TDMS Study 05704-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
RESORCINOL
NTP Experiment-Test: 05704-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: GAVAGE Time: 17:01:01
Facility: International Research and Development Corp.
Chemical CAS #: 108-46-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 9 9 11
Moribund 2 8 5
Accident 1
Survivors
Terminal Sacrifice 37 33 34
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49)
Gallbladder (43) (39)
Intestine Large, Cecum (48) (1) (44)
Intestine Large, Colon (50) (1) (48)
Intestine Large, Rectum (49) (1) (50)
Intestine Small, Duodenum (47) (2) (42)
Intestine Small, Ileum (44) (1) (41)
Intestine Small, Jejunum (47) (2) (42)
Liver (50) (5) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (20%) 3 (6%)
Hepatocellular Adenoma 1 (2%) 2 (4%)
Mesentery (1) (1) (2)
Pancreas (48) (48)
Salivary Glands (48) (47)
Stomach, Forestomach (49) (3) (46)
Squamous Cell Papilloma 1 (33%) 1 (2%)
Squamous Cell Papilloma, Multiple 1 (2%)
Stomach, Glandular (50) (46)
Tooth (1) (1)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (49)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (49)
Adenoma 1 (2%)
Adrenal Gland, Medulla (47) (48)
Islets, Pancreatic (48) (46)
Adenoma 1 (2%)
Pituitary Gland (48) (7) (50)
Pars Distalis, Adenoma 8 (17%) 5 (71%) 10 (20%)
Pars Intermedia, Adenoma 1 (2%) 1 (14%)
Thyroid Gland (49) (49)
Follicular Cell, Adenocarcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (49) (11) (49)
Cystadenoma 2 (4%)
Luteoma 2 (4%)
Teratoma 1 (9%)
Uterus (50) (36) (50)
Leiomyoma 1 (2%)
Polyp Stromal 2 (4%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (50) (7) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node, Mesenteric (47) (6) (48)
Spleen (50) (12) (49)
Hemangiosarcoma 1 (2%)
Thymus (43) (1) (39)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (1) (48)
Adenocarcinoma 1 (100%) 2 (4%)
Skin (49) (6) (50)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Mast Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (7) (49)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (43%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (50) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3)
Adenocarcinoma 1 (33%)
Adenoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (3) (50)
Cortex, Adenoma, Tubular 1 (2%)
Urinary Bladder (48) (45)
Page 4
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Lymphocytic 4 (8%) 2 (4%) 2 (4%)
Lymphoma Malignant Mixed 10 (20%) 5 (10%) 8 (16%)
Lymphoma Malignant Undifferentiated Cell 11 (22%) 4 (8%) 12 (24%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 112MG/KG 225MG/KG
F FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 21 33
Total Primary Neoplasms 48 25 52
Total Animals with Benign Neoplasms 16 8 16
Total Benign Neoplasms 19 8 22
Total Animals with Malignant Neoplasms 29 17 27
Total Malignant Neoplasms 29 17 30
Total Animals with Metastatic Neoplasms 4
Total Metastatic Neoplasm 7
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 6 4 3
Dead 6 3 12
Accident 1 1
Survivors
Terminal Sacrifice 36 43 34
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (49)
Gallbladder (41) (39)
Sarcoma, Metastatic, Epididymis 1 (3%)
Intestine Small (50) (5) (50)
Intestine Small, Duodenum (47) (2) (43)
Intestine Small, Ileum (48) (2) (43)
Intestine Small, Jejunum (46) (4) (43)
Adenocarcinoma 1 (2%)
Liver (50) (16) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (6%)
Carcinoma, Metastatic, Islets, Pancreatic 1 (6%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hemangioma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 6 (12%) 4 (25%) 3 (6%)
Hepatocellular Adenoma 6 (12%) 6 (38%) 4 (8%)
Hepatocellular Adenoma, Multiple 1 (6%)
Pancreas (50) (48)
Sarcoma, Metastatic, Epididymis 1 (2%)
Stomach, Forestomach (49) (46)
Squamous Cell Papilloma 3 (6%) 1 (2%)
Tooth (6) (1)
Odontoma 1 (17%)
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Page 7
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (1) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (1) (50)
Pheochromocytoma Benign 1 (100%)
Adrenal Gland, Cortex (49) (1) (49)
Adenoma 1 (2%)
Sarcoma, Metastatic, Epididymis 1 (2%)
Adrenal Gland, Medulla (47) (49)
Pheochromocytoma Benign 2 (4%)
Islets, Pancreatic (50) (1) (47)
Carcinoma 1 (2%) 1 (100%)
Pituitary Gland (45) (50)
Pars Distalis, Adenoma 1 (2%)
Thyroid Gland (49) (50)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Sarcoma 1 (2%)
Prostate (49) (48)
Sarcoma, Metastatic, Epididymis 1 (2%)
Testes (50) (1) (50)
Sarcoma, Metastatic, Epididymis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Lymph Node (49) (8) (50)
Sarcoma, Metastatic, Skin 1 (2%)
Axillary, Sarcoma, Metastatic, Skin 1 (13%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Page 8
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Metastatic, Lung 1 (2%)
Pancreatic, Carcinoma, Metastatic, Pancreas 1 (2%)
Lymph Node, Mesenteric (48) (5) (50)
Sarcoma, Metastatic, Epididymis 1 (2%)
Spleen (49) (4) (50)
Hemangioma 1 (2%)
Hemangiosarcoma 1 (2%)
Thymus (24) (35)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (9) (49)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (11%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Neurofibrosarcoma 1 (2%)
Subcutaneous Tissue, Sarcoma 5 (10%) 5 (56%) 1 (2%)
Subcutaneous Tissue, Sarcoma, Multiple 1 (2%)
Subcutaneous Tissue, Sarcoma, Metastatic,
Epididymis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (3)
Sarcoma 1 (33%)
Sarcoma, Metastatic, Skin 2 (67%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (7) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 3 (43%) 5 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (14%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 2 (29%)
Hepatocellular Carcinoma, Metastatic 1 (14%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (6%)
Sarcoma, Metastatic, Skin 1 (2%) 1 (14%)
Trachea (46) (1) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2)
Adenoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (3) (50)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%) 1 (33%)
Sarcoma, Metastatic, Epididymis 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (49) (48)
Hemangioma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 2 (4%) 4 (8%) 2 (4%)
Lymphoma Malignant Undifferentiated Cell 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05704-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC RESORCINOL Date: 09/18/94
Route: GAVAGE Time: 17:01:01
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 112MG/KG 225MG/KG
M MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 33 29 22
Total Primary Neoplasms 40 36 28
Total Animals with Benign Neoplasms 21 15 15
Total Benign Neoplasms 22 15 18
Total Animals with Malignant Neoplasms 18 19 9
Total Malignant Neoplasms 18 21 10
Total Animals with Metastatic Neoplasms 7 5 2
Total Metastatic Neoplasm 10 10 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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