TDMS Study 05704-02 Pathology Tables
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
Facility: International Research and Development Corp.
Chemical CAS #: 108-46-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Histiocytic Sarcoma, Metastatic | X |
Leukemia Mononuclear | X X X X X X X|
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Schwannoma Malignant | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X X X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pars Distalis, Adenoma | X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X|
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X X|
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | X X |
Inguinal, Mesothelioma Malignant | |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | X |
Mediastinal, Mesothelioma Malignant | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Leukemia Mononuclear | X X X X X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + I + M + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | X|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Abdominal, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Glioma NOS | X |
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | |
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Lymphoma Malignant Undifferentiated | |
Cell Type | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Undifferentiated | |
Cell Type | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Histiocytic Sarcoma, Metastatic | |
Leukemia Mononuclear | X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + +|
Mesothelioma Malignant | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Schwannoma Malignant | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X|
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pars Distalis, Adenoma | X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X X |
Interstitial Cell, Adenoma | X X X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Inguinal, Mesothelioma Malignant | X |
Mandibular, Leukemia Mononuclear | |
Mediastinal, Lymphoma Malignant | |
Undifferentiated Cell Type | |
Mediastinal, Mesothelioma Malignant | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Leukemia Mononuclear | X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Epidermis, Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Leukemia | |
Mononuclear | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Glioma NOS | |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Histiocytic Sarcoma, Metastatic, | |
Liver | |
Leukemia Mononuclear | X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Gland | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma, Metastatic, | |
Liver | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant Undifferentiated | |
Cell Type | |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 47 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 47 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 46 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 46 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Hepatocellular Adenoma | | 1 |
Histiocytic Sarcoma, Metastatic | | 1 |
Leukemia Mononuclear | X X X | 15 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 49 |
Mesothelioma Malignant | X | 3 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | X | 9 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + I + + + + | 49 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 9 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X X | 8 |
Pheochromocytoma Malignant | X | 5 |
Pheochromocytoma Benign | X X | 9 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M M + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pars Distalis, Adenoma | X X | 14 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
C-Cell, Adenoma | X | 3 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Mesothelioma Malignant | X | 4 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 50 |
Adenoma | X X X X | 8 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Mesothelioma Malignant | X | 4 |
Interstitial Cell, Adenoma | X | 8 |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X | 37 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Iliac, Leukemia Mononuclear | X | 1 |
Inguinal, Leukemia Mononuclear | X | 3 |
Inguinal, Mesothelioma Malignant | | 1 |
Mandibular, Leukemia Mononuclear | | 1 |
Mediastinal, Lymphoma Malignant | | |
Undifferentiated Cell Type | | 1 |
Mediastinal, Mesothelioma Malignant | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 9 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | X X X X | 17 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 46 |
Leukemia Mononuclear | X | 6 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 49 |
Adenocarcinoma | | 1 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Epidermis, Keratoacanthoma | X | 1 |
Subcutaneous Tissue, Fibroma | X | 3 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Abdominal, Mesothelioma Malignant | X | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Glioma NOS | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | X X | 10 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Gland | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Histiocytic Sarcoma, Metastatic, | | |
Liver | | 1 |
Leukemia Mononuclear | X | 8 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 17 |
Lymphoma Malignant Undifferentiated | | |
Cell Type | | 1 |
Mesothelioma Malignant | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + + + + +|
Leukemia Mononuclear | |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + A + + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + A + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Lipoma | X |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
Pheochromocytoma Benign, Multiple | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + M + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X|
Schwannoma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X X X |
Adenoma, Multiple | |
Carcinoma | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X|
Schwannoma Malignant, Metastatic, | |
Epididymis | |
Interstitial Cell, Adenoma | X X X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X X X |
Mandibular, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Popliteal, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Thymoma Benign | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Keratoacanthoma | X |
Epidermis, Squamous Cell Papilloma | X |
Epidermis, Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | |
Pelvis, Transitional Epithelium, | |
Papilloma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Mesothelioma Malignant | X|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + +|
Lipoma | |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Schwannoma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | X |
Adenoma, Multiple | X |
Carcinoma | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
Interstitial Cell, Adenoma | X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | X X |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Popliteal, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Epidermis, Keratoacanthoma | X |
Epidermis, Squamous Cell Papilloma | |
Epidermis, Trichoepithelioma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Schwannoma Malignant, Metastatic, | |
Epididymis | X |
Pelvis, Transitional Epithelium, | |
Papilloma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A + + | 46 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + | 47 |
Leukemia Mononuclear | X | 2 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + | 47 |
Leiomyosarcoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + | 47 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 25 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
Lipoma | | 1 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 10 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | | 8 |
Pheochromocytoma Benign, Multiple | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + I + + + + + + | 49 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
Pars Distalis, Adenoma | X X | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + | 49 |
C-Cell, Adenoma | X | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
Mesothelioma Malignant | | 2 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + | 49 |
Adenocarcinoma | | 1 |
Adenoma | | 4 |
Adenoma, Multiple | X | 2 |
Carcinoma | | 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 2 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
Interstitial Cell, Adenoma | X X | 7 |
Interstitial Cell, Adenoma, Multiple | X X X X X | 37 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 1 |
Inguinal, Leukemia Mononuclear | | 5 |
Mandibular, Leukemia Mononuclear | | 3 |
Mediastinal, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | | 2 |
Popliteal, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 14 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 25 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + | 46 |
Leukemia Mononuclear | X | 8 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Epidermis, Keratoacanthoma | | 2 |
Epidermis, Squamous Cell Papilloma | X | 2 |
Epidermis, Trichoepithelioma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 10 |
Schwannoma Malignant, Metastatic, | | |
Epididymis | | 1 |
Pelvis, Transitional Epithelium, | | |
Papilloma | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 25 |
Mesothelioma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + A + + + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + A + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + I A + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + A + + + A + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + A + A + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + A + + + A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M + M + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X|
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Chordoma, Metastatic, Uncertain | |
Primary Site | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Schwannoma Malignant | |
__________________________________________________________________________|
Eye | + A |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Cortex, Adenoma | |
Pelvis, Transitional Epithelium, | |
Papilloma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Leukemia Mononuclear | |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Keratoacanthoma | |
Subcutaneous Tissue, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Abdominal, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Chordoma, Metastatic, Uncertain | |
Primary Site | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Schwannoma Malignant | X |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Cortex, Adenoma | |
Pelvis, Transitional Epithelium, | |
Papilloma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + | 46 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + | 44 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 49 |
Leukemia Mononuclear | | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pheochromocytoma Benign | X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
Pars Distalis, Adenoma | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
C-Cell, Adenoma | | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
Adenoma | | 2 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Interstitial Cell, Adenoma | | 3 |
Interstitial Cell, Adenoma, Multiple | X X X X X | 28 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Inguinal, Leukemia Mononuclear | X | 1 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 5 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 49 |
Leukemia Mononuclear | X | 8 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + M | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | I + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Epidermis, Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibroma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Abdominal, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Chordoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Eye | + | 6 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Malignant | | 1 |
Cortex, Adenoma | X | 1 |
Pelvis, Transitional Epithelium, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05704-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC RESORCINOL Date: 04/09/97
Route: GAVAGE Time: 14:05:21
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Papilloma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
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