Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/5098

TDMS Study 05704-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             RESORCINOL


NTP Experiment-Test: 05704-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 17:58:54




       Facility:  International Research and Development Corp.

       Chemical CAS #:  108-46-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                          17           15           16                                                  
    Dead                                               5           10           21                                                  
    Accident                                                                     4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           25            9                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Inflammation, Chronic, Granulomatous                                       1 (2%)                                             
      Perforation                                                                1 (2%)                                             
   Intestine Large, Cecum                             (47)         (46)         (44)                                                
      Parasite Metazoan                                1 (2%)                    1 (2%)                                             
   Intestine Large, Colon                             (47)         (47)         (46)                                                
      Parasite Metazoan                                7 (15%)      5 (11%)      6 (13%)                                            
   Intestine Large, Rectum                            (47)         (49)         (47)                                                
      Parasite Metazoan                                9 (19%)      4 (8%)       5 (11%)                                            
   Intestine Small, Duodenum                          (47)         (47)         (44)                                                
      Ectopic Tissue                                                             1 (2%)                                             
      Erosion, Multifocal                              1 (2%)                                                                       
      Hyperplasia, Diffuse, Glandular                  2 (4%)                                                                       
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
   Intestine Small, Ileum                             (46)         (47)         (43)                                                
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (47)         (44)                                                
      Hyperplasia, Diffuse                             1 (2%)                                                                       
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Inflammation, Chronic Active, Diffuse                                      1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis, Focal                               3 (6%)       4 (8%)       1 (2%)                                             
      Basophilic Focus                                 7 (14%)      8 (16%)      3 (6%)                                             
      Basophilic Focus, Multiple                      14 (28%)     13 (26%)      6 (12%)                                            
      Clear Cell Focus                                 5 (10%)     10 (20%)                                                         
      Clear Cell Focus, Multiple                       8 (16%)     10 (20%)      3 (6%)                                             
      Congestion                                                    1 (2%)       2 (4%)                                             
      Cytoplasmic Alteration, Focal                    1 (2%)                    1 (2%)                                             
      Cytoplasmic Alteration, Multifocal                            1 (2%)                                                          
      Degeneration, Cystic, Focal                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration, Cystic, Multifocal                              1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)                    1 (2%)                                             
      Fatty Change, Focal                              1 (2%)       1 (2%)                                                          
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)                                                                       
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       4 (8%)       3 (6%)       3 (6%)                                             
      Hyperplasia, Focal                               1 (2%)       3 (6%)                                                          
      Inflammation, Chronic, Multifocal                4 (8%)       6 (12%)      5 (10%)                                            
      Inflammation, Multifocal, Subacute                                         1 (2%)                                             
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)       2 (4%)                                             
      Necrosis, Multifocal                                                       3 (6%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
      Bile Duct, Hyperplasia                          45 (90%)     46 (92%)     42 (84%)                                            
      Centrilobular, Fatty Change                     14 (28%)      1 (2%)       1 (2%)                                             
      Centrilobular, Necrosis                          3 (6%)       2 (4%)                                                          
      Periportal, Fatty Change                                      1 (2%)                                                          
   Mesentery                                          (3)          (5)          (1)                                                 
      Fat, Necrosis                                    1 (33%)      3 (60%)      1 (100%)                                           
   Pancreas                                           (49)         (50)         (50)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Atrophy, Focal                                  15 (31%)     11 (22%)      9 (18%)                                            
      Atrophy, Multifocal                             20 (41%)     16 (32%)      9 (18%)                                            
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Focal                                            2 (4%)                                                          
      Inflammation, Chronic, Diffuse                                             1 (2%)                                             
      Artery, Inflammation, Chronic                    2 (4%)                    2 (4%)                                             
      Duct, Ectasia, Focal                             1 (2%)                                                                       
      Interlobular, Edema, Diffuse                     1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
      Atrophy, Focal                                                1 (2%)                                                          
      Hyperplasia, Focal                                            1 (2%)       1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)                                                                       
      Infiltration Cellular, Focal, Mononuclear                                                                                     
          Cell                                                                   1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Erosion, Focal                                                2 (4%)                                                          
      Erosion, Multifocal                              1 (2%)                                                                       
      Hyperplasia, Diffuse, Squamous                   2 (4%)                                                                       
      Hyperplasia, Focal, Squamous                     2 (4%)       1 (2%)       2 (4%)                                             
      Inflammation, Acute                                           3 (6%)       1 (2%)                                             
      Inflammation, Chronic                            5 (10%)      2 (4%)       1 (2%)                                             
      Ulcer, Focal                                     2 (4%)       1 (2%)                                                          
      Ulcer, Multifocal                                2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (49)         (50)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ectopic Tissue                                                1 (2%)                                                          
      Erosion, Focal                                   4 (8%)                    2 (4%)                                             
      Erosion, Multifocal                              1 (2%)       2 (4%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hyperplasia, Focal, Glandular                    2 (4%)                                                                       
      Hyperplasia, Focal, Lymphoid                                  1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
      Mineralization, Diffuse                          1 (2%)                    1 (2%)                                             
      Ulcer, Focal                                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Aorta, Mineralization                                                      1 (100%)                                           
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Chronic, Focal                     6 (12%)      5 (10%)      6 (12%)                                            
      Inflammation, Chronic, Multifocal               14 (28%)     19 (38%)     10 (20%)                                            
      Mineralization, Multifocal                       1 (2%)                                                                       
      Atrium, Thrombosis                               3 (6%)       1 (2%)       1 (2%)                                             
      Epicardium, Inflammation, Chronic, Diffuse       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (49)                                                
      Angiectasis                                      1 (2%)       1 (2%)                                                          
      Congestion                                       2 (4%)       1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    3 (6%)       4 (8%)       1 (2%)                                             
      Cytoplasmic Alteration, Multifocal               1 (2%)                                                                       
      Degeneration, Fatty, Focal                      10 (20%)      6 (12%)      5 (10%)                                            
      Degeneration, Fatty, Multifocal                  3 (6%)       2 (4%)       2 (4%)                                             
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation, Multifocal     1 (2%)       4 (8%)       1 (2%)                                             
      Hyperplasia, Focal                              10 (20%)      7 (14%)      2 (4%)                                             
      Hyperplasia, Multifocal                          2 (4%)                    3 (6%)                                             
      Hypertrophy, Focal                               1 (2%)                    2 (4%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (49)                                                
      Atypia Nuclear                                                1 (2%)                                                          
      Hyperplasia, Focal                               7 (14%)      7 (14%)      6 (12%)                                            
      Hyperplasia, Multifocal                          2 (4%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (50)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
      Hyperplasia, Focal                               3 (6%)       2 (4%)       2 (4%)                                             
   Parathyroid Gland                                  (41)         (42)         (44)                                                
      Hyperplasia, Diffuse                             2 (5%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)                                                
      Angiectasis, Focal                                            1 (2%)                                                          
      Pars Distalis, Angiectasis, Focal                1 (2%)                                                                       
      Pars Distalis, Congestion                        1 (2%)                                                                       
      Pars Distalis, Cyst                              5 (10%)      3 (6%)                                                          
      Pars Distalis, Hyperplasia, Focal                8 (16%)      5 (10%)      3 (6%)                                             
      Pars Distalis, Hyperplasia, Multifocal           2 (4%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Infiltration Cellular, Focal,                                                                                  
           Histiocyte                                               1 (2%)                                                          
      Pars Intermedia, Cyst                                         2 (4%)                                                          
   Thyroid Gland                                      (49)         (49)         (49)                                                
      Congestion                                                                 1 (2%)                                             
      C-Cell, Hyperplasia, Focal                       9 (18%)      3 (6%)       2 (4%)                                             
      C-Cell, Hyperplasia, Multifocal                  4 (8%)       2 (4%)       1 (2%)                                             
      Follicular Cell, Depletion Secretory             1 (2%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia, Cystic, Focal                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Granuloma Sperm, Focal                                        1 (2%)                                                          
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
   Penis                                              (1)                                                                           
      Concretion                                       1 (100%)                                                                     
   Preputial Gland                                    (50)         (49)         (50)                                                
      Abscess                                          1 (2%)                    1 (2%)                                             
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             3 (6%)                                                                       
      Dilatation                                                    1 (2%)       1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Multifocal                          2 (4%)                                                                       
      Inflammation, Chronic, Focal                     2 (4%)       6 (12%)      8 (16%)                                            
      Inflammation, Chronic, Multifocal               32 (64%)     29 (59%)     18 (36%)                                            
   Prostate                                           (50)         (50)         (49)                                                
      Hyperplasia, Focal                               4 (8%)       9 (18%)      1 (2%)                                             
      Hyperplasia, Multifocal                          1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Acute, Focal                       1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Diffuse                   1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic, Focal                     8 (16%)      7 (14%)      8 (16%)                                            
   Seminal Vesicle                                    (1)          (1)                                                              
      Depletion Secretory                                           1 (100%)                                                        
   Testes                                             (50)         (50)         (50)                                                
      Mineralization, Multifocal                       2 (4%)                                                                       
      Interstitial Cell, Hyperplasia, Multifocal      30 (60%)     17 (34%)     22 (44%)                                            
      Seminiferous Tubule, Degeneration               26 (52%)     12 (24%)      9 (18%)                                            
      Serosa, Necrosis, Focal                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)                                                
      Crystals, Multifocal                             1 (2%)                                                                       
      Mineralization, Multifocal                       1 (2%)                                                                       
      Myelofibrosis, Focal                                          1 (2%)       1 (2%)                                             
      Erythroid Cell, Proliferation                    8 (16%)      7 (14%)      4 (8%)                                             
      Myeloid Cell, Proliferation                                   2 (4%)       2 (4%)                                             
   Lymph Node                                         (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                    1 (2%)                                             
      Ectasia                                                                    1 (2%)                                             
      Axillary, Hyperplasia, Lymphoid                                            1 (2%)                                             
      Axillary, Infiltration Cellular, Plasma Cell                               1 (2%)                                             
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)       2 (4%)                                                          
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
      Mediastinal, Inflammation, Suppurative           1 (2%)                                                                       
      Mediastinal, Pigmentation                        1 (2%)                                                                       
      Pancreatic, Angiectasis                          1 (2%)                                                                       
      Popliteal, Hyperplasia, Lymphoid                              1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (49)                                                
      Congestion                                       1 (2%)                                                                       
      Cyst, Multiple                                                1 (2%)                                                          
      Erythrophagocytosis                                           1 (2%)                                                          
      Hemorrhage                                       2 (4%)                                                                       
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Sinus, Ectasia                                                2 (4%)                                                          
   Spleen                                             (50)         (50)         (49)                                                
      Congestion                                                    1 (2%)                                                          
      Developmental Malformation                       1 (2%)                                                                       
      Fibrosis, Diffuse                                             1 (2%)                                                          
      Fibrosis, Focal                                  4 (8%)       3 (6%)       1 (2%)                                             
      Fibrosis, Multifocal                             1 (2%)       1 (2%)                                                          
      Hematocyst                                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 8 (16%)      4 (8%)       6 (12%)                                            
      Metaplasia, Focal, Osseous                                    1 (2%)                                                          
      Pigmentation, Diffuse, Hemosiderin               1 (2%)       2 (4%)                                                          
   Thymus                                             (46)         (46)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Cyst                                             2 (4%)       1 (2%)                                                          
      Hemorrhage                                       4 (9%)       4 (9%)      15 (31%)                                            
      Hemorrhage, Multifocal                                                     2 (4%)                                             
      Epithelial Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (49)                                                
      Galactocele                                      5 (10%)      3 (6%)                                                          
      Mineralization, Multifocal                       1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Subcutaneous Tissue, Abscess                                               1 (2%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)                                                
      Fibrous Osteodystrophy                           2 (4%)                    2 (4%)                                             
      Cranium, Hyperostosis                            1 (2%)                                                                       
      Trabecula, Hyperostosis, Multifocal              1 (2%)                                                                       
   Skeletal Muscle                                    (3)                       (1)                                                 
      Abdominal, Necrosis, Focal                       1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Mineralization, Multifocal                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       5 (10%)      6 (12%)     11 (22%)                                            
      Edema, Focal                                     1 (2%)                    1 (2%)                                             
      Emphysema                                                     1 (2%)       1 (2%)                                             
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage, Focal                                             2 (4%)       2 (4%)                                             
      Infiltration Cellular, Diffuse, Histiocyte                                 1 (2%)                                             
      Infiltration Cellular, Mononuclear Cell,                                                                                      
           Multifocal                                                            1 (2%)                                             
      Infiltration Cellular, Multifocal, Histiocyte                              1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Multifocal, Suppurative                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mineralization, Multifocal                       1 (2%)                                                                       
      Necrosis, Acute                                                            1 (2%)                                             
      Pigmentation, Multifocal                                                   1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       1 (2%)                                                          
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                               1 (2%)                                                          
      Alveolus, Inflammation, Chronic, Focal                        2 (4%)       1 (2%)                                             
      Alveolus, Inflammation, Chronic, Multifocal                   1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Diffuse                  1 (2%)                                                          
      Interstitium, Inflammation, Chronic, Focal       2 (4%)                    1 (2%)                                             
      Perivascular, Edema, Multifocal                                            1 (2%)                                             
   Nose                                               (49)         (49)         (50)                                                
      Congestion                                                                 2 (4%)                                             
      Foreign Body                                     4 (8%)       2 (4%)       4 (8%)                                             
      Fungus                                           4 (8%)                    2 (4%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            4 (8%)       1 (2%)       5 (10%)                                            
      Inflammation, Suppurative                        2 (4%)       2 (4%)       7 (14%)                                            
      Metaplasia, Squamous                                          1 (2%)                                                          
      Mucosa, Thrombosis, Multifocal                   2 (4%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)       3 (6%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)       1 (2%)       2 (4%)                                             
      Olfactory Epithelium, Metaplasia                 1 (2%)                                                                       
   Trachea                                            (50)         (50)         (49)                                                
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Epithelium, Metaplasia                           1 (2%)                                                                       
      Glands, Ectasia, Focal                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (4)          (6)                                                 
      Ectopic Tissue, Multifocal                       1 (17%)                                                                      
      Anterior Chamber, Hemorrhage                                  1 (25%)                                                         
      Anterior Chamber, Iris, Posterior Chamber,                                                                                    
           Inflammation                                             1 (25%)                                                         
      Cornea, Inflammation                                          1 (25%)                                                         
      Lens, Cataract                                   1 (17%)      3 (75%)                                                         
      Retina, Degeneration                             1 (17%)      2 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05704-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             RESORCINOL                                        Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 17:58:54  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      112MG/KG     225MG/KG                                               
                                                   MALE           MALE         MALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                    2 (4%)                                             
      Cyst                                                          4 (8%)       3 (6%)                                             
      Hydronephrosis, Chronic                                                    1 (2%)                                             
      Hyperplasia, Multifocal, Tubular                 2 (4%)       1 (2%)       5 (10%)                                            
      Necrosis, Acute, Focal                           1 (2%)                                                                       
      Nephropathy, Chronic                            48 (96%)     49 (98%)     43 (86%)                                            
      Pigmentation                                                               1 (2%)                                             
      Pigmentation, Diffuse                            1 (2%)       2 (4%)       1 (2%)                                             
      Cortex, Mineralization, Multifocal               2 (4%)                    1 (2%)                                             
      Cortex, Necrosis, Diffuse                                     1 (2%)                                                          
      Papilla, Transitional Epithelium, Hyperplasia    2 (4%)                    2 (4%)                                             
      Pelvis, Inflammation, Chronic                    1 (2%)                                                                       
      Pelvis, Mineralization                           1 (2%)                                                                       
      Pelvis, Parasite Metazoan                                     1 (2%)                                                          
      Proximal Convoluted Renal Tubule,                                                                                             
          Degeneration, Hyaline                        2 (4%)                                                                       
   Urinary Bladder                                    (50)         (50)         (49)                                                
      Concretion                                       1 (2%)       1 (2%)       4 (8%)                                             
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic, Diffuse                   2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 58881-58881/58881


--multipart-boundary--