TDMS Study 05217-03 Pathology Tables
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70 70
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Moribund Sacrifice 40 31 41 33 36
Natural Death 10 7 8 9 7
Survivors
Terminal Sacrifice 10 22 11 16 17
Other 2
Animals Examined Microscopically 70 70 70 68 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (68) (69) (70) (67) (70)
Inflammation, Subacute 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Intestine Large, Colon (70) (70) (69) (66) (69)
Edema 1 (1%)
Parasite Metazoan 6 (9%) 3 (4%) 4 (6%) 4 (6%) 5 (7%)
Ulcer 1 (1%)
Intestine Large, Rectum (69) (70) (69) (67) (69)
Edema 1 (1%)
Parasite Metazoan 2 (3%) 2 (3%) 6 (9%) 9 (13%)
Intestine Large, Cecum (70) (70) (70) (67) (70)
Edema 1 (1%) 2 (3%) 1 (1%) 2 (3%)
Parasite Metazoan 2 (3%) 2 (3%) 1 (1%) 3 (4%) 1 (1%)
Intestine Small, Duodenum (69) (70) (70) (67) (70)
Erosion 1 (1%)
Epithelium, Hyperplasia 1 (1%) 1 (1%)
Intestine Small, Ileum (70) (70) (68) (67) (68)
Inflammation, Chronic Active 1 (1%)
Epithelium, Hyperplasia 1 (1%)
Liver (70) (70) (70) (68) (70)
Angiectasis 1 (1%) 2 (3%) 2 (3%) 1 (1%) 2 (3%)
Basophilic Focus 26 (37%) 34 (49%) 31 (44%) 31 (46%) 29 (41%)
Clear Cell Focus 2 (3%) 4 (6%) 4 (6%) 5 (7%)
Degeneration, Cystic 1 (1%) 1 (1%) 1 (1%)
Eosinophilic Focus 10 (14%) 12 (17%) 13 (19%) 12 (18%) 17 (24%)
Eosinophilic Focus, Multiple 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 3 (4%) 1 (1%) 2 (3%)
Hemorrhage 4 (6%)
Hepatodiaphragmatic Nodule 14 (20%) 12 (17%) 10 (14%) 9 (13%) 19 (27%)
Inflammation, Granulomatous 12 (17%) 9 (13%) 9 (13%) 9 (13%) 10 (14%)
Mixed Cell Focus 2 (3%) 3 (4%) 6 (9%) 8 (12%) 7 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis, Focal 6 (9%) 2 (3%) 3 (4%) 5 (7%) 3 (4%)
Bile Duct, Cyst 1 (1%) 1 (1%)
Bile Duct, Hyperplasia 17 (24%) 18 (26%) 20 (29%) 18 (26%) 24 (34%)
Centrilobular, Atrophy 1 (1%)
Centrilobular, Necrosis 1 (1%) 1 (1%)
Hepatocyte, Vacuolization Cytoplasmic 14 (20%) 7 (10%) 14 (20%) 9 (13%) 3 (4%)
Kupffer Cell, Pigmentation 12 (17%) 9 (13%) 14 (20%) 7 (10%) 9 (13%)
Mesentery (11) (5) (13) (10) (7)
Accessory Spleen 1 (9%) 3 (60%) 1 (8%) 2 (29%)
Fat, Necrosis 9 (82%) 2 (40%) 12 (92%) 8 (80%) 5 (71%)
Pancreas (70) (70) (70) (67) (69)
Atrophy 20 (29%) 20 (29%) 22 (31%) 14 (21%) 13 (19%)
Metaplasia, Hepatocyte 1 (1%)
Acinus, Cytoplasmic Alteration 1 (1%) 1 (1%) 1 (1%)
Acinus, Hyperplasia, Focal 1 (1%) 2 (3%)
Salivary Glands (70) (70) (70) (68) (70)
Atrophy 2 (3%) 1 (1%)
Cyst 1 (1%)
Inflammation, Chronic 1 (1%)
Stomach, Forestomach (70) (70) (70) (67) (69)
Edema 4 (6%) 2 (3%) 3 (4%) 4 (6%)
Erosion 1 (1%) 2 (3%) 1 (1%)
Hyperplasia 1 (1%) 1 (1%)
Ulcer 2 (3%) 4 (6%) 4 (6%) 3 (4%) 2 (3%)
Mucosa, Hyperplasia 5 (7%) 9 (13%) 9 (13%) 8 (12%) 5 (7%)
Stomach, Glandular (70) (70) (70) (67) (70)
Edema 1 (1%) 1 (1%) 1 (1%) 2 (3%)
Erosion 3 (4%) 1 (1%) 2 (3%) 6 (9%) 2 (3%)
Ulcer 2 (3%) 4 (6%) 4 (6%) 1 (1%)
Tongue (1) (1) (1) (4) (1)
Epithelium, Hyperplasia 2 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (70) (70) (70) (68) (70)
Inflammation, Subacute 1 (1%)
Heart (70) (70) (70) (68) (70)
Cardiomyopathy 28 (40%) 35 (50%) 32 (46%) 26 (38%) 28 (40%)
Thrombosis 3 (4%) 1 (1%) 3 (4%)
Valve, Inflammation, Chronic 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70) (70) (68) (70)
Accessory Adrenal Cortical Nodule 14 (20%) 9 (13%) 14 (20%) 9 (13%) 10 (14%)
Atrophy 1 (1%)
Degeneration, Fatty 9 (13%) 8 (11%) 16 (23%) 17 (25%) 12 (17%)
Fibrosis 1 (1%)
Hemorrhage 1 (1%) 2 (3%) 1 (1%)
Hyperplasia, Diffuse 3 (4%) 1 (1%) 1 (1%) 1 (1%)
Hyperplasia, Focal 4 (6%) 6 (9%) 7 (10%) 4 (6%) 2 (3%)
Hypertrophy, Focal 9 (13%) 8 (11%) 6 (9%) 4 (6%) 7 (10%)
Metaplasia, Osseous 1 (1%)
Necrosis 2 (3%) 2 (3%) 1 (1%)
Adrenal Medulla (70) (70) (70) (68) (70)
Hyperplasia 5 (7%) 7 (10%) 11 (16%) 7 (10%) 7 (10%)
Islets, Pancreatic (70) (70) (69) (67) (69)
Hyperplasia 1 (1%) 1 (1%)
Parathyroid Gland (62) (64) (65) (63) (62)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (70) (69) (70) (67) (70)
Pars Distalis, Angiectasis 8 (11%) 7 (10%) 3 (4%) 6 (9%) 7 (10%)
Pars Distalis, Atypia Cellular 1 (1%)
Pars Distalis, Cyst 16 (23%) 11 (16%) 25 (36%) 17 (25%) 19 (27%)
Pars Distalis, Hyperplasia, Focal 9 (13%) 7 (10%) 15 (21%) 1 (1%) 9 (13%)
Pars Intermedia, Angiectasis 2 (3%) 2 (3%)
Pars Intermedia, Cyst 2 (3%) 5 (7%) 4 (6%) 3 (4%)
Thyroid Gland (70) (69) (70) (67) (70)
Ectopic Thymus 1 (1%) 1 (1%) 1 (1%)
Ultimobranchial Cyst 4 (6%) 2 (3%) 4 (6%) 2 (3%)
C-Cell, Hyperplasia 8 (11%) 9 (13%) 9 (13%) 3 (4%) 8 (11%)
Follicle, Cyst 1 (1%) 2 (3%) 1 (1%)
Follicular Cell, Hyperplasia 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (68) (69) (69) (68) (70)
Cyst 2 (3%) 5 (7%) 7 (10%) 6 (9%) 5 (7%)
Cyst, Multiple 1 (1%)
Fibrosis 1 (1%)
Hyperplasia 3 (4%) 4 (6%) 6 (9%) 3 (4%) 4 (6%)
Inflammation, Chronic 3 (4%) 1 (1%) 2 (3%) 2 (3%) 2 (3%)
Inflammation, Suppurative 2 (3%) 3 (4%) 3 (4%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (70) (70) (70) (67) (70)
Angiectasis 1 (1%)
Cyst 17 (24%) 9 (13%) 11 (16%) 19 (28%) 18 (26%)
Uterus (70) (70) (70) (68) (70)
Hydrometra 4 (6%) 9 (13%) 10 (14%) 4 (6%) 9 (13%)
Hyperplasia, Cystic 4 (6%) 4 (6%) 5 (7%) 2 (3%) 3 (4%)
Cervix, Hypertrophy 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70) (70) (67) (70)
Depletion Cellular 1 (1%) 1 (1%)
Fibrosis 1 (1%)
Hyperplasia 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%)
Inflammation, Granulomatous 1 (1%)
Myelofibrosis 2 (3%) 1 (1%) 4 (6%) 1 (1%) 3 (4%)
Stromal Cell, Hyperplasia 1 (1%)
Lymph Node (20) (14) (24) (19) (18)
Hyperplasia, Lymphoid 1 (4%)
Iliac, Hemorrhage 1 (7%)
Iliac, Hyperplasia, Lymphoid 1 (7%)
Inguinal, Ectasia 1 (5%)
Inguinal, Hemorrhage 1 (5%)
Inguinal, Hyperplasia, Lymphoid 1 (5%)
Mediastinal, Ectasia 1 (5%)
Mediastinal, Hemorrhage 3 (15%) 1 (7%) 1 (4%) 7 (37%)
Mediastinal, Hyperplasia, Lymphoid 1 (5%)
Mediastinal, Pigmentation 14 (70%) 3 (21%) 9 (38%) 11 (58%) 6 (33%)
Pancreatic, Hemorrhage 1 (5%)
Pancreatic, Pigmentation 1 (5%) 2 (14%) 6 (25%) 4 (21%) 4 (22%)
Renal, Hemorrhage 2 (11%)
Renal, Pigmentation 1 (5%) 3 (21%) 2 (8%) 7 (39%)
Lymph Node, Mandibular (69) (70) (70) (65) (70)
Ectasia 2 (3%) 2 (3%) 2 (3%) 4 (6%) 1 (1%)
Hemorrhage 5 (7%) 3 (4%) 3 (4%) 5 (8%) 2 (3%)
Hyperplasia, Lymphoid 13 (19%) 12 (17%) 9 (13%) 14 (22%) 7 (10%)
Hyperplasia, Plasma Cell 1 (1%) 1 (1%)
Pigmentation 20 (29%) 27 (39%) 19 (27%) 26 (40%) 25 (36%)
Lymph Node, Mesenteric (68) (69) (70) (65) (70)
Ectasia 2 (3%) 2 (3%) 2 (3%) 2 (3%)
Hemorrhage 4 (6%) 1 (1%) 9 (14%) 7 (10%)
Hyperplasia, Lymphoid 2 (3%) 4 (6%) 2 (3%) 3 (5%) 4 (6%)
Pigmentation 1 (1%) 1 (2%) 1 (1%)
Spleen (70) (70) (70) (67) (70)
Developmental Malformation 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Fibrosis 3 (4%) 4 (6%) 5 (7%) 3 (4%) 3 (4%)
Hematopoietic Cell Proliferation 15 (21%) 12 (17%) 12 (17%) 17 (25%) 11 (16%)
Hemorrhage 1 (1%)
Hyperplasia, Lymphoid 1 (1%)
Metaplasia, Lipocyte 1 (1%)
Necrosis 2 (3%) 2 (3%) 1 (1%)
Pigmentation, Hemosiderin 29 (41%) 31 (44%) 34 (49%) 41 (61%) 51 (73%)
Lymphoid Follicle, Atrophy 1 (1%) 1 (1%)
Red Pulp, Atrophy 1 (1%) 1 (1%) 1 (1%)
Thymus (66) (66) (70) (67) (67)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (70) (70) (69) (68) (70)
Dilatation 37 (53%) 33 (47%) 48 (70%) 39 (57%) 34 (49%)
Galactocele 5 (7%) 1 (1%) 4 (6%) 1 (1%) 5 (7%)
Hyperplasia 12 (17%) 12 (17%) 6 (9%) 11 (16%) 15 (21%)
Inflammation, Suppurative 1 (1%)
Skin (70) (69) (70) (67) (70)
Cyst Epithelial Inclusion 1 (1%) 1 (1%)
Hyperkeratosis 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%) 2 (3%)
Ulcer 2 (3%) 1 (1%) 1 (1%) 2 (3%)
Epidermis, Hyperplasia 1 (1%) 2 (3%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70) (69) (68) (70)
Fibrous Osteodystrophy 1 (1%) 1 (1%)
Hyperostosis 1 (1%)
Cranium, Osteopetrosis 8 (11%) 17 (24%) 9 (13%) 6 (9%) 9 (13%)
Femur, Osteopetrosis 9 (13%) 17 (24%) 10 (14%) 6 (9%) 5 (7%)
Skeletal Muscle (1) (1) (1) (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70) (70) (68) (70)
Atrophy 19 (27%) 22 (31%) 20 (29%) 25 (37%) 22 (31%)
Gliosis 1 (1%)
Hemorrhage 1 (1%)
Hydrocephalus 4 (6%) 4 (6%) 1 (1%) 3 (4%) 8 (11%)
Necrosis 1 (1%) 1 (1%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70) (70) (68) (70)
Congestion 1 (1%)
Edema 2 (3%) 1 (1%)
Hemorrhage 2 (3%) 1 (1%) 1 (1%) 1 (1%) 2 (3%)
Infiltration Cellular, Histiocyte 28 (40%) 33 (47%) 24 (34%) 30 (44%) 23 (33%)
Inflammation, Subacute 7 (10%) 4 (6%) 1 (1%) 3 (4%) 2 (3%)
Thrombosis 1 (1%)
Alveolar Epithelium, Hyperplasia 5 (7%) 6 (9%) 5 (7%) 2 (3%) 5 (7%)
Nose (70) (70) (70) (68) (70)
Foreign Body 3 (4%) 1 (1%) 3 (4%)
Inflammation, Suppurative 5 (7%) 3 (4%) 2 (3%) 11 (16%) 3 (4%)
Goblet Cell, Hyperplasia 10 (14%) 8 (11%) 2 (3%) 3 (4%) 7 (10%)
Mucosa, Hyperplasia 5 (7%) 1 (1%) 1 (1%) 12 (18%) 1 (1%)
Mucosa, Metaplasia, Squamous 3 (4%) 2 (3%) 4 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (1) (3) (1)
Cataract 3 (75%) 1 (100%) 3 (100%) 1 (100%)
Hemorrhage 1 (25%) 1 (33%)
Inflammation, Chronic 1 (33%)
Retina, Degeneration 4 (100%) 1 (100%) 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (67) (70)
Cyst 1 (1%) 3 (4%)
Hydronephrosis 1 (1%) 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%) 1 (1%) 3 (4%) 5 (7%)
Inflammation, Suppurative 2 (3%) 1 (1%) 1 (1%)
Mineralization 67 (96%) 62 (89%) 66 (94%) 54 (81%) 58 (83%)
Nephropathy 37 (53%) 38 (54%) 38 (54%) 37 (55%) 39 (56%)
Renal Tubule, Atrophy 1 (1%) 1 (1%) 4 (6%) 5 (7%)
Renal Tubule, Cytoplasmic Alteration 5 (7%) 3 (4%) 3 (4%) 4 (6%) 2 (3%)
Renal Tubule, Dilatation 1 (1%) 1 (1%)
Renal Tubule, Necrosis 2 (3%) 1 (1%) 1 (1%) 1 (1%) 2 (3%)
Renal Tubule, Pigmentation 15 (21%) 9 (13%) 16 (23%) 11 (16%) 16 (23%)
Transitional Epithelium, Hyperplasia 2 (3%) 4 (6%) 2 (3%) 6 (9%) 3 (4%)
Urinary Bladder (69) (70) (70) (68) (69)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (1%) 1 (1%) 1 (1%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70 70
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Moribund Sacrifice 48 41 51 50 42
Natural Death 4 7 2 7 4
Survivors
Terminal Sacrifice 8 12 7 1 14
Other 2
Animals Examined Microscopically 70 70 70 68 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (68) (70) (68) (68) (70)
Edema 1 (1%) 1 (1%)
Parasite Metazoan 7 (10%) 6 (9%) 6 (9%) 3 (4%) 3 (4%)
Intestine Large, Rectum (69) (68) (70) (68) (69)
Edema 2 (3%) 1 (1%) 1 (1%)
Hemorrhage 1 (1%)
Parasite Metazoan 6 (9%) 5 (7%) 1 (1%) 8 (12%)
Intestine Large, Cecum (70) (70) (68) (68) (70)
Edema 3 (4%) 2 (3%) 2 (3%) 3 (4%) 3 (4%)
Parasite Metazoan 1 (1%) 2 (3%) 2 (3%) 3 (4%)
Intestine Small, Duodenum (69) (70) (70) (68) (70)
Epithelium, Hyperplasia 2 (3%) 4 (6%)
Intestine Small, Jejunum (70) (69) (70) (67) (70)
Metaplasia, Osseous 1 (1%)
Epithelium, Hyperplasia 1 (1%) 1 (1%)
Intestine Small, Ileum (70) (69) (69) (68) (69)
Diverticulum 1 (1%)
Hyperplasia, Lymphoid 1 (1%)
Ulcer 1 (1%)
Liver (70) (70) (70) (68) (70)
Angiectasis 10 (14%) 5 (7%) 1 (1%) 4 (6%) 7 (10%)
Basophilic Focus 7 (10%) 7 (10%) 3 (4%) 2 (3%) 7 (10%)
Clear Cell Focus 1 (1%) 1 (1%) 3 (4%) 1 (1%) 5 (7%)
Congestion 1 (1%)
Degeneration, Cystic 23 (33%) 9 (13%) 16 (23%) 11 (16%) 5 (7%)
Eosinophilic Focus 10 (14%) 6 (9%) 4 (6%) 1 (1%) 4 (6%)
Eosinophilic Focus, Multiple 1 (1%)
Fibrosis 1 (1%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation 1 (1%) 1 (1%)
Hemorrhage 1 (1%) 1 (1%)
Hepatodiaphragmatic Nodule 7 (10%) 4 (6%) 8 (11%) 4 (6%) 8 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Subacute 1 (1%) 2 (3%) 1 (1%) 1 (1%) 2 (3%)
Mixed Cell Focus 2 (3%) 2 (3%)
Necrosis, Focal 8 (11%) 7 (10%) 6 (9%) 3 (4%) 2 (3%)
Thrombosis 1 (1%) 1 (1%) 3 (4%) 1 (1%)
Bile Duct, Cyst 2 (3%)
Bile Duct, Hyperplasia 52 (74%) 47 (67%) 49 (70%) 43 (63%) 26 (37%)
Centrilobular, Atrophy 1 (1%)
Centrilobular, Fibrosis 1 (1%)
Centrilobular, Necrosis 2 (3%) 3 (4%) 1 (1%) 2 (3%)
Hepatocyte, Vacuolization Cytoplasmic 6 (9%) 10 (14%) 4 (6%) 7 (10%) 3 (4%)
Kupffer Cell, Hyperplasia 1 (1%)
Kupffer Cell, Pigmentation 11 (16%) 15 (21%) 18 (26%) 8 (12%) 10 (14%)
Mesentery (20) (15) (11) (7) (16)
Accessory Spleen 1 (5%) 2 (13%) 3 (27%) 4 (25%)
Fat, Necrosis 16 (80%) 12 (80%) 7 (64%) 6 (86%) 13 (81%)
Pancreas (70) (70) (69) (68) (70)
Atrophy 16 (23%) 19 (27%) 19 (28%) 12 (18%) 17 (24%)
Acinus, Cytoplasmic Alteration 3 (4%) 1 (1%) 1 (1%) 1 (1%) 4 (6%)
Acinus, Hyperplasia, Focal 2 (3%) 1 (1%) 3 (4%) 2 (3%) 2 (3%)
Salivary Glands (70) (70) (70) (68) (70)
Atrophy 1 (1%) 1 (1%)
Stomach, Forestomach (70) (70) (70) (68) (69)
Edema 9 (13%) 2 (3%) 4 (6%) 5 (7%) 6 (9%)
Erosion 2 (3%) 2 (3%)
Hyperplasia 8 (11%) 7 (10%) 7 (10%) 9 (13%) 12 (17%)
Inflammation, Subacute 2 (3%)
Ulcer 8 (11%) 10 (14%) 1 (1%) 3 (4%) 7 (10%)
Mucosa, Hyperplasia 1 (1%) 1 (1%)
Stomach, Glandular (70) (70) (69) (68) (70)
Edema 1 (1%) 2 (3%) 1 (1%) 3 (4%) 3 (4%)
Erosion 1 (1%) 11 (16%) 3 (4%) 2 (3%) 1 (1%)
Mineralization 1 (1%) 2 (3%) 5 (7%)
Ulcer 3 (4%) 5 (7%) 3 (4%) 3 (4%)
Tongue (1) (2) (2) (1) (4)
Epithelium, Hyperplasia 1 (50%) 2 (100%) 1 (100%) 2 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (70) (70) (70) (68) (70)
Hypertrophy 1 (1%) 3 (4%) 1 (1%) 4 (6%)
Inflammation, Subacute 1 (1%) 1 (1%) 1 (1%)
Mineralization 1 (1%) 1 (1%)
Thrombosis 1 (1%)
Heart (70) (70) (70) (68) (70)
Cardiomyopathy 42 (60%) 42 (60%) 43 (61%) 37 (54%) 39 (56%)
Mineralization 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Necrosis 1 (1%)
Thrombosis 6 (9%) 9 (13%) 8 (11%) 4 (6%)
Endocardium, Hyperplasia 1 (1%)
Schwann Cell, Hyperplasia 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70) (70) (68) (70)
Accessory Adrenal Cortical Nodule 18 (26%) 17 (24%) 10 (14%) 12 (18%) 14 (20%)
Degeneration, Cystic 1 (1%)
Degeneration, Fatty 9 (13%) 7 (10%) 10 (14%) 8 (12%) 7 (10%)
Hemorrhage 1 (1%) 3 (4%) 2 (3%)
Hyperplasia, Focal 4 (6%) 2 (3%) 2 (3%) 2 (3%) 3 (4%)
Hypertrophy, Focal 6 (9%) 5 (7%) 5 (7%) 2 (3%) 2 (3%)
Necrosis 1 (1%) 1 (1%)
Adrenal Medulla (70) (70) (69) (68) (70)
Hyperplasia 26 (37%) 30 (43%) 22 (32%) 15 (22%) 12 (17%)
Islets, Pancreatic (70) (70) (69) (68) (70)
Hyperplasia 3 (4%) 3 (4%) 1 (1%) 2 (3%) 1 (1%)
Parathyroid Gland (65) (66) (64) (65) (66)
Hyperplasia 6 (9%) 1 (2%) 8 (13%) 7 (11%) 9 (14%)
Pituitary Gland (70) (69) (68) (66) (70)
Nuclear Alteration 1 (1%)
Pars Distalis, Angiectasis 4 (6%) 2 (3%) 2 (3%) 1 (2%)
Pars Distalis, Cyst 6 (9%) 9 (13%) 3 (4%) 4 (6%) 7 (10%)
Pars Distalis, Cyst, Hemorrhagic 1 (1%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 10 (14%) 10 (14%) 8 (12%) 8 (12%) 14 (20%)
Pars Intermedia, Angiectasis 1 (1%) 2 (3%) 1 (1%)
Pars Intermedia, Cyst 1 (1%) 8 (12%) 6 (9%) 5 (8%) 2 (3%)
Thyroid Gland (70) (70) (70) (68) (70)
Ectopic Thymus 1 (1%) 1 (1%)
Ultimobranchial Cyst 2 (3%) 3 (4%) 2 (3%) 1 (1%) 8 (11%)
C-Cell, Hyperplasia 9 (13%) 6 (9%) 8 (11%) 9 (13%) 7 (10%)
Follicle, Cyst 1 (1%) 1 (1%) 3 (4%) 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (70) (70) (67) (70)
Atypia Cellular 27 (39%) 29 (41%) 26 (37%) 28 (42%) 25 (36%)
Granuloma Sperm 1 (1%)
Preputial Gland (70) (70) (70) (68) (70)
Cyst 3 (4%) 3 (4%) 4 (6%) 4 (6%)
Hyperplasia 3 (4%) 1 (1%) 2 (3%) 4 (6%) 2 (3%)
Inflammation, Chronic 26 (37%) 12 (17%) 16 (23%) 18 (26%) 12 (17%)
Inflammation, Suppurative 3 (4%) 1 (1%) 7 (10%) 3 (4%) 5 (7%)
Prostate (70) (70) (70) (68) (70)
Cyst 1 (1%)
Fibrosis 3 (4%) 1 (1%)
Inflammation, Chronic 5 (7%) 2 (3%) 1 (1%)
Inflammation, Suppurative 36 (51%) 29 (41%) 41 (59%) 41 (60%) 23 (33%)
Epithelium, Hyperplasia 11 (16%) 12 (17%) 10 (14%) 6 (9%) 8 (11%)
Testes (70) (70) (70) (67) (70)
Interstitial Cell, Hyperplasia 4 (6%) 3 (4%) 7 (10%) 6 (9%) 3 (4%)
Seminiferous Tubule, Atrophy 7 (10%) 1 (1%) 6 (9%) 2 (3%) 5 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70) (70) (68) (70)
Depletion Cellular 1 (1%)
Hyperplasia 6 (9%) 5 (7%) 2 (3%) 7 (10%)
Infiltration Cellular, Histiocyte 2 (3%)
Myelofibrosis 4 (6%) 2 (3%) 8 (11%) 2 (3%)
Lymph Node (33) (37) (37) (36) (35)
Deep Cervical, Hyperplasia, Lymphoid 1 (3%)
Iliac, Hemorrhage 1 (3%)
Inguinal, Hyperplasia, Lymphoid 2 (6%) 1 (3%)
Mediastinal, Congestion 2 (6%)
Mediastinal, Hemorrhage 3 (9%) 5 (14%) 3 (8%) 3 (8%) 3 (9%)
Mediastinal, Hyperplasia, Lymphoid 1 (3%) 3 (8%) 2 (5%) 1 (3%) 2 (6%)
Mediastinal, Pigmentation 13 (39%) 14 (38%) 14 (38%) 17 (47%) 16 (46%)
Pancreatic, Ectasia 1 (3%)
Pancreatic, Hemorrhage 2 (5%)
Pancreatic, Hyperplasia, Plasma Cell 1 (3%)
Pancreatic, Pigmentation 9 (27%) 4 (11%) 3 (8%) 4 (11%) 3 (9%)
Renal, Ectasia 2 (6%)
Renal, Hemorrhage 1 (3%) 1 (3%) 1 (3%) 3 (8%) 2 (6%)
Renal, Hyperplasia, Lymphoid 1 (3%)
Renal, Pigmentation 8 (24%) 5 (14%) 8 (22%) 8 (22%) 7 (20%)
Lymph Node, Mandibular (70) (69) (70) (68) (70)
Ectasia 3 (4%) 8 (12%) 8 (11%) 7 (10%) 6 (9%)
Hemorrhage 2 (3%) 1 (1%) 2 (3%) 3 (4%)
Hyperplasia, Lymphoid 11 (16%) 11 (16%) 7 (10%) 10 (15%) 17 (24%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (1%) 1 (1%)
Pigmentation 6 (9%) 8 (12%) 3 (4%) 7 (10%) 5 (7%)
Lymph Node, Mesenteric (70) (68) (68) (67) (70)
Ectasia 7 (10%) 1 (1%) 1 (1%) 7 (10%) 10 (14%)
Hemorrhage 1 (1%) 3 (4%) 3 (4%) 1 (1%) 2 (3%)
Hyperplasia, Lymphoid 3 (4%) 2 (3%) 1 (1%) 10 (15%) 6 (9%)
Pigmentation 1 (1%)
Spleen (70) (70) (70) (68) (70)
Angiectasis 1 (1%)
Congestion 1 (1%)
Fibrosis 21 (30%) 19 (27%) 20 (29%) 9 (13%) 13 (19%)
Hematopoietic Cell Proliferation 7 (10%) 6 (9%) 6 (9%) 3 (4%) 8 (11%)
Metaplasia, Lipocyte 1 (1%)
Necrosis 2 (3%) 3 (4%) 2 (3%) 3 (4%)
Pigmentation, Hemosiderin 13 (19%) 11 (16%) 9 (13%) 14 (21%) 17 (24%)
Lymphoid Follicle, Atrophy 1 (1%)
Red Pulp, Atrophy 1 (1%)
Thymus (68) (65) (65) (64) (66)
Cyst 1 (2%)
Ectopic Parathyroid Gland 1 (2%) 2 (3%)
Hemorrhage 1 (2%) 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (67) (68) (67) (66) (68)
Dilatation 23 (34%) 27 (40%) 24 (36%) 17 (26%) 10 (15%)
Galactocele 5 (7%) 4 (6%) 1 (2%) 2 (3%)
Hyperplasia 7 (10%) 12 (18%) 4 (6%) 5 (8%) 6 (9%)
Skin (70) (70) (70) (67) (70)
Cyst Epithelial Inclusion 2 (3%) 1 (1%) 1 (1%) 1 (1%)
Hemorrhage 1 (1%)
Hyperkeratosis 1 (1%) 1 (1%) 2 (3%) 1 (1%)
Inflammation, Chronic 1 (1%) 1 (1%) 2 (3%)
Ulcer 1 (1%) 1 (1%)
Epidermis, Hyperplasia 1 (1%) 1 (1%) 1 (1%) 1 (1%) 1 (1%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (1%)
Subcutaneous Tissue, Thrombosis 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70) (70) (68) (70)
Fibrous Osteodystrophy 6 (9%) 1 (1%) 5 (7%) 5 (7%) 7 (10%)
Hyperostosis 1 (1%) 1 (1%)
Femur, Osteopetrosis 1 (1%) 2 (3%) 2 (3%) 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70) (70) (68) (70)
Angiectasis 1 (1%)
Atrophy 12 (17%) 6 (9%) 8 (11%) 8 (12%) 3 (4%)
Gliosis 1 (1%)
Hemorrhage 2 (3%) 1 (1%) 1 (1%) 1 (1%)
Hydrocephalus 4 (6%) 3 (4%) 3 (4%) 4 (6%)
Necrosis 1 (1%) 2 (3%) 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70) (70) (68) (70)
Congestion 2 (3%)
Edema 1 (1%) 1 (1%) 1 (1%)
Hemorrhage 3 (4%) 2 (3%) 5 (7%) 2 (3%) 2 (3%)
Infiltration Cellular, Histiocyte 19 (27%) 17 (24%) 21 (30%) 10 (15%) 14 (20%)
Inflammation, Subacute 4 (6%) 7 (10%) 7 (10%) 7 (10%) 8 (11%)
Metaplasia, Osseous 1 (1%)
Mineralization 1 (1%) 1 (1%)
Alveolar Epithelium, Hyperplasia 7 (10%) 8 (11%) 10 (14%) 6 (9%) 10 (14%)
Nose (70) (70) (70) (68) (70)
Foreign Body 6 (9%) 5 (7%) 8 (11%) 2 (3%) 2 (3%)
Inflammation, Suppurative 17 (24%) 10 (14%) 22 (31%) 15 (22%) 11 (16%)
Goblet Cell, Hyperplasia 5 (7%) 4 (6%) 3 (4%) 9 (13%) 20 (29%)
Mucosa, Hyperplasia 14 (20%) 8 (11%) 18 (26%) 13 (19%) 10 (14%)
Mucosa, Metaplasia, Squamous 8 (11%) 4 (6%) 13 (19%) 8 (12%) 7 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (4) (2) (1) (2)
Atrophy 2 (50%) 1 (50%)
Cataract 1 (25%) 2 (50%) 1 (50%)
Inflammation, Chronic 1 (25%) 1 (50%)
Retina, Degeneration 1 (25%) 2 (50%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (68) (70)
Cyst 2 (3%) 1 (1%) 3 (4%) 7 (10%) 11 (16%)
Developmental Malformation 1 (1%)
Inflammation, Suppurative 9 (13%) 8 (11%) 9 (13%) 20 (29%)
Mineralization 13 (19%) 13 (19%) 4 (6%) 2 (3%) 1 (1%)
Nephropathy 65 (93%) 64 (91%) 65 (93%) 62 (91%) 66 (94%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Accumulation, Hyaline Droplet 1 (1%) 3 (4%) 1 (1%) 2 (3%) 1 (1%)
Renal Tubule, Atrophy 1 (1%) 1 (1%)
Renal Tubule, Hyperplasia, Focal 1 (1%)
Renal Tubule, Necrosis 3 (4%) 1 (1%) 1 (1%) 1 (1%)
Renal Tubule, Pigmentation 18 (26%) 23 (33%) 26 (37%) 17 (25%) 15 (21%)
Transitional Epithelium, Hyperplasia 13 (19%) 2 (3%) 12 (17%) 11 (16%) 21 (30%)
Urinary Bladder (70) (70) (70) (68) (70)
Hemorrhage 1 (1%) 1 (1%)
Inflammation, Suppurative 1 (1%) 1 (1%)
Transitional Epithelium, Hyperplasia 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
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