TDMS Study 05704-03 Pathology Tables
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
Facility: International Research and Development Corp.
Chemical CAS #: 000108463
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5|
DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6|
| 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 2 |
Basophilic Focus | X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Clear Cell Focus, Multiple | X |
Congestion, Focal | |
Hematocyst | |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | X X |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 1 1 1 2 3 1 2 3 1 2 2 2 2 2 1 3 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 2 1 4 2 4 1 1 1 1 1 |
Centrilobular, Fatty Change | 3 3 |
Serosa, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 2 1 2 1 |
Focal Cellular Change | X |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Duct, Ectasia, Focal | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Squamous | |
Inflammation, Chronic, Diffuse | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5|
DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6|
| 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
__________________________________________________________________________|
Tooth | + |
Gingiva, Foreign Body | 3 |
Gingiva, Hyperplasia, Focal, Squamous| 3 |
Gingiva, Inflammation, Chronic, Focal| 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 1 2 2 |
Endocardium, Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Cyst | X |
Cytoplasmic Alteration, Focal | 1 |
Degeneration, Ballooning, Focal | 4 |
Degeneration, Fatty, Focal | 2 1 3 3 2 2 |
Hematocyst | |
Hyperplasia, Focal | 2 2 2 2 2 |
Hypertrophy, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + I + + + + + + + + + + + + + M +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | 4 3 3 |
Cyst | X X X X X X |
Cyst, Multiple | X X |
Ectasia | 3 |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 3 1 |
Follicular Cell, Metaplasia, Focal, | |
Squamous | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5|
DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6|
| 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + M + + M + + + + + + + +|
Dilatation | 4 |
Hyperplasia, Focal | 3 3 |
Inflammation, Chronic, Focal | 2 1 3 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Corpus Luteum, Necrosis | 4 |
Periovarian Tissue, Necrosis, Focal | 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Chronic, Cystic | 2 |
Cervix, Fibrosis | |
Serosa, Necrosis | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | 3 |
Erythroid Cell, Proliferation | 3 |
Myeloid Cell, Proliferation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Histiocyte | |
Iliac, Hyperplasia, Plasma Cell | |
Mandibular, Congestion | 4 |
Mandibular, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Hemorrhage | |
Mediastinal, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 3 3 2|
Hyperplasia, Lymphoid | |
Capsule, Fibrosis | 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + M +|
Cyst | X |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5|
DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6|
| 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | 2 1 |
Hemorrhage, Focal | |
Hyperplasia, Focal | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | X |
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Suppurative | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Nose, Rectum | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Lens, Cataract | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Glomerulosclerosis | |
Hyperplasia | |
Nephropathy, Chronic | 4 3 2 3 1 3 3 4 3 3 4 3 4 1 2 2 3 3 3 4 4 |
Pigmentation | 4 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 4| 6| 7| 6| 7| 7| 7| 5| 4| 7| 6| 7| 7| 7| 5| 7| 7| 7| 4| 7| 5|
DAY ON TEST | 4| 2| 3| 2| 5| 2| 3| 9| 3| 3| 2| 2| 5| 3| 9| 1| 3| 2| 7| 2| 3| 3| 5| 3| 6|
| 5| 9| 1| 9| 7| 3| 0| 5| 0| 0| 9| 1| 7| 0| 3| 7| 0| 9| 9| 9| 1| 1| 7| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pelvis, Hemorrhage | |
Pelvis, Hyperplasia | |
Pelvis, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9|
| 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X|
Basophilic Focus, Multiple | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X |
Clear Cell Focus, Multiple | X |
Congestion, Focal | 2 |
Hematocyst | X |
Hepatodiaphragmatic Nodule | |
Hepatodiaphragmatic Nodule, Multiple | X X |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 4 2 1 3 3 1 2 2 2 1 2 3 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 1 1 1 2 3 2 3 4 2 4 1 2 1 4 1 |
Centrilobular, Fatty Change | 4 2 3 3 3 |
Serosa, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 3 1 |
Focal Cellular Change | |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Duct, Ectasia, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Squamous | 4 |
Inflammation, Chronic, Diffuse | 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9|
| 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
__________________________________________________________________________|
Tooth | |
Gingiva, Foreign Body | |
Gingiva, Hyperplasia, Focal, Squamous| |
Gingiva, Inflammation, Chronic, Focal| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 2 2 2 2|
Endocardium, Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Cytoplasmic Alteration, Focal | 1 |
Degeneration, Ballooning, Focal | |
Degeneration, Fatty, Focal | 1 1 1 2 2 1 1 1 |
Hematocyst | X |
Hyperplasia, Focal | 1 1 2 3 2 2 2|
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 1 1 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Angiectasis | 4 3 3 4 |
Cyst | X X X X X X |
Cyst, Multiple | X X |
Ectasia | |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 2 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 1 |
Follicular Cell, Metaplasia, Focal, | |
Squamous | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9|
| 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M|
Dilatation | 2 |
Hyperplasia, Focal | 3 |
Inflammation, Chronic, Focal | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Corpus Luteum, Necrosis | |
Periovarian Tissue, Necrosis, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Chronic, Cystic | 3 |
Cervix, Fibrosis | |
Serosa, Necrosis | 3 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | |
Erythroid Cell, Proliferation | |
Myeloid Cell, Proliferation | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Histiocyte | 2 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Mandibular, Congestion | |
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Hemorrhage | 4 |
Mediastinal, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 3|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 1 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9|
| 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Foreign Body | |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 1 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 2 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Focal, Suppurative | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
__________________________________________________________________________|
Nose, Rectum | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Lens, Cataract | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Glomerulosclerosis | 3 |
Hyperplasia | |
Nephropathy, Chronic | 2 2 4 3 4 2 2 1 3 2 2 2 1 3 4 3 2 2 2|
Pigmentation | 3 2 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 6| 7| 7| 4| 4| 5| 7| 6| 7| 6| 4| 7| 6|
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 5| 5| 5| 3| 3| 8| 2| 2| 5| 5| 0| 3| 6| 3| 3| 5| 2| 9|
| 0| 0| 0| 9| 1| 1| 1| 7| 7| 3| 0| 1| 8| 9| 9| 7| 7| 9| 1| 2| 1| 0| 7| 9| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
VEHICLE/ | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Pelvis, Hemorrhage | |
Pelvis, Hyperplasia | 3 |
Pelvis, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | |
| 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 50 |
Parasite Metazoan | X | 5 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 51 |
Angiectasis, Focal | 2 | 3 2.3|
Basophilic Focus | X X X | 9 |
Basophilic Focus, Multiple | X X X X X | 32 |
Clear Cell Focus | | 10 |
Clear Cell Focus, Multiple | | 2 |
Congestion, Focal | | 1 2.0|
Hematocyst | | 1 |
Hepatodiaphragmatic Nodule | X X | 4 |
Hepatodiaphragmatic Nodule, Multiple | | 4 |
Hyperplasia, Focal | 3 | 1 3.0|
Inflammation, Chronic, Focal | 1 4 2 4 | 32 2.1|
Necrosis, Focal | 3 | 1 3.0|
Bile Duct, Hyperplasia | 1 2 4 1 | 32 2.0|
Centrilobular, Fatty Change | | 7 3.0|
Serosa, Fibrosis, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Atrophy, Focal | 2 2 1 2 2 | 17 1.7|
Focal Cellular Change | | 1 |
Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Inflammation, Chronic | | 1 2.0|
Duct, Ectasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | |
| 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperplasia, Diffuse, Squamous | | 1 4.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Erosion | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Gingiva, Foreign Body | | 1 3.0|
Gingiva, Hyperplasia, Focal, Squamous| | 1 3.0|
Gingiva, Inflammation, Chronic, Focal| | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 | 28 2.0|
Endocardium, Hemorrhage, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Angiectasis | | 4 2.0|
Cyst | | 1 |
Cytoplasmic Alteration, Focal | | 2 1.0|
Degeneration, Ballooning, Focal | | 1 4.0|
Degeneration, Fatty, Focal | 2 1 2 | 17 1.6|
Hematocyst | X | 2 |
Hyperplasia, Focal | 1 2 | 14 1.9|
Hypertrophy, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 48 |
Hyperplasia | 2 1 1 2 | 14 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I + + + + | 53 |
Amyloid Deposition | | 1 4.0|
Angiectasis | 2 4 3 | 10 3.3|
Cyst | X X X X X | 17 |
Cyst, Multiple | | 4 |
Ectasia | | 1 3.0|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 8 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | |
| 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 50 |
C-Cell, Hyperplasia, Focal | 2 1 | 9 1.8|
Follicular Cell, Metaplasia, Focal, | | |
Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + | 46 |
Dilatation | | 2 3.0|
Hyperplasia, Focal | | 3 3.0|
Inflammation, Chronic, Focal | 2 | 5 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 52 |
Cyst | | 7 |
Corpus Luteum, Necrosis | | 1 4.0|
Periovarian Tissue, Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 51 |
Hyperplasia, Chronic, Cystic | 2 3 | 4 2.5|
Cervix, Fibrosis | 4 | 1 4.0|
Serosa, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myelofibrosis, Focal | | 1 3.0|
Erythroid Cell, Proliferation | | 1 3.0|
Myeloid Cell, Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Axillary, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 1 3.0|
Mandibular, Congestion | | 1 4.0|
Mandibular, Hyperplasia, Plasma Cell | 4 | 2 4.0|
Mediastinal, Hemorrhage | | 1 4.0|
Mediastinal, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | |
| 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Congestion | | 1 2.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Angiectasis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 4 3.0|
Hyperplasia, Lymphoid | | 1 1.0|
Capsule, Fibrosis | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + | 47 |
Cyst | | 1 |
Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 51 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Femur, Osteopetrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hemorrhage, Focal | | 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 2 2 2 | 7 2.0|
Foreign Body | 2 | 3 1.7|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal | | 2 1.5|
Inflammation, Acute, Focal | 3 | 1 3.0|
Inflammation, Chronic, Focal | 1 | 6 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 49 |
Foreign Body | | 1 1.0|
Fungus | | 1 |
Inflammation, Chronic, Focal | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 4| 7| 4| | |
DAY ON TEST | 3| 1| 2| 3| 2| 2| 3| 5| 2| 5| | |
| 1| 7| 9| 0| 9| 9| 0| 7| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
VEHICLE/ | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Focal, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Nose, Rectum | + | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Cataract | | 1 3.0|
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Cyst | | 2 |
Glomerulosclerosis | | 1 3.0|
Hyperplasia | 4 | 1 4.0|
Nephropathy, Chronic | 4 2 2 2 2 3 4 | 47 2.7|
Pigmentation | 2 | 4 2.8|
Pelvis, Hemorrhage | 3 | 1 3.0|
Pelvis, Hyperplasia | | 1 3.0|
Pelvis, Inflammation, Chronic | 4 | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5|
| 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + M + + + + + + + |
Abscess | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Angiectasis, Focal | 1 |
Basophilic Focus | X X X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X X |
Congestion, Focal | 2 2 |
Cytoplasmic Alteration, Focal | 2 2 |
Granuloma, Focal | |
Hepatodiaphragmatic Nodule | X X X |
Hepatodiaphragmatic Nodule, Multiple | |
Inflammation, Chronic, Focal | 1 2 1 1 2 1 2 2 1 2 2 2 |
Necrosis, Focal | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 2 1 3 1 1 1 1 1 1 3 1 |
Centrilobular, Atrophy, Diffuse | |
Centrilobular, Fatty Change | 4 4 |
Serosa, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 3 2 2 2 2 1 1 1 |
Focal Cellular Change | |
Hyperplasia, Focal | |
Metaplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5|
| 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Erosion | |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 2 1 2 2 2 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty, Focal | 2 2 1 2 2 |
Hemorrhage, Focal | |
Hyperplasia, Focal | 2 2 3 |
Mineralization, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + + + + M + M + |
Hyperplasia, Focal | |
Hypoplasia, Diffuse | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 3 |
Cyst | X X X X X X X X X |
Cyst, Multiple | X X |
Pigmentation, Focal | |
Pars Distalis, Angiectasis, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Metaplasia, Focal, | |
Osseous | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Hemorrhage, Multifocal | |
C-Cell, Hyperplasia, Focal | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5|
| 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + |
Atrophy | 4 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | X |
Granuloma, Focal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + |
Dilatation | |
Fibrosis | 4 4 |
Hydrometra | |
Cervix, Fibrosis | 4 |
Lumen, Hemorrhage | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
Myelofibrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + |
Iliac, Ectasia | |
Iliac, Infiltration Cellular, | |
Histiocyte | |
Mandibular, Congestion | |
Mandibular, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Congestion | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Fibrosis, Focal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + |
Cyst | |
Cyst, Multiple | X |
Hemorrhage | |
Mediastinum, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Galactocele | |
Galactocele, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 6| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 5| 7| 7| 3| 2| 2| 5| 5| 2| 3| 6| 3| 3| 5| 2| 3| 5| 2| 7| 3| 5|
| 1| 1| 1| 1| 7| 3| 4| 1| 9| 9| 7| 7| 9| 1| 3| 1| 1| 7| 9| 0| 7| 9| 4| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Cranium, Hyperostosis | |
Femur, Hyperostosis | X X |
Femur, Osteopetrosis | |
Turbinate, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Hemorrhage, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Congestion | 2 3 2 2 |
Emphysema, Focal | |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Foreign Body | |
Fungus | X |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
Synechia | 3 |
Lens, Cataract | 2 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | X |
Hemorrhage, Focal | |
Nephropathy, Chronic | 3 3 2 2 2 2 3 2 2 1 4 2 2 3 2 1 2 4 |
Pigmentation | 2 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3|
| 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + +|
Abscess | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X X X X|
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X X |
Congestion, Focal | 2 |
Cytoplasmic Alteration, Focal | 2 |
Granuloma, Focal | 3|
Hepatodiaphragmatic Nodule | X X X X X X|
Hepatodiaphragmatic Nodule, Multiple | X X |
Inflammation, Chronic, Focal | 1 1 3 3 2 3 2 1 1 2 4|
Necrosis, Focal | 3 2 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 1 2 2 3 2 2 1 2 |
Centrilobular, Atrophy, Diffuse | 3 |
Centrilobular, Fatty Change | 4 2 4 |
Serosa, Fibrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + M + + + + + + + +|
Atrophy, Focal | 1 1 1 2 2 |
Focal Cellular Change | X |
Hyperplasia, Focal | 2 |
Metaplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | 3 |
Inflammation, Chronic, Focal | 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3|
| 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Tooth | + + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 3 2 2 2 2 2 2 2 2 2 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Fatty, Focal | 2 2 3 2 2 2 2 |
Hemorrhage, Focal | 3 |
Hyperplasia, Focal | 3 3 3 2 3 2 3|
Mineralization, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + M + + + + + + + I + + I +|
Hyperplasia, Focal | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + M + M + + + M + + + + M + + M + +|
Hyperplasia, Focal | 3 |
Hypoplasia, Diffuse | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 3 4 |
Cyst | X X X X X X X X X X X X X|
Cyst, Multiple | X |
Pigmentation, Focal | 3 |
Pars Distalis, Angiectasis, Focal | 3 4 |
Pars Distalis, Hyperplasia, Focal | 3 3 2 2 2 2|
Pars Distalis, Metaplasia, Focal, | |
Osseous | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 2 |
C-Cell, Hyperplasia, Focal | 3 2 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3|
| 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + M + + + + M + +|
Atrophy | |
Hyperplasia, Focal | 3 3 |
Inflammation, Chronic, Focal | 3 2 2|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Cyst | X X |
Granuloma, Focal | 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
Fibrosis | |
Hydrometra | 4 |
Cervix, Fibrosis | |
Lumen, Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Iliac, Ectasia | |
Iliac, Infiltration Cellular, | |
Histiocyte | |
Mandibular, Congestion | 3 |
Mandibular, Hyperplasia, Plasma Cell | |
Mediastinal, Congestion | 3 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + M + + M +|
Cyst | X |
Cyst, Multiple | |
Hemorrhage | 3 |
Mediastinum, Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Galactocele, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 5| 1| 7| 7| 7| 6| 7| 7| 6| 7| 7| 4| 6| 7| 4| 7| 6| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 7| 2| 2| 0| 3| 3| 1| 7| 3| 2| 4| 3| 2| 5| 2| 2| 5| 2| 9| 3| 6| 3| 3|
| 0| 1| 2| 9| 4| 1| 1| 0| 6| 8| 0| 9| 6| 0| 9| 7| 9| 9| 7| 9| 3| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
50 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Hyperostosis | X |
Femur, Hyperostosis | X |
Femur, Osteopetrosis | 4 4 |
Turbinate, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 2 3 2 2 2|
Emphysema, Focal | 2 |
Hemorrhage, Focal | |
Hyperplasia, Focal | 2 2 2 |
Inflammation, Chronic, Focal | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | X |
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + +|
Atrophy | 4 |
Synechia | 3 |
Lens, Cataract | 2 2 4 |
Retina, Degeneration | 4 4 4 |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Cyst | |
Hemorrhage, Focal | 2 |
Nephropathy, Chronic | 2 2 3 2 3 2 2 3 3 2 3 4 3 1 1 2 1 3 3 2 2|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | |
| 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 47 |
Abscess | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 50 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 50 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Angiectasis, Focal | 2 | 3 1.7|
Basophilic Focus | X X | 14 |
Basophilic Focus, Multiple | X X X X | 27 |
Clear Cell Focus | X | 5 |
Clear Cell Focus, Multiple | | 4 |
Congestion, Focal | | 3 2.0|
Cytoplasmic Alteration, Focal | | 3 2.0|
Granuloma, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | | 9 |
Hepatodiaphragmatic Nodule, Multiple | | 2 |
Inflammation, Chronic, Focal | 2 2 | 25 1.8|
Necrosis, Focal | | 2 2.5|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 1 3 | 23 1.6|
Centrilobular, Atrophy, Diffuse | | 1 3.0|
Centrilobular, Fatty Change | 4 3 2 | 8 3.4|
Serosa, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 49 |
Atrophy, Focal | 2 2 | 15 1.7|
Focal Cellular Change | | 1 |
Hyperplasia, Focal | | 1 2.0|
Metaplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Atrophy | 3 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | |
| 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 50 |
Hyperplasia, Focal, Squamous | | 1 3.0|
Inflammation, Chronic, Focal | | 3 2.7|
Ulcer | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Erosion | | 1 3.0|
Ulcer | | 2 3.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Inflammation, Chronic | | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Inflammation, Chronic, Focal | 2 2 2 2 1 | 28 2.0|
Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 50 |
Angiectasis | | 3 2.3|
Cytoplasmic Alteration, Focal | | 1 2.0|
Degeneration, Fatty, Focal | 2 2 2 | 15 2.0|
Hemorrhage, Focal | | 1 3.0|
Hyperplasia, Focal | 2 2 1 | 13 2.4|
Mineralization, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 49 |
Hyperplasia | 1 2 1 1 | 15 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 47 |
Hyperplasia, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + | 39 |
Hyperplasia, Focal | | 1 3.0|
Hypoplasia, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 51 |
Angiectasis | | 6 3.2|
Cyst | X | 23 |
Cyst, Multiple | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | |
| 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pigmentation, Focal | | 1 3.0|
Pars Distalis, Angiectasis, Focal | | 3 3.0|
Pars Distalis, Hyperplasia, Focal | | 8 2.3|
Pars Distalis, Metaplasia, Focal, | | |
Osseous | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + | 49 |
Hemorrhage, Multifocal | | 1 2.0|
C-Cell, Hyperplasia, Focal | 1 1 | 12 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M M + + + M M M | 41 |
Atrophy | | 1 4.0|
Hyperplasia, Focal | | 3 2.7|
Inflammation, Chronic, Focal | | 4 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 50 |
Congestion | | 2 2.0|
Cyst | X X | 5 |
Granuloma, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 52 |
Dilatation | | 2 2.5|
Fibrosis | | 2 4.0|
Hydrometra | | 1 4.0|
Cervix, Fibrosis | | 1 4.0|
Lumen, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myelofibrosis, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Iliac, Ectasia | 2 | 1 2.0|
Iliac, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
Mandibular, Congestion | | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | | 1 2.0|
Mediastinal, Congestion | | 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | |
| 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 50 |
Congestion | | 1 3.0|
Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + | 45 |
Cyst | | 1 |
Cyst, Multiple | X | 2 |
Hemorrhage | | 1 3.0|
Mediastinum, Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
Galactocele | X | 1 |
Galactocele, Multiple | X | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Cranium, Hyperostosis | | 1 |
Femur, Hyperostosis | | 3 |
Femur, Osteopetrosis | | 2 4.0|
Turbinate, Hyperostosis | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Hemorrhage, Focal | 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion | 2 | 12 2.4|
Emphysema, Focal | | 1 2.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia, Focal | | 4 2.0|
Inflammation, Chronic, Focal | 3 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Foreign Body | | 1 1.0|
Fungus | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 4| 7| 7| 7| 6| 6| 6| | |
DAY ON TEST | 5| 5| 3| 5| 2| 3| 3| 9| 8| 8| | |
| 6| 7| 0| 7| 9| 0| 0| 9| 0| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
50 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Focal, Suppurative | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 7 |
Atrophy | | 2 4.0|
Synechia | | 2 3.0|
Lens, Cataract | | 5 2.6|
Retina, Degeneration | 4 | 5 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Congestion | | 2 2.5|
Cyst | | 1 |
Hemorrhage, Focal | | 1 2.0|
Nephropathy, Chronic | 4 4 2 2 3 4 3 3 | 47 2.5|
Pigmentation | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2|
| 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 2 2 2 |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X X X X X X X |
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Cytoplasmic Alteration, Focal | 2 |
Fibrosis, Focal | 1 |
Hepatodiaphragmatic Nodule | X X X X |
Hepatodiaphragmatic Nodule, Multiple | X |
Inflammation, Chronic, Focal | 3 2 2 3 3 1 1 2 1 2 1 |
Necrosis, Focal | |
Pigmentation | 3 |
Bile Duct, Hyperplasia | 4 1 2 1 1 2 2 1 1 1 1 2 |
Centrilobular, Fatty Change | 3 3 |
Periportal, Fatty Change | |
Serosa, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 2 1 2 2 |
Inflammation, Chronic, Focal | |
Artery, Inflammation, Chronic, Focal | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + I + + + +|
Hyperplasia, Diffuse, Squamous | 4 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic, Diffuse | 4 |
Inflammation, Chronic, Focal | |
Mineralization | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2|
| 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 1|
Mineralization | 4 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 3 2 2 1 2 2 |
Mineralization, Multifocal | 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy, Diffuse | 3 |
Congestion | 4 |
Cytoplasmic Alteration, Focal | |
Degeneration, Fatty, Focal | 2 2 2 2 1 3 2 2 3 2 2 |
Hyperplasia, Focal | 1 2 1 1 |
Hypertrophy, Focal | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + M + +|
Hematocyst | X |
Hyperplasia | 1 4 1 3 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + I M + + +|
Hyperplasia, Diffuse | 4 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 3 2 3 |
Cyst | X X X X X X X X X X X X X X X |
Cyst, Multiple | X|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 2 1 2 2 |
Pars Distalis, Hypoplasia | 3 |
Pars Nervosa, Metaplasia, Focal, | |
Osseous | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M M + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2|
| 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Concretion | 2 |
Dilatation | 4 |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Chronic, Cystic | |
Hyperplasia, Cystic | 2 |
Lumen, Hemorrhage | |
__________________________________________________________________________|
Vagina | + |
Inflammation, Subacute | 4 |
Necrosis, Acute, Diffuse | 4 |
Prolapse | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | 2 4 |
Erythroid Cell, Proliferation | 4 |
Myeloid Cell, Proliferation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Histiocyte | |
Inguinal, Ectasia | 2 |
Inguinal, Hyperplasia, Lymphoid | 4 |
Inguinal, Hyperplasia, Plasma Cell | 4 |
Mandibular, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | 2 |
Fibrosis, Focal | 4 |
Hematopoietic Cell Proliferation | |
Thrombosis | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Glandular | 2 3 |
Mineralization | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2|
| 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X |
Femur, Hyperostosis | |
Maxilla, Hyperostosis | |
Turbinate, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | |
Congestion | 2 4 2 3 3 |
Foreign Body | 2 |
Granuloma, Focal | 3 |
Hemorrhage, Focal | |
Hyperplasia, Focal | 2 1 2 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic, Focal | 3 |
Metaplasia, Focal, Osseous | |
Interstitium, Mineralization, Diffuse| 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 2 |
Fungus | |
Inflammation, Acute, Focal | 3 2 |
Inflammation, Acute | |
Inflammation, Chronic, Focal | |
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 4| 7| 7| 6| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 3| 7| 1| 5| 3| 2| 3| 3| 3| 3| 5| 3| 4| 2| 5| 2| 3| 2| 3| 3| 2| 6| 0| 3| 2|
| 0| 9| 6| 7| 1| 9| 1| 0| 0| 1| 7| 0| 6| 9| 7| 9| 0| 7| 0| 0| 9| 3| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Degeneration, Diffuse, Hyaline | 3 |
Mineralization | 4 |
Nephropathy, Chronic | 4 1 1 2 2 2 3 3 2 3 4 4 1 3 3 3 2 1 1 2 |
Pigmentation | 4 3 |
Pelvis, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2|
| 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X X X X |
Basophilic Focus, Multiple | X X X X X|
Clear Cell Focus | |
Clear Cell Focus, Multiple | X |
Cytoplasmic Alteration, Focal | |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X |
Hepatodiaphragmatic Nodule, Multiple | |
Inflammation, Chronic, Focal | 2 1 1 3 2 1 2 1 1 3 3|
Necrosis, Focal | 2 |
Pigmentation | |
Bile Duct, Hyperplasia | 1 1 2 1 1 3 2 2 1|
Centrilobular, Fatty Change | 4 4 |
Periportal, Fatty Change | 3 |
Serosa, Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 1 1 1 1 2 1|
Inflammation, Chronic, Focal | |
Artery, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Squamous | 3 |
Hyperplasia, Focal, Squamous | 2 |
Inflammation, Chronic, Diffuse | 3 |
Inflammation, Chronic, Focal | 2 |
Mineralization | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2|
| 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Mineralization | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 2 2 1 2 1 2 2 1 2 2 2 2|
Mineralization, Multifocal | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Atrophy, Diffuse | |
Congestion | |
Cytoplasmic Alteration, Focal | 1 |
Degeneration, Fatty, Focal | 1 2 3 2 1 3 2 2 1|
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | |
Pigmentation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M M + + + +|
Hematocyst | |
Hyperplasia | 1 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + + + M M + + +|
Hyperplasia, Diffuse | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X |
Cyst, Multiple | X X X X X X|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 2 |
Pars Distalis, Hypoplasia | |
Pars Nervosa, Metaplasia, Focal, | |
Osseous | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + M + M + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2|
| 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Concretion | |
Dilatation | |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia, Chronic, Cystic | 3 |
Hyperplasia, Cystic | |
Lumen, Hemorrhage | 3 |
__________________________________________________________________________|
Vagina | |
Inflammation, Subacute | |
Necrosis, Acute, Diffuse | |
Prolapse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Myelofibrosis, Focal | 1 |
Erythroid Cell, Proliferation | 3 4 |
Myeloid Cell, Proliferation | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Histiocyte | 2 |
Inguinal, Ectasia | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | |
Mandibular, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 3 2 4 |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic, Glandular | |
Mineralization | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2|
| 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | |
Femur, Hyperostosis | X |
Maxilla, Hyperostosis | X |
Turbinate, Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 3 |
Congestion | 3 2 3 2|
Foreign Body | |
Granuloma, Focal | 1 1 |
Hemorrhage, Focal | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | |
Metaplasia, Focal, Osseous | 3 |
Interstitium, Mineralization, Diffuse| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | |
Inflammation, Acute, Focal | |
Inflammation, Acute | |
Inflammation, Chronic, Focal | 2 |
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 4| 7| 7| 6| 6| 6| 6| 7| 7| 6| 5| 4| 4| 6| 4| 4| 6| 7| 7| 4| 7|
DAY ON TEST | 5| 0| 7| 5| 5| 3| 2| 7| 6| 3| 8| 1| 3| 2| 2| 3| 5| 8| 5| 5| 6| 2| 3| 5| 2|
| 7| 2| 8| 5| 7| 1| 9| 3| 2| 7| 9| 6| 1| 3| 4| 0| 7| 8| 7| 7| 6| 9| 1| 7| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 MG/K | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Degeneration, Diffuse, Hyaline | |
Mineralization | |
Nephropathy, Chronic | 3 1 1 2 2 2 4 1 1 2 1 1 2 2 2 2 2 2 3|
Pigmentation | 4 |
Pelvis, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M M + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | |
| 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M + + M | 46 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Angiectasis, Focal | 1 | 5 1.8|
Basophilic Focus | X X | 11 |
Basophilic Focus, Multiple | X X X X X | 19 |
Clear Cell Focus | X | 1 |
Clear Cell Focus, Multiple | X | 3 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Fibrosis, Focal | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 7 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Inflammation, Chronic, Focal | 2 1 2 2 1 2 1 | 29 1.8|
Necrosis, Focal | | 1 2.0|
Pigmentation | | 1 3.0|
Bile Duct, Hyperplasia | 2 2 1 1 2 | 26 1.6|
Centrilobular, Fatty Change | 4 | 5 3.6|
Periportal, Fatty Change | | 1 3.0|
Serosa, Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Atrophy, Focal | 4 3 1 2 2 1 | 19 1.8|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Artery, Inflammation, Chronic, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 48 |
Atrophy | | 2 3.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 48 |
Hyperplasia, Diffuse, Squamous | | 2 3.5|
Hyperplasia, Focal, Squamous | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | |
| 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Diffuse | | 2 3.5|
Inflammation, Chronic, Focal | | 1 2.0|
Mineralization | | 1 2.0|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
Erosion | | 2 1.5|
Mineralization | | 1 4.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Inflammation, Chronic, Focal | 2 1 1 2 2 | 29 1.8|
Mineralization, Multifocal | | 1 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Angiectasis | | 2 3.0|
Atrophy, Diffuse | | 1 3.0|
Congestion | | 1 4.0|
Cytoplasmic Alteration, Focal | | 1 1.0|
Degeneration, Fatty, Focal | 2 2 | 22 2.0|
Hyperplasia, Focal | 1 | 7 1.4|
Hypertrophy, Focal | 3 1 | 3 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 45 |
Hematocyst | | 1 |
Hyperplasia | 1 1 | 14 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M | 42 |
Hyperplasia, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 52 |
Angiectasis | 3 | 7 2.9|
Cyst | X X X X X | 21 |
Cyst, Multiple | X X | 9 |
Pars Distalis, Angiectasis, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 4 | 11 2.2|
Pars Distalis, Hypoplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | |
| 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Nervosa, Metaplasia, Focal, | | |
Osseous | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
C-Cell, Hyperplasia, Focal | 1 3 | 10 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + + | 42 |
Concretion | | 1 2.0|
Dilatation | | 1 4.0|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + | 49 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 52 |
Dilatation | 3 | 1 3.0|
Hyperplasia, Chronic, Cystic | | 1 3.0|
Hyperplasia, Cystic | | 1 2.0|
Lumen, Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Subacute | | 1 4.0|
Necrosis, Acute, Diffuse | | 1 4.0|
Prolapse | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Myelofibrosis, Focal | | 3 2.3|
Erythroid Cell, Proliferation | | 3 3.7|
Myeloid Cell, Proliferation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 50 |
Axillary, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Inguinal, Ectasia | | 2 2.5|
Inguinal, Hyperplasia, Lymphoid | | 1 4.0|
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
Mandibular, Hyperplasia, Plasma Cell | | 2 4.0|
Mediastinal, Pigmentation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | |
| 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + | 48 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 51 |
Congestion, Focal | | 1 2.0|
Fibrosis, Focal | | 2 3.0|
Hematopoietic Cell Proliferation | | 3 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 48 |
Cyst | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 50 |
Hyperplasia, Cystic, Glandular | | 2 2.5|
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 51 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Femur, Fibrous Osteodystrophy | | 1 |
Femur, Hyperostosis | | 1 |
Maxilla, Hyperostosis | | 1 |
Turbinate, Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 51 |
Congestion, Diffuse | | 1 3.0|
Congestion | 2 1 | 11 2.5|
Foreign Body | | 1 2.0|
Granuloma, Focal | | 3 1.7|
Hemorrhage, Focal | 2 3 | 2 2.5|
Hyperplasia, Focal | 3 | 5 2.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
Metaplasia, Focal, Osseous | | 1 3.0|
Interstitium, Mineralization, Diffuse| | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 2| 2| 7| 5| 3| 2| 2| 3| 1| | |
| 0| 9| 9| 4| 7| 1| 9| 9| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 MG/K | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Foreign Body | | 2 2.5|
Fungus | X | 1 |
Inflammation, Acute, Focal | | 2 2.5|
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic, Focal | | 1 2.0|
Metaplasia, Squamous | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Lens, Cataract | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Congestion | | 2 3.0|
Cyst | | 2 |
Degeneration, Diffuse, Hyaline | | 1 3.0|
Mineralization | | 1 4.0|
Nephropathy, Chronic | 2 3 2 2 2 3 2 2 2 | 48 2.1|
Pigmentation | 3 | 4 3.5|
Pelvis, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 48 |
Inflammation, Chronic, Focal | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5|
| 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X |
Basophilic Focus, Multiple | X X X X X X X X X X |
Clear Cell Focus | X X X X X |
Clear Cell Focus, Multiple | |
Cytoplasmic Alteration, Focal | |
Granuloma, Focal | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Chronic, Focal | 3 1 2 2 3 4 3 3 1 |
Necrosis, Focal | |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 1 1 3 1 1 2 2 2 3 1 2 2 2 1 |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + |
Atrophy, Focal | 1 2 2 1 2 |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Acute, Diffuse | |
Mineralization | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + |
Erosion | |
Inflammation, Acute, Focal | 2 |
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5|
| 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic, Focal | 2 2 2 2 1 2 2 3 |
Mineralization, Multifocal | |
Artery, Hyperplasia, Focal | |
Artery, Mineralization | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Degeneration, Diffuse, Fatty | |
Degeneration, Fatty, Focal | 2 3 3 |
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 3 |
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M M + + + + + + + M + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Cyst | X X X X X X X |
Cyst, Multiple | X |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + |
C-Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + |
Atrophy | 4 |
Dilatation | 4 |
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + |
Dilatation | |
Hydrometra | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5|
| 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Chronic, Cystic | 3 |
Inflammation, Suppurative | |
Artery, Mineralization, Focal | |
Cervix, Fibrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + M + + + + + + + + + |
Erythroid Cell, Proliferation | 4 |
Myeloid Cell, Proliferation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Axillary, Hyperplasia, Plasma Cell | 4 |
Mandibular, Congestion | |
Mandibular, Hyperplasia, Plasma Cell | 4 |
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Granuloma, Focal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Congestion, Focal | 2 |
Hematocyst | |
Hematopoietic Cell Proliferation | 2 3 |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 |
Necrosis, Acute, Focal | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + |
Cyst | X |
Hemorrhage | 2 2 3 |
Epithelial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + M + + + + + + + + + |
Femur, Fibrous Osteodystrophy | |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 7| 6| 7| 4| 7| 2| 5| 7| 3| 4| 7| 7| 3| 6| 7| 7| 3| 7| 6| 4| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 1| 3| 4| 3| 1| 7| 3| 0| 5| 2| 3| 2| 7| 2| 2| 8| 3| 0| 5| 3| 5| 3| 3| 5|
| 1| 8| 1| 7| 0| 3| 3| 1| 3| 7| 9| 0| 3| 8| 9| 9| 6| 1| 1| 7| 1| 7| 4| 0| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Focal | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 3 2 3 3 |
Emphysema, Focal | |
Hemorrhage, Focal | 2 |
Hyperplasia, Focal | 1 1 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 |
Interstitium, Mineralization, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + |
Foreign Body | 2 2 |
Fungus | X X |
Inflammation, Chronic, Focal | 3 |
Inflammation, Focal, Suppurative | 1 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Cyst | |
Hydronephrosis | 4 |
Mineralization | 1 |
Nephropathy, Chronic | 3 2 2 3 4 4 2 1 2 1 2 2 1 4 1 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + + M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + A + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + M + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Basophilic Focus | X X|
Basophilic Focus, Multiple | X X X X X X X X X X X X |
Clear Cell Focus | X X |
Clear Cell Focus, Multiple | X |
Cytoplasmic Alteration, Focal | 3 |
Granuloma, Focal | 4 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Chronic, Focal | 1 1 4 2 3 2 2 3 1 2 2|
Necrosis, Focal | 1 1 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 2 4 1 3 1 3 3 2 2 2 2 2 2 1|
Centrilobular, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + A + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 2 1 2 2 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Diffuse | 3 |
Mineralization | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Inflammation, Acute, Focal | |
Mineralization | 3 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | 3 2 2 2 2 2 2 2 2 2|
Mineralization, Multifocal | 3 |
Artery, Hyperplasia, Focal | 3 |
Artery, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Diffuse, Fatty | 4 |
Degeneration, Fatty, Focal | 1 2 2 3 |
Hyperplasia, Focal | 2 3 2 1 |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 2 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + A + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + M + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 3 |
Cyst | X X X X X X X X |
Cyst, Multiple | X |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + +|
Atrophy | |
Dilatation | 3 4 |
Hyperplasia, Focal | 3 |
Inflammation, Chronic, Focal | 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hydrometra | 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Chronic, Cystic | |
Inflammation, Suppurative | 4 |
Artery, Mineralization, Focal | 2 |
Cervix, Fibrosis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + A + + + + + + + + + + + + + + +|
Erythroid Cell, Proliferation | |
Myeloid Cell, Proliferation | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Axillary, Hyperplasia, Plasma Cell | |
Mandibular, Congestion | 3 |
Mandibular, Hyperplasia, Plasma Cell | 2 |
Mediastinal, Congestion | 2 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Plasma Cell| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Granuloma, Focal | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | |
Hematocyst | X |
Hematopoietic Cell Proliferation | 3 4 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis, Acute, Focal | 3 |
Capsule, Fibrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M M|
Cyst | |
Hemorrhage | 1 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Femur, Fibrous Osteodystrophy | X |
Femur, Osteopetrosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
_____________________________________________________________________________________________________________________
| 3| 6| 7| 6| 4| 7| 4| 6| 7| 4| 2| 7| 7| 4| 2| 7| 6| 6| 6| 3| 7| 7| 6| 7| 7|
DAY ON TEST | 8| 9| 3| 9| 5| 3| 4| 2| 2| 5| 1| 0| 3| 5| 9| 3| 3| 5| 8| 1| 2| 3| 9| 2| 3|
| 5| 0| 0| 5| 7| 1| 4| 1| 9| 7| 8| 2| 1| 7| 0| 0| 1| 8| 9| 0| 9| 1| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
150 MG/K | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 2 2 3 |
Emphysema, Focal | 2 |
Hemorrhage, Focal | 1 |
Hyperplasia, Focal | |
Inflammation, Acute, Focal | 2 |
Inflammation, Chronic, Focal | 2 3 2 1 |
Interstitium, Mineralization, Focal | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | |
Inflammation, Chronic, Focal | |
Inflammation, Focal, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | 2 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | X |
Hydronephrosis | |
Mineralization | 3 |
Nephropathy, Chronic | 4 3 3 1 2 2 1 3 2 3 2 1 1 1 3 2 3 1 3 3|
Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | |
| 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 46 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 48 |
Parasite Metazoan | | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 47 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 51 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X | 7 |
Basophilic Focus, Multiple | X X X X X | 27 |
Clear Cell Focus | | 7 |
Clear Cell Focus, Multiple | | 1 |
Cytoplasmic Alteration, Focal | | 1 3.0|
Granuloma, Focal | | 1 4.0|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | | 7 |
Inflammation, Chronic, Focal | 2 2 2 2 | 24 2.2|
Necrosis, Focal | | 2 1.0|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 4 4 1 2 3 2 | 35 2.1|
Centrilobular, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 49 |
Atrophy, Focal | 1 | 13 1.5|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Inflammation, Acute, Diffuse | | 1 3.0|
Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | |
| 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion | | 1 1.0|
Inflammation, Acute, Focal | | 1 2.0|
Mineralization | | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Inflammation, Chronic, Focal | 1 2 3 1 | 22 2.0|
Mineralization, Multifocal | | 1 3.0|
Artery, Hyperplasia, Focal | | 1 3.0|
Artery, Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Degeneration, Diffuse, Fatty | | 1 4.0|
Degeneration, Fatty, Focal | 2 1 2 | 10 2.1|
Hyperplasia, Focal | 2 | 7 2.0|
Hypertrophy, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + M + | 48 |
Angiectasis | | 1 3.0|
Hyperplasia | | 8 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
Hyperplasia, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 52 |
Angiectasis | 3 | 7 2.7|
Cyst | X X X X | 19 |
Cyst, Multiple | | 2 |
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
C-Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | |
| 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 49 |
Atrophy | | 1 4.0|
Dilatation | | 3 3.7|
Hyperplasia, Focal | 2 | 3 2.3|
Inflammation, Chronic, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 51 |
Cyst | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 52 |
Dilatation | | 1 3.0|
Hydrometra | | 1 2.0|
Hyperplasia, Chronic, Cystic | 2 | 2 2.5|
Inflammation, Suppurative | | 1 4.0|
Artery, Mineralization, Focal | | 1 2.0|
Cervix, Fibrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 48 |
Erythroid Cell, Proliferation | | 1 4.0|
Myeloid Cell, Proliferation | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Congestion | | 1 2.0|
Axillary, Hyperplasia, Plasma Cell | | 1 4.0|
Mandibular, Congestion | | 1 3.0|
Mandibular, Hyperplasia, Plasma Cell | | 2 3.0|
Mediastinal, Congestion | | 1 2.0|
Mediastinal, Hemorrhage | 2 | 2 2.5|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 50 |
Granuloma, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Congestion, Focal | 2 | 2 2.0|
Hematocyst | | 1 |
Hematopoietic Cell Proliferation | | 5 2.8|
Hematopoietic Cell Proliferation | | |
Granulocytic | | 1 4.0|
Necrosis, Acute, Focal | | 1 3.0|
Capsule, Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 48 |
Cyst | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
__________________________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | |
| 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 5 2.0|
Epithelial Cell, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 49 |
Femur, Fibrous Osteodystrophy | | 1 |
Femur, Osteopetrosis | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 49 |
Hemorrhage, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Congestion | | 8 2.8|
Emphysema, Focal | | 1 2.0|
Hemorrhage, Focal | | 2 1.5|
Hyperplasia, Focal | | 2 1.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Chronic, Focal | | 5 1.8|
Interstitium, Mineralization, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
Foreign Body | 2 | 4 1.8|
Fungus | X | 3 |
Inflammation, Chronic, Focal | | 1 3.0|
Inflammation, Focal, Suppurative | 2 | 6 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
Mineralization, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05704-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 07:49:44
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| 4| 4| 6| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 5| 2| 1| 0| 5| 2| 2| 3| 3| | |
| 7| 7| 4| 6| 2| 7| 9| 9| 0| 0| | T (*) |
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| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
150 MG/K | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
G | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
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SPECIAL SENSES SYSTEM - cont | | |
| | |
Retina, Degeneration | | 1 4.0|
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URINARY SYSTEM | | |
| | |
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Kidney | + + + + + + + | 50 |
Congestion | 2 2 | 3 2.3|
Cyst | | 1 |
Hydronephrosis | | 1 4.0|
Mineralization | | 2 2.0|
Nephropathy, Chronic | 2 2 1 2 3 3 2 | 43 2.2|
Pigmentation | 4 | 3 3.0|
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Urinary Bladder | + + + + + + + | 49 |
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* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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