 593 603 604 612 626 |
| 626 626 632 641 661 670 674 688 691 691 |
| 698 707 714 719 730 732 745 752 753 754 |
| 759 773 778 780 786 786 786 796 802 808 |
| 808 808 822 841 841 841 841 892 898 900 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 38 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 600 630 641 671 677 683 696 712 730 730 |
| 731 732 732 732 743 743 745 754 755 759 |
| 778 793 796 796 796 807 817 820 828 837 |
| 841 845 855 866 890 895 902 910 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 911 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 911 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 100.0 100.0 100.0 100.0 98.3 98.3 86.7 75.0 16.7 |
|U | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.3 95.0 36.7 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTROL 0.5% |
| U |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.7% 36.7% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.003N P=0.003N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 721.2 770.2 |
|NATURAL DEATHS (C) | (14.0) (12.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 658.4 717.6 |
|(STANDARD ERROR) | (30.6) (32.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 911 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 42 CENSORED DEATHS 10 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 504 562 575 593 626 638 641 677 688 691 |
| 698 710 711 725 730 731 752 771 777 780 |
| 786 788 793 808 808 820 822 823 827 828 |
| 828 837 837 856 856 862 866 870 870 872 |
| 880 892 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 36 CENSORED DEATHS 10 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 400 499 540 593 607 649 672 673 688 696 |
| 712 741 753 768 773 780 780 788 796 802 |
| 823 837 837 841 841 849 852 855 856 856 |
| 862 866 872 885 897 909 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 911 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 911 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 100.0 100.0 100.0 100.0 100.0 98.3 93.3 88.3 30.0 |
|U | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 98.3 98.3 95.0 93.3 90.0 40.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTROL 0.5% |
| U |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 30.0% 40.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.259N P=0.259N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 762.1 762.4 |
|NATURAL DEATHS (C) | (15.2) (20.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 704.7 717.6 |
|(STANDARD ERROR) | (32.3) (33.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATDCONTROL = 1
0.5% = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2
| 1 1 1 2 22
| 1 2 2
| 1 1 222
90 + 11 22
| 11 2 2 2
| 1 1
|
80 + 1
| 11 1 22
P | 11
E | 111 22
R 70 +
C | 11 22 2
E | 11 2 2
N | 11
T 60 + 1 1
| 11 222
S | 11 22
U | 22
R 50 + 11 22
V | 111 22
I | 22
V | 11 2 2
A 40 + 22
L | 11 22
| 11
|
30 + 1 1
| 1 1
|
| 1 1
20 + 11
| 11
|
|
10 +
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 20 obs hidden.
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATDCONTROL = 1
0.5% = 2
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 1 2 11
| 2 1 1
| 12 112
90 + 2 2
| 1 211
P | 22
E | 11 1 2
R 80 + 22
C | 111 2 2
E | 22
N | 1 1 122
T 70 + 22
| 1112 2
S | 22
U | 111 22
R 60 +
V | 1 1 22
I | 2
V | 1
A 50 + 22
L | 11 22
| 1 1 22
| 11 2 22
40 + 2
| 11
|
| 111
30 + 1 1
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 29 obs hidden.