TDMS Study 05704-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
RESORCINOL
NTP Experiment-Test: 05704-03 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 18:48:42
Facility: International Research and Development Corp.
Chemical CAS #: 000108463
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 15 11 16 12
Dead 1 5 6 13
Accident 1
Dosing Accident 1
Survivors
Terminal Sacrifice 34 33 27 24
Dead 1
Animals Examined Microscopically 58 53 55 57
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ALIMENTARY SYSTEM
Esophagus (48) (47) (46) (48)
Abscess 1 (2%)
Intestine Large, Cecum (50) (50) (49) (46)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Colon (50) (50) (50) (48)
Parasite Metazoan 6 (12%) 4 (8%) 4 (8%) 6 (13%)
Intestine Large, Rectum (50) (50) (50) (47)
Parasite Metazoan 5 (10%) 4 (8%) 4 (9%)
Intestine Small, Duodenum (50) (50) (49) (48)
Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (50) (50) (49) (47)
Parasite Metazoan 1 (2%)
Liver (51) (50) (50) (51)
Angiectasis, Focal 3 (6%) 3 (6%) 5 (10%) 1 (2%)
Basophilic Focus 9 (18%) 14 (28%) 11 (22%) 7 (14%)
Basophilic Focus, Multiple 32 (63%) 27 (54%) 19 (38%) 27 (53%)
Clear Cell Focus 10 (20%) 5 (10%) 1 (2%) 7 (14%)
Clear Cell Focus, Multiple 2 (4%) 4 (8%) 3 (6%) 1 (2%)
Congestion, Focal 1 (2%) 3 (6%)
Cytoplasmic Alteration, Focal 3 (6%) 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Granuloma, Focal 1 (2%) 1 (2%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hepatodiaphragmatic Nodule 4 (8%) 9 (18%) 7 (14%) 7 (14%)
Hepatodiaphragmatic Nodule, Multiple 4 (8%) 2 (4%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Inflammation, Chronic, Focal 32 (63%) 25 (50%) 29 (58%) 24 (47%)
Necrosis, Focal 1 (2%) 2 (4%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pigmentation 1 (2%)
Bile Duct, Cyst 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 32 (63%) 23 (46%) 26 (52%) 35 (69%)
Centrilobular, Atrophy, Diffuse 1 (2%)
Centrilobular, Fatty Change 7 (14%) 8 (16%) 5 (10%) 1 (2%)
Periportal, Fatty Change 1 (2%)
Serosa, Fibrosis, Focal 2 (4%) 1 (2%)
Serosa, Inflammation, Chronic, Focal 1 (2%)
Mesentery (2) (2) (3)
Fat, Necrosis 2 (100%) 2 (100%) 2 (67%)
Pancreas (50) (49) (50) (49)
Atrophy, Focal 17 (34%) 15 (31%) 19 (38%) 13 (27%)
Focal Cellular Change 1 (2%) 1 (2%)
Hyperplasia, Focal 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Metaplasia, Focal 1 (2%)
Artery, Inflammation, Chronic, Focal 1 (2%)
Salivary Glands (50) (50) (48) (50)
Atrophy 3 (6%) 2 (4%)
Cyst 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Duct, Ectasia, Focal 1 (2%)
Stomach, Forestomach (50) (50) (48) (50)
Hyperplasia, Diffuse, Squamous 1 (2%) 2 (4%)
Hyperplasia, Focal, Squamous 1 (2%) 1 (2%)
Inflammation, Acute, Diffuse 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 3 (6%) 1 (2%)
Mineralization 1 (2%) 2 (4%)
Ulcer 1 (2%) 1 (2%) 2 (4%)
Stomach, Glandular (50) (50) (50) (50)
Erosion 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Mineralization 1 (2%) 2 (4%)
Ulcer 2 (4%) 1 (2%)
Tongue (1)
Epithelium, Hyperplasia, Focal 1 (100%)
Tooth (1) (3) (1)
Inflammation, Chronic 2 (67%) 1 (100%)
Gingiva, Foreign Body 1 (100%)
Gingiva, Hyperplasia, Focal, Squamous 1 (100%)
Gingiva, Inflammation, Chronic, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Inflammation, Chronic, Focal 28 (56%) 28 (56%) 29 (58%) 22 (44%)
Mineralization, Multifocal 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Artery, Hyperplasia, Focal 1 (2%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 1 (2%)
Endocardium, Hemorrhage, Focal 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Angiectasis 4 (8%) 3 (6%) 2 (4%)
Atrophy, Diffuse 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Cytoplasmic Alteration, Focal 2 (4%) 1 (2%) 1 (2%)
Degeneration, Ballooning, Focal 1 (2%)
Degeneration, Diffuse, Fatty 1 (2%)
Degeneration, Fatty, Focal 17 (34%) 15 (30%) 22 (44%) 10 (20%)
Hematocyst 2 (4%)
Hemorrhage, Focal 1 (2%)
Hyperplasia, Focal 14 (28%) 13 (26%) 7 (14%) 7 (14%)
Hypertrophy, Focal 2 (4%) 3 (6%) 2 (4%)
Mineralization, Focal 1 (2%)
Pigmentation 1 (2%)
Adrenal Gland, Medulla (48) (49) (45) (48)
Angiectasis 1 (2%)
Hematocyst 1 (2%)
Hyperplasia 14 (29%) 15 (31%) 14 (31%) 8 (17%)
Islets, Pancreatic (50) (47) (49) (49)
Hyperplasia, Focal 2 (4%) 2 (4%)
Parathyroid Gland (46) (39) (42) (41)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 1 (3%)
Hypoplasia, Diffuse 1 (3%)
Pituitary Gland (53) (51) (52) (52)
Amyloid Deposition 1 (2%)
Angiectasis 10 (19%) 6 (12%) 7 (13%) 7 (13%)
Cyst 17 (32%) 23 (45%) 21 (40%) 19 (37%)
Cyst, Multiple 4 (8%) 3 (6%) 9 (17%) 2 (4%)
Ectasia 1 (2%)
Pigmentation, Focal 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Angiectasis, Focal 3 (6%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia, Focal 8 (15%) 8 (16%) 11 (21%) 5 (10%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%)
Pars Distalis, Hypoplasia 1 (2%)
Pars Distalis, Metaplasia, Focal, Osseous 1 (2%)
Pars Nervosa, Metaplasia, Focal, Osseous 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Hemorrhage, Multifocal 1 (2%)
C-Cell, Hyperplasia, Focal 9 (18%) 12 (24%) 10 (20%) 1 (2%)
Follicular Cell, Metaplasia, Focal, Squamous 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (46) (41) (42) (49)
Atrophy 1 (2%) 1 (2%)
Concretion 1 (2%)
Dilatation 2 (4%) 1 (2%) 3 (6%)
Hyperplasia, Focal 3 (7%) 3 (7%) 1 (2%) 3 (6%)
Inflammation, Chronic, Focal 5 (11%) 4 (10%) 1 (2%) 2 (4%)
Inflammation, Suppurative 1 (2%)
Ovary (52) (50) (49) (51)
Congestion 2 (4%)
Cyst 7 (13%) 5 (10%) 4 (8%) 2 (4%)
Granuloma, Focal 1 (2%)
Corpus Luteum, Necrosis 1 (2%)
Periovarian Tissue, Necrosis, Focal 1 (2%)
Uterus (51) (52) (52) (52)
Dilatation 2 (4%) 1 (2%) 1 (2%)
Fibrosis 2 (4%)
Hydrometra 1 (2%) 1 (2%)
Hyperplasia, Chronic, Cystic 4 (8%) 1 (2%) 2 (4%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Suppurative 1 (2%)
Artery, Mineralization, Focal 1 (2%)
Cervix, Fibrosis 1 (2%) 1 (2%) 1 (2%)
Lumen, Hemorrhage 1 (2%) 1 (2%)
Serosa, Necrosis 1 (2%)
Vagina (2) (1)
Inflammation, Subacute 1 (100%)
Necrosis, Acute, Diffuse 1 (100%)
Prolapse 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (48)
Myelofibrosis, Focal 1 (2%) 1 (2%) 3 (6%)
Erythroid Cell, Proliferation 1 (2%) 3 (6%) 1 (2%)
Myeloid Cell, Proliferation 1 (2%) 1 (2%) 2 (4%)
Lymph Node (50) (50) (50) (50)
Congestion 1 (2%)
Axillary, Hyperplasia, Plasma Cell 1 (2%)
Axillary, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Iliac, Ectasia 1 (2%)
Iliac, Hyperplasia, Plasma Cell 1 (2%)
Iliac, Infiltration Cellular, Histiocyte 1 (2%)
Inguinal, Ectasia 2 (4%)
Inguinal, Hyperplasia, Lymphoid 1 (2%)
Inguinal, Hyperplasia, Plasma Cell 1 (2%)
Mandibular, Congestion 1 (2%) 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 2 (4%) 1 (2%) 2 (4%) 2 (4%)
Mediastinal, Congestion 2 (4%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%) 2 (4%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Mediastinal, Inflammation, Suppurative 1 (2%)
Mediastinal, Pigmentation 1 (2%)
Lymph Node, Mesenteric (50) (50) (48) (50)
Congestion 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Granuloma, Focal 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Spleen (50) (50) (51) (50)
Angiectasis 1 (2%)
Congestion, Focal 1 (2%) 2 (4%)
Fibrosis, Focal 2 (4%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 4 (8%) 2 (4%) 3 (6%) 5 (10%)
Hematopoietic Cell Proliferation Granulocytic 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis, Acute, Focal 1 (2%)
Thrombosis 1 (2%)
Capsule, Fibrosis 1 (2%) 1 (2%)
Thymus (47) (45) (48) (48)
Cyst 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Cyst, Multiple 2 (4%)
Hemorrhage 1 (2%) 1 (2%) 5 (10%)
Epithelial Cell, Hyperplasia 1 (2%)
Mediastinum, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (51) (50) (50) (50)
Galactocele 1 (2%) 1 (2%)
Galactocele, Multiple 1 (2%)
Hyperplasia, Cystic, Glandular 2 (4%)
Mineralization 1 (2%)
Skin (50) (50) (51) (50)
Developmental Malformation 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
Cranium, Hyperostosis 1 (2%)
Femur, Fibrous Osteodystrophy 1 (2%) 1 (2%)
Femur, Hyperostosis 3 (6%) 1 (2%)
Femur, Osteopetrosis 1 (2%) 2 (4%) 2 (4%)
Maxilla, Hyperostosis 1 (2%)
Turbinate, Hyperostosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Hemorrhage, Focal 2 (4%) 3 (6%) 1 (2%)
Spinal Cord (1)
Hemorrhage, Focal 1 (100%)
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RESPIRATORY SYSTEM
Lung (50) (50) (51) (50)
Congestion 7 (14%) 12 (24%) 11 (22%) 8 (16%)
Congestion, Diffuse 1 (2%)
Emphysema, Focal 1 (2%) 1 (2%)
Foreign Body 3 (6%) 1 (2%)
Granuloma, Focal 3 (6%)
Hemorrhage, Focal 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Focal 2 (4%) 4 (8%) 5 (10%) 2 (4%)
Inflammation, Acute, Focal 1 (2%) 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic, Focal 6 (12%) 3 (6%) 1 (2%) 5 (10%)
Metaplasia, Focal, Osseous 1 (2%)
Interstitium, Mineralization, Diffuse 1 (2%)
Interstitium, Mineralization, Focal 1 (2%)
Nose (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Foreign Body 1 (2%) 1 (2%) 2 (4%) 4 (8%)
Fungus 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Inflammation, Acute 1 (2%)
Inflammation, Acute, Focal 2 (4%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Focal, Suppurative 1 (2%) 2 (4%) 6 (12%)
Metaplasia, Squamous 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%) 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Trachea (50) (50) (50) (50)
Mineralization, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (7) (1) (3)
Atrophy 2 (29%)
Cataract 1 (33%)
Synechia 2 (29%)
Lens, Cataract 1 (33%) 5 (71%) 1 (100%) 2 (67%)
Retina, Degeneration 5 (71%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Congestion 2 (4%) 2 (4%) 3 (6%)
Cyst 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Degeneration, Diffuse, Hyaline 1 (2%)
Glomerulosclerosis 1 (2%)
Hemorrhage, Focal 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia 1 (2%)
Mineralization 1 (2%) 2 (4%)
Nephropathy, Chronic 47 (94%) 47 (94%) 48 (96%) 43 (86%)
Pigmentation 4 (8%) 2 (4%) 4 (8%) 3 (6%)
Pelvis, Hemorrhage 1 (2%)
Pelvis, Hyperplasia 1 (2%)
Pelvis, Inflammation, Chronic 2 (4%)
Pelvis, Mineralization 1 (2%)
Urinary Bladder (50) (49) (48) (49)
Inflammation, Chronic, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
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