TDMS Study 05704-03 Pathology Tables
NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 Facility: International Research and Development Corp. Chemical CAS #: 000108463 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5| DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6| | 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + I +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | + | Fat, Leukemia Mononuclear | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pharynx | | Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + I + + + + + + + + + + + + + M +| Leukemia Mononuclear | X X | Pheochromocytoma Complex | | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M M + + + + + + + + + + + M + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5| DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6| | 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X X X X X | Pars Distalis, Carcinoma | X | Pars Distalis, Leukemia Mononuclear | X | Pars Intermedia, Leukemia Mononuclear| X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + + + + M + + M + + + + + + + +| Adenoma | X X X | Adenoma, Multiple | | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X | Cervix, Leukemia Mononuclear | | __________________________________________________________________________| Vagina | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | X X | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | X X | Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5| DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6| | 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Adenoma | X | Fibroadenoma | X X X X X X X X X X X| Fibroadenoma, Multiple | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Epidermis, Basal Cell Adenoma | | Epidermis, Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | | Carcinoma, Metastatic, Thyroid Gland | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | | __________________________________________________________________________| Nose, Rectum | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5| DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6| | 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9| | 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | | Fat, Leukemia Mononuclear | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Pharynx | + | Squamous Cell Papilloma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Complex | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9| | 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X | Pars Distalis, Adenoma | X X X X X X X X X X X X| Pars Distalis, Carcinoma | | Pars Distalis, Leukemia Mononuclear | | Pars Intermedia, Leukemia Mononuclear| | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | C-Cell, Adenoma | | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M| Adenoma | X X X X | Adenoma, Multiple | | Leukemia Mononuclear | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Polyp Stromal | X X | Cervix, Leukemia Mononuclear | X | __________________________________________________________________________| Vagina | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X X | Mandibular, Leukemia Mononuclear | X X X | Mediastinal, Leukemia Mononuclear | X X X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9| | 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Adenoma | | Fibroadenoma | X X X X X X X X X X| Fibroadenoma, Multiple | | Leukemia Mononuclear | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Epidermis, Basal Cell Adenoma | X | Epidermis, Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | | Carcinoma, Metastatic, Thyroid Gland | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Osteosarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Nose, Rectum | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Thyroid Gland | | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6| DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9| | 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | | | 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + | 51 | Hepatocellular Adenoma | | 1 | Leukemia Mononuclear | X | 13 | __________________________________________________________________________|____________| Mesentery | + | 2 | Fat, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 50 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Pharynx | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Stomach | + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + | 50 | Leukemia Mononuclear | | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + | 48 | Leukemia Mononuclear | | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | | | 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + | 46 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + I + + + + | 53 | Adenoma | | 1 | Leukemia Mononuclear | | 3 | Pars Distalis, Adenoma | X X X X | 27 | Pars Distalis, Carcinoma | | 1 | Pars Distalis, Leukemia Mononuclear | | 1 | Pars Intermedia, Leukemia Mononuclear| | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + | 50 | Leukemia Mononuclear | | 2 | C-Cell, Adenoma | X | 2 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | | 2 | Follicular Cell, Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + M + + + | 46 | Adenoma | X | 8 | Adenoma, Multiple | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 52 | Granulosa Cell Tumor Benign | X | 1 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 51 | Leukemia Mononuclear | | 3 | Polyp Stromal | X X | 9 | Cervix, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Vagina | + | 2 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | | | 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 50 | Axillary, Leukemia Mononuclear | | 2 | Iliac, Leukemia Mononuclear | | 1 | Inguinal, Leukemia Mononuclear | | 4 | Mandibular, Leukemia Mononuclear | | 5 | Mediastinal, Leukemia Mononuclear | | 5 | Renal, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 50 | Leukemia Mononuclear | | 7 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 50 | Leukemia Mononuclear | X | 14 | __________________________________________________________________________|____________| Thymus | + + M + + + + + | 47 | Leukemia Mononuclear | | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 51 | Adenocarcinoma | | 1 | Adenoma | | 1 | Fibroadenoma | X X | 23 | Fibroadenoma, Multiple | X X | 3 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 50 | Epidermis, Basal Cell Adenoma | | 1 | Epidermis, Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 50 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + | 1 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | | DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | | | 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Leukemia Mononuclear | | 8 | Osteosarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + | 49 | Adenoma | X | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose, Rectum | + | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 50 | Carcinoma, Metastatic, Thyroid Gland | X | 1 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 50 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + | 50 | Leukemia Mononuclear | | 5 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + | 58 | Leukemia Mononuclear | X | 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5| | 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + M + + + M + + + + + + + | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + | Adenocarcinoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + | Adenoma | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Bilateral, Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + | Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + M + + M + + + + + + M + M + | Leukemia Mononuclear | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5| | 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X | Pars Distalis, Leukemia Mononuclear | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + | Adenoma | X X X X | Adenoma, Multiple | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Polyp Stromal | X X X X | Cervix, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + | Axillary, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + | Adenocarcinoma | | Fibroadenoma | X X X X X X X X | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5| | 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Epidermis, Basal Cell Adenoma | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Liposarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3| | 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | + | __________________________________________________________________________| Tooth | + + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Bilateral, Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + M + + + + + + + I + + I +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + M + M + M + + + M + + + + M + + M + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3| | 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X | Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + + M + + + + + + M + + + + M + +| Adenoma | X X | Adenoma, Multiple | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X | Cervix, Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X X X | Mediastinal, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + M + + + + + + + + M + + M +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X X X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7| DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3| | 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Epidermis, Basal Cell Adenoma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Liposarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + + +| __________________________________________________________________________| Harderian Gland | +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | | | 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + | 47 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + | 50 | Adenocarcinoma | | 1 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + | 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + | 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + | 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 50 | Leukemia Mononuclear | X X X X | 16 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + | 49 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | | 1 | __________________________________________________________________________|____________| Tooth | | 3 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + | 50 | Leukemia Mononuclear | X X X | 8 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + | 50 | Adenoma | | 1 | Leukemia Mononuclear | X X X X | 8 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + | 49 | Leukemia Mononuclear | X | 6 | Bilateral, Pheochromocytoma Benign | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | | | 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + | 47 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + | 39 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + | 51 | Leukemia Mononuclear | X | 3 | Pars Distalis, Adenoma | X X X X X X X X | 27 | Pars Distalis, Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Thyroid Gland | M + + + + + + + | 49 | Leukemia Mononuclear | | 1 | C-Cell, Adenoma | | 3 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M M + + + M M M | 41 | Adenoma | X | 7 | Adenoma, Multiple | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + | 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Uterus | + + + + + + + + | 52 | Leukemia Mononuclear | | 2 | Polyp Stromal | X X | 11 | Cervix, Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + | 50 | Leukemia Mononuclear | X X X | 7 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + | 50 | Axillary, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 1 | Inguinal, Leukemia Mononuclear | X | 3 | Mandibular, Leukemia Mononuclear | X X X | 7 | Mediastinal, Leukemia Mononuclear | X X X | 6 | Pancreatic, Leukemia Mononuclear | X X | 3 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | | | 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + | 50 | Leukemia Mononuclear | X X X X | 15 | __________________________________________________________________________|____________| Thymus | M + + + + + + + | 45 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + | 50 | Adenocarcinoma | X | 2 | Fibroadenoma | X | 14 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | Epidermis, Basal Cell Adenoma | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Liposarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + | 50 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + | 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Nose | + + + + + + + + | 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 7 | __________________________________________________________________________|____________| Harderian Gland | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + | 50 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + M + + + + + | 49 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + | 53 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | | | 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Mononuclear | X X X X | 16 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2| | 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +| Leiomyosarcoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + +| Leukemia Mononuclear | X| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + M + + + + + + I + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + M + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | X X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + I M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| Pars Distalis, Adenoma | X X X X X X X X X X | Pars Distalis, Carcinoma | | Pars Distalis, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2| | 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Intermedia, Leukemia Mononuclear| | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M M + + + + M + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Histiocytic Sarcoma | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X X X | Fibroadenoma, Multiple | X X | Leukemia Mononuclear | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | | Epidermis, Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6| DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2| | 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Leukemia Mononuclear | X X X X X| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7| DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2| | 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + +| Leiomyosarcoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Schwannoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + M M + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + I + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Parathyroid Gland | M + + + + M + + + + + + + + M M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Pars Distalis, Adenoma | X X X X X X X| Pars Distalis, Carcinoma | X | Pars Distalis, Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7| DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2| | 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Intermedia, Leukemia Mononuclear| X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M + + + + M + M + + + + + + M + + + +| Adenoma | X X | Carcinoma | X X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X X| __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + +| Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X X | Pancreatic, Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + M + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X | Fibroadenoma, Multiple | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | Epidermis, Squamous Cell Papilloma | | Subcutaneous Tissue, Fibroma | X | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7| DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2| | 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + + | Carcinoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + M M + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | | | 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + + M | 46 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + | 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + | 49 | Leiomyosarcoma | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + | 50 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 11 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + | 50 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + | 48 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + | 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + | 50 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 7 | Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + | 45 | Leukemia Mononuclear | X | 5 | Pheochromocytoma Benign | | 6 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + | 49 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M | 42 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | | | 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 52 | Leukemia Mononuclear | | 2 | Pars Distalis, Adenoma | X X X X | 21 | Pars Distalis, Carcinoma | | 1 | Pars Distalis, Leukemia Mononuclear | X | 3 | Pars Intermedia, Leukemia Mononuclear| | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + | 50 | C-Cell, Adenoma | | 4 | Follicular Cell, Adenoma | X | 1 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + M + + + + + | 42 | Adenoma | X X X | 6 | Carcinoma | | 3 | __________________________________________________________________________|____________| Ovary | + + + M + + + + + | 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 52 | Leukemia Mononuclear | | 2 | Polyp Stromal | X X | 10 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + | 50 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 50 | Mandibular, Leukemia Mononuclear | | 2 | Mediastinal, Leukemia Mononuclear | | 3 | Pancreatic, Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + | 48 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 51 | Leukemia Mononuclear | X X | 11 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + | 48 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | | | 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + | 50 | Adenocarcinoma | | 1 | Fibroadenoma | X X X X | 9 | Fibroadenoma, Multiple | | 3 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + | 51 | Keratoacanthoma | | 1 | Epidermis, Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + | 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + | 51 | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Nose | + + + + + + + + + | 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + | 50 | Leukemia Mononuclear | | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 2 | Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + | 50 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + | 48 | Leukemia Mononuclear | | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 55 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | | | 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | | 1 | Leukemia Mononuclear | X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4| DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5| | 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + | Schwannoma Malignant, Metastatic, | | Salivary Glands | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X | Lymphoma Malignant Mixed | | Schwannoma Malignant | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4| DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5| | 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Parathyroid Gland | + + M + + M + + M M + + + + + + + M + + M | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + | Schwannoma Malignant, Metastatic, | | Salivary Glands | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + | Adenoma | X X | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + | Deciduoma Benign | | Leukemia Mononuclear | X X | Lymphoma Malignant Mixed | | Polyp Stromal | X X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + M + + + + + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4| DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5| | 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Axillary, Leukemia Mononuclear | | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + | Adenocarcinoma | X X | Adenoma, Multiple | | Fibroadenoma | X X X | Fibroadenoma, Multiple | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + M + + + + + + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X | __________________________________________________________________________| Spinal Cord | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | + | Schwannoma Malignant, Metastatic, | | Salivary Glands | X | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4| DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5| | 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + | Leukemia Mononuclear | X X X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + | Leiomyosarcoma | X | Leukemia Mononuclear | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7| DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3| | 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + M + + + M + + + +| Schwannoma Malignant, Metastatic, | | Salivary Glands | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + A + + + + A + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + M + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + A + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + A + + + + A + + + + + + +| Leukemia Mononuclear | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + A + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + + | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Pancreas | + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Mixed | X | Schwannoma Malignant | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7| DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3| | 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + M + M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pars Distalis, Adenoma | X X X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + +| Schwannoma Malignant, Metastatic, | | Salivary Glands | | C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + +| Adenoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | X | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | X | Polyp Stromal | X X X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + A + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7| DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3| | 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Axillary, Leukemia Mononuclear | X | Iliac, Leukemia Mononuclear | X | Inguinal, Leukemia Mononuclear | X | Mandibular, Leukemia Mononuclear | X X | Mediastinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + M M| Leukemia Mononuclear | X X X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Adenoma, Multiple | X | Fibroadenoma | X X X | Fibroadenoma, Multiple | X| Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + M + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Spinal Cord | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Larynx | | Schwannoma Malignant, Metastatic, | | Salivary Glands | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 _____________________________________________________________________________________________________________________ | 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7| DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3| | 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + +| Leiomyosarcoma | | Leukemia Mononuclear | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | | | 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + | 48 | Schwannoma Malignant, Metastatic, | | | Salivary Glands | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + | 46 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + | 48 | Leukemia Mononuclear | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + | 47 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + | 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + | 48 | Leukemia Mononuclear | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + | 47 | Leukemia Mononuclear | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + | 48 | Leukemia Mononuclear | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + | 51 | Leukemia Mononuclear | X X | 15 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + | 49 | Leukemia Mononuclear | | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + | 50 | Leukemia Mononuclear | | 3 | Lymphoma Malignant Mixed | | 1 | Schwannoma Malignant | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + | 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + | 50 | Leukemia Mononuclear | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 42 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | | | 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + | 50 | Leukemia Mononuclear | | 9 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + | 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + | 50 | Leukemia Mononuclear | | 6 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + M + | 48 | Leukemia Mononuclear | | 2 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + | 41 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + | 52 | Leukemia Mononuclear | | 2 | Pars Distalis, Adenoma | X | 23 | Pars Distalis, Adenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + | 50 | Schwannoma Malignant, Metastatic, | | | Salivary Glands | | 1 | C-Cell, Adenoma | X | 4 | C-Cell, Carcinoma | | 1 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + | 49 | Adenoma | X | 4 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + | 51 | Leukemia Mononuclear | | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + | 52 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | | | 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Deciduoma Benign | | 1 | Leukemia Mononuclear | | 3 | Lymphoma Malignant Mixed | | 1 | Polyp Stromal | X X X | 8 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + | 48 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + | 50 | Axillary, Leukemia Mononuclear | | 1 | Iliac, Leukemia Mononuclear | | 2 | Inguinal, Leukemia Mononuclear | | 2 | Mandibular, Leukemia Mononuclear | | 4 | Mediastinal, Leukemia Mononuclear | | 3 | Pancreatic, Leukemia Mononuclear | | 2 | Renal, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + | 50 | Leukemia Mononuclear | X X | 9 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + | 50 | Leukemia Mononuclear | X X | 15 | __________________________________________________________________________|____________| Thymus | + + + + + + + | 48 | Leukemia Mononuclear | X X | 8 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + | 50 | Adenocarcinoma | | 3 | Adenoma, Multiple | | 1 | Fibroadenoma | X X | 8 | Fibroadenoma, Multiple | | 1 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + | 50 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + | 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05704-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC RESORCINOL Date: 04/09/97 Route: GAVAGE Time: 15:44:57 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | | | 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L | G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + | 49 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Spinal Cord | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | | 1 | Schwannoma Malignant, Metastatic, | | | Salivary Glands | | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + | 50 | Leukemia Mononuclear | X X | 10 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + | 50 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Trachea | + + + + + + + | 50 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + | 50 | Leukemia Mononuclear | | 9 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + | 49 | Leiomyosarcoma | | 1 | Leukemia Mononuclear | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + | 57 | Leukemia Mononuclear | X X | 15 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------