TDMS Study 05217-03 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
T-BUTYLHYDROQUINONE
NTP Experiment-Test: 05217-03 Report: PEIRPT09
Study Type: CHRONIC Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
LIFETIME CORE STUDY
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 UNTREATD CONTROL
Include 002 UNTREATD CONTROL
Include 003 0.125%
Include 004 0.125%
Include 005 0.25%
Include 006 0.25%
Include 007 0.5%
Include 008 0.5%
Page 1
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|
| 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 1 2 1 1 4 2 3|
Clear Cell Focus | |
Degeneration, Cystic | |
Eosinophilic Focus | 3 3 3 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous | 2 1 1 2 3 |
Mixed Cell Focus | |
Necrosis, Focal | 4 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 3|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 4 2 3 2 3|
Kupffer Cell, Pigmentation | 3 2 3 1 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | |
Fat, Necrosis | 3 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 1 1 2 1|
Metaplasia, Hepatocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 3 |
Erosion | |
Ulcer | |
Mucosa, Hyperplasia | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 2 |
Ulcer | 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|
| 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 1 2 2 3 3 1 2 3|
Thrombosis | 3 |
Valve, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 |
Atrophy | 4 |
Degeneration, Fatty | 1 4 2 |
Hemorrhage | 3 |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M M + + + M|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 3 4 |
Pars Distalis, Cyst | 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 3 1 |
Pars Intermedia, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 1 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Cyst | 3 3 |
Cyst, Multiple | 2 |
Hyperplasia | 3 3|
Inflammation, Chronic | |
Inflammation, Suppurative | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|
| 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | M M M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Hyperplasia | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | 4 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | 3 3 3 3 4 3 |
Pancreatic, Pigmentation | |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 2 2 |
Hyperplasia, Plasma Cell | 3 |
Pigmentation | 2 2 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + I + +|
Ectasia | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 4 2 2 2 1 2 3 3 1 |
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 3 2 |
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 2 1 2 3 1 3 3 2 2 2 2 2 |
Galactocele | 2 4 4 |
Hyperplasia | 3 2 2 2 1 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperkeratosis | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|
| 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 3 3 3 |
Femur, Osteopetrosis | 3 3 3 2 2 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 3 3 3 2 3 |
Hydrocephalus | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 4 |
Infiltration Cellular, Histiocyte | 1 3 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Subacute | 3 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 3 |
Goblet Cell, Hyperplasia | 1 1 1 2 |
Mucosa, Hyperplasia | 2 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
Cataract | 2 3 |
Hemorrhage | 2 |
Retina, Degeneration | 3 3 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | 1 3 |
Mineralization | 3 3 3 2 3 3 2 3 2 2 3 1 2 3 3 2 2 3 3 2 2 1 3 3|
Nephropathy | 3 1 3 1 3 2 1 1 1 1 1 2|
Renal Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 8| 6| 2| 6| 3| 6| 5| 7| 5| 7| 8| 6| 8| 7| 7| 7| 6| 8| 7| 7| 7| 6| 7|
DAY ON TEST | 7| 9| 8| 4| 9| 2| 0| 9| 7| 7| 4| 1| 5| 1| 0| 9| 2| 6| 2| 9| 3| 6| 2| 3| 3|
| 8| 8| 8| 9| 7| 8| 2| 0| 9| 8| 0| 2| 4| 3| 2| 6| 4| 1| 7| 8| 6| 6| 2| 8| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
UNTREATD | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Cytoplasmic Alteration | 3 3 |
Renal Tubule, Necrosis | 3 3 |
Renal Tubule, Pigmentation | 2 2 2 3 2 3 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|
DAY ON TEST | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|
| 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 3 1 1 4 2 3 3 1 3 3 |
Clear Cell Focus | 4 |
Degeneration, Cystic | 1 |
Eosinophilic Focus | 3 3 4 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X X|
Inflammation, Granulomatous | 1 2 1 |
Mixed Cell Focus | 3 4|
Necrosis, Focal | 1 |
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 3 1|
Hepatocyte, Vacuolization Cytoplasmic| 4 3 3 3 4 |
Kupffer Cell, Pigmentation | 2 3 3 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 3 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 4 2 1 1 2 1 |
Metaplasia, Hepatocyte | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 4 |
Erosion | |
Ulcer | 4 |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|
DAY ON TEST | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|
| 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 3 3 2 2 1 2 2 3 2 2|
Thrombosis | 4 3 |
Valve, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 2 1 1 1 3 |
Atrophy | |
Degeneration, Fatty | 2 3 |
Hemorrhage | |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | 2 3 2 |
Hypertrophy, Focal | 2 1 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + I + + + + + + + + + + M|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | 3 3 3 3 2 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 3 2 |
Pars Intermedia, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Cyst | |
Cyst, Multiple | |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|
DAY ON TEST | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|
| 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 |
Hyperplasia, Cystic | 1 2 |
__________________________________________________________________________|
Vagina | M M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Hyperplasia | |
Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 2 3 3 2 4 |
Pancreatic, Pigmentation | 3 |
Renal, Pigmentation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 2 2 2 2 2 2|
Hyperplasia, Plasma Cell | |
Pigmentation | 2 2 2 2 2 2 3 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 2 1 1 |
Pigmentation, Hemosiderin | 3 2 2 3 3 3 3 2 2 3 3|
Lymphoid Follicle, Atrophy | 4 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + I + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 3 2 2 3 1 3 2 2 1 2 |
Galactocele | 4|
Hyperplasia | 3 2 3 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 3 |
Inflammation, Chronic | 3 |
Epidermis, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|
DAY ON TEST | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|
| 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 3 |
Femur, Osteopetrosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 4 4 3 4 4 3|
Hydrocephalus | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 3 1 1 1 2 1 1 3 1 1|
Inflammation, Subacute | 4 |
Thrombosis | 2 |
Alveolar Epithelium, Hyperplasia | 1 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 2 3 2 |
Goblet Cell, Hyperplasia | 1 1 1 1 1 |
Mucosa, Hyperplasia | 1 3 3 |
Mucosa, Metaplasia, Squamous | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Hemorrhage | |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Mineralization | 2 2 1 2 2 2 2 1 2 3 2 3 3 2 3 3 3 3 2 2 3 3 2 2|
Nephropathy | 2 1 1 3 1 2 2 3 1 1 1 1 1 3 2 1 3|
Renal Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 8| 7| 4| 4| 5| 8| 7| 8| 6| 7| 7| 7| 7| 7| 8| 6| 6| 7| 4| 8| 7| 8| 3| 8|
DAY ON TEST | 4| 3| 0| 1| 2| 4| 9| 5| 3| 4| 6| 9| 7| 9| 6| 9| 6| 9| 9| 9| 8| 8| 9| 8| 0|
| 6| 0| 4| 8| 1| 0| 8| 8| 1| 0| 5| 9| 7| 5| 5| 8| 1| 4| 5| 7| 0| 5| 8| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
UNTREATD | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|
CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Cytoplasmic Alteration | 2 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 1 1 3 4 3 3 2|
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| | |
DAY ON TEST | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8| | |
| 8| 8| 5| 3| 6| 8| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + I + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Parasite Metazoan | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | 3 3 3 1 3 4 3 4 | 26 2.4|
Clear Cell Focus | 1 | 2 2.5|
Degeneration, Cystic | | 1 1.0|
Eosinophilic Focus | 2 3 2 2 | 10 2.8|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 12 |
Inflammation, Granulomatous | 2 1 3 1 | 12 1.7|
Mixed Cell Focus | | 2 3.5|
Necrosis, Focal | 2 1 | 6 1.7|
Bile Duct, Hyperplasia | 2 | 17 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 14 3.0|
Kupffer Cell, Pigmentation | 1 | 12 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 11 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 | 9 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 2 2 2 | 20 1.6|
Metaplasia, Hepatocyte | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 4 3.3|
Erosion | 2 | 1 2.0|
Ulcer | 2 | 2 3.0|
Mucosa, Hyperplasia | 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| | |
DAY ON TEST | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8| | |
| 8| 8| 5| 3| 6| 8| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
Erosion | | 3 2.3|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 | 28 2.1|
Thrombosis | | 3 3.3|
Valve, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 1 2 3 | 11 1.8|
Atrophy | | 1 4.0|
Degeneration, Fatty | 1 1 3 1 | 9 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Diffuse | 3 | 3 3.0|
Hyperplasia, Focal | | 3 2.3|
Hypertrophy, Focal | 1 3 2 | 9 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 5 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + | 52 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 4 4 | 8 3.0|
Pars Distalis, Cyst | 3 3 | 14 2.9|
Pars Distalis, Hyperplasia, Focal | 2 | 9 2.3|
Pars Intermedia, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | 3 | 2 3.0|
C-Cell, Hyperplasia | | 8 1.1|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| | |
DAY ON TEST | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8| | |
| 8| 8| 5| 3| 6| 8| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 58 |
Cyst | | 2 3.0|
Cyst, Multiple | | 1 2.0|
Hyperplasia | | 3 2.7|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 3 | 17 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 3 3 | 3 2.7|
Hyperplasia, Cystic | 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Vagina | M M | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Depletion Cellular | | 1 3.0|
Hyperplasia | | 1 3.0|
Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 20 |
Mediastinal, Ectasia | | 1 3.0|
Mediastinal, Hemorrhage | | 3 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | 3 3 3 | 14 3.0|
Pancreatic, Pigmentation | | 1 3.0|
Renal, Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + | 59 |
Ectasia | | 2 2.0|
Hemorrhage | 1 | 3 1.3|
Hyperplasia, Lymphoid | 3 2 3 | 13 2.3|
Hyperplasia, Plasma Cell | | 1 3.0|
Pigmentation | 2 2 | 20 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Ectasia | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 | 3 2.7|
Hematopoietic Cell Proliferation | 2 3 | 15 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| | |
DAY ON TEST | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8| | |
| 8| 8| 5| 3| 6| 8| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 2 2 3 | 24 2.4|
Lymphoid Follicle, Atrophy | | 1 4.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 3 1 2 3 2 3 2 | 37 2.1|
Galactocele | 3 | 5 3.4|
Hyperplasia | | 12 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Epidermis, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Osteopetrosis | 2 | 8 2.8|
Femur, Osteopetrosis | 4 3 | 9 2.9|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy | 3 3 3 | 19 3.3|
Hydrocephalus | 3 | 4 2.3|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | | 2 3.5|
Infiltration Cellular, Histiocyte | 1 1 1 3 1 | 28 1.3|
Inflammation, Subacute | | 3 3.3|
Thrombosis | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 7| 8| 8| 8| 8| 8| 7| | |
DAY ON TEST | 9| 9| 5| 3| 5| 9| 9| 7| 9| 8| | |
| 8| 8| 5| 3| 6| 8| 8| 9| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
UNTREATD | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Suppurative | 2 | 5 2.4|
Goblet Cell, Hyperplasia | 1 | 10 1.1|
Mucosa, Hyperplasia | 2 | 5 2.2|
Mucosa, Metaplasia, Squamous | 2 | 3 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 3 3.0|
Hemorrhage | | 1 2.0|
Retina, Degeneration | | 4 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
Mineralization | 3 3 3 3 3 2 2 2 2 | 57 2.4|
Nephropathy | 1 3 2 2 1 2 1 1 | 37 1.7|
Renal Tubule, Atrophy | 3 | 1 3.0|
Renal Tubule, Cytoplasmic Alteration | 3 | 5 2.6|
Renal Tubule, Necrosis | | 2 3.0|
Renal Tubule, Pigmentation | 1 | 15 2.3|
Transitional Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|
DAY ON TEST | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|
| 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 2 3 3 4 3 3 1 3 2 2 2 |
Eosinophilic Focus | 3 4 3 2 4 3 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | 1 2 1 3 |
Mixed Cell Focus | 3 3 |
Necrosis, Focal | 1 1 3 |
Bile Duct, Hyperplasia | 2 2 1 2 2 2 1|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 4 3 |
Kupffer Cell, Pigmentation | 2 3 3 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | |
Fat, Necrosis | 3 3 3 3 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 1 3 1 1 |
Acinus, Cytoplasmic Alteration | |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Ulcer | 3 |
Mucosa, Hyperplasia | 3 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Ulcer | 2 2 |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|
DAY ON TEST | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|
| 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 1 2 2 1 3 2 2 2 2 2 |
Thrombosis | 4 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 2 2 2 3|
Degeneration, Fatty | 2 3 1 2 2 4 3 2 |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | |
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 3 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 3 3 1 3 3|
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 2 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 3 |
Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Vagina | M M M M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|
DAY ON TEST | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|
| 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 2 3 2 2 3 |
Pancreatic, Pigmentation | 3 3 |
Renal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | 2 2 3 1 1 2 |
Necrosis | |
Pigmentation, Hemosiderin | 3 3 3 2 2 3 3 2 2 2 2 3 2 3|
Lymphoid Follicle, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 2 3 2 3 1 2 3 2 2 2 3 2 2 3 2|
Galactocele | 4 4 4 4 |
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + I + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 |
Femur, Osteopetrosis | 3 3 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 4 3 2 1 3 3 4 3 3 |
Hydrocephalus | |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 4| 8| 4| 7| 8| 7| 8| 8| 7| 6| 7| 7| 4| 8| 6| 8| 5| 7| 5| 6| 8| 8| 8| 8| 6|
DAY ON TEST | 8| 9| 8| 2| 4| 9| 9| 0| 8| 5| 6| 3| 9| 9| 2| 6| 8| 9| 3| 6| 3| 7| 3| 9| 6|
| 1| 8| 0| 2| 5| 9| 8| 6| 1| 6| 1| 3| 8| 8| 5| 3| 3| 5| 7| 8| 1| 3| 4| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 2 1 2 |
Alveolar Epithelium, Hyperplasia | 2 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Goblet Cell, Hyperplasia | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Mineralization | 3 3 2 2 2 2 3 3 3 2 1 3 3 2 1 3 3 2 3 3 2 2 2 3|
Nephropathy | 2 1 3 3 3 1 1 3 2 2 1 1 2 1 3 |
Renal Tubule, Atrophy | |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 3 2 3 2 |
Transitional Epithelium, Hyperplasia | 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|
DAY ON TEST | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|
| 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 3 2 3 3 3 3 3 3 2 4 1 3 |
Eosinophilic Focus | 3 3 3 3 4 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous | 2 2 2 |
Mixed Cell Focus | 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 2 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 3 4 4 3 3 3 1 |
Kupffer Cell, Pigmentation | 2 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Accessory Spleen | X |
Fat, Necrosis | 2 3 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 2 1 3 1 3 4 3 |
Acinus, Cytoplasmic Alteration | 3 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 3 3|
Mucosa, Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 |
Ulcer | 3|
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|
DAY ON TEST | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|
| 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 3 2 2 2 3 1 2 2 1 3 |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 2 2 1|
Degeneration, Fatty | 1 2 3 4 1 1 2|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 3 1 |
Hypertrophy, Focal | 2 3 1 2|
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 3 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 2 3 3 3 3|
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 |
Hyperplasia, Cystic | 2 2 3 2 |
__________________________________________________________________________|
Vagina | M M M M M M M M|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|
DAY ON TEST | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|
| 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Myelofibrosis | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 2 |
Mediastinal, Pigmentation | 3 4 |
Pancreatic, Pigmentation | 2 3 |
Renal, Pigmentation | 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 3 |
Pigmentation | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 2 3 1 1 |
Necrosis | 4 |
Pigmentation, Hemosiderin | 2 3 2 3 2 2 2 3 3 |
Lymphoid Follicle, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Dilatation | 1 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1 3 3 2|
Galactocele | |
Hyperplasia | 3 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 3 3 2 3 2 2 2 3|
Femur, Osteopetrosis | 3 2 3 2 2|
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 2 |
Hydrocephalus | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
_____________________________________________________________________________________________________________________
| 5| 7| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8| 7| 8| 7| 5| 6| 7| 8| 8| 7| 7| 8| 8| 6|
DAY ON TEST | 7| 7| 4| 6| 3| 9| 9| 9| 6| 9| 9| 0| 9| 5| 3| 3| 9| 3| 9| 9| 4| 8| 9| 0| 2|
| 6| 4| 9| 9| 8| 8| 8| 8| 2| 8| 8| 6| 2| 9| 5| 7| 7| 6| 0| 8| 9| 9| 7| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.125% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 2|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 2 1 1 1 1 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Goblet Cell, Hyperplasia | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydronephrosis | 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | |
Mineralization | 3 3 2 2 3 3 3 1 2 2 2 3 3 1 2 3 3 3 3 3 2 2 3 2 3|
Nephropathy | 1 1 1 2 2 3 1 2 1 1 2 1 1 2 2 1 2 1|
Renal Tubule, Atrophy | 2 2 |
Renal Tubule, Cytoplasmic Alteration | 2 2 3 |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 2 3 1 2 2 1 3 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 7| 6| 8| 8| 6| 6| 6| | |
DAY ON TEST | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8| | |
| 5| 0| 8| 5| 0| 1| 4| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.125% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 2 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 3.0|
Basophilic Focus | 2 2 2 3 3 1 | 31 2.5|
Eosinophilic Focus | 3 3 | 13 3.2|
Hepatodiaphragmatic Nodule | X X X | 10 |
Inflammation, Granulomatous | 1 1 | 9 1.7|
Mixed Cell Focus | 3 3 3 | 6 2.8|
Necrosis, Focal | | 3 1.7|
Bile Duct, Hyperplasia | 3 2 2 1 | 20 1.7|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 | 14 3.1|
Kupffer Cell, Pigmentation | 2 3 2 | 14 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 13 |
Accessory Spleen | | 1 |
Fat, Necrosis | 3 3 | 12 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 1 1 2 | 21 1.9|
Acinus, Cytoplasmic Alteration | | 1 3.0|
Acinus, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 2 | 3 2.3|
Ulcer | 3 | 4 3.0|
Mucosa, Hyperplasia | 1 2 2 1 | 9 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 7| 6| 8| 8| 6| 6| 6| | |
DAY ON TEST | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8| | |
| 5| 0| 8| 5| 0| 1| 4| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.125% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 2 1.5|
Ulcer | 2 | 4 2.3|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 1 1 2 1 | 32 1.9|
Thrombosis | | 3 3.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 2 2 2 | 14 1.9|
Degeneration, Fatty | 2 | 16 2.2|
Hyperplasia, Diffuse | | 1 3.0|
Hyperplasia, Focal | 2 1 2 | 6 2.0|
Hypertrophy, Focal | 2 3 | 6 2.2|
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 | 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 3 | 3 3.3|
Pars Distalis, Cyst | 3 3 | 24 3.0|
Pars Distalis, Hyperplasia, Focal | 2 | 15 2.6|
Pars Intermedia, Angiectasis | | 2 3.0|
Pars Intermedia, Cyst | 3 | 5 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 3 | 9 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Cyst | 3 | 7 3.0|
Hyperplasia | 2 3 | 6 2.2|
Inflammation, Chronic | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 7| 6| 8| 8| 6| 6| 6| | |
DAY ON TEST | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8| | |
| 5| 0| 8| 5| 0| 1| 4| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.125% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 3 3 3 | 11 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 5 2.2|
Hyperplasia, Cystic | | 5 2.2|
__________________________________________________________________________|____________|
Vagina | + M | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 4 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 24 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Pigmentation | 3 | 9 2.8|
Pancreatic, Pigmentation | 3 3 | 6 2.8|
Renal, Pigmentation | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | 2 | 2 2.0|
Hemorrhage | | 2 1.5|
Hyperplasia, Lymphoid | 2 | 9 2.1|
Pigmentation | 2 2 2 | 19 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | 3 | 2 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 | 5 2.8|
Hematopoietic Cell Proliferation | 3 | 12 1.9|
Necrosis | 3 | 2 3.5|
Pigmentation, Hemosiderin | 3 2 3 3 | 27 2.5|
Lymphoid Follicle, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Dilatation | 2 2 2 2 2 2 2 1 3 1 | 48 2.1|
Galactocele | | 4 4.0|
Hyperplasia | | 6 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 7| 6| 8| 8| 6| 6| 6| | |
DAY ON TEST | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8| | |
| 5| 0| 8| 5| 0| 1| 4| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.125% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Cranium, Osteopetrosis | | 9 2.6|
Femur, Osteopetrosis | 3 2 | 10 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy | 3 3 3 4 3 | 20 3.0|
Hydrocephalus | 2 | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 1 | 23 1.3|
Alveolar Epithelium, Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 1.0|
Goblet Cell, Hyperplasia | 1 | 2 1.5|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 4 | 1 4.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 22:28:16
__________________________________________________________________________________________________________________________________
| 7| 8| 8| 7| 6| 8| 8| 6| 6| 6| | |
DAY ON TEST | 0| 1| 9| 0| 4| 3| 9| 5| 1| 8| | |
| 5| 0| 8| 5| 0| 1| 4| 9| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.125% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Hydronephrosis | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | 1 | 1 1.0|
Mineralization | 2 2 2 2 2 2 2 | 56 2.4|
Nephropathy | 2 3 1 2 3 | 38 1.8|
Renal Tubule, Atrophy | 2 1 | 4 1.8|
Renal Tubule, Cytoplasmic Alteration | | 3 2.3|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | 2 3 3 1 2 | 16 2.2|
Transitional Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M :