TDMS Study 05217-05 Pathology Tables
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 08/04/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 9 8 9 6
Early Deaths
Moribund Sacrifice 11 7 6 6
Natural Death 2 10 5 5
Survivors
Terminal Sacrifice 37 35 40 42
Natural Death 1 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (58) (58) (56) (60)
Cyst 1 (2%)
Intestine Small, Duodenum (60) (59) (57) (59)
Erosion 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Intestine Small, Jejunum (60) (59) (57) (59)
Perforation, Chronic 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Ileum (60) (59) (56) (59)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 2 (3%) 1 (2%)
Basophilic Focus 2 (3%) 1 (2%) 1 (2%)
Clear Cell Focus 2 (3%) 2 (3%)
Eosinophilic Focus 4 (7%) 9 (15%) 9 (15%) 11 (18%)
Eosinophilic Focus, Multiple 3 (5%) 5 (8%) 1 (2%) 1 (2%)
Fatty Change 4 (7%) 1 (2%)
Fatty Change, Focal 2 (3%) 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 1 (2%) 1 (2%) 2 (3%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Mixed Cell 2 (3%) 1 (2%) 1 (2%) 3 (5%)
Inflammation, Focal 3 (5%) 1 (2%) 2 (3%) 2 (3%)
Mineralization, Focal 1 (2%)
Mixed Cell Focus 1 (2%) 4 (7%) 2 (3%) 1 (2%)
Mixed Cell Focus, Multiple 1 (2%)
Necrosis, Focal 1 (2%) 1 (2%) 2 (3%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
Mesentery (10) (13) (7) (9)
Hemorrhage 1 (8%)
Inflammation, Chronic 1 (10%) 1 (8%) 3 (43%) 4 (44%)
Fat, Necrosis 8 (80%) 5 (38%) 1 (14%) 2 (22%)
Pancreas (60) (60) (58) (60)
Atrophy, Focal 1 (2%) 1 (2%) 2 (3%)
Duct, Cyst 1 (2%)
Salivary Glands (60) (60) (60) (58)
Vacuolization Cytoplasmic 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Erosion 3 (5%) 1 (2%)
Inflammation, Chronic 5 (8%) 1 (2%) 3 (5%)
Pigmentation, Focal 1 (2%)
Ulcer 1 (2%) 2 (3%)
Epithelium, Hyperplasia 5 (8%) 1 (2%) 4 (7%)
Stomach, Glandular (60) (60) (58) (60)
Erosion 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Pigmentation, Focal 1 (2%)
Ulcer 1 (2%)
Glands, Degeneration, Cystic, Focal 1 (2%)
Tooth (2) (4) (1)
Incisor, Dysplasia 2 (100%) 4 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (59) (60) (60) (60)
Mesenteric Artery, Inflammation, Chronic 1 (2%)
Heart (60) (60) (60) (60)
Inflammation, Chronic, Focal 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic 2 (3%)
Myocardium, Mineralization, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (59) (59) (60)
Accessory Adrenal Cortical Nodule 2 (3%) 4 (7%) 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Capsule, Hyperplasia 1 (2%)
Subcapsular, Hyperplasia, Focal 2 (3%)
Adrenal Medulla (60) (59) (60) (60)
Hyperplasia 1 (2%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Islets, Pancreatic (60) (60) (57) (60)
Hyperplasia 1 (2%)
Parathyroid Gland (55) (56) (58) (55)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (58) (52) (55) (55)
Angiectasis 2 (3%) 2 (4%) 1 (2%)
Cyst 1 (2%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cytoplasmic Alteration, Focal 2 (3%) 3 (6%) 2 (4%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 3 (5%) 3 (6%) 2 (4%) 1 (2%)
Pars Intermedia, Hyperplasia, Focal 1 (2%)
Thyroid Gland (60) (59) (59) (60)
Degeneration, Cystic, Focal 1 (2%) 1 (2%)
Inflammation 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 2 (3%)
C-Cell, Hyperplasia 2 (3%) 1 (2%)
Follicular Cell, Hyperplasia 12 (20%) 19 (32%) 24 (41%) 24 (40%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (60) (59) (60)
Degeneration, Cystic 4 (7%) 2 (3%) 3 (5%)
Ovary (59) (57) (56) (56)
Angiectasis 2 (3%) 2 (4%) 3 (5%)
Cyst 19 (32%) 10 (18%) 11 (20%) 12 (21%)
Hemorrhage 1 (2%)
Hyperplasia, Tubular 1 (2%)
Inflammation, Suppurative 2 (3%) 2 (4%) 2 (4%) 5 (9%)
Thrombosis 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (60) (60) (59) (60)
Cyst 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 17 (28%) 12 (20%) 13 (22%) 16 (27%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Inflammation, Suppurative 4 (7%) 2 (3%) 3 (5%)
Endometrium, Hyperplasia, Cystic 59 (98%) 60 (100%) 58 (98%) 57 (95%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hyperplasia 2 (3%)
Hyperplasia, Focal, Histiocytic 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (7) (8) (12) (9)
Hyperplasia, Cystic 1 (14%)
Iliac, Hemorrhage 1 (14%)
Iliac, Hyperplasia 2 (29%) 1 (13%) 1 (11%)
Inguinal, Hyperplasia 2 (17%)
Lumbar, Hyperplasia 1 (11%)
Mediastinal, Hyperplasia 1 (14%) 1 (13%) 2 (17%) 1 (11%)
Mediastinal, Hyperplasia, Lymphoid 1 (14%) 1 (11%)
Mediastinal, Inflammation, Focal, Suppurative 1 (11%)
Renal, Hemorrhage 1 (14%)
Renal, Hyperplasia 2 (29%) 2 (25%) 1 (8%) 3 (33%)
Lymph Node, Mandibular (57) (60) (59) (57)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (3%) 1 (2%)
Lymph Node, Mesenteric (59) (56) (58) (56)
Amyloid Deposition 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 6 (10%) 3 (5%) 3 (5%) 1 (2%)
Spleen (60) (60) (59) (60)
Angiectasis 1 (2%)
Congestion 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 14 (23%) 14 (23%) 13 (22%) 13 (22%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 3 (5%) 8 (13%) 7 (12%) 7 (12%)
Necrosis, Focal 1 (2%)
Thymus (53) (59) (56) (54)
Cyst 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (59) (60) (60)
Ectasia 3 (5%) 1 (2%)
Hyperplasia 1 (2%)
Skin (60) (60) (60) (60)
Alopecia, Focal 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Chronic, Focal 1 (2%)
Ulcer 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic,
Focal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1) (2)
Inflammation, Suppurative 1 (100%) 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Atrophy, Focal 3 (5%) 4 (7%) 1 (2%) 1 (2%)
Artery, Meninges, Inflammation, Chronic 1 (2%)
Meninges, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 2 (3%)
Inflammation, Chronic, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (3%) 2 (3%)
Interstitium, Inflammation, Suppurative 2 (3%) 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Pleura, Mediastinum, Inflammation, Chronic 1 (2%) 1 (2%)
Nose (60) (60) (58) (59)
Inflammation, Suppurative 1 (2%) 1 (2%)
Mucosa, Glands, Dilatation, Focal 16 (27%) 27 (45%) 16 (28%) 26 (44%)
Nasolacrimal Duct, Cyst 1 (2%)
Trachea (60) (60) (59) (60)
Artery, Peritracheal Tissue, Inflammation,
Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59) (59)
Congestion 2 (3%)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Metaplasia, Focal, Osseous 1 (2%)
Nephropathy 30 (50%) 32 (53%) 35 (59%) 28 (47%)
Artery, Inflammation, Chronic 1 (2%)
Renal Tubule, Casts 1 (2%)
Renal Tubule, Dilatation, Focal 2 (3%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Pigmentation, Hemoglobin 1 (2%)
Urinary Bladder (60) (59) (59) (59)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 9 9
Early Deaths
Natural Death 4 1 6 2
Moribund Sacrifice 6 3 7 7
Accidently Killed 1
Survivors
Terminal Sacrifice 39 46 38 42
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (60) (60) (57) (59)
Perforation 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%)
Intestine Small, Ileum (59) (59) (58) (58)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 2 (3%) 1 (2%) 1 (2%)
Basophilic Focus 5 (8%) 2 (3%) 2 (3%) 5 (8%)
Clear Cell Focus 4 (7%) 3 (5%) 7 (12%) 3 (5%)
Clear Cell Focus, Multiple 2 (3%) 4 (7%) 2 (3%) 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 7 (12%) 4 (7%) 4 (7%) 3 (5%)
Eosinophilic Focus, Multiple 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Fatty Change 1 (2%)
Fatty Change, Focal 7 (12%) 8 (13%) 6 (10%) 3 (5%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Focal 2 (3%) 1 (2%)
Mixed Cell Focus 5 (8%) 8 (13%) 4 (7%) 5 (8%)
Mixed Cell Focus, Multiple 3 (5%)
Necrosis, Focal 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Pigmentation, Focal 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Necrosis 1 (2%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (2) (7) (15) (1)
Inflammation, Chronic 1 (14%) 3 (20%)
Artery, Inflammation, Chronic 1 (50%) 1 (7%)
Fat, Necrosis 5 (71%) 7 (47%) 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (59) (60) (60) (60)
Atrophy, Diffuse 1 (2%) 1 (2%)
Atrophy, Focal 2 (3%)
Duct, Cyst 1 (2%) 2 (3%)
Stomach, Forestomach (59) (60) (60) (60)
Edema 1 (2%)
Erosion 1 (2%) 1 (2%)
Inflammation, Chronic 3 (5%) 2 (3%) 1 (2%)
Epithelium, Hyperplasia 4 (7%) 2 (3%) 1 (2%)
Stomach, Glandular (59) (60) (60) (59)
Edema 1 (2%)
Erosion 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (2%)
Pigmentation, Focal 1 (2%)
Epithelium, Hyperplasia, Cystic 1 (2%)
Tooth (29) (27) (18) (28)
Incisor, Dysplasia 29 (100%) 27 (100%) 18 (100%) 28 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Inflammation, Chronic, Focal 2 (3%)
Artery, Degeneration 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (59) (60)
Accessory Adrenal Cortical Nodule 3 (5%) 1 (2%) 2 (3%)
Cyst 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%) 3 (5%) 2 (3%)
Fibrosis 1 (2%) 1 (2%)
Subcapsular, Hyperplasia 1 (2%) 2 (3%)
Subcapsular, Hyperplasia, Focal 5 (8%) 4 (7%) 6 (10%) 8 (13%)
Islets, Pancreatic (60) (60) (60) (60)
Cyst 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (59) (56) (58) (53)
Cyst 2 (3%) 2 (4%)
Pituitary Gland (55) (52) (53) (57)
Angiectasis 1 (2%)
Cyst 1 (2%) 2 (4%) 3 (6%) 3 (5%)
Thyroid Gland (60) (60) (59) (60)
Degeneration, Cystic, Focal 7 (12%) 5 (8%) 6 (10%) 6 (10%)
Fibrosis, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 1 (2%)
Follicle, Hypertrophy, Focal 1 (2%)
Follicular Cell, Hyperplasia 6 (10%) 12 (20%) 6 (10%) 6 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3)
Pelvic, Inflammation, Chronic 2 (67%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (4) (6) (2) (1)
Inflammation, Chronic 1 (100%)
Epididymis (60) (60) (60) (59)
Spermatocele 1 (2%)
Preputial Gland (60) (59) (59) (59)
Degeneration, Cystic 22 (37%) 30 (51%) 33 (56%) 29 (49%)
Inflammation, Chronic 8 (13%) 5 (8%) 8 (14%) 5 (8%)
Prostate (59) (60) (60) (60)
Inflammation, Chronic, Focal 1 (2%)
Epithelium, Hyperplasia, Focal 1 (2%) 2 (3%) 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Inflammation, Chronic 1 (2%) 1 (2%)
Testes (60) (60) (60) (60)
Fibrosis 1 (2%)
Granuloma Sperm 1 (2%)
Mineralization, Focal 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Angiectasis 1 (2%)
Hyperplasia 1 (2%)
Myelofibrosis 1 (2%)
Lymph Node (3) (3) (6) (3)
Bronchial, Hyperplasia 1 (17%)
Iliac, Hemorrhage 1 (17%)
Inguinal, Hyperplasia 2 (67%) 1 (33%)
Inguinal, Hyperplasia, Lymphoid 1 (33%) 1 (17%)
Inguinal, Pigmentation 1 (33%)
Mediastinal, Hyperplasia 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hyperplasia, Lymphoid 1 (33%)
Renal, Hemorrhage 1 (17%)
Lymph Node, Mandibular (58) (58) (58) (60)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Lymph Node, Mesenteric (60) (58) (60) (60)
Ectasia 2 (3%)
Hematopoietic Cell Proliferation 1 (2%) 2 (3%) 2 (3%)
Hemorrhage 12 (20%) 11 (19%) 9 (15%) 9 (15%)
Hyperplasia 1 (2%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 3 (5%) 2 (3%) 1 (2%)
Spleen (60) (60) (60) (60)
Accessory Spleen 1 (2%)
Hematopoietic Cell Proliferation 8 (13%) 12 (20%) 17 (28%) 11 (18%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%)
Thymus (53) (48) (52) (51)
Cyst 4 (8%) 8 (17%) 5 (10%) 4 (8%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Alopecia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 2 (3%)
Ulcer 1 (2%)
Epidermis, Hyperplasia, Focal 1 (2%)
Subcutaneous Tissue, Edema 2 (3%) 1 (2%)
Subcutaneous Tissue, Mineralization, Focal 1 (2%) 1 (2%)
Subcutaneous Tissue, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (1)
Mineralization, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Atrophy, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05217-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 08:56:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREATD 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (58) (60) (60)
Congestion 1 (2%) 1 (2%)
Hemorrhage 2 (3%)
Hyperplasia, Histiocytic 2 (3%) 4 (7%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%) 1 (2%) 1 (2%)
Thrombosis, Multiple 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%) 5 (9%) 4 (7%) 9 (15%)
Interstitium, Edema 1 (2%)
Mediastinum, Edema 1 (2%)
Nose (60) (60) (60) (60)
Inflammation, Suppurative 2 (3%) 2 (3%)
Mucosa, Cyst 1 (2%)
Mucosa, Polyp, Inflammatory 1 (2%)
Mucosa, Glands, Dilatation, Focal 9 (15%) 18 (30%) 10 (17%) 9 (15%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (9) (6) (3)
Hyperplasia, Focal 1 (11%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Necrosis, Focal 1 (2%)
Nephropathy 50 (83%) 47 (78%) 48 (80%) 50 (83%)
Pelvis, Inflammation, Suppurative 1 (2%)
Renal Tubule, Dilatation, Diffuse 1 (2%)
Renal Tubule, Dilatation, Focal 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia, Focal 1 (2%) 1 (2%)
Urinary Bladder (60) (60) (60) (60)
Calculus Micro Observation Only 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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