TDMS Study 05217-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 03 TIME: 07:17:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948-33-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst T-BUTYLHYDROQUINONE DATE: 04/04/96
EXPERIMENT: 05217 TEST: 03 TIME: 07:17:48
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948-33-0
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 857 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 52 CENSORED DEATHS 10 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 381 489 499 500 528 534 544 556 563 618 |
| 618 622 626 642 659 667 668 673 674 674 |
| 674 674 687 687 694 704 705 708 710 719 |
| 729 730 736 738 750 752 752 757 758 759 |
| 761 774 774 785 786 786 786 795 807 808 |
| 824 831 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 48 CENSORED DEATHS 10 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 375 577 591 613 613 617 620 625 638 651 |
| 655 661 667 672 673 675 691 694 701 702 |
| 712 715 719 722 722 730 735 749 757 758 |
| 762 765 786 807 810 810 814 821 827 829 |
| 830 831 837 837 839 841 850 852 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 53 CENSORED DEATHS 10 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 289 373 394 467 535 535 547 554 562 564 |
| 583 619 634 647 655 656 662 666 667 668 |
| 677 682 684 684 697 697 697 702 708 708 |
| 722 722 725 729 730 730 730 744 744 745 |
| 761 765 766 768 773 786 786 808 814 830 |
| 831 852 852 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 857 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 68 UNCENSORED DEATHS 57 CENSORED DEATHS 10 TERMINAL 1 |
| |
| UNCENSORED DEATHS |
| 408 464 473 493 501 526 535 535 552 562 |
| 562 570 578 591 591 591 604 614 618 619 |
| 625 640 642 655 661 673 674 677 682 691 |
| 694 695 695 710 725 729 729 730 738 744 |
| 757 757 761 766 767 773 777 786 792 795 |
| 806 810 815 845 852 852 852 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 46 CENSORED DEATHS 10 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 423 487 487 508 520 537 551 589 603 621 |
| 626 626 626 627 632 642 647 647 647 655 |
| 668 675 682 691 702 702 708 719 730 730 |
| 730 739 745 745 750 766 767 773 773 786 |
| 786 806 807 808 810 839 |
| CENSORED DEATHS |
| 92 92 92 92 92 92 92 92 92 92 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 857 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 857 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 100.0 98.3 98.3 88.3 85.0 75.0 13.3 |
|CONTROL | |
| | |
|0.0% | 100.0 100.0 100.0 100.0 98.3 98.3 98.3 95.0 80.0 20.0 |
| | |
| | |
|0.125% | 100.0 100.0 100.0 98.3 95.0 93.3 90.0 81.7 71.7 11.7 |
| | |
| | |
|0.25% | 100.0 100.0 100.0 100.0 98.3 94.8 86.2 70.7 56.9 1.7 |
| | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 98.3 98.3 90.0 85.0 66.7 23.3 |
| | |
| | |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 857 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.0% 0.125% 0.25% 0.5% |
| CONTROL |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 13.3% 20.0% 11.7% 1.7% 23.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.842 ----- P=0.856 P=0.075 P=0.361N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 686.1 724.5 677.8 673.0 676.9 |
|NATURAL DEATHS (C) | (13.8) (13.8) (16.2) (14.6) (14.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 620.7 656.9 612.1 590.2 629.4 |
|(STANDARD ERROR) | (28.7) (29.9) (29.1) (28.2) (29.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 898 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = UNTREATD CONTROL |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 50 CENSORED DEATHS 10 TERMINAL 10 |
| |
| UNCENSORED DEATHS |
| 297 302 380 418 421 497 540 540 546 578 |
| 579 613 627 628 638 640 649 661 690 694 |
| 704 712 722 724 733 733 736 758 761 765 |
| 765 766 777 778 785 789 795 795 796 799 |
| 802 808 830 831 854 855 856 879 880 888 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 38 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 351 408 509 523 600 601 633 648 648 668 |
| 708 717 729 733 738 738 744 756 775 777 |
| 788 802 810 810 817 817 825 830 831 849 |
| 858 859 859 861 863 865 885 890 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.125% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 49 CENSORED DEATHS 10 TERMINAL 11 |
| |
| UNCENSORED DEATHS |
| 480 481 498 537 537 576 583 618 625 625 |
| 640 649 656 659 666 668 669 683 697 705 |
| 705 722 733 735 736 738 749 761 774 781 |
| 789 792 795 799 806 806 807 810 831 831 |
| 834 845 859 862 863 873 890 894 897 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 898 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.25% |
| --------------------- |
| |
| TOTAL 68 UNCENSORED DEATHS 42 CENSORED DEATHS 10 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 197 425 498 578 600 613 632 649 657 658 |
| 661 666 667 682 703 721 738 757 758 767 |
| 767 772 772 774 774 788 789 789 799 801 |
| 816 817 817 845 856 860 883 883 888 890 |
| 891 894 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5% |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 43 CENSORED DEATHS 10 TERMINAL 17 |
| |
| UNCENSORED DEATHS |
| 501 572 591 596 600 613 628 628 633 640 |
| 659 666 673 673 690 691 705 712 750 752 |
| 774 777 789 789 789 807 810 830 831 831 |
| 839 841 845 856 858 862 869 879 888 891 |
| 891 894 897 |
| CENSORED DEATHS |
| 93 93 93 93 93 93 93 93 93 93 |
| |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 898 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 898 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|UNTREATD | 100.0 100.0 100.0 96.7 91.7 91.7 86.7 81.7 70.0 16.7 |
|CONTROL | |
| | |
|0.0% | 100.0 100.0 100.0 98.3 96.7 96.7 93.3 90.0 85.0 36.7 |
| | |
| | |
|0.125% | 100.0 100.0 100.0 100.0 100.0 96.7 91.7 88.3 76.7 18.3 |
| | |
| | |
|0.25% | 100.0 100.0 98.3 98.3 96.6 96.6 94.8 91.4 81.0 27.6 |
| | |
| | |
|0.5% | 100.0 100.0 100.0 100.0 100.0 100.0 98.3 91.7 81.7 28.3 |
| | |
| | |
==================================================================================
T-BUTYLHYDROQUINONE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 898 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| UNTREATD 0.0% 0.125% 0.25% 0.5% |
| CONTROL |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 16.7% 36.7% 18.3% 27.6% 28.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.356N ----- P=0.564N P=0.063N P=0.030N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 692.3 740.1 725.9 733.1 751.4 |
|NATURAL DEATHS (C) | (20.9) (21.2) (16.2) (21.2) (16.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 636.1 697.3 662.5 677.8 692.9 |
|(STANDARD ERROR) | (31.7) (32.9) (31.1) (33.5) (32.1) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.0% = 2
0.125% = 3
0.25% = 4
0.5% = 5
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 1 4 5
| 3 1 34 5 44 11 2 2
| 3 34 4 5 2 2
| 3 415511 22
90 + 411
| 111 55 222
| 44 1 5 1 22
| 3 3 35 22
80 + 44 11 22
| 4 4 113122
| 55 11
| 44 5531122
P 70 + 444 22
E | 5533 22
R | 444 533 2
C | 11 22
E 60 + 4 4 115
N | 4 4 11522
T | 311 22
| 44 31 52 2
S 50 + 4 131
U | 44 11 22 2
R | 33 2 2
V | 4 44 11 5
I 40 + 44 22
V | 33115 22
A | 44 5 5
L | 3 11 5 5
30 + 4 4 22
| 1 1
| 43 3 5 22
| 4 113 522
20 + 4 4113 2
| 44131
| 44 1 3
| 1 1
10 + 44
| 4 44
|
| 4
0 +
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 112 obs hidden.
T-BUTYLHYDROQUINONE
KAPLAN-MEIER SURVIVAL CURVES
UNTREATD CONTROL = 1
0.0% = 2
0.125% = 3
0.25% = 4
0.5% = 5
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
106.67 +
|
| 1 4 11 2 2 3 5 5
| 4 1 1 214 3 322 3 5 55
93.33 + 11 14 2 3 3 25
| 1 1 33 2432 2
P | 1 1 335242
E | 1 1 33342 2
R 80.00 + 1 1 3345 2 2
C | 11 3354 4 22
E | 1113 3 44 22
N | 1 1135 4242
T 66.67 + 1113 542 22
| 113 4 522
S | 113 5 22
U | 11 14 4 522
R 53.33 + 11344 2 2
V | 333 5552
I | 11 3 4 55
V | 11334 422
A 40.00 + 11 442522
L | 13 3 4 422
| 11 333 44
| 1 1 333 55
26.67 + 1 133 44
| 1 313
| 133
| 1 1
13.33 +
|
---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
0 20 40 60 80 100 120 140
WEEK
NOTE: 106 obs hidden.