TDMS Study 05704-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
RESORCINOL
NTP Experiment-Test: 05704-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 17:00:58
Facility: International Research and Development Corp.
Chemical CAS #: 108-46-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 9 9 11
Moribund 2 8 5
Accident 1
Survivors
Terminal Sacrifice 37 33 34
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Inflammation, Subacute 1 (2%)
Perforation 1 (2%)
Gallbladder (43) (39)
Serosa, Inflammation, Acute 1 (2%)
Intestine Large (50) (1) (50)
Anorectal Junction, Inflammation, Chronic,
Focal 2 (4%)
Intestine Large, Cecum (48) (1) (44)
Parasite Metazoan 1 (2%)
Serosa, Inflammation, Chronic, Diffuse 1 (100%)
Intestine Large, Colon (50) (1) (48)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Parasite Metazoan 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Serosa, Inflammation, Chronic, Diffuse 1 (100%)
Intestine Small, Duodenum (47) (2) (42)
Hyperplasia, Atypical, Focal 1 (50%)
Serosa, Inflammation, Acute 1 (2%)
Serosa, Inflammation, Chronic, Diffuse 1 (50%)
Intestine Small, Ileum (44) (1) (41)
Hyperplasia, Focal, Lymphoid 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Intestine Small, Jejunum (47) (2) (42)
Diverticulum 1 (50%) 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Serosa, Inflammation, Chronic, Diffuse 1 (50%)
Liver (50) (5) (50)
Erythrophagocytosis, Diffuse 3 (6%)
Fatty Change, Diffuse 2 (4%)
Hematopoietic Cell Proliferation, Diffuse 1 (20%)
Hematopoietic Cell Proliferation, Multifocal 2 (4%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 13 (26%) 9 (18%)
Inflammation, Focal, Subacute 1 (2%)
Necrosis, Acute, Focal 1 (2%) 1 (2%)
Necrosis, Focal, Subacute 1 (2%)
Pigmentation, Diffuse, Hemosiderin 2 (4%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Centrilobular, Fatty Change 2 (4%) 1 (2%)
Periportal, Fatty Change 1 (2%)
Serosa, Inflammation, Chronic, Focal 1 (20%)
Serosa, Inflammation, Subacute 1 (2%)
Mesentery (1) (1) (2)
Cyst 1 (100%)
Fat, Necrosis 1 (100%) 1 (100%)
Pancreas (48) (48)
Atrophy, Diffuse 1 (2%)
Cyst 2 (4%)
Hyperplasia, Focal, Glandular 2 (4%)
Hyperplasia, Glandular, Multifocal 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Inflammation, Acute 2 (4%)
Salivary Glands (48) (47)
Infiltration Cellular, Focal, Mononuclear
Cell 4 (8%) 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 13 (27%) 22 (47%)
Infiltration Cellular, Multifocal, Plasma
Cell 1 (2%)
Stomach, Forestomach (49) (3) (46)
Hyperplasia, Focal, Squamous 1 (2%) 1 (33%) 5 (11%)
Hyperplasia, Multifocal 1 (2%)
Hyperplasia, Multifocal, Squamous 2 (4%) 1 (33%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%)
Ulcer, Acute, Multifocal 2 (4%)
Stomach, Glandular (50) (46)
Cyst 1 (2%)
Erosion, Focal 2 (4%)
Erosion, Multifocal 1 (2%)
Ulcer, Acute, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Serosa, Inflammation, Chronic 1 (2%)
Tooth (1) (1)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (49)
Coronary Artery, Hyperplasia, Chronic,
Multifocal 1 (2%)
Epicardium, Inflammation, Diffuse, Subacute 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (49)
Congestion, Focal 1 (2%)
Hypertrophy, Focal 1 (2%)
Inflammation, Subacute 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Vacuolization Cytoplasmic, Multifocal 2 (4%)
Spindle Cell, Hyperplasia 1 (2%)
Parathyroid Gland (24) (20)
Cyst 1 (5%)
Infiltration Cellular, Focal, Plasma Cell 1 (4%)
Pituitary Gland (48) (7) (50)
Pars Distalis, Congestion, Diffuse 1 (14%)
Pars Distalis, Ectasia, Focal 1 (2%)
Pars Distalis, Hyperplasia, Focal 9 (19%) 1 (14%) 10 (20%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%) 2 (4%)
Thyroid Gland (49) (49)
Depletion Secretory 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 5 (10%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (11) (49)
Abscess 2 (4%)
Angiectasis, Focal 1 (2%)
Cyst 3 (6%) 8 (73%) 7 (14%)
Cyst Multilocular 6 (12%) 4 (36%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hemorrhage 3 (6%)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 2 (4%) 3 (6%)
Uterus (50) (36) (50)
Abscess 1 (2%)
Amyloid Deposition, Diffuse 1 (2%)
Dilatation 2 (4%) 1 (2%)
Hemorrhage, Chronic 1 (3%) 1 (2%)
Hyperplasia, Chronic, Cystic, Diffuse 41 (82%) 35 (97%) 41 (82%)
Hyperplasia, Diffuse, Lymphoid 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
Serosa, Inflammation, Chronic, Diffuse 1 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Myelofibrosis 2 (4%)
Pigmentation, Diffuse, Hemosiderin 2 (4%)
Lymph Node (50) (7) (50)
Axillary, Infiltration Cellular, Diffuse,
Plasma Cell 1 (2%)
Iliac, Hematopoietic Cell Proliferation,
Diffuse 1 (2%)
Iliac, Hyperplasia, Diffuse, Lymphoid 2 (4%)
Mediastinal, Infiltration Cellular, Diffuse,
Plasma Cell 1 (2%)
Renal, Hyperplasia, Diffuse, Lymphoid 1 (2%)
Lymph Node, Mesenteric (47) (6) (48)
Giant Cell, Diffuse 1 (2%)
Hematopoietic Cell Proliferation, Diffuse 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%)
Spleen (50) (12) (49)
Congestion, Diffuse 2 (4%)
Erythrophagocytosis, Diffuse 3 (6%)
Hematopoietic Cell Proliferation, Diffuse 5 (10%) 2 (17%) 7 (14%)
Hyperplasia, Diffuse, Lymphoid 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Capsule, Inflammation, Acute 1 (2%)
Thymus (43) (1) (39)
Atrophy, Diffuse 3 (8%)
Medulla, Hyperplasia, Focal, Lymphoid 6 (14%) 4 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (1) (48)
Inflammation, Chronic 1 (2%)
Skin (49) (6) (50)
Inflammation, Chronic 1 (2%) 3 (50%) 7 (14%)
Subcutaneous Tissue, Necrosis 1 (17%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Hyperostosis 2 (4%)
Osteoporosis 1 (2%) 1 (2%)
Skeletal Muscle (1)
Hemorrhage, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Mineralization, Multifocal 21 (43%) 19 (38%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (7) (49)
Abscess 1 (14%)
Atelectasis, Diffuse 1 (14%)
Congestion, Diffuse 1 (2%) 2 (29%) 3 (6%)
Foreign Body 1 (14%)
Hyperplasia, Focal, Adenomatous 1 (2%) 1 (2%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 35 (70%) 35 (71%)
Alveolus, Infiltration Cellular, Histiocyte 1 (14%)
Bronchiole, Inflammation, Acute 1 (14%)
Mediastinum, Bacterium 1 (2%)
Mediastinum, Inflammation, Chronic,
Multifocal 1 (2%)
Nose (50) (50)
Foreign Body 2 (4%) 1 (2%)
Inflammation, Acute 3 (6%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Degeneration, Chronic, Diffuse 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (3) (50)
Casts 3 (6%)
Cyst 2 (4%)
Hydronephrosis 3 (6%)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 34 (68%) 32 (64%)
Nephropathy, Diffuse 1 (33%) 3 (6%)
Glomerulus, Amyloid Deposition, Diffuse 1 (2%) 1 (2%)
Papilla, Mineralization, Multifocal 1 (2%)
Urinary Bladder (48) (45)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 6 (13%) 5 (11%)
Inflammation, Diffuse, Subacute 1 (2%)
Serosa, Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 6 4 3
Dead 6 3 12
Accident 1 1
Survivors
Terminal Sacrifice 36 43 34
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49)
Serosa, Inflammation, Subacute 1 (2%)
Gallbladder (41) (39)
Cyst 1 (3%)
Intestine Large, Cecum (49) (45)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (48) (47)
Parasite Metazoan 2 (4%)
Intestine Large, Rectum (47) (49)
Inflammation, Acute, Focal 1 (2%)
Intestine Small (50) (5) (50)
Diverticulum 1 (20%)
Intestine Small, Duodenum (47) (2) (43)
Amyloid Deposition, Chronic, Diffuse 1 (2%)
Intestine Small, Jejunum (46) (4) (43)
Diverticulum 1 (2%) 3 (75%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Liver (50) (16) (50)
Basophilic Focus 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation, Multifocal 1 (2%)
Inclusion Body Intranuclear, Diffuse 1 (2%)
Infarct 1 (2%) 1 (6%)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Karyomegaly, Diffuse 1 (2%)
Mixed Cell Focus 1 (6%) 2 (4%)
Necrosis, Acute, Focal 2 (4%)
Necrosis, Acute, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Centrilobular, Fatty Change 2 (4%) 2 (4%)
Centrilobular, Necrosis, Acute, Diffuse 1 (2%)
Pancreas (50) (48)
Atrophy, Focal 1 (2%)
Edema, Acute, Diffuse 1 (2%)
Hyperplasia, Focal, Glandular 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Salivary Glands (50) (50)
Infiltration Cellular, Focal, Mononuclear
Cell 2 (4%) 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 17 (34%) 16 (32%)
Stomach, Forestomach (49) (46)
Cyst 1 (2%)
Cyst Epithelial Inclusion 2 (4%)
Diverticulum, Focal 1 (2%)
Hyperplasia, Focal, Squamous 2 (4%) 2 (4%)
Inflammation, Chronic, Focal 1 (2%) 2 (4%)
Stomach, Glandular (47) (47)
Cyst, Focal 1 (2%)
Cyst Epithelial Inclusion, Focal 1 (2%)
Degeneration, Cystic, Focal 1 (2%)
Edema, Diffuse 1 (2%)
Erosion, Focal 1 (2%)
Hyperplasia, Focal 1 (2%)
Hyperplasia, Adenomatous 1 (2%)
Tooth (6) (1)
Inflammation, Chronic 6 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (1) (49)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia, Focal 3 (6%) 1 (2%)
Hypertrophy, Focal 5 (10%) 8 (16%)
Hypertrophy, Multifocal 1 (2%)
Spindle Cell, Hyperplasia, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Adrenal Gland, Medulla (47) (49)
Hyperplasia, Multifocal 1 (2%)
Islets, Pancreatic (50) (1) (47)
Hyperplasia, Focal 3 (6%)
Parathyroid Gland (20) (31)
Cyst 1 (3%)
Pituitary Gland (45) (50)
Pars Distalis, Cyst 2 (4%) 3 (6%)
Thyroid Gland (49) (50)
Cyst 1 (2%)
Depletion Secretory 1 (2%)
Hemorrhage, Acute, Focal 1 (2%)
Inflammation, Subacute 1 (2%)
C-Cell, Hyperplasia, Chronic, Focal 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Penis (1) (1)
Congestion 1 (100%) 1 (100%)
Inflammation, Chronic 1 (100%)
Preputial Gland (2) (3) (2)
Abscess 1 (50%) 3 (100%) 1 (50%)
Inflammation, Chronic 1 (50%) 1 (50%)
Prostate (49) (48)
Dilatation 1 (2%)
Seminal Vesicle (2)
Dilatation 2 (100%)
Inflammation, Chronic, Diffuse 1 (50%)
Testes (50) (1) (50)
Atrophy, Diffuse 1 (2%) 1 (100%) 1 (2%)
Degeneration, Diffuse 1 (2%)
Granuloma Sperm, Focal 1 (2%)
Mineralization, Focal 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (49) (8) (50)
Congestion 1 (13%)
Hematopoietic Cell Proliferation, Diffuse 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation 1 (13%)
Thrombosis 1 (2%)
Thoracic, Angiectasis 1 (13%)
Lymph Node, Mesenteric (48) (5) (50)
Congestion, Diffuse 5 (10%)
Ectasia, Diffuse 3 (6%)
Giant Cell, Diffuse 6 (13%) 2 (4%)
Hematopoietic Cell Proliferation, Diffuse 2 (4%)
Hemorrhage, Diffuse 2 (4%)
Hyperplasia, Diffuse, Re Cell 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
Spleen (49) (4) (50)
Hematopoietic Cell Proliferation, Diffuse 10 (20%) 3 (75%) 4 (8%)
Hyperplasia, Lymphoid 4 (8%)
Thymus (24) (35)
Atrophy, Diffuse 2 (6%)
Cyst 2 (8%) 1 (3%)
Mediastinum, Inflammation, Acute 1 (3%)
Medulla, Hyperplasia, Focal, Lymphoid 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (9) (49)
Abscess 1 (2%)
Cyst 1 (2%)
Edema, Acute, Diffuse 1 (2%)
Inflammation, Chronic 6 (12%) 3 (33%) 4 (8%)
Inflammation, Subacute 1 (2%)
Hair Follicle, Atrophy, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Cartilage, Proliferation, Chronic, Focal 1 (2%)
Coccygeal, Hyperostosis 1 (2%)
Cranium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Demyelination, Multifocal 1 (2%)
Hemorrhage, Focal 1 (2%)
Hydrocephalus 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Mineralization, Multifocal 24 (48%) 24 (48%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (7) (50)
Congestion, Diffuse 2 (4%) 5 (10%)
Hemorrhage, Focal 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Hyperplasia, Focal, Adenomatous 4 (8%) 1 (14%) 1 (2%)
Infiltration Cellular, Diffuse, Histiocyte 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 25 (50%) 26 (52%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Pleura, Inflammation, Subacute 1 (2%)
Nose (50) (50)
Foreign Body 8 (16%) 1 (2%)
Hyperplasia, Focal, Glandular 1 (2%)
Inflammation, Acute 6 (12%) 3 (6%)
Inflammation, Chronic 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (3) (50)
Cyst 2 (4%) 5 (10%)
Ectopic Tissue 1 (2%)
Hyperplasia, Focal, Tubular 1 (2%) 1 (2%)
Hyperplasia, Multifocal, Tubular 1 (2%)
Infiltration Cellular, Focal, Mononuclear
Cell 1 (2%)
Infiltration Cellular, Mononuclear Cell,
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:00:58
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Multifocal 39 (78%) 36 (72%)
Inflammation, Chronic 1 (2%)
Nephropathy, Diffuse 1 (2%) 3 (6%)
Vacuolization Cytoplasmic, Multifocal 1 (2%)
Cortex, Degeneration, Diffuse, Hyaline 1 (2%) 1 (2%)
Cortex, Vacuolization Cytoplasmic, Multifocal 1 (2%)
Glomerulus, Amyloid Deposition, Diffuse 1 (2%)
Glomerulus, Inflammation, Diffuse, Subacute,
Suppurative 1 (2%)
Proximal Convoluted Renal Tubule,
Degeneration, Focal 1 (2%)
Proximal Convoluted Renal Tubule, Dilatation,
Diffuse 1 (33%)
Urinary Bladder (49) (48)
Concretion 6 (12%) 2 (4%)
Edema, Acute, Diffuse 1 (2%)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (2%)
Inflammation, Acute, Diffuse 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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