TDMS Study 05217-05 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
T-BUTYLHYDROQUINONE
NTP Experiment-Test: 05217-05 Report: PEIRPT09
Study Type: CHRONIC Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
2 YEAR CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 08/04/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 002 UNTREATDCONTROL
Include 004 0.125%
Include 006 0.25%
Include 008 0.5%
Include 001 UNTREATDCONTROL
Include 003 0.125%
Include 005 0.25%
Include 007 0.5%
Page 1
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 2 |
Eosinophilic Focus | 2 1 |
Eosinophilic Focus, Multiple | 2 2 2 |
Fatty Change, Focal | |
Fatty Change | 1 3 3 |
Hematopoietic Cell Proliferation | |
Infarct | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 1 2 |
Mixed Cell Focus | 4 |
Necrosis, Focal | 3 |
Thrombosis | 3 |
Bile Duct, Cyst | |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | |
Fat, Necrosis | 2 3 1 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 1 1 |
Ulcer | |
Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Cytoplasmic Alteration, Focal | |
Hematopoietic Cell Proliferation | |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + I + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 |
Inflammation, Chronic, Focal | |
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 1 2 2 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 3 4 2 2 |
Hemorrhage | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 3 3 3 4 4 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 3 3 3 3 3 3 2 3 3 3 3 3 2 3 3 3 3 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | 2 |
Hyperplasia | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + |
Hyperplasia, Cystic | 4 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hemorrhage | 3 |
Iliac, Hyperplasia | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
Renal, Hemorrhage | 2 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 3 2 2 |
Hyperplasia, Lymphoid | 3 2 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + I + + + + + + I + + + + + + M|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 4 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Alveolar Epithelium, Hyperplasia | 2 |
Interstitium, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 1| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 6| 3| 6| 3| 3| 3| 2| 1|
| 9| 5| 5| 4| 5| 5| 2| 5| 5| 5| 3| 4| 4| 4| 4| 4| 6| 7| 6| 1| 6| 6| 4| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 3 1 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Nephropathy | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | |
Eosinophilic Focus | 2 2|
Eosinophilic Focus, Multiple | |
Fatty Change, Focal | 1 3 |
Fatty Change | 4 |
Hematopoietic Cell Proliferation | 1 3 2 |
Infarct | 2 |
Infiltration Cellular, Mixed Cell | 3 2 |
Inflammation, Focal | 1 |
Mixed Cell Focus | |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Cyst | 1 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 4 |
Fat, Necrosis | 1 3 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 1 |
Inflammation, Chronic | 2 1 |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | 1 |
Hematopoietic Cell Proliferation | 2 |
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | |
Inflammation, Chronic, Focal | 1 |
C-Cell, Hyperplasia | 1 3 |
Follicular Cell, Hyperplasia | 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Cyst | 3 2 3 2 3 2 3 3 4 |
Hemorrhage | 2 |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 3 3 |
Inflammation, Suppurative | 3 3 3 |
Endometrium, Hyperplasia, Cystic | 4 4 2 3 3 4 3 3 3 3 3 3 3 3 4 3 4 3 3 3 3 4 2 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | |
Hyperplasia | 3 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hemorrhage | |
Iliac, Hyperplasia | 2 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia | 3 |
Renal, Hemorrhage | |
Renal, Hyperplasia | 4 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Amyloid Deposition | 1 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 2 3 3|
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 3 4 3 |
Hyperplasia, Lymphoid | 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + M + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 6| 3| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 1| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 7| 4| 6| 6| 6| 6| 7| 6| 6| 4| 6| 3| 5| 8| 0| 5| 4| 5| 4| 4| 5| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
UNTREATD | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|
CONTROL | 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 2 2 2 1 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 3 2 |
Nephropathy | 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 51 |
__________________________________________________________________________|____________|
Gallbladder | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 51 |
Erosion | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 51 |
__________________________________________________________________________|____________|
Liver | + | 51 |
Angiectasis | | 2 1.5|
Basophilic Focus | | 2 2.5|
Eosinophilic Focus | | 4 1.8|
Eosinophilic Focus, Multiple | | 3 2.0|
Fatty Change, Focal | | 2 2.0|
Fatty Change | | 4 2.8|
Hematopoietic Cell Proliferation | | 3 2.0|
Infarct | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 2 2.5|
Inflammation, Focal | | 3 1.3|
Mixed Cell Focus | | 1 4.0|
Necrosis, Focal | | 1 3.0|
Thrombosis | | 1 3.0|
Bile Duct, Cyst | | 1 1.0|
Centrilobular, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 10 |
Inflammation, Chronic | | 1 4.0|
Fat, Necrosis | | 8 2.3|
__________________________________________________________________________|____________|
Pancreas | + | 51 |
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Erosion | 1 | 3 1.0|
Inflammation, Chronic | 1 | 5 1.2|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 1 | 5 1.2|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 51 |
Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 50 |
__________________________________________________________________________|____________|
Heart | + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 51 |
Accessory Adrenal Cortical Nodule | | 2 1.0|
Cytoplasmic Alteration, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 51 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 49 |
Angiectasis | | 2 1.5|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 2 1.5|
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 51 |
Degeneration, Cystic, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
C-Cell, Hyperplasia | | 2 2.0|
Follicular Cell, Hyperplasia | 2 | 12 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 51 |
__________________________________________________________________________|____________|
Ovary | + | 50 |
Angiectasis | | 2 3.0|
Cyst | | 15 2.8|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | | 2 4.0|
__________________________________________________________________________|____________|
Uterus | + | 51 |
Hydrometra | 2 | 13 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 3 3.0|
Endometrium, Hyperplasia, Cystic | 2 | 50 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Hyperplasia | | 2 3.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | | 7 |
Hyperplasia, Cystic | | 1 4.0|
Iliac, Hemorrhage | | 1 3.0|
Iliac, Hyperplasia | | 2 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia | | 1 3.0|
Renal, Hemorrhage | | 1 2.0|
Renal, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 48 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 50 |
Amyloid Deposition | | 1 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 6 2.7|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + | 51 |
Hematopoietic Cell Proliferation | 2 | 14 2.7|
Hyperplasia, Lymphoid | | 3 2.7|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + | 45 |
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
Ectasia | | 3 2.0|
__________________________________________________________________________|____________|
Skin | + | 51 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 3| | A |
UNTREATD | 0| | L |
CONTROL | 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Atrophy, Focal | | 3 3.3|
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Congestion | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Interstitium, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + | 51 |
Mucosa, Glands, Dilatation, Focal | 2 | 16 1.9|
__________________________________________________________________________|____________|
Trachea | + | 51 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 51 |
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 2 2.5|
Nephropathy | 2 | 30 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + | 51 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|
| 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + M + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | 1 1 2 |
Eosinophilic Focus, Multiple | 2 3 3 3 |
Fatty Change | 3 |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 1 |
Mixed Cell Focus | 3 4 |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Hemorrhage | 3 |
Inflammation, Chronic | |
Fat, Necrosis | 1 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Pigmentation, Focal | |
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + M + + + + +|
Accessory Adrenal Cortical Nodule | 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + M|
Cyst | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|
| 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | |
Pars Intermedia, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + I + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 3 2 3 2 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + M + + + M + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 4 3 2 4 3 2 2|
Inflammation, Suppurative | |
Interstitial Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hemorrhage | |
Hydrometra | 3 3 3 3 3 |
Hyperplasia, Focal, Histiocytic | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia | |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M M + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mediastinal | +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 3 3 2 3 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3|
DAY ON TEST | 3| 3| 3| 6| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 2| 3| 3| 3| 2| 9|
| 4| 5| 4| 2| 4| 4| 4| 7| 4| 5| 5| 6| 5| 5| 8| 6| 6| 4| 6| 5| 6| 6| 5| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 6| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 2 4 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Glands, Dilatation, Focal | 1 2 2 2 2 2 1 2 1 2 2 1 1 |
Nasolacrimal Duct, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Nephropathy | 1 1 1 1 2 2 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|
| 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Eosinophilic Focus | 2 1 1 2 3 |
Eosinophilic Focus, Multiple | 2 |
Fatty Change | |
Hematopoietic Cell Proliferation | 3 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | |
Mixed Cell Focus | 4 |
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | + + + + |
Hemorrhage | |
Inflammation, Chronic | |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Pigmentation, Focal | |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + M + M + + + I + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|
| 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 |
Pars Intermedia, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 2 |
Cyst | 3 3 3 |
Inflammation, Suppurative | 4 |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 4|
Hydrometra | 3 3 3 2 3 4|
Hyperplasia, Focal, Histiocytic | 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 2 2 4 3 3 3 3 3 3 2 2 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia | |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + M + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 2 3 3 2 2 3 3|
Hyperplasia, Lymphoid | 2 3 3 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 3| 5| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 1| 2| 3| 3| 5| 3| 3| 6| 0| 3| 3| 3|
| 8| 5| 5| 5| 5| 3| 4| 6| 6| 6| 4| 6| 9| 0| 9| 6| 5| 4| 4| 5| 5| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.125% | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Mucosa, Glands, Dilatation, Focal | 1 1 1 1 2 2 2 1 1 2 2 1 1 1|
Nasolacrimal Duct, Cyst | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 |
Nephropathy | 1 1 2 2 1 1 1 1 1 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 52 |
__________________________________________________________________________|____________|
Gallbladder | + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 51 |
__________________________________________________________________________|____________|
Liver | + + | 52 |
Basophilic Focus | | 1 2.0|
Eosinophilic Focus | 2 | 9 1.7|
Eosinophilic Focus, Multiple | | 5 2.6|
Fatty Change | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Infiltration Cellular, Mixed Cell | 3 | 1 3.0|
Inflammation, Focal | | 1 1.0|
Mixed Cell Focus | | 3 3.7|
Necrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 13 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Fat, Necrosis | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + | 52 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + | 52 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 52 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 52 |
Erosion | 2 | 1 2.0|
Pigmentation, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Incisor, Dysplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 52 |
__________________________________________________________________________|____________|
Heart | + + | 52 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 51 |
Accessory Adrenal Cortical Nodule | | 4 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 51 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 49 |
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + M | 44 |
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 3 1.7|
Pars Distalis, Hyperplasia, Focal | | 3 1.7|
Pars Intermedia, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + | 51 |
Follicular Cell, Hyperplasia | | 19 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 52 |
Degeneration, Cystic | | 4 3.0|
__________________________________________________________________________|____________|
Ovary | + + | 49 |
Angiectasis | | 2 2.0|
Cyst | | 10 2.9|
Inflammation, Suppurative | 4 | 2 4.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + | 52 |
Cyst | | 1 3.0|
Hemorrhage | | 1 4.0|
Hydrometra | | 11 3.0|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 4 3 | 52 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 52 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Iliac, Hyperplasia | 3 | 1 3.0|
Mediastinal, Hyperplasia | 3 | 1 3.0|
Renal, Hyperplasia | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 52 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 52 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 4 | 14 2.7|
Hyperplasia, Lymphoid | 2 | 8 2.4|
__________________________________________________________________________|____________|
Thymus | + + | 51 |
Cyst | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 51 |
Ectasia | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + | 52 |
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 52 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 52 |
Atrophy, Focal | | 4 3.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 52 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + | 52 |
Inflammation, Suppurative | | 1 1.0|
Mucosa, Glands, Dilatation, Focal | | 27 1.5|
Nasolacrimal Duct, Cyst | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 6| | |
DAY ON TEST | 3| 1| | |
| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.125% | 5| 6| | L |
| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 52 |
Congestion | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Nephropathy | 2 2 | 32 1.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + M + + + + + + + + + + + + + + A + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Perforation, Chronic | 3|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + A +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Clear Cell Focus | 2 |
Eosinophilic Focus | 2 2 1 1 2 2 |
Eosinophilic Focus, Multiple | 3 |
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation | |
Infarct | |
Infiltration Cellular, Mixed Cell | 4 |
Inflammation, Focal | |
Mineralization, Focal | |
Mixed Cell Focus | |
Mixed Cell Focus, Multiple | |
Bile Duct, Cyst | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Chronic | 3 3|
Fat, Necrosis | 3 |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
Atrophy, Focal | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Glands, Degeneration, Cystic, Focal | |
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 3|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Thrombosis | |
Artery, Inflammation, Chronic | 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + I + +|
Angiectasis | 1 1 |
Cyst | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2|
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia | 2 1 1 3 2 1 3 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + M + + + + + + + + + + + + + + + + M +|
Cyst | 2 3 3 2 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 2 2 3 2 3 2 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 1 2 3 4 2 2 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Inguinal, Hyperplasia | 3 |
Mediastinal, Hyperplasia | 3 3|
Renal, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 3 4 2 4 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 3 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | +|
Inflammation, Suppurative | 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Artery, Meninges, Inflammation, | |
Chronic | 2|
Meninges, Cyst | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 1 |
Pleura, Mediastinum, Inflammation, | |
Chronic | 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 1 2 2 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Peritracheal Tissue, | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 2|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 2| 3| 3| 3| 1| 1| 8|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 4| 5| 6| 4| 6| 6| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25% | 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
| 1| 2| 3| 5| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
Nephropathy | 1 2 1 1 1 2 1 2 2 1 2 1 1 1 1 1 1 1 1 2 |
Artery, Inflammation, Chronic | 3|
Renal Tubule, Dilatation, Focal | 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + + + + + + + A + + + + +|
Cyst | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A A + + + + + + + + + + + + + +|
Perforation, Chronic | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A A + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 3 |
Eosinophilic Focus | 1 1 2 |
Eosinophilic Focus, Multiple | |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 4 |
Infarct | 4 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 1 1 |
Mineralization, Focal | 2|
Mixed Cell Focus | 2 |
Mixed Cell Focus, Multiple | 4 |
Bile Duct, Cyst | 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation, Chronic | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Glands, Degeneration, Cystic, Focal | 2 |
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
Thrombosis | 3 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + I + +|
Angiectasis | |
Cyst | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Inflammation | |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 2 2 1 2 2 2 1 4 2 1 1 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Degeneration, Cystic | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + + + + + + + + M + + +|
Cyst | 2 2 4 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hydrometra | 3 3 3 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 4 3 2 3 2 3 3 3 2 3 3 3 3 3 2 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia | 2 |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 4 3 3 3 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + A M + + + + + I + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Artery, Meninges, Inflammation, | |
Chronic | |
Meninges, Cyst | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Alveolar Epithelium, Hyperplasia | |
Pleura, Mediastinum, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Glands, Dilatation, Focal | 1 1 1 2 1 1 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
Artery, Peritracheal Tissue, | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 3| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 7| 4| 3| 3| 6| 3|
| 6| 6| 6| 4| 6| 6| 6| 3| 6| 1| 5| 6| 5| 5| 4| 6| 6| 6| 6| 6| 8| 5| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25% | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 1 1 1 2 2 1 1 2 2 1 2 1 1|
Artery, Inflammation, Chronic | |
Renal Tubule, Dilatation, Focal | |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + | 47 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 48 |
Perforation, Chronic | | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 47 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + | 51 |
Basophilic Focus | | 1 2.0|
Clear Cell Focus | | 2 2.5|
Eosinophilic Focus | | 9 1.6|
Eosinophilic Focus, Multiple | | 1 3.0|
Fatty Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Infarct | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 1 4.0|
Inflammation, Focal | | 2 1.0|
Mineralization, Focal | | 1 2.0|
Mixed Cell Focus | | 1 2.0|
Mixed Cell Focus, Multiple | | 1 4.0|
Bile Duct, Cyst | | 1 3.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Inflammation, Chronic | | 3 2.7|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 49 |
Atrophy, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + | 51 |
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 51 |
Erosion | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 49 |
Glands, Degeneration, Cystic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Incisor, Dysplasia | | 4 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 51 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + | 51 |
Inflammation, Chronic, Focal | | 1 3.0|
Thrombosis | | 1 3.0|
Artery, Inflammation, Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 51 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | M | 46 |
Angiectasis | | 2 1.0|
Cyst | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 2 2.0|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 50 |
Inflammation | | 1 2.0|
C-Cell, Hyperplasia | | 1 1.0|
Follicular Cell, Hyperplasia | 2 | 24 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 50 |
Degeneration, Cystic | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + | 47 |
Cyst | 4 | 10 2.8|
Inflammation, Suppurative | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + | 50 |
Hydrometra | | 12 2.7|
Endometrium, Hyperplasia, Cystic | 3 | 50 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 51 |
__________________________________________________________________________|____________|
Lymph Node | | 12 |
Inguinal, Hyperplasia | | 2 2.5|
Mediastinal, Hyperplasia | | 2 3.0|
Renal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 49 |
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 2 |
__________________________________________________________________________|____________|
Spleen | + | 50 |
Hematopoietic Cell Proliferation | | 13 3.2|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 7 2.3|
__________________________________________________________________________|____________|
Thymus | + | 47 |
Cyst | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 51 |
__________________________________________________________________________|____________|
Skin | + | 51 |
Inflammation, Chronic, Focal | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 51 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 51 |
Atrophy, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| | |
DAY ON TEST | 3| | |
| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 4| | A |
0.25% | 2| | L |
| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Artery, Meninges, Inflammation, | | |
Chronic | | 1 2.0|
Meninges, Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 51 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Pleura, Mediastinum, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + | 49 |
Mucosa, Glands, Dilatation, Focal | | 16 1.3|
__________________________________________________________________________|____________|
Trachea | + | 50 |
Artery, Peritracheal Tissue, | | |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 50 |
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy | 1 | 35 1.3|
Artery, Inflammation, Chronic | | 1 3.0|
Renal Tubule, Dilatation, Focal | | 1 1.0|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 50 |
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Clear Cell Focus | 3 |
Eosinophilic Focus | 1 4 1 2 1 2 2 |
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | |
Hemorrhage, Focal | |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 2 3 |
Inflammation, Focal | 1 1 |
Mixed Cell Focus | |
Necrosis, Focal | 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic | 3 2 3 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Pigmentation, Focal | |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Subcapsular, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + M M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 |
Follicular Cell, Hyperplasia | 1 1 1 2 2 1 2 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
__________________________________________________________________________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + M + +|
Angiectasis | 3 2 |
Cyst | 2 4 3 2 3|
Hyperplasia, Tubular | |
Inflammation, Suppurative | 3 4 3 4 |
Thrombosis | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydrometra | 2 2 3 3|
Inflammation, Suppurative | 3 2 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 1 3 1 3 2 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia | |
Lumbar, Hyperplasia | 4 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia | |
Mediastinal, Inflammation, Focal, | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Suppurative | |
Renal, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + M + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 3 2 4 |
Hyperplasia, Lymphoid | 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + M + + + + + + + M|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia, Focal | |
Epidermis, Hyperplasia, Focal | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Mixed Cell | 2 3 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia | 2 1 |
Interstitium, Inflammation, | |
Suppurative | |
Mediastinum, Inflammation, Chronic | |
Pleura, Mediastinum, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 2| 7| 7| 7| 0| 7| 5| 7| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 3| 2| 3| 8| 3| 3| 3| 3| 2|
| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 5| 9| 5| 6| 6| 3| 6| 2| 6| 8| 4| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Glands, Dilatation, Focal | 2 1 2 2 2 2 2 1 1 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Inflammation, Chronic | 3 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Casts | 3 |
Renal Tubule, Pigmentation, | |
Hemoglobin | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 2 |
Eosinophilic Focus | 4 2 3 |
Eosinophilic Focus, Multiple | 3|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage, Focal | |
Hyperplasia, Focal, Lymphoid | |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | |
Mixed Cell Focus | 3 |
Necrosis, Focal | |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + +|
Inflammation, Chronic | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 |
Pigmentation, Focal | |
Ulcer | 3 |
Epithelium, Hyperplasia | 2 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Subcapsular, Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + M + + + + M|
Angiectasis | 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Follicular Cell, Hyperplasia | 1 1 2 1 1 3 1 2 1 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 3 |
__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 3 2 2 2 4 |
Hyperplasia, Tubular | 2 |
Inflammation, Suppurative | |
Thrombosis | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydrometra | 3 3 3 3 3 3 2 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 2 3 4 3 3 3 3 1 3 4 3 2 3 3 3 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia | |
Lumbar, Hyperplasia | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia | |
Mediastinal, Inflammation, Focal, | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Suppurative | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Lymphoid | 2 3 2 |
__________________________________________________________________________|
Thymus | I + M + + + + + + + + + + + + M + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia, Focal | 2 |
Epidermis, Hyperplasia, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation, | |
Suppurative | |
Mediastinum, Inflammation, Chronic | |
Pleura, Mediastinum, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 8| 5| 5| 5| 5| 4| 6| 3| 6| 6| 6| 4| 4| 8| 4| 4| 4| 5| 5| 5| 5| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5% | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Mucosa, Glands, Dilatation, Focal | 2 1 2 2 1 1 1 1 2 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Nephropathy | 1 1 1 2 1 1 1 1 1 1 1 1|
Renal Tubule, Casts | |
Renal Tubule, Pigmentation, | |
Hemoglobin | |
__________________________________________________________________________|
Urinary Bladder | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 53 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Angiectasis | | 1 2.0|
Clear Cell Focus | | 2 2.5|
Eosinophilic Focus | 3 | 11 2.3|
Eosinophilic Focus, Multiple | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 | 3 2.3|
Inflammation, Focal | | 2 1.0|
Mixed Cell Focus | | 1 3.0|
Necrosis, Focal | 4 | 2 3.0|
Centrilobular, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 8 |
Inflammation, Chronic | 3 | 4 2.8|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 54 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
Inflammation, Chronic | | 3 2.0|
Pigmentation, Focal | 2 | 1 2.0|
Ulcer | | 2 2.5|
Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
Erosion | 1 | 1 1.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 54 |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Myocardium, Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Subcapsular, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Hyperplasia | | 4 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 54 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M | 49 |
Angiectasis | | 1 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 54 |
Inflammation, Chronic, Focal | 1 | 2 1.0|
Follicular Cell, Hyperplasia | 1 1 | 24 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 54 |
Degeneration, Cystic | | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + | 50 |
Angiectasis | | 3 2.3|
Cyst | | 11 2.6|
Hyperplasia, Tubular | | 1 2.0|
Inflammation, Suppurative | 4 | 5 3.6|
Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + | 54 |
Cyst | | 1 2.0|
Hydrometra | 3 3 | 14 2.9|
Inflammation, Suppurative | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Hyperplasia, Cystic | 3 3 3 | 51 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Iliac, Hyperplasia | 3 | 1 3.0|
Lumbar, Hyperplasia | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hyperplasia | 3 | 1 3.0|
Mediastinal, Inflammation, Focal, | | |
Suppurative | 3 | 1 3.0|
Renal, Hyperplasia | 4 | 3 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 52 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 50 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Angiectasis | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | 4 4 | 13 2.8|
Hyperplasia, Lymphoid | 2 | 7 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + | 48 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 54 |
__________________________________________________________________________|____________|
Skin | + + + + | 54 |
Alopecia, Focal | | 1 2.0|
Epidermis, Hyperplasia, Focal | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| | |
DAY ON TEST | 3| 0| 2| 3| | |
| 5| 1| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.5% | 7| 7| 7| 8| | L |
| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Hemorrhage | | 1 4.0|
Infiltration Cellular, Mixed Cell | | 2 2.5|
Inflammation, Chronic, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
Interstitium, Inflammation, | | |
Suppurative | 2 | 1 2.0|
Mediastinum, Inflammation, Chronic | 2 | 1 2.0|
Pleura, Mediastinum, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + | 53 |
Inflammation, Suppurative | | 1 1.0|
Mucosa, Glands, Dilatation, Focal | 1 1 | 26 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Cyst | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
Nephropathy | 1 2 1 | 28 1.1|
Renal Tubule, Casts | | 1 3.0|
Renal Tubule, Pigmentation, | | |
Hemoglobin | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05217-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 09/07/94
Route: DOSED FEED Time: 19:29:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 0| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 8| 2| 2| 2| 2|
| 7| 8| 8| 5| 7| 7| 8| 8| 7| 8| 8| 9| 9| 9| 2| 7| 9| 9| 9| 9| 0| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus