TDMS Study 05704-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
RESORCINOL
NTP Experiment-Test: 05704-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 17:58:54
Facility: International Research and Development Corp.
Chemical CAS #: 108-46-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 17 15 16
Dead 5 10 21
Accident 4
Survivors
Terminal Sacrifice 28 25 9
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50)
Inflammation, Chronic, Granulomatous 1 (2%)
Perforation 1 (2%)
Intestine Large, Cecum (47) (46) (44)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Colon (47) (47) (46)
Parasite Metazoan 7 (15%) 5 (11%) 6 (13%)
Intestine Large, Rectum (47) (49) (47)
Parasite Metazoan 9 (19%) 4 (8%) 5 (11%)
Intestine Small, Duodenum (47) (47) (44)
Ectopic Tissue 1 (2%)
Erosion, Multifocal 1 (2%)
Hyperplasia, Diffuse, Glandular 2 (4%)
Inflammation, Chronic Active, Diffuse 1 (2%)
Intestine Small, Ileum (46) (47) (43)
Inflammation, Chronic Active, Diffuse 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Small, Jejunum (46) (47) (44)
Hyperplasia, Diffuse 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Chronic Active, Diffuse 1 (2%)
Liver (50) (50) (50)
Angiectasis, Focal 3 (6%) 4 (8%) 1 (2%)
Basophilic Focus 7 (14%) 8 (16%) 3 (6%)
Basophilic Focus, Multiple 14 (28%) 13 (26%) 6 (12%)
Clear Cell Focus 5 (10%) 10 (20%)
Clear Cell Focus, Multiple 8 (16%) 10 (20%) 3 (6%)
Congestion 1 (2%) 2 (4%)
Cytoplasmic Alteration, Focal 1 (2%) 1 (2%)
Cytoplasmic Alteration, Multifocal 1 (2%)
Degeneration, Cystic, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Degeneration, Cystic, Multifocal 1 (2%)
Eosinophilic Focus 1 (2%) 1 (2%)
Fatty Change, Focal 1 (2%) 1 (2%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Hemorrhage, Focal 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 3 (6%) 3 (6%)
Hyperplasia, Focal 1 (2%) 3 (6%)
Inflammation, Chronic, Multifocal 4 (8%) 6 (12%) 5 (10%)
Inflammation, Multifocal, Subacute 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 1 (2%) 2 (4%)
Necrosis, Multifocal 3 (6%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Bile Duct, Hyperplasia 45 (90%) 46 (92%) 42 (84%)
Centrilobular, Fatty Change 14 (28%) 1 (2%) 1 (2%)
Centrilobular, Necrosis 3 (6%) 2 (4%)
Periportal, Fatty Change 1 (2%)
Mesentery (3) (5) (1)
Fat, Necrosis 1 (33%) 3 (60%) 1 (100%)
Pancreas (49) (50) (50)
Atrophy, Diffuse 1 (2%)
Atrophy, Focal 15 (31%) 11 (22%) 9 (18%)
Atrophy, Multifocal 20 (41%) 16 (32%) 9 (18%)
Cyst 1 (2%)
Hyperplasia, Focal 2 (4%)
Inflammation, Chronic, Diffuse 1 (2%)
Artery, Inflammation, Chronic 2 (4%) 2 (4%)
Duct, Ectasia, Focal 1 (2%)
Interlobular, Edema, Diffuse 1 (2%)
Salivary Glands (50) (50) (50)
Atrophy, Focal 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hyperplasia, Multifocal 1 (2%)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Stomach, Forestomach (49) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Erosion, Focal 2 (4%)
Erosion, Multifocal 1 (2%)
Hyperplasia, Diffuse, Squamous 2 (4%)
Hyperplasia, Focal, Squamous 2 (4%) 1 (2%) 2 (4%)
Inflammation, Acute 3 (6%) 1 (2%)
Inflammation, Chronic 5 (10%) 2 (4%) 1 (2%)
Ulcer, Focal 2 (4%) 1 (2%)
Ulcer, Multifocal 2 (4%) 1 (2%)
Stomach, Glandular (49) (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Ectopic Tissue 1 (2%)
Erosion, Focal 4 (8%) 2 (4%)
Erosion, Multifocal 1 (2%) 2 (4%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Focal, Glandular 2 (4%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 2 (4%) 1 (2%)
Mineralization, Diffuse 1 (2%) 1 (2%)
Ulcer, Focal 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50)
Inflammation, Chronic, Focal 6 (12%) 5 (10%) 6 (12%)
Inflammation, Chronic, Multifocal 14 (28%) 19 (38%) 10 (20%)
Mineralization, Multifocal 1 (2%)
Atrium, Thrombosis 3 (6%) 1 (2%) 1 (2%)
Epicardium, Inflammation, Chronic, Diffuse 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (49)
Angiectasis 1 (2%) 1 (2%)
Congestion 2 (4%) 1 (2%)
Cytoplasmic Alteration, Focal 3 (6%) 4 (8%) 1 (2%)
Cytoplasmic Alteration, Multifocal 1 (2%)
Degeneration, Fatty, Focal 10 (20%) 6 (12%) 5 (10%)
Degeneration, Fatty, Multifocal 3 (6%) 2 (4%) 2 (4%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%) 4 (8%) 1 (2%)
Hyperplasia, Focal 10 (20%) 7 (14%) 2 (4%)
Hyperplasia, Multifocal 2 (4%) 3 (6%)
Hypertrophy, Focal 1 (2%) 2 (4%)
Adrenal Gland, Medulla (49) (50) (49)
Atypia Nuclear 1 (2%)
Hyperplasia, Focal 7 (14%) 7 (14%) 6 (12%)
Hyperplasia, Multifocal 2 (4%)
Islets, Pancreatic (49) (49) (50)
Angiectasis, Focal 1 (2%)
Hyperplasia, Focal 3 (6%) 2 (4%) 2 (4%)
Parathyroid Gland (41) (42) (44)
Hyperplasia, Diffuse 2 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia, Focal 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (49)
Angiectasis, Focal 1 (2%)
Pars Distalis, Angiectasis, Focal 1 (2%)
Pars Distalis, Congestion 1 (2%)
Pars Distalis, Cyst 5 (10%) 3 (6%)
Pars Distalis, Hyperplasia, Focal 8 (16%) 5 (10%) 3 (6%)
Pars Distalis, Hyperplasia, Multifocal 2 (4%) 1 (2%) 2 (4%)
Pars Distalis, Infiltration Cellular, Focal,
Histiocyte 1 (2%)
Pars Intermedia, Cyst 2 (4%)
Thyroid Gland (49) (49) (49)
Congestion 1 (2%)
C-Cell, Hyperplasia, Focal 9 (18%) 3 (6%) 2 (4%)
C-Cell, Hyperplasia, Multifocal 4 (8%) 2 (4%) 1 (2%)
Follicular Cell, Depletion Secretory 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia, Cystic, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50)
Atrophy, Diffuse 1 (2%)
Granuloma Sperm, Focal 1 (2%)
Inflammation, Acute 2 (4%) 1 (2%)
Necrosis 1 (2%)
Penis (1)
Concretion 1 (100%)
Preputial Gland (50) (49) (50)
Abscess 1 (2%) 1 (2%)
Atrophy 1 (2%)
Cyst 3 (6%)
Dilatation 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Multifocal 2 (4%)
Inflammation, Chronic, Focal 2 (4%) 6 (12%) 8 (16%)
Inflammation, Chronic, Multifocal 32 (64%) 29 (59%) 18 (36%)
Prostate (50) (50) (49)
Hyperplasia, Focal 4 (8%) 9 (18%) 1 (2%)
Hyperplasia, Multifocal 1 (2%) 1 (2%) 1 (2%)
Inflammation, Acute, Focal 1 (2%) 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic, Focal 8 (16%) 7 (14%) 8 (16%)
Seminal Vesicle (1) (1)
Depletion Secretory 1 (100%)
Testes (50) (50) (50)
Mineralization, Multifocal 2 (4%)
Interstitial Cell, Hyperplasia, Multifocal 30 (60%) 17 (34%) 22 (44%)
Seminiferous Tubule, Degeneration 26 (52%) 12 (24%) 9 (18%)
Serosa, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49)
Crystals, Multifocal 1 (2%)
Mineralization, Multifocal 1 (2%)
Myelofibrosis, Focal 1 (2%) 1 (2%)
Erythroid Cell, Proliferation 8 (16%) 7 (14%) 4 (8%)
Myeloid Cell, Proliferation 2 (4%) 2 (4%)
Lymph Node (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Ectasia 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Axillary, Infiltration Cellular, Plasma Cell 1 (2%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%) 2 (4%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Mediastinal, Inflammation, Suppurative 1 (2%)
Mediastinal, Pigmentation 1 (2%)
Pancreatic, Angiectasis 1 (2%)
Popliteal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (50) (50) (49)
Congestion 1 (2%)
Cyst, Multiple 1 (2%)
Erythrophagocytosis 1 (2%)
Hemorrhage 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Sinus, Ectasia 2 (4%)
Spleen (50) (50) (49)
Congestion 1 (2%)
Developmental Malformation 1 (2%)
Fibrosis, Diffuse 1 (2%)
Fibrosis, Focal 4 (8%) 3 (6%) 1 (2%)
Fibrosis, Multifocal 1 (2%) 1 (2%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 8 (16%) 4 (8%) 6 (12%)
Metaplasia, Focal, Osseous 1 (2%)
Pigmentation, Diffuse, Hemosiderin 1 (2%) 2 (4%)
Thymus (46) (46) (48)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cyst 2 (4%) 1 (2%)
Hemorrhage 4 (9%) 4 (9%) 15 (31%)
Hemorrhage, Multifocal 2 (4%)
Epithelial Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (50) (49)
Galactocele 5 (10%) 3 (6%)
Mineralization, Multifocal 1 (2%)
Skin (50) (50) (50)
Subcutaneous Tissue, Abscess 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49)
Fibrous Osteodystrophy 2 (4%) 2 (4%)
Cranium, Hyperostosis 1 (2%)
Trabecula, Hyperostosis, Multifocal 1 (2%)
Skeletal Muscle (3) (1)
Abdominal, Necrosis, Focal 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
Inflammation, Chronic, Focal 1 (2%)
Mineralization, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Congestion 5 (10%) 6 (12%) 11 (22%)
Edema, Focal 1 (2%) 1 (2%)
Emphysema 1 (2%) 1 (2%)
Foreign Body 1 (2%)
Hemorrhage, Focal 2 (4%) 2 (4%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Multifocal, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mineralization, Multifocal 1 (2%)
Necrosis, Acute 1 (2%)
Pigmentation, Multifocal 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 2 (4%) 1 (2%)
Alveolus, Infiltration Cellular, Multifocal,
Histiocyte 1 (2%)
Alveolus, Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Alveolus, Inflammation, Chronic, Multifocal 1 (2%)
Interstitium, Inflammation, Chronic, Diffuse 1 (2%)
Interstitium, Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Perivascular, Edema, Multifocal 1 (2%)
Nose (49) (49) (50)
Congestion 2 (4%)
Foreign Body 4 (8%) 2 (4%) 4 (8%)
Fungus 4 (8%) 2 (4%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 4 (8%) 1 (2%) 5 (10%)
Inflammation, Suppurative 2 (4%) 2 (4%) 7 (14%)
Metaplasia, Squamous 1 (2%)
Mucosa, Thrombosis, Multifocal 2 (4%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%)
Olfactory Epithelium, Metaplasia 1 (2%)
Trachea (50) (50) (49)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Epithelium, Metaplasia 1 (2%)
Glands, Ectasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (4) (6)
Ectopic Tissue, Multifocal 1 (17%)
Anterior Chamber, Hemorrhage 1 (25%)
Anterior Chamber, Iris, Posterior Chamber,
Inflammation 1 (25%)
Cornea, Inflammation 1 (25%)
Lens, Cataract 1 (17%) 3 (75%)
Retina, Degeneration 1 (17%) 2 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05704-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:58:54
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 112MG/KG 225MG/KG
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Congestion 1 (2%) 2 (4%)
Cyst 4 (8%) 3 (6%)
Hydronephrosis, Chronic 1 (2%)
Hyperplasia, Multifocal, Tubular 2 (4%) 1 (2%) 5 (10%)
Necrosis, Acute, Focal 1 (2%)
Nephropathy, Chronic 48 (96%) 49 (98%) 43 (86%)
Pigmentation 1 (2%)
Pigmentation, Diffuse 1 (2%) 2 (4%) 1 (2%)
Cortex, Mineralization, Multifocal 2 (4%) 1 (2%)
Cortex, Necrosis, Diffuse 1 (2%)
Papilla, Transitional Epithelium, Hyperplasia 2 (4%) 2 (4%)
Pelvis, Inflammation, Chronic 1 (2%)
Pelvis, Mineralization 1 (2%)
Pelvis, Parasite Metazoan 1 (2%)
Proximal Convoluted Renal Tubule,
Degeneration, Hyaline 2 (4%)
Urinary Bladder (50) (50) (49)
Concretion 1 (2%) 1 (2%) 4 (8%)
Cyst 1 (2%)
Inflammation, Chronic, Diffuse 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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