TDMS Study 05217-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 05 TIME: 09:19:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: D.R. FARNELL CAS: 1948-33-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 05 TIME: 09:19:27
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: D.R. FARNELL CAS: 1948-33-0
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 11 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 539 595 619 647 651 673 680 705 712 723 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 651 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 4 CENSORED DEATHS 10 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 619 630 654 710 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 9 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 409 520 549 550 619 654 657 666 669 673 |
| 680 710 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 9 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 171 589 595 614 615 628 630 680 688 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 727 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 727 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 90.0 79.8 |
|U | |
| | |
|0.125% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 98.3 98.3 96.4 92.4 86.5 74.7 |
| | |
| | |
|0.5% | 100.0 98.3 98.3 98.3 98.3 98.3 98.3 94.4 86.5 82.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTR0.125% 0.25% 0.5% |
| U |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 79.8% 92.0% 74.7% 82.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.778 P=0.143N P=0.643 P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 654.4 653.3 621.5 578.9 |
|NATURAL DEATHS (C) | (18.2) (20.3) (24.9) (52.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 668.5 676.9 663.5 664.1 |
|(STANDARD ERROR) | (13.2) (13.1) (13.7) (15.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATDCONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 9 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 364 461 550 567 582 617 618 619 622 667 |
| 673 677 723 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 8 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 365 399 469 494 503 562 598 612 623 623 |
| 654 668 697 706 710 725 729 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 9 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 288 456 548 555 618 651 664 676 718 723 |
| 724 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 6 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 82 296 418 429 538 629 701 703 722 723 |
| 728 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATDCON|ROL100.0 100.0 100.0 98.3 98.3 96.4 96.4 90.5 82.6 74.7 |
|U | |
| | |
|0.125% | 100.0 100.0 100.0 98.3 96.7 94.7 90.9 87.0 79.3 67.7 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 98.3 98.3 96.7 96.7 92.7 86.8 78.9 |
| | |
| | |
|0.5% | 98.3 98.3 98.3 96.7 95.0 93.3 91.5 91.5 89.6 80.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATDCONTR0.125% 0.25% 0.5% |
| U |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 74.7% 67.7% 78.9% 80.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.360N P=0.567 P=0.766N P=0.684N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 595.4 596.3 601.9 542.6 |
|NATURAL DEATHS (C) | (26.7) (27.7) (40.5) (64.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 662.4 658.1 668.2 671.2 |
|(STANDARD ERROR) | (14.5) (15.0) (15.1) (17.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATDCONTROL = 1
0.125% = 2
0.25% = 3
0.5% = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100.0 +1 4 3 1 2
|
|
| 4 3 3 1 1 22
97.5 +
|
| 3 3 1 12 2
|
95.0 +
| 4 4
| 1 12 2
|
P 92.5 + 3 3
E | 2 2
R |
C | 434 3
E 90.0 + 1 1
N |
T |
| 11
S 87.5 +
U |
R | 4 3 3 4
V | 1 1
I 85.0 +
V | 44
A | 11
L |
82.5 + 33 4 4
| 1 1
|
| 33
80.0 + 1
|
| 3 3
|
77.5 +
| 3 3
|
|
75.0 + 3
|
-+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATDCONTROL = 1
0.125% = 2
0.25% = 3
0.5% = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 12
| 4 34 12 2 1
|
| 4 2 4 12 1
95 + 4 4 2 2 131
| 4 4
P | 22 31 1 3
E | 2 4 2 34 3
R 90 + 1 14 4
C | 2 2 3 3
E | 2 2
N | 3 3 4 4
T 85 + 22 3 3
|
S | 1 1 33
U | 2 2 11
R 80 + 4 4
V | 2 2 3 3
I | 2 2
V | 1 1
A 75 + 22 1 1
L | 22
|
| 2 2
70 + 2 2
|
| 2
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.