TDMS Study 05704-02 Pathology Tables
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
Facility: International Research and Development Corp.
Chemical CAS #: 108-46-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + M + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + +|
Erosion, Multifocal | |
Hyperplasia, Diffuse, Glandular | 4|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X X X |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | 2 |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hemorrhage, Focal | 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Multifocal | 2 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic, Diffuse | |
Bile Duct, Hyperplasia | 2 3 3 3 3 2 4 4 3 4 2 2 3 2 2 1 2 2 3|
Centrilobular, Fatty Change | 2 3 3 3 3 1 |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 2 |
Atrophy, Focal | 1 1 1 2 2 1 |
Atrophy, Multifocal | 2 2 3 1 2 2 1 2 2|
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Ectasia, Focal | |
Interlobular, Edema, Diffuse | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 3|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Multifocal | 3|
Hyperplasia, Diffuse, Squamous | 3|
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic | 4 4|
Ulcer, Focal | 3 |
Ulcer, Multifocal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 1 1 |
Erosion, Multifocal | 2|
Hemorrhage, Focal | 2 |
Hyperplasia, Focal, Glandular | 2 |
Inflammation, Chronic | 3 |
Mineralization, Diffuse | 3 |
Ulcer, Focal | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 2 2 2 |
Inflammation, Chronic, Multifocal | 2 3 2 2|
Mineralization, Multifocal | 2 |
Atrium, Thrombosis | X |
Epicardium, Inflammation, Chronic, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Cytoplasmic Alteration, Focal | 1 2 |
Cytoplasmic Alteration, Multifocal | |
Degeneration, Fatty, Focal | 1 2 |
Degeneration, Fatty, Multifocal | 2|
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia, Focal | 2 3 2 3 2 2 |
Hyperplasia, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2|
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 1 |
Hyperplasia, Focal | 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + + + M + + + + + + + + + + +|
Hyperplasia, Diffuse | 4 4|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Congestion | |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 3 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 3|
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 4 1 2 1 |
C-Cell, Hyperplasia, Multifocal | |
Follicular Cell, Depletion Secretory | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Penis | + |
Concretion | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | 4 |
Cyst | X X |
Hyperplasia, Multifocal | 1 2 |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic, Multifocal | 2 3 3 2 2 2 3 3 2 1 2 2 2 1|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 4 |
Hyperplasia, Multifocal | |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | 2 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | |
Interstitial Cell, Hyperplasia, | |
Multifocal | 3 2 2 2 3 2 2 1 3 3 3 3|
Seminiferous Tubule, Degeneration | 4 3 3 4 4 4 4 4 4 4|
Serosa, Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Crystals, Multifocal | |
Mineralization, Multifocal | |
Erythroid Cell, Proliferation | 3 4 3 3 3|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inguinal, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation, | |
Suppurative | |
Mediastinal, Pigmentation | 4 |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis, Focal | 3 2 |
Fibrosis, Multifocal | 3 |
Hematopoietic Cell Proliferation | 3 4 3 |
Pigmentation, Diffuse, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + I + + + + + + I + M + + + + + + + +|
Cyst | X X|
Hemorrhage | 1 |
Epithelial Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X X |
Mineralization, Multifocal | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cranium, Hyperostosis | |
Trabecula, Hyperostosis, Multifocal | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Abdominal, Necrosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 2 |
Edema, Focal | 2 |
Mineralization, Multifocal | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 1 |
Fungus | X X X |
Inflammation, Acute | |
Inflammation, Chronic | 2 3 2 2 |
Inflammation, Suppurative | 3 |
Mucosa, Thrombosis, Multifocal | X |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Metaplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Epithelium, Metaplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Ectopic Tissue, Multifocal | X |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 5| 7| 6| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 3| 4| 6| 7| 6| 6| 2| 2| 4| 6| 7|
DAY ON TEST | 5| 5| 2| 7| 2| 6| 3| 2| 2| 6| 5| 3| 2| 2| 8| 5| 9| 3| 1| 4| 8| 8| 9| 5| 3|
| 6| 8| 9| 7| 9| 3| 0| 9| 9| 0| 6| 0| 9| 9| 4| 6| 2| 0| 0| 4| 7| 7| 9| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Tubular | 1 |
Necrosis, Acute, Focal | 3 |
Nephropathy, Chronic | 4 3 2 2 1 2 3 3 4 2 3 4 1 3 3 4 2 2 2 4|
Pigmentation, Diffuse | |
Cortex, Mineralization, Multifocal | 4 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 3 |
Pelvis, Inflammation, Chronic | 3 |
Pelvis, Mineralization | 1 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Cyst | |
Inflammation, Chronic, Diffuse | 2 3 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + + + + + + + + +|
Erosion, Multifocal | 2 |
Hyperplasia, Diffuse, Glandular | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + + +|
Hyperplasia, Diffuse | 4 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X X X X X X |
Clear Cell Focus | X |
Clear Cell Focus, Multiple | X X X X |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic, Focal | 2 |
Eosinophilic Focus | |
Fatty Change, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Inflammation, Chronic, Multifocal | 2 |
Mixed Cell Focus | |
Vacuolization Cytoplasmic, Diffuse | |
Bile Duct, Hyperplasia | 2 3 4 3 2 4 1 3 3 2 3 3 4 3 3 2|
Centrilobular, Fatty Change | 2 2 2 3 3 |
Centrilobular, Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Focal | 1 2 2 1 3 3 1|
Atrophy, Multifocal | 3 2 4 1 3 |
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Duct, Ectasia, Focal | 2|
Interlobular, Edema, Diffuse | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + +|
Erosion, Multifocal | |
Hyperplasia, Diffuse, Squamous | 4 |
Hyperplasia, Focal, Squamous | 3 |
Inflammation, Chronic | 3 4 4 |
Ulcer, Focal | 2|
Ulcer, Multifocal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + +|
Erosion, Focal | 2 1 |
Erosion, Multifocal | |
Hemorrhage, Focal | |
Hyperplasia, Focal, Glandular | 3 |
Inflammation, Chronic | |
Mineralization, Diffuse | |
Ulcer, Focal | 3 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 3 |
Mineralization, Multifocal | |
Atrium, Thrombosis | X |
Epicardium, Inflammation, Chronic, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 |
Cytoplasmic Alteration, Focal | 2 |
Cytoplasmic Alteration, Multifocal | 2 |
Degeneration, Fatty, Focal | 1 2 2 2 1 1 |
Degeneration, Fatty, Multifocal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia, Focal | 2 2 2 2 |
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + +|
Hyperplasia, Focal | 2 3 2 |
Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + +|
Angiectasis, Focal | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + +|
Hyperplasia, Diffuse | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 1 |
Pars Distalis, Congestion | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 3 1 3 |
C-Cell, Hyperplasia, Multifocal | 1 1 2 |
Follicular Cell, Depletion Secretory | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 |
Inflammation, Acute | 2|
__________________________________________________________________________|
Penis | |
Concretion | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Abscess | |
Atrophy | |
Cyst | X |
Hyperplasia, Multifocal | |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 3 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
Hyperplasia, Multifocal | 3 |
Inflammation, Acute, Focal | 3 |
Inflammation, Chronic, Diffuse | 4 |
Inflammation, Chronic, Focal | 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 2 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2 3 2 2 2 2 3 2 2 1 2|
Seminiferous Tubule, Degeneration | 4 4 3 4 4 2 2 4 4 4 4 4|
Serosa, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Crystals, Multifocal | 3 |
Mineralization, Multifocal | 3 |
Erythroid Cell, Proliferation | 4 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Congestion | |
Inguinal, Hyperplasia, Plasma Cell | |
Mediastinal, Hyperplasia, Plasma Cell| |
Mediastinal, Inflammation, | |
Suppurative | |
Mediastinal, Pigmentation | |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis, Focal | 1 4 |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | 4 |
Pigmentation, Diffuse, Hemosiderin | 4 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | |
Epithelial Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + I + + + + + + + + + + + + + + + +|
Galactocele | X X |
Mineralization, Multifocal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Cranium, Hyperostosis | |
Trabecula, Hyperostosis, Multifocal | X |
__________________________________________________________________________|
Skeletal Muscle | |
Abdominal, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 |
Edema, Focal | |
Mineralization, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | X |
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Mucosa, Thrombosis, Multifocal | 4 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Metaplasia | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2|
Epithelium, Metaplasia | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Ectopic Tissue, Multifocal | |
Lens, Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 4| 4| 6| 7| 7| 4| 4| 4| 5| 7| 4| 7| 7| 6| 7| 4| 7| 6| 7| 6|
DAY ON TEST | 5| 3| 3| 6| 2| 5| 5| 4| 3| 3| 5| 5| 5| 8| 2| 7| 3| 3| 2| 2| 5| 2| 5| 2| 9|
| 6| 0| 0| 9| 9| 6| 6| 2| 0| 0| 6| 6| 6| 5| 9| 8| 0| 0| 9| 9| 6| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Tubular | |
Necrosis, Acute, Focal | |
Nephropathy, Chronic | 3 3 2 3 2 3 3 2 3 2 3 4 1 2 3 2 4 3|
Pigmentation, Diffuse | 4 |
Cortex, Mineralization, Multifocal | 1 |
Papilla, Transitional Epithelium, | |
Hyperplasia | |
Pelvis, Inflammation, Chronic | |
Pelvis, Mineralization | |
Proximal Convoluted Renal Tubule, | |
Degeneration, Hyaline | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Concretion | |
Cyst | X |
Inflammation, Chronic, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 47 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 47 |
Parasite Metazoan | X X | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + + + + + | 47 |
Parasite Metazoan | X X | 9 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 47 |
Erosion, Multifocal | | 1 2.0|
Hyperplasia, Diffuse, Glandular | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 46 |
Hyperplasia, Diffuse | | 1 4.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis, Focal | 2 | 3 2.3|
Basophilic Focus | X | 7 |
Basophilic Focus, Multiple | X X X X | 14 |
Clear Cell Focus | X X | 5 |
Clear Cell Focus, Multiple | X | 8 |
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Degeneration, Cystic, Focal | | 1 2.0|
Eosinophilic Focus | | 1 2.0|
Fatty Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Hemorrhage, Focal | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 4 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic, Multifocal | 2 | 4 2.0|
Mixed Cell Focus | 2 | 1 2.0|
Vacuolization Cytoplasmic, Diffuse | 3 | 1 3.0|
Bile Duct, Hyperplasia | 3 3 3 2 2 3 4 2 2 2 | 45 2.7|
Centrilobular, Fatty Change | 3 3 3 | 14 2.6|
Centrilobular, Necrosis | 3 | 3 3.3|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 49 |
Atrophy, Diffuse | | 1 2.0|
Atrophy, Focal | 2 2 | 15 1.7|
Atrophy, Multifocal | 4 2 2 1 2 2 | 20 2.2|
Artery, Inflammation, Chronic | | 2 2.0|
Duct, Ectasia, Focal | | 1 2.0|
Interlobular, Edema, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
Erosion, Multifocal | | 1 3.0|
Hyperplasia, Diffuse, Squamous | | 2 3.5|
Hyperplasia, Focal, Squamous | 2 | 2 2.5|
Inflammation, Chronic | | 5 3.8|
Ulcer, Focal | | 2 2.5|
Ulcer, Multifocal | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 49 |
Erosion, Focal | | 4 1.3|
Erosion, Multifocal | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal, Glandular | | 2 2.5|
Inflammation, Chronic | | 1 3.0|
Mineralization, Diffuse | | 1 3.0|
Ulcer, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Inflammation, Chronic, Focal | | 6 2.2|
Inflammation, Chronic, Multifocal | 3 2 2 2 | 14 2.2|
Mineralization, Multifocal | | 1 2.0|
Atrium, Thrombosis | X | 3 |
Epicardium, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + I + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | 2 | 1 2.0|
Congestion | 2 | 2 2.5|
Cytoplasmic Alteration, Focal | | 3 1.7|
Cytoplasmic Alteration, Multifocal | | 1 2.0|
Degeneration, Fatty, Focal | 1 2 | 10 1.5|
Degeneration, Fatty, Multifocal | 1 | 3 1.7|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 | 1 1.0|
Hyperplasia, Focal | | 10 2.2|
Hyperplasia, Multifocal | 3 | 2 3.0|
Hypertrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Hyperplasia, Focal | 2 | 7 2.3|
Hyperplasia, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
Angiectasis, Focal | | 1 1.0|
Hyperplasia, Focal | 3 | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M M + + + | 41 |
Hyperplasia, Diffuse | | 2 4.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis, Focal | | 1 1.0|
Pars Distalis, Congestion | | 1 3.0|
Pars Distalis, Cyst | X | 5 |
Pars Distalis, Hyperplasia, Focal | 2 | 8 2.1|
Pars Distalis, Hyperplasia, | | |
Multifocal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
C-Cell, Hyperplasia, Focal | 1 | 9 1.9|
C-Cell, Hyperplasia, Multifocal | 1 | 4 1.3|
Follicular Cell, Depletion Secretory | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Atrophy, Diffuse | | 1 3.0|
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
Concretion | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 50 |
Abscess | 4 | 1 4.0|
Atrophy | | 1 4.0|
Cyst | | 3 |
Hyperplasia, Multifocal | | 2 1.5|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 1 | 32 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 50 |
Hyperplasia, Focal | 1 | 4 2.0|
Hyperplasia, Multifocal | | 1 3.0|
Inflammation, Acute, Focal | | 1 3.0|
Inflammation, Chronic, Diffuse | | 1 4.0|
Inflammation, Chronic, Focal | 2 | 8 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Mineralization, Multifocal | | 2 1.5|
Interstitial Cell, Hyperplasia, | | |
Multifocal | 3 2 2 2 2 2 | 30 2.2|
Seminiferous Tubule, Degeneration | 4 4 4 4 | 26 3.7|
Serosa, Necrosis, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Crystals, Multifocal | | 1 3.0|
Mineralization, Multifocal | | 1 3.0|
Erythroid Cell, Proliferation | 3 | 8 3.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Congestion | 4 | 1 4.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 1 3.0|
Mediastinal, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Mediastinal, Pigmentation | | 1 4.0|
Pancreatic, Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Congestion | | 1 3.0|
Hemorrhage | 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Developmental Malformation | X | 1 |
Fibrosis, Focal | | 4 2.5|
Fibrosis, Multifocal | | 1 3.0|
Hematopoietic Cell Proliferation | 4 2 3 2 | 8 3.1|
Pigmentation, Diffuse, Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 46 |
Cyst | | 2 |
Hemorrhage | 2 3 3 | 4 2.3|
Epithelial Cell, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 49 |
Galactocele | | 5 |
Mineralization, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Fibrous Osteodystrophy | | 2 4.0|
Cranium, Hyperostosis | X | 1 |
Trabecula, Hyperostosis, Multifocal | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Abdominal, Necrosis, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Inflammation, Chronic, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion | | 5 2.6|
Edema, Focal | | 1 2.0|
Mineralization, Multifocal | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 3| 2| 2| 3| 2| 3| 2| 2| | |
| 7| 0| 0| 9| 9| 0| 9| 0| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | 1 | 4 1.5|
Fungus | | 4 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | | 4 2.3|
Inflammation, Suppurative | 2 | 2 2.5|
Mucosa, Thrombosis, Multifocal | | 2 4.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
Olfactory Epithelium, Metaplasia | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Epithelium, Metaplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 6 |
Ectopic Tissue, Multifocal | | 1 |
Lens, Cataract | 3 | 1 3.0|
Retina, Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Hyperplasia, Multifocal, Tubular | 1 | 2 1.0|
Necrosis, Acute, Focal | | 1 3.0|
Nephropathy, Chronic | 2 3 1 3 3 2 2 2 3 3 | 48 2.6|
Pigmentation, Diffuse | | 1 4.0|
Cortex, Mineralization, Multifocal | | 2 2.5|
Papilla, Transitional Epithelium, | | |
Hyperplasia | 2 | 2 2.5|
Pelvis, Inflammation, Chronic | | 1 3.0|
Pelvis, Mineralization | | 1 1.0|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Hyaline | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Concretion | | 1 2.0|
Cyst | | 1 |
Inflammation, Chronic, Diffuse | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + A + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + A + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X |
Basophilic Focus, Multiple | X X X X X X X|
Clear Cell Focus | X X X X X X |
Clear Cell Focus, Multiple | X X X X|
Congestion | 3 |
Cytoplasmic Alteration, Multifocal | 3|
Degeneration, Cystic, Multifocal | |
Fatty Change, Focal | 2 |
Granuloma | |
Hepatodiaphragmatic Nodule | X X X|
Hyperplasia, Focal | 3 2 |
Inflammation, Chronic, Multifocal | 2 1 3 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 1 3 4 2 2 2 4 4 2 3 4 2 3 2 3 2 2 4 3 3|
Centrilobular, Fatty Change | |
Centrilobular, Necrosis | 4 |
Periportal, Fatty Change | 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 1 1 |
Atrophy, Multifocal | 3 4 2 3 2 2|
Cyst | |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Hyperplasia, Focal, Squamous | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 4 |
Inflammation, Chronic | |
Ulcer, Focal | |
Ulcer, Multifocal | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Erosion, Multifocal | 3 |
Hyperplasia, Focal, Lymphoid | |
Inflammation, Acute | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 2 2 3 |
Inflammation, Chronic, Multifocal | 3 2 2 3 3 2 2 2|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 3 |
Cytoplasmic Alteration, Focal | 1 2 |
Degeneration, Fatty, Focal | 2|
Degeneration, Fatty, Multifocal | 1 |
Granuloma | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hyperplasia, Focal | 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Nuclear | 2 |
Hyperplasia, Focal | 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + M + M M M + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 2 3|
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Distalis, Infiltration Cellular,| |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Focal, Histiocyte | 2 |
Pars Intermedia, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 1 2 |
C-Cell, Hyperplasia, Multifocal | |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm, Focal | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic, Focal | 2 2 |
Inflammation, Chronic, Multifocal | 3 2 2 2 3 2 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 1 2 2 |
Hyperplasia, Multifocal | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 2 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + |
Depletion Secretory | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2 2 2 2 2 1 3 |
Seminiferous Tubule, Degeneration | 2 4 4 2 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | 2 |
Erythroid Cell, Proliferation | 3 4 3 |
Myeloid Cell, Proliferation | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
Popliteal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | X |
Erythrophagocytosis | |
Hyperplasia, Lymphoid | |
Sinus, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Diffuse | 4 |
Fibrosis, Focal | 3 2 |
Fibrosis, Multifocal | 3|
Hematocyst | X |
Hematopoietic Cell Proliferation | 3 |
Metaplasia, Focal, Osseous | |
Pigmentation, Diffuse, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + +|
Cyst | X |
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 3 |
Emphysema | 3 |
Hemorrhage, Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | |
Alveolus, Inflammation, Chronic, | |
Focal | 2 |
Alveolus, Inflammation, Chronic, | |
Multifocal | |
Interstitium, Inflammation, Chronic, | |
Diffuse | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 5| 7| 5| 7| 7| 4| 7| 7| 7| 6| 6| 7| 6| 6| 3| 4| 7| 6| 6| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 9| 2| 0| 5| 2| 3| 2| 5| 7| 2| 9| 5| 8| 5| 1| 3| 0| 2| 3| 2| 3| 3| 3|
| 2| 9| 6| 9| 8| 6| 9| 0| 9| 0| 9| 9| 2| 0| 0| 6| 4| 9| 1| 9| 0| 9| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 4 4 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Ectasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Anterior Chamber, Hemorrhage | 3 |
Anterior Chamber, Iris, Posterior | |
Chamber, Inflammation | |
Cornea, Inflammation | 3 |
Lens, Cataract | 3 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Multifocal, Tubular | 2 |
Nephropathy, Chronic | 3 3 4 4 4 4 3 4 4 4 3 3 3 1 4 3 2 2 3 3 4 3 3|
Pigmentation, Diffuse | |
Cortex, Necrosis, Diffuse | |
Pelvis, Parasite Metazoan | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 |
Basophilic Focus | X X X X X X |
Basophilic Focus, Multiple | X X X |
Clear Cell Focus | X X X X |
Clear Cell Focus, Multiple | X X X X X |
Congestion | |
Cytoplasmic Alteration, Multifocal | |
Degeneration, Cystic, Multifocal | 2 |
Fatty Change, Focal | |
Granuloma | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Multifocal | 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 4 3 3 2 3 3 4 3 4 2 3 3 2 1 3 2 3 3|
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis | 1 |
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | + +|
Fat, Necrosis | 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 2 2 2 2|
Atrophy, Multifocal | 3 3 2 2 3 |
Cyst | X |
Hyperplasia, Focal | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
Hyperplasia, Focal, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 2 |
Ulcer, Focal | 3 |
Ulcer, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Erosion, Multifocal | 2 |
Hyperplasia, Focal, Lymphoid | 2 |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 2 2 3 3 2 3 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Cytoplasmic Alteration, Focal | 3 2 |
Degeneration, Fatty, Focal | 2 2 3 2 1 |
Degeneration, Fatty, Multifocal | 2 |
Granuloma | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hyperplasia, Focal | 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + +|
Atypia Nuclear | |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
Pars Distalis, Infiltration Cellular,| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Focal, Histiocyte | |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 1 1 |
Follicular Cell, Hyperplasia, Cystic,| |
Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + +|
Granuloma Sperm, Focal | |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Chronic, Focal | 1 3|
Inflammation, Chronic, Multifocal | 3 2 3 3 2 4 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 2 |
Hyperplasia, Multifocal | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | 2 3 2 |
__________________________________________________________________________|
Seminal Vesicle | |
Depletion Secretory | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2 2 1 |
Seminiferous Tubule, Degeneration | 2 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | |
Erythroid Cell, Proliferation | 3 3 |
Myeloid Cell, Proliferation | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + +|
Inguinal, Hyperplasia, Plasma Cell | |
Popliteal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Cyst, Multiple | |
Erythrophagocytosis | 2 |
Hyperplasia, Lymphoid | 4 |
Sinus, Ectasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fibrosis, Diffuse | |
Fibrosis, Focal | 3 |
Fibrosis, Multifocal | |
Hematocyst | |
Hematopoietic Cell Proliferation | 4 |
Metaplasia, Focal, Osseous | 2 |
Pigmentation, Diffuse, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + +|
Cyst | |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | 3|
Emphysema | |
Hemorrhage, Focal | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Multifocal, Histiocyte | |
Alveolus, Inflammation, Chronic, | |
Focal | |
Alveolus, Inflammation, Chronic, | |
Multifocal | 2 |
Interstitium, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + M + +|
Foreign Body | 2 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 5| 7| 6| 4| 4| 4| 5| 5|
DAY ON TEST | 5| 1| 2| 2| 3| 5| 3| 2| 6| 1| 1| 3| 2| 3| 3| 5| 5| 6| 2| 2| 5| 5| 5| 6| 8|
| 6| 6| 9| 9| 0| 6| 2| 9| 6| 2| 9| 0| 9| 0| 0| 6| 6| 2| 9| 4| 6| 6| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + +|
Glands, Ectasia, Focal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Anterior Chamber, Hemorrhage | |
Anterior Chamber, Iris, Posterior | |
Chamber, Inflammation | 2 |
Cornea, Inflammation | |
Lens, Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hyperplasia, Multifocal, Tubular | |
Nephropathy, Chronic | 2 3 2 3 3 3 3 4 3 3 4 2 3 2 3 2 2 3|
Pigmentation, Diffuse | 3 |
Cortex, Necrosis, Diffuse | 4 |
Pelvis, Parasite Metazoan | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +|
Concretion | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + | 47 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + | 49 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Angiectasis, Focal | | 4 2.0|
Basophilic Focus | X | 8 |
Basophilic Focus, Multiple | X X X | 13 |
Clear Cell Focus | | 10 |
Clear Cell Focus, Multiple | X | 10 |
Congestion | | 1 3.0|
Cytoplasmic Alteration, Multifocal | | 1 3.0|
Degeneration, Cystic, Multifocal | | 1 2.0|
Fatty Change, Focal | | 1 2.0|
Granuloma | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | | 3 |
Hyperplasia, Focal | | 3 2.3|
Inflammation, Chronic, Multifocal | 1 | 6 1.8|
Necrosis, Focal | 1 | 1 1.0|
Bile Duct, Hyperplasia | 2 3 3 3 4 2 3 | 46 2.8|
Centrilobular, Fatty Change | | 1 2.0|
Centrilobular, Necrosis | | 2 2.5|
Periportal, Fatty Change | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis | | 3 3.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Atrophy, Focal | 2 | 11 1.8|
Atrophy, Multifocal | 4 3 2 4 1 | 16 2.7|
Cyst | | 1 |
Hyperplasia, Focal | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Erosion, Focal | 2 | 2 2.0|
Hyperplasia, Focal, Squamous | | 1 2.0|
Inflammation, Acute | 2 | 3 3.3|
Inflammation, Chronic | | 2 2.0|
Ulcer, Focal | | 1 3.0|
Ulcer, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Ectopic Tissue | | 1 |
Erosion, Multifocal | | 2 2.5|
Hyperplasia, Focal, Lymphoid | | 1 2.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Inflammation, Chronic, Focal | 2 | 5 2.4|
Inflammation, Chronic, Multifocal | 2 3 2 2 | 19 2.4|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Congestion | | 1 3.0|
Cytoplasmic Alteration, Focal | | 4 2.0|
Degeneration, Fatty, Focal | | 6 2.0|
Degeneration, Fatty, Multifocal | | 2 1.5|
Granuloma | 4 | 1 4.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 | 4 2.0|
Hyperplasia, Focal | 2 | 7 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
Atypia Nuclear | | 1 2.0|
Hyperplasia, Focal | 2 2 | 7 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + I + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + | 42 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Angiectasis, Focal | | 1 3.0|
Pars Distalis, Cyst | | 3 |
Pars Distalis, Hyperplasia, Focal | 2 | 5 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | 3 | 1 3.0|
Pars Distalis, Infiltration Cellular,| | |
Focal, Histiocyte | | 1 2.0|
Pars Intermedia, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + | 49 |
C-Cell, Hyperplasia, Focal | | 3 1.7|
C-Cell, Hyperplasia, Multifocal | | 2 1.0|
Follicular Cell, Hyperplasia, Cystic,| | |
Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
Granuloma Sperm, Focal | 1 | 1 1.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + M + + | 49 |
Dilatation | | 1 4.0|
Inflammation, Chronic, Focal | 1 1 | 6 1.7|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 | 29 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 50 |
Hyperplasia, Focal | 1 | 9 1.6|
Hyperplasia, Multifocal | | 1 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 7 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | | 1 |
Depletion Secretory | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Interstitial Cell, Hyperplasia, | | |
Multifocal | 3 3 2 2 2 | 17 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Degeneration | 4 4 4 | 12 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Myelofibrosis, Focal | | 1 2.0|
Erythroid Cell, Proliferation | 4 4 | 7 3.4|
Myeloid Cell, Proliferation | 4 | 2 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Inguinal, Hyperplasia, Plasma Cell | 3 4 | 2 3.5|
Popliteal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 50 |
Cyst, Multiple | | 1 |
Erythrophagocytosis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
Sinus, Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Congestion | | 1 4.0|
Fibrosis, Diffuse | | 1 4.0|
Fibrosis, Focal | | 3 2.7|
Fibrosis, Multifocal | | 1 3.0|
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | 4 3 | 4 3.5|
Metaplasia, Focal, Osseous | | 1 2.0|
Pigmentation, Diffuse, Hemosiderin | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + | 46 |
Cyst | | 1 |
Hemorrhage | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Galactocele | | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Subcutaneous Tissue, Edema | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Congestion | 3 2 | 6 2.5|
Emphysema | | 1 3.0|
Hemorrhage, Focal | | 2 1.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Multifocal, Histiocyte | 1 | 1 1.0|
Alveolus, Inflammation, Chronic, | | |
Focal | 2 | 2 2.0|
Alveolus, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Interstitium, Inflammation, Chronic, | | |
Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 49 |
Foreign Body | 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | 3 | 2 3.0|
Metaplasia, Squamous | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 3 3.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
Glands, Ectasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Anterior Chamber, Hemorrhage | | 1 3.0|
Anterior Chamber, Iris, Posterior | | |
Chamber, Inflammation | | 1 2.0|
Cornea, Inflammation | | 1 3.0|
Lens, Cataract | | 3 3.0|
Retina, Degeneration | | 2 4.0|
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 2| 4| 4| 7| 7| 7| 7| 6| 4| 7| | |
DAY ON TEST | 7| 5| 9| 3| 2| 2| 3| 3| 9| 3| | |
| 9| 6| 2| 0| 9| 9| 0| 7| 2| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Cyst | | 4 |
Hyperplasia, Multifocal, Tubular | | 1 2.0|
Nephropathy, Chronic | 2 2 4 3 2 3 2 3 | 49 3.0|
Pigmentation, Diffuse | 4 | 2 3.5|
Cortex, Necrosis, Diffuse | | 1 4.0|
Pelvis, Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Concretion | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Granulomatous | |
Perforation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + A + + + A + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + A + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + I A + + + + + + + + A + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + A + + + A + + +|
Ectopic Tissue | |
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + A + A + A + + +|
Inflammation, Chronic Active, Diffuse| |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + A + + + A + + +|
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X |
Basophilic Focus, Multiple | X X|
Clear Cell Focus, Multiple | X X|
Congestion | 3 |
Cytoplasmic Alteration, Focal | 2|
Eosinophilic Focus | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic, Multifocal | 1 2 1 |
Inflammation, Multifocal, Subacute | 2 |
Necrosis, Focal | 1 |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia | 2 3 2 2 1 2 3 1 3 3 1 3 4 1 2 2 3|
Centrilobular, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 3 2 2 1|
Atrophy, Multifocal | 3 3 3 2 3 |
Inflammation, Chronic, Diffuse | |
Artery, Inflammation, Chronic | 3 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Focal, | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Focal, Squamous | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + +|
Erosion, Focal | |
Inflammation, Chronic | 2 |
Mineralization, Diffuse | 3 |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 1 2 2 |
Inflammation, Chronic, Multifocal | 3 2 2 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 1|
Degeneration, Fatty, Focal | 2 3 2 |
Degeneration, Fatty, Multifocal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 3 3 2|
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M + M + + + + M +|
Hyperplasia, Diffuse | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | |
Follicular Cell, Depletion Secretory | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Dilatation | |
Hyperplasia | 2 |
Inflammation, Chronic, Focal | 3 1 2 |
Inflammation, Chronic, Multifocal | 2 1 1 1 2 2 2 3 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia, | |
Multifocal | 1 2 1 2 2 2 2 2 2 |
Seminiferous Tubule, Degeneration | 4 3 4 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | 2 |
Erythroid Cell, Proliferation | 3 3 |
Myeloid Cell, Proliferation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | 4 |
Axillary, Hyperplasia, Lymphoid | 2 |
Axillary, Infiltration Cellular, | |
Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + M + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 1 4 1 3 |
Hemorrhage, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 3 |
Edema, Focal | |
Emphysema | |
Foreign Body | |
Hemorrhage, Focal | 2 2 |
Infiltration Cellular, Diffuse, | |
Histiocyte | 3 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Inflammation, Acute | |
Inflammation, Multifocal, Suppurative| |
Necrosis, Acute | |
Pigmentation, Multifocal | |
Alveolus, Inflammation, Chronic, | |
Focal | |
Interstitium, Inflammation, Chronic, | |
Focal | |
Perivascular, Edema, Multifocal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Foreign Body | 1 1 1 |
Fungus | X|
Inflammation, Chronic | 1 2 2|
Inflammation, Suppurative | 1 1 |
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 0| 3| 3| 4| 7| 1| 3| 3| 4| 7| 4| 4| 7| 5| 7| 1| 4| 4| 5| 7| 2| 4| 5| 5| 7|
DAY ON TEST | 4| 1| 1| 3| 3| 1| 0| 0| 0| 2| 1| 3| 2| 8| 2| 8| 2| 4| 2| 2| 1| 5| 7| 9| 3|
| 4| 7| 7| 4| 0| 9| 3| 3| 0| 8| 2| 6| 9| 6| 9| 2| 9| 0| 7| 9| 7| 6| 4| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + A |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Hydronephrosis, Chronic | |
Hyperplasia, Multifocal, Tubular | 1 1 1 |
Nephropathy, Chronic | 1 2 4 2 1 2 4 2 3 3 4 1 2 2 4 2 3 2|
Pigmentation, Diffuse | |
Pigmentation | |
Cortex, Mineralization, Multifocal | 3 |
Papilla, Transitional Epithelium, | |
Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Concretion | 3 2 |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Granulomatous | |
Perforation | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Inflammation, Chronic Active, Diffuse| 3 |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Diffuse| 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Diffuse| 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | |
Basophilic Focus, Multiple | X X X |
Clear Cell Focus, Multiple | X |
Congestion | |
Cytoplasmic Alteration, Focal | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X|
Inflammation, Chronic, Multifocal | 2 1 |
Inflammation, Multifocal, Subacute | |
Necrosis, Focal | |
Necrosis, Multifocal | 2 2 2 |
Bile Duct, Hyperplasia | 2 3 3 3 1 3 2 3 2 2 2 2 2 2 2 4 3 2 |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 4 1 2 |
Atrophy, Multifocal | 2 2 3 |
Inflammation, Chronic, Diffuse | 3 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Infiltration Cellular, Focal, | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mononuclear Cell | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia, Focal, Squamous | 3 |
Inflammation, Acute | |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 1 |
Inflammation, Chronic | |
Mineralization, Diffuse | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic, Multifocal | 2 3 2 3 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty, Focal | 1 |
Degeneration, Fatty, Multifocal | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia, Diffuse | |
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 1 |
Pars Distalis, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 2 |
Follicular Cell, Depletion Secretory | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Dilatation | 4 |
Hyperplasia | |
Inflammation, Chronic, Focal | 1 2 2 1 |
Inflammation, Chronic, Multifocal | 3 2 3 2 2 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | |
Inflammation, Chronic, Focal | 2 1 1 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2 3 2 2 3 2 2 2 3 2 1|
Seminiferous Tubule, Degeneration | 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + M + + + + + + + +|
Myelofibrosis, Focal | |
Erythroid Cell, Proliferation | 3 |
Myeloid Cell, Proliferation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Ectasia | |
Axillary, Hyperplasia, Lymphoid | |
Axillary, Infiltration Cellular, | |
Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 2 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 4 3 3 3 3|
Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Edema, Focal | 2|
Emphysema | 4 |
Foreign Body | 1 |
Hemorrhage, Focal | |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 |
Inflammation, Acute | 3 |
Inflammation, Multifocal, Suppurative| 3 |
Necrosis, Acute | 4 |
Pigmentation, Multifocal | 2 |
Alveolus, Inflammation, Chronic, | |
Focal | 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 |
Perivascular, Edema, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Foreign Body | 1 |
Fungus | X |
Inflammation, Chronic | 3 2 |
Inflammation, Suppurative | 2 2 2 2 2|
Nasolacrimal Duct, Inflammation, | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
_____________________________________________________________________________________________________________________
| 2| 2| 5| 7| 7| 3| 3| 6| 7| 6| 4| 4| 4| 4| 5| 0| 4| 4| 5| 5| 2| 5| 7| 3| 3|
DAY ON TEST | 5| 6| 7| 2| 3| 0| 9| 1| 3| 2| 2| 5| 5| 5| 6| 1| 5| 9| 0| 7| 8| 3| 0| 3| 3|
| 5| 2| 6| 9| 0| 7| 9| 1| 0| 5| 9| 6| 6| 6| 0| 0| 4| 2| 3| 4| 2| 7| 6| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + +|
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X X |
Hydronephrosis, Chronic | 2 |
Hyperplasia, Multifocal, Tubular | 1 1 |
Nephropathy, Chronic | 1 2 3 3 1 2 3 2 3 2 3 2 2 2 4 2 1 1|
Pigmentation, Diffuse | 4 |
Pigmentation | 4 |
Cortex, Mineralization, Multifocal | |
Papilla, Transitional Epithelium, | |
Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
Inflammation, Chronic, Granulomatous | 4 | 1 4.0|
Perforation | X | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + | 44 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + | 46 |
Parasite Metazoan | X X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 47 |
Parasite Metazoan | X X | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + | 44 |
Ectopic Tissue | | 1 |
Inflammation, Chronic Active, Diffuse| | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + | 43 |
Inflammation, Chronic Active, Diffuse| | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + | 44 |
Inflammation, Chronic Active, Diffuse| | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X | 3 |
Basophilic Focus, Multiple | X | 6 |
Clear Cell Focus, Multiple | | 3 |
Congestion | 3 | 2 3.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Eosinophilic Focus | | 1 2.0|
Hepatodiaphragmatic Nodule | | 3 |
Inflammation, Chronic, Multifocal | | 5 1.4|
Inflammation, Multifocal, Subacute | | 1 2.0|
Necrosis, Focal | 1 | 2 1.0|
Necrosis, Multifocal | | 3 2.0|
Bile Duct, Hyperplasia | 1 1 1 3 2 4 1 | 42 2.2|
Centrilobular, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Atrophy, Focal | | 9 2.1|
Atrophy, Multifocal | 2 | 9 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Diffuse | | 1 3.0|
Artery, Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Hyperplasia, Focal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Cyst Epithelial Inclusion | | 1 |
Hyperplasia, Focal, Squamous | | 2 2.5|
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 49 |
Erosion, Focal | | 2 1.5|
Inflammation, Chronic | | 1 2.0|
Mineralization, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Inflammation, Chronic, Focal | 2 2 | 6 1.8|
Inflammation, Chronic, Multifocal | 2 3 | 10 2.5|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 49 |
Cytoplasmic Alteration, Focal | | 1 1.0|
Degeneration, Fatty, Focal | 2 | 5 2.0|
Degeneration, Fatty, Multifocal | | 2 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Hyperplasia, Focal | 3 | 2 2.5|
Hyperplasia, Multifocal | | 3 2.7|
Hypertrophy, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Hyperplasia, Focal | 3 2 | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + | 44 |
Hyperplasia, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 49 |
Pars Distalis, Hyperplasia, Focal | 1 | 3 1.3|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Congestion | 2 | 1 2.0|
C-Cell, Hyperplasia, Focal | 2 2 | 2 2.0|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
Follicular Cell, Depletion Secretory | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 50 |
Abscess | | 1 4.0|
Dilatation | | 1 4.0|
Hyperplasia | | 1 2.0|
Inflammation, Chronic, Focal | 1 | 8 1.6|
Inflammation, Chronic, Multifocal | 2 3 | 18 2.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 49 |
Hyperplasia, Focal | | 1 1.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 3 | 8 1.9|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Interstitial Cell, Hyperplasia, | | |
Multifocal | 3 | 22 2.0|
Seminiferous Tubule, Degeneration | 3 | 9 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 49 |
Myelofibrosis, Focal | | 1 2.0|
Erythroid Cell, Proliferation | 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myeloid Cell, Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Ectasia | | 1 4.0|
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Axillary, Infiltration Cellular, | | |
Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 49 |
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 6 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M | 48 |
Hemorrhage | 4 2 2 | 15 2.7|
Hemorrhage, Multifocal | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | I + + + + + + + | 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Subcutaneous Tissue, Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 49 |
Fibrous Osteodystrophy | | 2 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Mineralization, Multifocal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 3 3 3 3 3 | 11 3.1|
Edema, Focal | | 1 2.0|
Emphysema | | 1 4.0|
Foreign Body | | 1 1.0|
Hemorrhage, Focal | | 2 2.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 1 1.0|
Inflammation, Acute | | 1 3.0|
Inflammation, Multifocal, Suppurative| | 1 3.0|
Necrosis, Acute | | 1 4.0|
Pigmentation, Multifocal | | 1 2.0|
Alveolus, Inflammation, Chronic, | | |
Focal | | 1 1.0|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 2.0|
Perivascular, Edema, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Congestion | | 2 3.5|
Foreign Body | | 4 1.0|
Fungus | | 2 |
Inflammation, Chronic | | 5 2.0|
Inflammation, Suppurative | | 7 1.7|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 49 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 6 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Congestion | 2 | 2 2.5|
Cyst | | 3 |
Hydronephrosis, Chronic | | 1 2.0|
Hyperplasia, Multifocal, Tubular | | 5 1.0|
Nephropathy, Chronic | 1 2 3 4 2 4 4 | 43 2.4|
Pigmentation, Diffuse | | 1 4.0|
Pigmentation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05704-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:29:59
__________________________________________________________________________________________________________________________________
| 0| 2| 4| 7| 6| 4| 4| 5| 7| 7| | |
DAY ON TEST | 5| 6| 1| 3| 5| 4| 6| 3| 2| 2| | |
| 8| 9| 9| 0| 3| 3| 9| 8| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cortex, Mineralization, Multifocal | | 1 3.0|
Papilla, Transitional Epithelium, | | |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
Concretion | 3 | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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