TDMS Study 05704-03 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
RESORCINOL
NTP Experiment-Test: 05704-03 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 18:48:44
Facility: International Research and Development Corp.
Chemical CAS #: 000108463
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:44
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FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
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DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 15 11 16 12
Dead 1 5 6 13
Accident 1
Dosing Accident 1
Survivors
Terminal Sacrifice 34 33 27 24
Dead 1
Animals Examined Microscopically 58 53 55 57
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ALIMENTARY SYSTEM
Esophagus (48) (47) (46) (48)
Schwannoma Malignant, Metastatic, Salivary
Glands 1 (2%)
Intestine Large, Cecum (50) (50) (49) (46)
Adenocarcinoma 1 (2%)
Intestine Large, Colon (50) (50) (50) (48)
Intestine Large, Rectum (50) (50) (50) (47)
Intestine Small, Duodenum (50) (50) (49) (48)
Intestine Small, Ileum (50) (50) (49) (47)
Intestine Small, Jejunum (50) (50) (49) (48)
Leiomyosarcoma 1 (2%)
Liver (51) (50) (50) (51)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Mesentery (2) (2) (3)
Pancreas (50) (49) (50) (49)
Pharynx (1)
Squamous Cell Papilloma 1 (100%)
Salivary Glands (50) (50) (48) (50)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (50) (48) (50)
Stomach, Glandular (50) (50) (50) (50)
Tooth (1) (3) (1)
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NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Schwannoma Malignant 1 (2%)
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ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Adrenal Gland, Medulla (48) (49) (45) (48)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 6 (13%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (47) (49) (49)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Parathyroid Gland (46) (39) (42) (41)
Pituitary Gland (53) (51) (52) (52)
Adenoma 1 (2%)
Pars Distalis, Adenoma 27 (51%) 27 (53%) 21 (40%) 23 (44%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (50) (49) (50) (50)
Schwannoma Malignant, Metastatic, Salivary
Glands 1 (2%)
C-Cell, Adenoma 2 (4%) 3 (6%) 4 (8%) 4 (8%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 1 (2%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (46) (41) (42) (49)
Adenoma 8 (17%) 7 (17%) 6 (14%) 4 (8%)
Adenoma, Multiple 1 (2%) 1 (2%)
Carcinoma 3 (7%)
Ovary (52) (50) (49) (51)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (51) (52) (52) (52)
Deciduoma Benign 1 (2%)
Polyp Stromal 9 (18%) 11 (21%) 10 (19%) 8 (15%)
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NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Sarcoma Stromal 1 (2%)
Vagina (2) (1)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (48)
Lymph Node (50) (50) (50) (50)
Pancreatic, Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (50) (48) (50)
Spleen (50) (50) (51) (50)
Thymus (47) (45) (48) (48)
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INTEGUMENTARY SYSTEM
Mammary Gland (51) (50) (50) (50)
Adenocarcinoma 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Adenoma 1 (2%)
Adenoma, Multiple 1 (2%)
Fibroadenoma 23 (45%) 14 (28%) 9 (18%) 8 (16%)
Fibroadenoma, Multiple 3 (6%) 3 (6%) 1 (2%)
Skin (50) (50) (51) (50)
Keratoacanthoma 1 (2%)
Epidermis, Basal Cell Adenoma 1 (2%) 1 (2%)
Epidermis, Squamous Cell Papilloma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Liposarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (49)
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NERVOUS SYSTEM
Brain (50) (50) (50) (49)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Spinal Cord (1)
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NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (1) (1)
Carcinoma, Metastatic, Thyroid Gland 1 (100%)
Schwannoma Malignant, Metastatic, Salivary
Glands 1 (100%)
Lung (50) (50) (51) (50)
Histiocytic Sarcoma 1 (2%)
Osteosarcoma, Metastatic, Uncertain Primary
Site 1 (2%)
Nose (49) (50) (50) (50)
Adenoma 1 (2%)
Trachea (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
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SPECIAL SENSES SYSTEM
Harderian Gland (1)
Zymbal's Gland (2)
Carcinoma 2 (100%)
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URINARY SYSTEM
Kidney (50) (50) (50) (50)
Urinary Bladder (50) (49) (48) (49)
Leiomyosarcoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(58) *(53) *(55) *(57)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 14 (24%) 16 (30%) 11 (20%) 15 (26%)
Lymphoma Malignant Mixed 1 (2%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05704-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 18:48:44
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE/ 50 MG/KG 100 MG/K 150 MG/K
CONTROL G G
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 53 49 47 46
Total Primary Neoplasms 107 89 87 76
Total Animals with Benign Neoplasms 47 44 39 36
Total Benign Neoplasms 86 67 63 53
Total Animals with Malignant Neoplasms 20 21 21 21
Total Malignant Neoplasms 21 22 24 23
Total Animals with Metastatic Neoplasms 2 1 1
Total Metastatic Neoplasm 3 1 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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