TDMS Study 05704-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05704 RESORCINOL TIME: 18:06:24
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 05970A
CONT: 05700-04 CAS: 108-46-3
PATHOLOGIST: F. VOELKER S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05704 RESORCINOL TIME: 18:06:24
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 05970A
CONT: 05700-04 CAS: 108-46-3
PATHOLOGIST: F. VOELKER S. EUSTIS
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 287 287 384 478 499 558 563 569 585 610 |
| 629 642 644 652 657 657 660 677 692 694 |
| 721 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 112MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 10 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 279 380 492 492 532 532 562 566 588 596 |
| 601 616 624 629 637 639 650 650 666 679 |
| 692 708 712 714 719 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 225MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 14 TERMINAL 9 |
| |
| UNCENSORED DEATHS |
| 10 44 58 119 182 217 255 262 269 303 |
| 303 307 317 317 339 399 400 419 429 492 |
| 503 527 537 538 560 574 574 576 586 594 |
| 611 625 653 706 721 721 728 |
| CENSORED DEATHS |
| 282 330 412 429 434 436 440 443 454 456 |
| 456 456 456 469 |
| |
==================================================================================
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 96.7 95.0 93.0 91.0 82.9 66.7 56.6 |
| | |
| | |
|112MG/KG | 100.0 100.0 100.0 98.3 96.7 96.7 88.6 78.5 64.4 50.3 |
| | |
| | |
|225MG/KG | 95.0 93.3 85.0 74.8 69.5 67.7 55.2 40.1 32.6 22.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 112MG/KG 225MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.6% 50.3% 22.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.647 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 585.1 598.2 426.4 |
|NATURAL DEATHS (C) | (27.1) (21.1) (33.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 630.8 629.0 471.5 |
|(STANDARD ERROR) | (16.5) (15.4) (24.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 225MG/KG |
| --------------------- |
| |
| TOTAL 16 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 44 48 50 63 69 72 72 77 77 79 |
| 98 119 121 141 147 149 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 99999 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 1E5 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|225MG/KG | 37.5 6.3 6.3 6.3 6.3 6.3 6.3 6.3 6.3 6.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 225MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 6.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | ----- |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 89.1 |
|NATURAL DEATHS (C) | ( 8.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 89.1 |
|(STANDARD ERROR) | ( 8.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RESORCINOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
112MG/KG = 2
225MG/KG = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 21
| 3 3 3 21 1 2
| 3 3 1 1
| 3 3 3 1 21 2
90 + 3 3 1 11
| 333 2 11
| 3 3 21 1
| 1 2 1
P 80 + 3 3 1 1 1
E | 3 3 2 2 2
R | 3 3 1 1
C | 33 3 22
E 70 + 3 3 22
N | 3 3 221 1 1
T | 33 2 21 1
| 3 3 22 11
S 60 + 33 2 21 1
U | 2 211 1
R | 3 3
V | 3 3 22
I 50 + 2 2
V | 33
A | 33
L | 3 3
40 + 3 3
| 3 3
| 3 3
| 3 3
30 + 3 3
|
| 33
| 3 3
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
RESORCINOL
KAPLAN-MEIER SURVIVAL CURVES
225MG/KG = 1
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1
|
|
|
90 +
| 1 1
|
| 1 1
80 +
|
| 1 1
|
P 70 + 1 1
E |
R |
C |
E 60 +
N |
T |
|
S 50 +
U |
R | 1 1
V |
I 40 +
V | 1 1
A |
L | 1 1
30 +
|
| 1 1
|
20 + 1 1
|
|
|
10 +
| 1 1
|
|
0 +
|
---+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+----+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
WEEK