TDMS Study 05217-05 Pathology Tables
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
CORE ANIMALS
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 08/04/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Mesentery | + + + + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Histiocytic Sarcoma | X |
Luteoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Endometrium, Adenoma | X |
Endometrium, Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Histiocytic Sarcoma | X |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + I + + + + + + I + + + + + + M|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Basal Cell Carcinoma, Metastatic, | |
Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Mediastinum, Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X X|
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Histiocytic Sarcoma | |
Luteoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Endometrium, Adenoma | |
Endometrium, Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Histiocytic Sarcoma | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + M + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, Sarcoma | X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Basal Cell Carcinoma, Metastatic, | |
Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Mediastinum, Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 51 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 7 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 8 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 10 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 50 |
__________________________________________________________________________|____________|
Heart | + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
__________________________________________________________________________|____________|
Ovary | + | 50 |
Cystadenoma | | 2 |
Histiocytic Sarcoma | | 1 |
Luteoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + | 51 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
Endometrium, Adenoma | | 1 |
Endometrium, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Iliac, Histiocytic Sarcoma | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 51 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + | 45 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Basal Cell Carcinoma, Metastatic, | | |
Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Mediastinum, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + | 51 |
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|
| 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Lymphoma Malignant | X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X |
Sarcoma | |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + M + + + + +|
Pars Distalis, Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|
| 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + I + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + M + + + M + + + + + + + + + + + + +|
Cystadenoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Inguinal, Histiocytic Sarcoma | X |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X X X |
Pancreatic, Lymphoma Malignant | X X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M M + + + +|
Lymphoma Malignant | X X X X X X X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|
| 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
Mediastinum, Lymphoma Malignant | X |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X X X X X X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|
| 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + + + + |
Lymphoma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Sarcoma | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + M + M + + + I + + + + M + + + + +|
Pars Distalis, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|
| 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cystadenoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Histiocytic Sarcoma | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + M + + + + + +|
Lymphoma Malignant | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|
| 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
Mediastinum, Lymphoma Malignant | |
Mediastinum, Squamous Cell Carcinoma,| |
Metastatic, Stomach, Forestomach| X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 52 |
__________________________________________________________________________|____________|
Gallbladder | + + | 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 51 |
__________________________________________________________________________|____________|
Liver | + + | 52 |
Hemangioma | | 1 |
Hepatocellular Carcinoma | | 8 |
Hepatocellular Adenoma | X | 11 |
Hepatocellular Adenoma, Multiple | | 9 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Mesentery | + | 13 |
Lymphoma Malignant | | 7 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 52 |
Carcinoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 52 |
Lymphoma Malignant | | 4 |
Sarcoma | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 52 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 52 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 52 |
__________________________________________________________________________|____________|
Heart | + + | 52 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 51 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 44 |
Pars Distalis, Adenoma | | 5 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 51 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 52 |
__________________________________________________________________________|____________|
Ovary | + + | 49 |
Cystadenoma | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + | 52 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 52 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Inguinal, Histiocytic Sarcoma | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 4 |
Pancreatic, Lymphoma Malignant | | 3 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 52 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 48 |
Lymphoma Malignant | | 7 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 52 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + | 51 |
Lymphoma Malignant | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 51 |
__________________________________________________________________________|____________|
Skin | + + | 52 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 2 |
Subcutaneous Tissue, Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 52 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 52 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 52 |
Alveolar/Bronchiolar Adenoma | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
Mediastinum, Lymphoma Malignant | | 1 |
Mediastinum, Squamous Cell Carcinoma,| | |
Metastatic, Stomach, Forestomach| | 1 |
__________________________________________________________________________|____________|
Nose | + + | 52 |
__________________________________________________________________________|____________|
Trachea | + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 52 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 51 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 52 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 9 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + A +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Mesentery | + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hepatocellular Carcinoma, | |
Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + I + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Pelvic, Hemangiosarcoma, Multiple | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + + + + M +|
Cystadenoma | X X |
Granulosa Cell Tumor Malignant | |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Endometrium, Adenoma | X |
Endometrium, Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Lymphoma Malignant | X |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | |
Mediastinal, Hepatocellular | |
Carcinoma, Metastatic, Liver | |
Mediastinal, Histiocytic Sarcoma | X |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X X X |
Renal, Histiocytic Sarcoma | X |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myoepithelioma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A A + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A A + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A A + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +|
Capsule, Hepatocellular Carcinoma, | |
Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + I + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant | X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Pelvic, Hemangiosarcoma, Multiple | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + + + + + + + + M + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Endometrium, Adenoma | |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Lymphoma Malignant | |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | X X |
Mediastinal, Hepatocellular | |
Carcinoma, Metastatic, Liver | X |
Mediastinal, Histiocytic Sarcoma | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + A M + + + + + I + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myoepithelioma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatoblastoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 47 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | | 7 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | | 11 |
Hepatocellular Adenoma, Multiple | | 5 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Mesentery | | 7 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 49 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 49 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
__________________________________________________________________________|____________|
Heart | + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 50 |
Capsule, Hepatocellular Carcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Pheochromocytoma Malignant | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | M | 46 |
Pars Distalis, Adenoma | | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
Lymphoma Malignant | | 1 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Pelvic, Hemangiosarcoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Ovary | + | 47 |
Cystadenoma | | 3 |
Granulosa Cell Tumor Malignant | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Uterus | + | 50 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 1 |
Endometrium, Adenoma | | 1 |
Endometrium, Polyp Stromal | | 3 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 12 |
Lymphoma Malignant | | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 2 |
Mediastinal, Hepatocellular | | |
Carcinoma, Metastatic, Liver | | 1 |
Mediastinal, Histiocytic Sarcoma | | 1 |
Mediastinal, Lymphoma Malignant | | 2 |
Pancreatic, Lymphoma Malignant | | 3 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 50 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 49 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 50 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Thymus | + | 47 |
Lymphoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Myoepithelioma | | 1 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Alveolar/Bronchiolar Adenoma | | 4 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 4 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + | 49 |
__________________________________________________________________________|____________|
Trachea | + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
Adenoma | | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 51 |
Histiocytic Sarcoma | | 3 |
Lymphoma Malignant | | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + + |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + M + +|
Cystadenoma | |
Teratoma NOS | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma | X |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + M + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + M + + + + + + + M|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Osteosarcoma, Metastatic, Bone | X|
Mediastinum, Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Mesentery | + + +|
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X|
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + M + + + + M|
Pars Distalis, Adenoma | X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X |
Teratoma NOS | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyosarcoma | |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node | + + + |
Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Thymus | I + M + + + + + + + + + + + + M + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X|
Osteosarcoma, Metastatic, Bone | |
Mediastinum, Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 54 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 53 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 4 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X | 4 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Mesentery | + | 8 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 54 |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M | 49 |
Pars Distalis, Adenoma | | 4 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
Lymphoma Malignant | | 1 |
Follicular Cell, Adenoma | | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Ovary | + + + + | 50 |
Cystadenoma | | 2 |
Teratoma NOS | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + | 54 |
Histiocytic Sarcoma | X | 1 |
Leiomyosarcoma | | 1 |
Endometrium, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Lymphoma Malignant | | 2 |
Iliac, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 2 |
Mediastinal, Lymphoma Malignant | | 3 |
Renal, Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 52 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 50 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + | 48 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Alveolar/Bronchiolar Adenoma | | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
Osteosarcoma, Metastatic, Bone | | 1 |
Mediastinum, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | X | 4 |
Lymphoma Malignant | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2|
| 7| 8| 8| 5| 7| 7| 8| 8| 7| 8| 8| 9| 9| 9| 2| 7| 9| 9| 9| 9| 0| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Hemangiosarcoma, Multiple | X X |
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X X X X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + I + + + + + + + I + + + I + +|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2|
| 7| 8| 8| 5| 7| 7| 8| 8| 7| 8| 8| 9| 9| 9| 2| 7| 9| 9| 9| 9| 0| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + I + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X X|
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + M + + + + + I + + M + I + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M + M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Subcutaneous Tissue, Hemangiosarcoma | X|
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemangiosarcoma, Multiple | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic,| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2|
| 7| 8| 8| 5| 7| 7| 8| 8| 7| 8| 8| 9| 9| 9| 2| 7| 9| 9| 9| 9| 0| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Liver | X X X X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 1| 2| 2| 5| 3| 9| 2| 7| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 9| 9| 9| 9| 9| 1| 9| 5| 9| 3| 7| 7| 7| 1| 7| 8| 8| 8| 8| 7| 7| 7| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Carcinoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Multiple | | 2 |
Hepatocellular Carcinoma | X X X | 5 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X X X X X X X X X X X X| 21 |
Hepatocellular Adenoma, Multiple | X X X X X X | 7 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + +| 28 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcapsular, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 1| 2| 2| 5| 3| 9| 2| 7| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 9| 9| 9| 9| 9| 1| 9| 5| 9| 3| 7| 7| 7| 1| 7| 8| 8| 8| 8| 7| 7| 7| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Pars Distalis, Adenoma | X| 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + + +| 4 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 4 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + M| 44 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M + M| 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basal Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | X | 2 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 1| 2| 2| 5| 3| 9| 2| 7| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 7| 9| 9| 9| 9| 9| 1| 9| 5| 9| 3| 7| 7| 7| 1| 7| 8| 8| 8| 8| 7| 7| 7| 7| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
UNTREATD | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L |
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hemangiosarcoma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X X X X | 11 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 4 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Adenoma | X | 2 |
Bilateral, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | M | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 1|
| 8| 7| 8| 8| 8| 7| 8| 8| 0| 9| 9| 7| 9| 9| 9| 7| 9| 0| 9| 8| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 5| 6| 7| 8| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X X X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoid Tumor Benign | X |
__________________________________________________________________________|
Tooth | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcapsular, Adenoma | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + M M + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 1|
| 8| 7| 8| 8| 8| 7| 8| 8| 0| 9| 9| 7| 9| 9| 9| 7| 9| 0| 9| 8| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 5| 6| 7| 8| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | |
Inguinal, Histiocytic Sarcoma | |
Mediastinal, Histiocytic Sarcoma | |
Renal, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M M + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + M + I + M M + M + + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M M M M M M M M M M M M M + M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| 2| 2| 2| 2| 1|
| 8| 7| 8| 8| 8| 7| 8| 8| 0| 9| 9| 7| 9| 9| 9| 7| 9| 0| 9| 8| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.125% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 4| 5| 6| 7| 8| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05217-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/17/97
Route: DOSED FEED Time: 11:14:18
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
| 8| 8| 8| 8| 8| 7| 7| 4| 7| 7| 9| 9| 7| 9| 9| 7| 9| 9| 9| 9| 9| 7| 7| 7| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
0.125% | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| L |
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 6| 7| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma |