TDMS Study 05217-03 Pathology Tables
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70 70
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Moribund Sacrifice 40 31 41 33 36
Natural Death 10 7 8 9 7
Survivors
Terminal Sacrifice 10 22 11 16 17
Other 2
Animals Examined Microscopically 70 70 70 68 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (70) (70) (69) (66) (69)
Intestine Large, Rectum (69) (70) (69) (67) (69)
Intestine Large, Cecum (70) (70) (70) (67) (70)
Intestine Small, Duodenum (69) (70) (70) (67) (70)
Carcinoma 1 (1%)
Intestine Small, Jejunum (69) (70) (69) (66) (70)
Carcinoma 1 (2%)
Intestine Small, Ileum (70) (70) (68) (67) (68)
Leiomyosarcoma 1 (1%)
Liver (70) (70) (70) (68) (70)
Fibrous Histiocytoma, Metastatic, Skin 1 (1%)
Hepatocellular Adenoma 1 (1%) 2 (3%) 1 (1%)
Hepatocellular Adenoma, Multiple 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Mesentery (11) (5) (13) (10) (7)
Sarcoma Stromal, Metastatic, Uterus 1 (9%)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (70) (70) (70) (67) (69)
Sarcoma Stromal, Metastatic, Uterus 1 (1%)
Salivary Glands (70) (70) (70) (68) (70)
Carcinoma 1 (1%)
Stomach, Forestomach (70) (70) (70) (67) (69)
Squamous Cell Papilloma 1 (1%)
Stomach, Glandular (70) (70) (70) (67) (70)
Tongue (1) (1) (1) (4) (1)
Squamous Cell Carcinoma 1 (25%)
Squamous Cell Papilloma 1 (100%) 1 (100%) 1 (25%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (70) (70) (68) (70)
Schwannoma Benign 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70) (70) (68) (70)
Adenoma 4 (6%) 1 (1%)
Adrenal Medulla (70) (70) (70) (68) (70)
Pheochromocytoma Malignant 1 (1%) 1 (1%)
Pheochromocytoma Benign 2 (3%) 2 (3%) 2 (3%) 1 (1%) 3 (4%)
Islets, Pancreatic (70) (70) (69) (67) (69)
Adenoma 2 (3%) 1 (1%) 1 (1%) 3 (4%) 2 (3%)
Carcinoma 1 (1%)
Parathyroid Gland (62) (64) (65) (63) (62)
Adenoma 2 (3%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Pituitary Gland (70) (69) (70) (67) (70)
Pars Distalis, Adenoma 26 (37%) 31 (45%) 27 (39%) 34 (51%) 28 (40%)
Pars Distalis, Carcinoma 2 (3%) 2 (3%) 1 (1%) 1 (1%) 3 (4%)
Thyroid Gland (70) (69) (70) (67) (70)
C-Cell, Adenoma 7 (10%) 6 (9%) 7 (10%) 7 (10%) 6 (9%)
C-Cell, Carcinoma 1 (1%) 2 (3%) 2 (3%) 1 (1%)
Follicular Cell, Adenoma 1 (1%)
Follicular Cell, Carcinoma 1 (1%) 1 (1%) 1 (1%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (68) (69) (69) (68) (70)
Adenoma 6 (9%) 3 (4%) 6 (9%) 5 (7%) 6 (9%)
Adenoma, Multiple 1 (1%) 1 (1%)
Carcinoma 6 (9%) 1 (1%) 4 (6%) 5 (7%) 8 (11%)
Carcinoma, Multiple 1 (1%)
Ovary (70) (70) (70) (67) (70)
Carcinoma 1 (1%)
Granulosa Cell Tumor Malignant 1 (1%)
Granulosa Cell Tumor Benign 1 (1%) 1 (1%) 1 (1%)
Uterus (70) (70) (70) (68) (70)
Adenoma 1 (1%) 1 (1%)
Carcinoma 1 (1%)
Page 3
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Leiomyoma 1 (1%) 1 (1%) 1 (1%)
Polyp Stromal 6 (9%) 9 (13%) 12 (17%) 5 (7%) 9 (13%)
Polyp Stromal, Multiple 1 (1%)
Sarcoma Stromal 2 (3%) 1 (1%) 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70) (70) (67) (70)
Lymph Node (20) (14) (24) (19) (18)
Pancreatic, Carcinoma, Metastatic, Ovary 1 (5%)
Lymph Node, Mandibular (69) (70) (70) (65) (70)
Lymph Node, Mesenteric (68) (69) (70) (65) (70)
Carcinoma, Metastatic, Ovary 1 (2%)
Spleen (70) (70) (70) (67) (70)
Hemangiosarcoma 1 (1%)
Osteosarcoma, Metastatic, Bone 1 (1%)
Thymus (66) (66) (70) (67) (67)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Thymoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (70) (70) (69) (68) (70)
Adenoma 3 (4%) 3 (4%) 1 (1%) 2 (3%)
Carcinoma 8 (11%) 1 (1%) 6 (9%) 2 (3%) 3 (4%)
Carcinoma, Multiple 1 (1%)
Fibroadenoma 28 (40%) 21 (30%) 16 (23%) 25 (37%) 20 (29%)
Fibroadenoma, Multiple 15 (21%) 2 (3%) 17 (25%) 9 (13%) 7 (10%)
Skin (70) (69) (70) (67) (70)
Basal Cell Carcinoma 1 (1%) 1 (1%)
Keratoacanthoma 1 (1%) 1 (1%)
Squamous Cell Papilloma 2 (3%)
Subcutaneous Tissue, Fibroma 3 (4%) 2 (3%) 2 (3%) 1 (1%) 1 (1%)
Subcutaneous Tissue, Fibroma, Multiple 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 1 (1%) 1 (1%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (1%)
Subcutaneous Tissue, Hemangiosarcoma 1 (1%)
Subcutaneous Tissue, Lipoma 1 (1%)
Subcutaneous Tissue, Sarcoma 1 (1%)
Subcutaneous Tissue, Schwannoma Benign 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70) (69) (68) (70)
Osteosarcoma 1 (1%)
Skeletal Muscle (1) (1) (1) (1) (1)
Fibrous Histiocytoma, Metastatic, Skin 1 (100%)
Sarcoma 1 (100%)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70) (70) (68) (70)
Carcinoma, Metastatic, Mammary Gland 1 (1%)
Carcinoma, Metastatic, Pituitary Gland 1 (1%) 1 (1%)
Oligodendroglioma Malignant 1 (1%)
Spinal Cord (2) (1) (2) (3) (4)
Astrocytoma Malignant 1 (25%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70) (70) (68) (70)
Alveolar/Bronchiolar Adenoma 2 (3%) 2 (3%) 1 (1%) 1 (1%)
Alveolar/Bronchiolar Carcinoma 1 (1%)
Carcinoma, Metastatic, Ovary 1 (1%)
Carcinoma, Metastatic, Thyroid Gland 1 (1%)
Fibrous Histiocytoma, Metastatic, Skin 1 (1%)
Nose (70) (70) (70) (68) (70)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (67) (70)
Fibrous Histiocytoma, Metastatic, Skin 1 (1%)
Sarcoma Stromal, Metastatic, Uterus 1 (1%)
Renal Tubule, Adenoma 1 (1%)
Urinary Bladder (69) (70) (70) (68) (69)
Page 5
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Papilloma 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(70) *(70) *(68) *(70)
Leukemia Mononuclear 27 (39%) 25 (36%) 33 (47%) 22 (32%) 27 (39%)
Mesothelioma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 6
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 54 59 56 59
Total Primary Neoplasms 164 121 147 145 148
Total Animals with Benign Neoplasms 52 45 51 49 50
Total Benign Neoplasms 112 84 99 100 95
Total Animals with Malignant Neoplasms 41 32 39 38 38
Total Malignant Neoplasms 52 37 48 45 53
Total Animals with Metastatic Neoplasms 2 2 2 4
Total Metastatic Neoplasm 5 6 5 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 7
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70 70 70 70
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Moribund Sacrifice 48 41 51 50 42
Natural Death 4 7 2 7 4
Survivors
Terminal Sacrifice 8 12 7 1 14
Other 2
Animals Examined Microscopically 70 70 70 68 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (68) (70) (68) (68) (70)
Leiomyosarcoma 1 (1%)
Intestine Large, Rectum (69) (68) (70) (68) (69)
Carcinoma 1 (1%)
Intestine Large, Cecum (70) (70) (68) (68) (70)
Intestine Small, Duodenum (69) (70) (70) (68) (70)
Intestine Small, Jejunum (70) (69) (70) (67) (70)
Carcinoma 1 (1%)
Intestine Small, Ileum (70) (69) (69) (68) (69)
Leiomyoma 1 (1%)
Liver (70) (70) (70) (68) (70)
Hemangiosarcoma 1 (1%)
Hepatocellular Carcinoma 2 (3%)
Hepatocellular Adenoma 4 (6%) 1 (1%) 4 (6%) 3 (4%)
Histiocytic Sarcoma 1 (1%)
Leiomyosarcoma, Metastatic, Intestine Large,
Colon 1 (1%)
Osteosarcoma, Metastatic, Mesentery 1 (1%)
Mesentery (20) (15) (11) (7) (16)
Histiocytic Sarcoma 1 (5%)
Leiomyosarcoma, Metastatic, Intestine Large,
Colon 1 (9%)
Osteosarcoma 1 (14%)
Schwannoma Malignant 1 (5%)
Oral Mucosa (1) (2) (2)
Squamous Cell Carcinoma 1 (100%) 1 (50%) 2 (100%)
Squamous Cell Papilloma 1 (50%)
Pancreas (70) (70) (69) (68) (70)
Leiomyosarcoma, Metastatic, Intestine Large,
Colon 1 (1%)
Page 8
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Mixed Tumor Benign 1 (1%)
Acinus, Adenoma 3 (4%) 1 (1%)
Salivary Glands (70) (70) (70) (68) (70)
Carcinoma 1 (1%)
Fibrosarcoma, Metastatic, Skin 1 (1%)
Stomach, Forestomach (70) (70) (70) (68) (69)
Squamous Cell Papilloma 2 (3%) 1 (1%) 1 (1%)
Stomach, Glandular (70) (70) (69) (68) (70)
Tongue (1) (2) (2) (1) (4)
Squamous Cell Carcinoma 1 (100%) 1 (50%)
Squamous Cell Papilloma 2 (50%)
Tooth (1) (1) (2) (1)
Odontoma 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (70) (70) (68) (70)
Schwannoma Malignant 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (70) (70) (70) (68) (70)
Adenoma 1 (1%) 1 (1%) 1 (1%)
Adrenal Medulla (70) (70) (69) (68) (70)
Pheochromocytoma Malignant 1 (1%) 1 (1%) 3 (4%) 1 (1%) 3 (4%)
Pheochromocytoma Complex 1 (1%)
Pheochromocytoma Benign 13 (19%) 11 (16%) 16 (23%) 11 (16%) 11 (16%)
Pheochromocytoma Benign, Multiple 1 (1%) 1 (1%) 4 (6%) 4 (6%) 1 (1%)
Islets, Pancreatic (70) (70) (69) (68) (70)
Adenoma 5 (7%) 2 (3%) 2 (3%) 1 (1%) 3 (4%)
Carcinoma 1 (1%)
Pituitary Gland (70) (69) (68) (66) (70)
Pars Distalis, Adenoma 19 (27%) 19 (28%) 16 (24%) 17 (26%) 6 (9%)
Pars Distalis, Carcinoma 1 (1%) 1 (1%) 1 (2%) 1 (1%)
Thyroid Gland (70) (70) (70) (68) (70)
C-Cell, Adenoma 5 (7%) 5 (7%) 2 (3%) 2 (3%) 4 (6%)
C-Cell, Carcinoma 1 (1%) 1 (1%) 2 (3%)
Follicular Cell, Adenoma 1 (1%) 1 (1%)
Follicular Cell, Carcinoma 3 (4%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (3)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (70) (70) (70) (67) (70)
Preputial Gland (70) (70) (70) (68) (70)
Adenoma 5 (7%) 3 (4%) 6 (9%) 3 (4%)
Carcinoma 2 (3%) 2 (3%) 1 (1%) 5 (7%)
Carcinoma, Multiple 1 (1%)
Prostate (70) (70) (70) (68) (70)
Adenoma 2 (3%) 3 (4%) 2 (3%) 1 (1%) 1 (1%)
Seminal Vesicle (70) (70) (70) (68) (70)
Leiomyosarcoma, Metastatic, Intestine Large,
Colon 1 (1%)
Testes (70) (70) (70) (67) (70)
Bilateral, Interstitial Cell, Adenoma 42 (60%) 53 (76%) 40 (57%) 45 (67%) 50 (71%)
Interstitial Cell, Adenoma 13 (19%) 5 (7%) 9 (13%) 11 (16%) 9 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (70) (70) (70) (68) (70)
Lymph Node (33) (37) (37) (36) (35)
Mediastinal, Osteosarcoma, Metastatic,
Mesentery 1 (3%)
Lymph Node, Mandibular (70) (69) (70) (68) (70)
Carcinoma, Metastatic, Zymbal's Gland 1 (1%)
Fibrosarcoma, Metastatic, Skin 1 (1%)
Lymph Node, Mesenteric (70) (68) (68) (67) (70)
Hemangioma 1 (1%)
Spleen (70) (70) (70) (68) (70)
Fibroma 2 (3%) 1 (1%) 1 (1%)
Hemangiosarcoma 1 (1%)
Histiocytic Sarcoma 1 (1%)
Leiomyosarcoma, Metastatic, Intestine Large,
Colon 1 (1%)
Osteosarcoma, Metastatic, Mesentery 1 (1%)
Sarcoma 1 (1%) 1 (1%) 1 (1%)
Thymus (68) (65) (65) (64) (66)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (67) (68) (67) (66) (68)
Adenoma 1 (1%) 1 (1%) 1 (2%)
Fibroadenoma 9 (13%) 6 (9%) 4 (6%) 4 (6%) 6 (9%)
Fibroadenoma, Multiple 1 (1%) 1 (1%)
Skin (70) (70) (70) (67) (70)
Basal Cell Carcinoma 1 (1%)
Hemangioma 1 (1%)
Keratoacanthoma 3 (4%) 2 (3%) 4 (6%) 4 (6%) 4 (6%)
Keratoacanthoma, Multiple 1 (1%)
Squamous Cell Carcinoma, Metastatic, Tongue 1 (1%)
Squamous Cell Papilloma 2 (3%) 1 (1%) 1 (1%) 2 (3%)
Squamous Cell Papilloma, Multiple 1 (1%)
Trichoepithelioma 2 (3%) 1 (1%) 1 (1%) 1 (1%)
Sebaceous Gland, Adenoma 1 (1%) 1 (1%)
Subcutaneous Tissue, Fibroma 3 (4%) 7 (10%) 8 (11%) 6 (9%) 6 (9%)
Subcutaneous Tissue, Fibroma, Multiple 1 (1%)
Subcutaneous Tissue, Fibrosarcoma 1 (1%) 3 (4%) 1 (1%) 1 (1%) 1 (1%)
Subcutaneous Tissue, Hemangioma 1 (1%)
Subcutaneous Tissue, Hemangiosarcoma 1 (1%)
Subcutaneous Tissue, Schwannoma Benign 1 (1%)
Subcutaneous Tissue, Schwannoma Malignant 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (70) (70) (68) (70)
Osteosarcoma 1 (1%)
Skeletal Muscle (2) (2)
Leiomyosarcoma, Metastatic, Intestine Large,
Colon 1 (50%)
Osteosarcoma, Metastatic, Mesentery 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (70) (70) (68) (70)
Astrocytoma Malignant 1 (1%) 1 (1%)
Carcinoma, Metastatic, Pituitary Gland 1 (1%)
Oligodendroglioma Malignant 1 (1%)
Spinal Cord (2) (3) (1) (1)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (70) (70) (70) (68) (70)
Alveolar/Bronchiolar Adenoma 3 (4%) 2 (3%) 2 (3%) 1 (1%) 1 (1%)
Alveolar/Bronchiolar Carcinoma 3 (4%) 1 (1%)
Carcinoma, Metastatic, Salivary Glands 1 (1%)
Histiocytic Sarcoma 1 (1%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (1%)
Nose (70) (70) (70) (68) (70)
Squamous Cell Carcinoma 1 (1%)
Squamous Cell Papilloma 1 (1%)
Pleura (1)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1) (1)
Squamous Cell Papilloma 1 (100%)
Eye (4) (4) (2) (1) (2)
Carcinoma, Metastatic, Salivary Glands 1 (100%)
Schwannoma Malignant 1 (25%)
Zymbal's Gland (2) (1) (1) (3) (4)
Adenoma 1 (25%)
Carcinoma 2 (100%) 1 (100%) 1 (100%) 3 (100%) 3 (75%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (70) (70) (68) (70)
Lipoma 1 (1%)
Osteosarcoma, Metastatic, Mesentery 1 (1%)
Renal Tubule, Adenoma 2 (3%) 1 (1%) 1 (1%)
Transitional Epithelium, Carcinoma 1 (1%)
Urinary Bladder (70) (70) (70) (68) (70)
Papilloma 1 (1%) 1 (1%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(70) *(70) *(70) *(68) *(70)
Histiocytic Sarcoma 1 (1%)
Leukemia Mononuclear 39 (56%) 45 (64%) 47 (67%) 40 (59%) 32 (46%)
Lymphoma Malignant 1 (1%)
Mesothelioma Malignant 1 (1%) 1 (1%) 3 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05217-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/04/96
Route: DOSED FEED Time: 06:47:05
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD 0.0% 0.125% 0.25% 0.5%
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 60 59 57 60
Total Primary Neoplasms 207 186 185 178 179
Total Animals with Benign Neoplasms 60 59 56 56 59
Total Benign Neoplasms 148 126 125 120 120
Total Animals with Malignant Neoplasms 51 51 53 50 47
Total Malignant Neoplasms 59 60 60 58 59
Total Animals with Metastatic Neoplasms 2 1 5 2
Total Metastatic Neoplasm 2 6 11 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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