TDMS Study 05704-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05704 RESORCINOL TIME: 18:56:24
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 05970B
CONT: 000000570004 CAS: 000108463
PATHOLOGIST: F. VOELKER S. EUSTIS
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REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05704 RESORCINOL TIME: 18:56:24
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 05970B
CONT: 000000570004 CAS: 000108463
PATHOLOGIST: F. VOELKER S. EUSTIS
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE/CONTROL |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 509 521 545 561 579 623 629 630 653 662 |
| 688 693 693 695 717 717 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 11 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 101 472 524 629 646 656 663 668 673 674 |
| 674 678 680 681 693 699 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| 716 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 430 455 463 524 579 608 623 627 627 637 |
| 646 662 666 673 674 678 688 689 702 712 |
| 716 716 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 457 457 457 457 |
| |
==================================================================================
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 150 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 25 CENSORED DEATHS 11 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 218 290 303 310 323 385 386 434 444 447 |
| 573 601 618 621 624 631 658 678 689 690 |
| 694 695 702 702 716 |
| CENSORED DEATHS |
| 213 457 457 457 457 457 457 457 457 457 |
| 457 |
| |
==================================================================================
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE/CON|ROL100.0 100.0 100.0 100.0 100.0 100.0 94.0 90.0 80.0 68.0 |
|V | |
| | |
|50 MG/KG | 100.0 98.3 98.3 98.3 98.3 96.3 94.3 94.3 86.3 68.2 |
| | |
| | |
|100 MG/KG | 100.0 100.0 100.0 100.0 100.0 94.7 92.6 90.6 76.5 56.4 |
| | |
| | |
|150 MG/KG | 100.0 100.0 98.3 91.5 88.1 83.1 83.1 78.8 68.1 51.1 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE/CONTR50 MG/KG 100 MG/KG 150 MG/KG|
| V |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 68.0% 68.2% 56.4% 51.1% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.017 P=1.000 P=0.281 P=0.051 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.2 613.2 627.0 537.3 |
|NATURAL DEATHS (C) | (17.5) (37.5) (18.3) (32.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 657.9 652.6 646.3 595.2 |
|(STANDARD ERROR) | (13.6) (16.3) (14.2) (20.5) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)