TDMS Study 05217-05 Pathology Tables
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 Facility: Southern Research Institute Chemical CAS #: 1948-33-0 Lock Date: 08/04/92 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Scheduled Sacrifice 9 8 9 6 Early Deaths Moribund Sacrifice 11 7 6 6 Natural Death 2 10 5 5 Survivors Terminal Sacrifice 37 35 40 42 Natural Death 1 1 Animals Examined Microscopically 60 60 60 60 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (58) (58) (56) (60) Cyst 1 (2%) Intestine Small, Duodenum (60) (59) (57) (59) Erosion 1 (2%) Inflammation, Chronic, Focal 1 (2%) Intestine Small, Jejunum (60) (59) (57) (59) Perforation, Chronic 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Intestine Small, Ileum (60) (59) (56) (59) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%) Liver (60) (60) (60) (60) Angiectasis 2 (3%) 1 (2%) Basophilic Focus 2 (3%) 1 (2%) 1 (2%) Clear Cell Focus 2 (3%) 2 (3%) Eosinophilic Focus 4 (7%) 9 (15%) 9 (15%) 11 (18%) Eosinophilic Focus, Multiple 3 (5%) 5 (8%) 1 (2%) 1 (2%) Fatty Change 4 (7%) 1 (2%) Fatty Change, Focal 2 (3%) 1 (2%) Hematopoietic Cell Proliferation 3 (5%) 1 (2%) 1 (2%) 2 (3%) Hemorrhage, Focal 1 (2%) Hyperplasia, Focal, Lymphoid 1 (2%) Infarct 1 (2%) 1 (2%) Infiltration Cellular, Mixed Cell 2 (3%) 1 (2%) 1 (2%) 3 (5%) Inflammation, Focal 3 (5%) 1 (2%) 2 (3%) 2 (3%) Mineralization, Focal 1 (2%) Mixed Cell Focus 1 (2%) 4 (7%) 2 (3%) 1 (2%) Mixed Cell Focus, Multiple 1 (2%) Necrosis, Focal 1 (2%) 1 (2%) 2 (3%) Thrombosis 1 (2%) Vacuolization Cytoplasmic, Focal 1 (2%) Bile Duct, Cyst 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%) Mesentery (10) (13) (7) (9) Hemorrhage 1 (8%) Inflammation, Chronic 1 (10%) 1 (8%) 3 (43%) 4 (44%) Fat, Necrosis 8 (80%) 5 (38%) 1 (14%) 2 (22%) Pancreas (60) (60) (58) (60) Atrophy, Focal 1 (2%) 1 (2%) 2 (3%) Duct, Cyst 1 (2%) Salivary Glands (60) (60) (60) (58) Vacuolization Cytoplasmic 1 (2%) Stomach, Forestomach (60) (60) (60) (60) Erosion 3 (5%) 1 (2%) Inflammation, Chronic 5 (8%) 1 (2%) 3 (5%) Pigmentation, Focal 1 (2%) Ulcer 1 (2%) 2 (3%) Epithelium, Hyperplasia 5 (8%) 1 (2%) 4 (7%) Stomach, Glandular (60) (60) (58) (60) Erosion 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) Pigmentation, Focal 1 (2%) Ulcer 1 (2%) Glands, Degeneration, Cystic, Focal 1 (2%) Tooth (2) (4) (1) Incisor, Dysplasia 2 (100%) 4 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (59) (60) (60) (60) Mesenteric Artery, Inflammation, Chronic 1 (2%) Heart (60) (60) (60) (60) Inflammation, Chronic, Focal 1 (2%) Thrombosis 1 (2%) Artery, Inflammation, Chronic 2 (3%) Myocardium, Mineralization, Focal 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (60) (59) (59) (60) Accessory Adrenal Cortical Nodule 2 (3%) 4 (7%) 1 (2%) 1 (2%) Cytoplasmic Alteration, Focal 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Capsule, Hyperplasia 1 (2%) Subcapsular, Hyperplasia, Focal 2 (3%) Adrenal Medulla (60) (59) (60) (60) Hyperplasia 1 (2%) 4 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Islets, Pancreatic (60) (60) (57) (60) Hyperplasia 1 (2%) Parathyroid Gland (55) (56) (58) (55) Cyst 1 (2%) Hyperplasia 1 (2%) Pituitary Gland (58) (52) (55) (55) Angiectasis 2 (3%) 2 (4%) 1 (2%) Cyst 1 (2%) Pars Distalis, Angiectasis 1 (2%) Pars Distalis, Cytoplasmic Alteration, Focal 2 (3%) 3 (6%) 2 (4%) 1 (2%) Pars Distalis, Hyperplasia, Focal 3 (5%) 3 (6%) 2 (4%) 1 (2%) Pars Intermedia, Hyperplasia, Focal 1 (2%) Thyroid Gland (60) (59) (59) (60) Degeneration, Cystic, Focal 1 (2%) 1 (2%) Inflammation 1 (2%) Inflammation, Chronic, Focal 1 (2%) 2 (3%) C-Cell, Hyperplasia 2 (3%) 1 (2%) Follicular Cell, Hyperplasia 12 (20%) 19 (32%) 24 (41%) 24 (40%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (60) (60) (59) (60) Degeneration, Cystic 4 (7%) 2 (3%) 3 (5%) Ovary (59) (57) (56) (56) Angiectasis 2 (3%) 2 (4%) 3 (5%) Cyst 19 (32%) 10 (18%) 11 (20%) 12 (21%) Hemorrhage 1 (2%) Hyperplasia, Tubular 1 (2%) Inflammation, Suppurative 2 (3%) 2 (4%) 2 (4%) 5 (9%) Thrombosis 1 (2%) Interstitial Cell, Hyperplasia 1 (2%) Uterus (60) (60) (59) (60) Cyst 1 (2%) 1 (2%) Hemorrhage 1 (2%) Hydrometra 17 (28%) 12 (20%) 13 (22%) 16 (27%) Hyperplasia, Focal, Histiocytic 1 (2%) Inflammation, Suppurative 4 (7%) 2 (3%) 3 (5%) Endometrium, Hyperplasia, Cystic 59 (98%) 60 (100%) 58 (98%) 57 (95%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (60) (60) (60) (60) Hyperplasia 2 (3%) Hyperplasia, Focal, Histiocytic 1 (2%) Myelofibrosis 1 (2%) Lymph Node (7) (8) (12) (9) Hyperplasia, Cystic 1 (14%) Iliac, Hemorrhage 1 (14%) Iliac, Hyperplasia 2 (29%) 1 (13%) 1 (11%) Inguinal, Hyperplasia 2 (17%) Lumbar, Hyperplasia 1 (11%) Mediastinal, Hyperplasia 1 (14%) 1 (13%) 2 (17%) 1 (11%) Mediastinal, Hyperplasia, Lymphoid 1 (14%) 1 (11%) Mediastinal, Inflammation, Focal, Suppurative 1 (11%) Renal, Hemorrhage 1 (14%) Renal, Hyperplasia 2 (29%) 2 (25%) 1 (8%) 3 (33%) Lymph Node, Mandibular (57) (60) (59) (57) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 2 (4%) 2 (3%) 1 (2%) Lymph Node, Mesenteric (59) (56) (58) (56) Amyloid Deposition 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%) Hyperplasia 1 (2%) 2 (4%) 1 (2%) Hyperplasia, Histiocytic 1 (2%) Hyperplasia, Lymphoid 6 (10%) 3 (5%) 3 (5%) 1 (2%) Spleen (60) (60) (59) (60) Angiectasis 1 (2%) Congestion 1 (2%) Fibrosis, Focal 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 14 (23%) 14 (23%) 13 (22%) 13 (22%) Hemorrhage 1 (2%) Hyperplasia, Lymphoid 3 (5%) 8 (13%) 7 (12%) 7 (12%) Necrosis, Focal 1 (2%) Thymus (53) (59) (56) (54) Cyst 1 (2%) 1 (2%) 1 (2%) Hyperplasia, Histiocytic 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (60) (59) (60) (60) Ectasia 3 (5%) 1 (2%) Hyperplasia 1 (2%) Skin (60) (60) (60) (60) Alopecia, Focal 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - CONT Inflammation, Chronic, Focal 1 (2%) Ulcer 1 (2%) Epidermis, Hyperplasia, Focal 1 (2%) Subcutaneous Tissue, Edema 1 (2%) Subcutaneous Tissue, Inflammation, Chronic, Focal 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (1) (1) (2) Inflammation, Suppurative 1 (100%) 1 (100%) 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (60) (60) (60) (60) Atrophy, Focal 3 (5%) 4 (7%) 1 (2%) 1 (2%) Artery, Meninges, Inflammation, Chronic 1 (2%) Meninges, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (60) (60) (60) (60) Congestion 1 (2%) Hemorrhage 1 (2%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) Infiltration Cellular, Mixed Cell 1 (2%) 2 (3%) Inflammation, Chronic, Focal 1 (2%) Alveolar Epithelium, Hyperplasia 1 (2%) 2 (3%) 2 (3%) Interstitium, Inflammation, Suppurative 2 (3%) 1 (2%) Mediastinum, Inflammation, Chronic 1 (2%) Pleura, Mediastinum, Inflammation, Chronic 1 (2%) 1 (2%) Nose (60) (60) (58) (59) Inflammation, Suppurative 1 (2%) 1 (2%) Mucosa, Glands, Dilatation, Focal 16 (27%) 27 (45%) 16 (28%) 26 (44%) Nasolacrimal Duct, Cyst 1 (2%) Trachea (60) (60) (59) (60) Artery, Peritracheal Tissue, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) Cornea, Inflammation, Chronic 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (60) (60) (59) (59) Congestion 2 (3%) Cyst 1 (2%) Hydronephrosis 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Inflammation, Chronic 2 (3%) 1 (2%) Metaplasia, Focal, Osseous 1 (2%) Nephropathy 30 (50%) 32 (53%) 35 (59%) 28 (47%) Artery, Inflammation, Chronic 1 (2%) Renal Tubule, Casts 1 (2%) Renal Tubule, Dilatation, Focal 2 (3%) Renal Tubule, Pigmentation 1 (2%) Renal Tubule, Pigmentation, Hemoglobin 1 (2%) Urinary Bladder (60) (59) (59) (59) Angiectasis 1 (2%) Hyperplasia, Lymphoid 2 (3%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 60 60 60 60 Scheduled Sacrifice 10 10 9 9 Early Deaths Natural Death 4 1 6 2 Moribund Sacrifice 6 3 7 7 Accidently Killed 1 Survivors Terminal Sacrifice 39 46 38 42 Animals Examined Microscopically 60 60 60 60 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Small, Jejunum (60) (60) (57) (59) Perforation 1 (2%) Peyer's Patch, Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%) Intestine Small, Ileum (59) (59) (58) (58) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Liver (60) (60) (60) (60) Angiectasis 2 (3%) 1 (2%) 1 (2%) Basophilic Focus 5 (8%) 2 (3%) 2 (3%) 5 (8%) Clear Cell Focus 4 (7%) 3 (5%) 7 (12%) 3 (5%) Clear Cell Focus, Multiple 2 (3%) 4 (7%) 2 (3%) 1 (2%) Cyst 1 (2%) Eosinophilic Focus 7 (12%) 4 (7%) 4 (7%) 3 (5%) Eosinophilic Focus, Multiple 1 (2%) 1 (2%) 1 (2%) 1 (2%) Fatty Change 1 (2%) Fatty Change, Focal 7 (12%) 8 (13%) 6 (10%) 3 (5%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) Infiltration Cellular, Mixed Cell 1 (2%) Inflammation, Focal 2 (3%) 1 (2%) Mixed Cell Focus 5 (8%) 8 (13%) 4 (7%) 5 (8%) Mixed Cell Focus, Multiple 3 (5%) Necrosis, Focal 2 (3%) 1 (2%) 2 (3%) 1 (2%) Pigmentation, Focal 1 (2%) Thrombosis 1 (2%) Bile Duct, Hyperplasia 1 (2%) Centrilobular, Necrosis 1 (2%) Oval Cell, Hyperplasia 1 (2%) Mesentery (2) (7) (15) (1) Inflammation, Chronic 1 (14%) 3 (20%) Artery, Inflammation, Chronic 1 (50%) 1 (7%) Fat, Necrosis 5 (71%) 7 (47%) 1 (100%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Pancreas (59) (60) (60) (60) Atrophy, Diffuse 1 (2%) 1 (2%) Atrophy, Focal 2 (3%) Duct, Cyst 1 (2%) 2 (3%) Stomach, Forestomach (59) (60) (60) (60) Edema 1 (2%) Erosion 1 (2%) 1 (2%) Inflammation, Chronic 3 (5%) 2 (3%) 1 (2%) Epithelium, Hyperplasia 4 (7%) 2 (3%) 1 (2%) Stomach, Glandular (59) (60) (60) (59) Edema 1 (2%) Erosion 1 (2%) 1 (2%) Mineralization 1 (2%) 1 (2%) Pigmentation, Focal 1 (2%) Epithelium, Hyperplasia, Cystic 1 (2%) Tooth (29) (27) (18) (28) Incisor, Dysplasia 29 (100%) 27 (100%) 18 (100%) 28 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (60) (60) (60) (60) Inflammation, Chronic, Focal 2 (3%) Artery, Degeneration 1 (2%) Artery, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (60) (60) (59) (60) Accessory Adrenal Cortical Nodule 3 (5%) 1 (2%) 2 (3%) Cyst 1 (2%) 1 (2%) Cytoplasmic Alteration, Focal 1 (2%) 3 (5%) 2 (3%) Fibrosis 1 (2%) 1 (2%) Subcapsular, Hyperplasia 1 (2%) 2 (3%) Subcapsular, Hyperplasia, Focal 5 (8%) 4 (7%) 6 (10%) 8 (13%) Islets, Pancreatic (60) (60) (60) (60) Cyst 1 (2%) Hyperplasia 1 (2%) 1 (2%) Parathyroid Gland (59) (56) (58) (53) Cyst 2 (3%) 2 (4%) Pituitary Gland (55) (52) (53) (57) Angiectasis 1 (2%) Cyst 1 (2%) 2 (4%) 3 (6%) 3 (5%) Thyroid Gland (60) (60) (59) (60) Degeneration, Cystic, Focal 7 (12%) 5 (8%) 6 (10%) 6 (10%) Fibrosis, Focal 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT C-Cell, Hyperplasia 1 (2%) Follicle, Hypertrophy, Focal 1 (2%) Follicular Cell, Hyperplasia 6 (10%) 12 (20%) 6 (10%) 6 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM Tissue NOS (3) Pelvic, Inflammation, Chronic 2 (67%) ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Coagulating Gland (4) (6) (2) (1) Inflammation, Chronic 1 (100%) Epididymis (60) (60) (60) (59) Spermatocele 1 (2%) Preputial Gland (60) (59) (59) (59) Degeneration, Cystic 22 (37%) 30 (51%) 33 (56%) 29 (49%) Inflammation, Chronic 8 (13%) 5 (8%) 8 (14%) 5 (8%) Prostate (59) (60) (60) (60) Inflammation, Chronic, Focal 1 (2%) Epithelium, Hyperplasia, Focal 1 (2%) 2 (3%) 1 (2%) Seminal Vesicle (60) (60) (60) (60) Inflammation, Chronic 1 (2%) 1 (2%) Testes (60) (60) (60) (60) Fibrosis 1 (2%) Granuloma Sperm 1 (2%) Mineralization, Focal 1 (2%) 1 (2%) Thrombosis 1 (2%) Artery, Inflammation, Chronic 1 (2%) Germinal Epithelium, Degeneration 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (60) (60) (60) (60) Angiectasis 1 (2%) Hyperplasia 1 (2%) Myelofibrosis 1 (2%) Lymph Node (3) (3) (6) (3) Bronchial, Hyperplasia 1 (17%) Iliac, Hemorrhage 1 (17%) Inguinal, Hyperplasia 2 (67%) 1 (33%) Inguinal, Hyperplasia, Lymphoid 1 (33%) 1 (17%) Inguinal, Pigmentation 1 (33%) Mediastinal, Hyperplasia 1 (33%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Mediastinal, Hyperplasia, Lymphoid 1 (33%) Renal, Hemorrhage 1 (17%) Lymph Node, Mandibular (58) (58) (58) (60) Hyperplasia, Lymphoid 1 (2%) 1 (2%) Lymph Node, Mesenteric (60) (58) (60) (60) Ectasia 2 (3%) Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 2 (3%) Hemorrhage 12 (20%) 11 (19%) 9 (15%) 9 (15%) Hyperplasia 1 (2%) Hyperplasia, Histiocytic 1 (2%) 1 (2%) Hyperplasia, Lymphoid 2 (3%) 3 (5%) 2 (3%) 1 (2%) Spleen (60) (60) (60) (60) Accessory Spleen 1 (2%) Hematopoietic Cell Proliferation 8 (13%) 12 (20%) 17 (28%) 11 (18%) Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%) Thymus (53) (48) (52) (51) Cyst 4 (8%) 8 (17%) 5 (10%) 4 (8%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (60) (60) (60) (60) Alopecia 1 (2%) 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic, Focal 2 (3%) Ulcer 1 (2%) Epidermis, Hyperplasia, Focal 1 (2%) Subcutaneous Tissue, Edema 2 (3%) 1 (2%) Subcutaneous Tissue, Mineralization, Focal 1 (2%) 1 (2%) Subcutaneous Tissue, Necrosis, Focal 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Skeletal Muscle (2) (1) (1) Mineralization, Focal 1 (50%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (60) (60) (60) (60) Atrophy, Focal 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96 Route: DOSED FEED Time: 08:56:45 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5% CONTROL ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (60) (58) (60) (60) Congestion 1 (2%) 1 (2%) Hemorrhage 2 (3%) Hyperplasia, Histiocytic 2 (3%) 4 (7%) 1 (2%) 1 (2%) Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%) Thrombosis, Multiple 1 (2%) Alveolar Epithelium, Hyperplasia 4 (7%) 5 (9%) 4 (7%) 9 (15%) Interstitium, Edema 1 (2%) Mediastinum, Edema 1 (2%) Nose (60) (60) (60) (60) Inflammation, Suppurative 2 (3%) 2 (3%) Mucosa, Cyst 1 (2%) Mucosa, Polyp, Inflammatory 1 (2%) Mucosa, Glands, Dilatation, Focal 9 (15%) 18 (30%) 10 (17%) 9 (15%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Harderian Gland (3) (9) (6) (3) Hyperplasia, Focal 1 (11%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (60) (60) (60) (60) Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%) Fibrosis, Focal 1 (2%) Hydronephrosis 1 (2%) 1 (2%) Hyperplasia, Focal 1 (2%) Necrosis, Focal 1 (2%) Nephropathy 50 (83%) 47 (78%) 48 (80%) 50 (83%) Pelvis, Inflammation, Suppurative 1 (2%) Renal Tubule, Dilatation, Diffuse 1 (2%) Renal Tubule, Dilatation, Focal 1 (2%) 1 (2%) Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%) Urinary Bladder (60) (60) (60) (60) Calculus Micro Observation Only 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------