TDMS Study 05704-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC RESORCINOL DATE: 09/18/94
EXPERIMENT: 05704 TEST: 02 TIME: 18:06:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: 05700-04 ROUTE: GAVAGE NTP C#: 05970A
PATHOLOGIST: F. VOELKER S. EUSTIS CAS: 108-46-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC RESORCINOL DATE: 09/18/94
EXPERIMENT: 05704 TEST: 02 TIME: 18:06:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 05700-04 ROUTE: GAVAGE NTP C#: 05970A
PATHOLOGIST: F. VOELKER S. EUSTIS CAS: 108-46-3
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: IRDC RESORCINOL DATE: 09/18/94
EXPERIMENT: 05704 TEST: 02 TIME: 18:06:20
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: 05700-04 ROUTE: GAVAGE NTP C#: 05970A
PATHOLOGIST: F. VOELKER S. EUSTIS CAS: 108-46-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF RESORCINOL
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Malignant
Pheochromocytoma: Benign, Complex, Malignant, NOS
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
====================================================================================================
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/49 (18%) 9/50 (18%) 5/49 (10%) |
|ADJUSTED (b) | 27.3% 32.9% 39.2% |
|TERMINAL (d) | 5/27 (19%) 7/25 (28%) 2/9 (22%) |
|FIRST INCIDENCE (DAYS) | 558 666 576 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.272 P=0.525 P=0.323 |
|INCIDENTAL TUMOR | P=0.415 P=0.579 P=0.545 |
|LOGISTIC REGRESSION | P=0.425 P=0.592 P=0.525 |
|COCHRAN-ARMITAGE | P=0.164N |
|FISHER EXACT | P=0.584N P=0.194N |
|==============================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/49 (10%) 2/50 (4%) 0/49 (0%) |
|ADJUSTED (b) | 16.2% 6.8% 0.0% |
|TERMINAL (d) | 3/27 (11%) 1/25 (4%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 644 650 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.089N P=0.255N P=0.200N |
|INCIDENTAL TUMOR | P=0.060N P=0.224N P=0.135N |
|LOGISTIC REGRESSION | P=0.053N P=0.216N P=0.136N |
|COCHRAN-ARMITAGE | P=0.016N* |
|FISHER EXACT | P=0.210N P=0.028N* |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 14/49 (29%) 11/50 (22%) 5/49 (10%) |
|ADJUSTED (b) | 40.8% 38.5% 39.2% |
|TERMINAL (d) | 8/27 (30%) 8/25 (32%) 2/9 (22%) |
|FIRST INCIDENCE (DAYS) | 558 650 576 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.493N P=0.415N P=0.591N |
|INCIDENTAL TUMOR | P=0.301N P=0.343N P=0.325N |
|LOGISTIC REGRESSION | P=0.284N P=0.327N P=0.347N |
|COCHRAN-ARMITAGE | P=0.016N* |
|FISHER EXACT | P=0.301N P=0.020N* |
|==============================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 6/49 (12%) 2/50 (4%) |
|ADJUSTED (b) | 26.6% 19.3% 15.2% |
|TERMINAL (d) | 7/28 (25%) 3/25 (12%) 1/9 (11%) |
|FIRST INCIDENCE (DAYS) | 499 492 560 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.349N P=0.459N P=0.456N |
|INCIDENTAL TUMOR | P=0.153N P=0.387N P=0.282N |
|LOGISTIC REGRESSION | P=0.166N P=0.409N P=0.263N |
|COCHRAN-ARMITAGE | P=0.038N* |
|FISHER EXACT | P=0.403N P=0.046N* |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 7/49 (14%) 3/50 (6%) |
|ADJUSTED (b) | 28.9% 21.6% 25.8% |
|TERMINAL (d) | 7/28 (25%) 3/25 (12%) 2/9 (22%) |
|FIRST INCIDENCE (DAYS) | 499 492 560 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.472N P=0.471N P=0.593N |
|INCIDENTAL TUMOR | P=0.218N P=0.388N P=0.406N |
|LOGISTIC REGRESSION | P=0.238N P=0.415N P=0.379N |
|COCHRAN-ARMITAGE | P=0.050N* |
|FISHER EXACT | P=0.410N P=0.061N |
|==============================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/49 (4%) 2/49 (4%) 0/50 (0%) |
|ADJUSTED (b) | 7.1% 6.3% 0.0% |
|TERMINAL (d) | 2/28 (7%) 1/24 (4%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 562 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.402N P=0.652 P=0.509N |
|INCIDENTAL TUMOR | P=0.337N P=0.685 P=0.509N |
|LOGISTIC REGRESSION | P=0.300N P=0.689 P=0.509N |
|COCHRAN-ARMITAGE | P=0.172N |
|FISHER EXACT | P=0.691N P=0.242N |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.7% 0.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 0/25 (0%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 558 --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.171N P=0.255N P=0.455N |
|INCIDENTAL TUMOR | P=0.131N P=0.227N P=0.356N |
|LOGISTIC REGRESSION | P=0.101N P=0.238N P=0.314N |
|COCHRAN-ARMITAGE | P=0.096N |
|FISHER EXACT | P=0.247N P=0.247N |
|==============================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 6.3% 4.0% 0.0% |
|TERMINAL (d) | 1/28 (4%) 1/25 (4%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 657 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.313N P=0.540N P=0.494N |
|INCIDENTAL TUMOR | P=0.285N P=0.526N P=0.438N |
|LOGISTIC REGRESSION | P=0.257N P=0.512N P=0.403N |
|COCHRAN-ARMITAGE | P=0.142N |
|FISHER EXACT | P=0.500N P=0.247N |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 9.7% 4.0% 0.0% |
|TERMINAL (d) | 2/28 (7%) 1/25 (4%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 657 729 (T) --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.179N P=0.348N P=0.367N |
|INCIDENTAL TUMOR | P=0.163N P=0.337N P=0.327N |
|LOGISTIC REGRESSION | P=0.142N P=0.321N P=0.289N |
|COCHRAN-ARMITAGE | P=0.061N |
|FISHER EXACT | P=0.309N P=0.121N |
|==============================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 14/50 (28%) 9/50 (18%) 3/49 (6%) |
|ADJUSTED (b) | 40.1% 24.9% 28.7% |
|TERMINAL (d) | 8/28 (29%) 3/25 (12%) 2/9 (22%) |
|FIRST INCIDENCE (DAYS) | 569 532 721 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.176N P=0.250N P=0.289N |
|INCIDENTAL TUMOR | P=0.041N* P=0.154N P=0.145N |
|LOGISTIC REGRESSION | P=0.041N* P=0.173N P=0.132N |
|COCHRAN-ARMITAGE | P=0.003N** |
|FISHER EXACT | P=0.171N P=0.004N** |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 2.8% 7.7% 11.1% |
|TERMINAL (d) | 0/28 (0%) 1/25 (4%) 1/9 (11%) |
|FIRST INCIDENCE (DAYS) | 657 719 729 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.323 P=0.457 P=0.506 |
|INCIDENTAL TUMOR | P=0.376 P=0.487 P=0.562 |
|LOGISTIC REGRESSION | P=0.381 P=0.490 P=0.597 |
|COCHRAN-ARMITAGE | P=0.622N |
|FISHER EXACT | P=0.500 P=0.753N |
|==============================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 6.0% 0.0% |
|TERMINAL (d) | 0/28 (0%) 1/25 (4%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | --- 492 --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.517 P=0.232 (e) |
|INCIDENTAL TUMOR | P=0.644N P=0.281 (e) |
|LOGISTIC REGRESSION | P=0.677 P=0.234 (e) |
|COCHRAN-ARMITAGE | P=0.667N |
|FISHER EXACT | P=0.247 (e) |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) 1/50 (2%) |
|ADJUSTED (b) | 2.8% 16.6% 11.1% |
|TERMINAL (d) | 0/28 (0%) 2/25 (8%) 1/9 (11%) |
|FIRST INCIDENCE (DAYS) | 657 492 729 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.236 P=0.090 P=0.506 |
|INCIDENTAL TUMOR | P=0.394 P=0.112 P=0.562 |
|LOGISTIC REGRESSION | P=0.354 P=0.103 P=0.597 |
|COCHRAN-ARMITAGE | P=0.592N |
|FISHER EXACT | P=0.102 P=0.753N |
|==============================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 1/50 (2%) |
|ADJUSTED (b) | 9.1% 2.9% 8.3% |
|TERMINAL (d) | 2/28 (7%) 0/25 (0%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 478 650 721 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.457N P=0.334N P=0.658N |
|INCIDENTAL TUMOR | P=0.279N P=0.282N P=0.441N |
|LOGISTIC REGRESSION | P=0.300N P=0.305N P=0.506N |
|COCHRAN-ARMITAGE | P=0.202N |
|FISHER EXACT | P=0.309N P=0.309N |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 12.6% 5.5% 8.3% |
|TERMINAL (d) | 3/28 (11%) 0/25 (0%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 478 624 721 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.376N P=0.375N P=0.549N |
|INCIDENTAL TUMOR | P=0.197N P=0.310N P=0.349N |
|LOGISTIC REGRESSION | P=0.211N P=0.336N P=0.395N |
|COCHRAN-ARMITAGE | P=0.118N |
|FISHER EXACT | P=0.339N P=0.181N |
|==============================================================================|
| |
|Testes |
| Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 45/50 (90%) 44/50 (88%) 31/50 (62%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% |
|TERMINAL (d) | 28/28 (100%) 25/25 (100%) 9/9 (100%) |
|FIRST INCIDENCE (DAYS) | 478 380 400 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.363 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.159 P=0.528N P=0.182 |
|LOGISTIC REGRESSION | P=0.134 P=0.446N P=0.159 |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.500N P<0.001N** |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 4/49 (8%) 5/49 (10%) |
|ADJUSTED (b) | 8.8% 14.9% 38.9% |
|TERMINAL (d) | 1/28 (4%) 3/25 (12%) 3/9 (33%) |
|FIRST INCIDENCE (DAYS) | 499 692 412 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.028 * P=0.446 P=0.041 * |
|INCIDENTAL TUMOR | P=0.101 P=0.504 P=0.189 |
|LOGISTIC REGRESSION | P=0.099 P=0.498 P=0.158 |
|COCHRAN-ARMITAGE | P=0.290 |
|FISHER EXACT | P=0.500 P=0.357 |
|==============================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 17/50 (34%) 25/50 (50%) 8/50 (16%) |
|ADJUSTED (b) | 48.5% 61.5% 49.4% |
|TERMINAL (d) | 11/28 (39%) 10/25 (40%) 3/9 (33%) |
|FIRST INCIDENCE (DAYS) | 569 492 503 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.183 P=0.066 P=0.347 |
|INCIDENTAL TUMOR | P=0.442N P=0.076 P=0.445N |
|LOGISTIC REGRESSION | P=0.491N P=0.072 P=0.443N |
|COCHRAN-ARMITAGE | P=0.035N* |
|FISHER EXACT | P=0.078 P=0.032N* |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 10.9% 8.0% 7.7% |
|TERMINAL (d) | 1/28 (4%) 2/25 (8%) 0/9 (0%) |
|FIRST INCIDENCE (DAYS) | 478 729 (T) 706 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.375N P=0.382N P=0.523N |
|INCIDENTAL TUMOR | P=0.218N P=0.325N P=0.267N |
|LOGISTIC REGRESSION | P=0.220N P=0.337N P=0.305N |
|COCHRAN-ARMITAGE | P=0.118N |
|FISHER EXACT | P=0.339N P=0.181N |
|==============================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 46/50 (92%) 48/50 (96%) 31/50 (62%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% |
|TERMINAL (d) | 28/28 (100%) 25/25 (100%) 9/9 (100%) |
|FIRST INCIDENCE (DAYS) | 478 380 400 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.001 ** P=0.212 P=0.001 ** |
|INCIDENTAL TUMOR | P=0.321 P=0.389 P=0.332 |
|LOGISTIC REGRESSION | P=0.304 P=0.420 P=0.325 |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.339 P<0.001N** |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
|==============================================================================|
|DOSE | CONTROL 112MG/KG 225MG/KG |
| | MALE MALE MALE |
|==============================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 28/50 (56%) 32/50 (64%) 13/50 (26%) |
|ADJUSTED (b) | 66.1% 75.7% 68.5% |
|TERMINAL (d) | 14/28 (50%) 15/25 (60%) 4/9 (44%) |
|FIRST INCIDENCE (DAYS) | 384 492 492 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.210 P=0.198 P=0.324 |
|INCIDENTAL TUMOR | P=0.160N P=0.302 P=0.131N |
|LOGISTIC REGRESSION | P=0.216N P=0.262 P=0.208N |
|COCHRAN-ARMITAGE | P=0.002N** |
|FISHER EXACT | P=0.270 P=0.002N** |
|==============================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 47/50 (94%) 49/50 (98%) 31/50 (62%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% |
|TERMINAL (d) | 28/28 (100%) 25/25 (100%) 9/9 (100%) |
|FIRST INCIDENCE (DAYS) | 384 380 400 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.002 ** P=0.217 P=0.002 ** |
|INCIDENTAL TUMOR | P=0.604N P=0.455 P=0.716 |
|LOGISTIC REGRESSION | P=0.534N P=0.400 P=0.718 |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.309 P<0.001N** |
|==============================================================================|
DATE: 09/18/94 EXPERIMENT: 05704 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE RATS(FISCHER344) -- RESORCINOL
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
--multipart-boundary
Content-type: text/plain
Range: bytes 52657-52657/52657
--multipart-boundary--