TDMS Study 05704-01 Pathology Tables
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
Facility: International Research and Development Corp.
Chemical CAS #: 108-46-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 1| 5| 0| 3| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 3| 4| 6| 0| 5| 0| 5| 3| 1| 5| 7| 7| 6| 0| 3| 0| 5| 6| 0| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Perforation | |
__________________________________________________________________________|
Gallbladder | + + + + A + + + + + + A + + + + + + + + +|
Serosa, Inflammation, Acute | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
Parasite Metazoan | |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + +|
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + A + A A + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + A + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
Serosa, Inflammation, Acute | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 2 1 1 1 |
Necrosis, Acute, Focal | |
Necrosis, Focal, Subacute | 1 |
Vacuolization Cytoplasmic, Focal | 1 |
Centrilobular, Fatty Change | |
Periportal, Fatty Change | 2 |
Serosa, Inflammation, Subacute | 4 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + +|
Atrophy, Diffuse | |
Cyst | X X |
Hyperplasia, Focal, Glandular | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
Inflammation, Acute | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 1| 5| 0| 3| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 3| 4| 6| 0| 5| 0| 5| 3| 1| 5| 7| 7| 6| 0| 3| 0| 5| 6| 0| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 2 2|
Infiltration Cellular, Multifocal, | |
Plasma Cell | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + I + + + + + + + + +|
Hyperplasia, Focal, Squamous | 2 |
Hyperplasia, Multifocal | |
Hyperplasia, Multifocal, Squamous | 2 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Erosion, Multifocal | 2 |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Hyperplasia, | |
Chronic, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | |
Inflammation, Subacute | 2 |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M + + M M + + + M + M M M I M + + M|
Infiltration Cellular, Focal, Plasma | |
Cell | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Ectasia, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 3 2 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + M + + + + + + + + +|
Depletion Secretory | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 1| 5| 0| 3| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 3| 4| 6| 0| 5| 0| 5| 3| 1| 5| 7| 7| 6| 0| 3| 0| 5| 6| 0| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 4 |
Cyst | X X X|
Cyst Multilocular | X X X |
Hemorrhage | 3 3 |
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Dilatation | 2 4 |
Hyperplasia, Chronic, Cystic, Diffuse| 2 4 3 3 3 4 3 4 3 2 3 3 2 4 3 4 4|
Hyperplasia, Diffuse, Lymphoid | |
Serosa, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Diffuse, Plasma Cell | |
Iliac, Hematopoietic Cell | |
Proliferation, Diffuse | 3 |
Iliac, Hyperplasia, Diffuse, Lymphoid| 2 4 |
Mediastinal, Infiltration Cellular, | |
Diffuse, Plasma Cell | |
Renal, Hyperplasia, Diffuse, Lymphoid| 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + +|
Giant Cell, Diffuse | 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Diffuse, | |
Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 4 4 4 |
Hyperplasia, Diffuse, Lymphoid | 4 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 1| 5| 0| 3| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 3| 4| 6| 0| 5| 0| 5| 3| 1| 5| 7| 7| 6| 0| 3| 0| 5| 6| 0| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Capsule, Inflammation, Acute | 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + M + M + I + + +|
Medulla, Hyperplasia, Focal, Lymphoid| 3 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Osteoporosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + M + + + + + + + + +|
Hemorrhage, Multifocal | 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
Mineralization, Multifocal | 2 2 2 1 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | |
Hyperplasia, Focal, Adenomatous | 2 |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 3 3 3 2 1 2 2 2 1 1 2 1|
Mediastinum, Bacterium | |
Mediastinum, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation, Acute | 2 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + M + |
Degeneration, Chronic, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 6| 4| 5| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 2| 1| 5| 0| 3| 3| 3| 5| 3| 3| 3| 3|
| 6| 4| 4| 3| 4| 6| 0| 5| 0| 5| 3| 1| 5| 7| 7| 6| 0| 3| 0| 5| 6| 0| 5| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 2 2 1 2 2 1 4 2 1 1 1 2 2|
Glomerulus, Amyloid Deposition, | |
Diffuse | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 2 2 2|
Serosa, Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 9| 5| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 7| 3| 1|
| 3| 6| 3| 3| 0| 6| 5| 0| 4| 0| 6| 9| 3| 4| 5| 7| 3| 4| 0| 3| 6| 4| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 4 |
Perforation | X |
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + A + + + + + + + +|
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
Parasite Metazoan | |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | 3 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | 3 |
Serosa, Inflammation, Acute | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Multifocal | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 1 |
Necrosis, Acute, Focal | |
Necrosis, Focal, Subacute | |
Vacuolization Cytoplasmic, Focal | |
Centrilobular, Fatty Change | 3 |
Periportal, Fatty Change | |
Serosa, Inflammation, Subacute | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Cyst | |
Hyperplasia, Focal, Glandular | 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 9| 5| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 7| 3| 1|
| 3| 6| 3| 3| 0| 6| 5| 0| 4| 0| 6| 9| 3| 4| 5| 7| 3| 4| 0| 3| 6| 4| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 2 2 1 2 2 2 2 2|
Infiltration Cellular, Multifocal, | |
Plasma Cell | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Hyperplasia, Multifocal | 3 |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Erosion, Multifocal | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Coronary Artery, Hyperplasia, | |
Chronic, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Congestion, Focal | 2 |
Inflammation, Subacute | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic, Multifocal| 2 2 |
Spindle Cell, Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M + + + M + M + + M + M + + + M +|
Infiltration Cellular, Focal, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Ectasia, Focal | 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Depletion Secretory | 4 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 9| 5| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 7| 3| 1|
| 3| 6| 3| 3| 0| 6| 5| 0| 4| 0| 6| 9| 3| 4| 5| 7| 3| 4| 0| 3| 6| 4| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + I + + + + +|
Abscess | |
Cyst | |
Cyst Multilocular | X X X |
Hemorrhage | 4 |
Infiltration Cellular, Focal, | |
Mononuclear Cell | 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Dilatation | |
Hyperplasia, Chronic, Cystic, Diffuse| 4 3 4 3 4 3 4 4 4 3 2 3 4 3 3 4|
Hyperplasia, Diffuse, Lymphoid | 3 |
Serosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Infiltration Cellular, | |
Diffuse, Plasma Cell | |
Iliac, Hematopoietic Cell | |
Proliferation, Diffuse | |
Iliac, Hyperplasia, Diffuse, Lymphoid| |
Mediastinal, Infiltration Cellular, | |
Diffuse, Plasma Cell | 3 |
Renal, Hyperplasia, Diffuse, Lymphoid| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Giant Cell, Diffuse | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 2 |
Hyperplasia, Diffuse, Lymphoid | |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 9| 5| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 7| 3| 1|
| 3| 6| 3| 3| 0| 6| 5| 0| 4| 0| 6| 9| 3| 4| 5| 7| 3| 4| 0| 3| 6| 4| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Capsule, Inflammation, Acute | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + M + + + + M + + + + +|
Medulla, Hyperplasia, Focal, Lymphoid| 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X 3 |
Osteoporosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
Mineralization, Multifocal | 2 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 3 |
Hyperplasia, Focal, Adenomatous | |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 2 2 2 1 1 2 1 2 1 2 2 1 2 2 3 |
Mediastinum, Bacterium | X |
Mediastinum, Inflammation, Chronic, | |
Multifocal | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation, Acute | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration, Chronic, Diffuse | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 7| 7|
DAY ON TEST | 9| 5| 3| 3| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 7| 3| 1|
| 3| 6| 3| 3| 0| 6| 5| 0| 4| 0| 6| 9| 3| 4| 5| 7| 3| 4| 0| 3| 6| 4| 2| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 2 1 2 1 2 1 1 1 3 1 2 2 2 2 |
Glomerulus, Amyloid Deposition, | |
Diffuse | 2 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 3 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
Serosa, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 4| 6| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 2| 3| 5| 2| 3| 3| 9| | |
| 6| 5| 0| 5| 5| 6| 2| 0| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
Inflammation, Subacute | | 1 4.0|
Perforation | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + A + A + + A | 43 |
Serosa, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + | 48 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 50 |
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 2.0|
Parasite Metazoan | X | 1 |
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + | 47 |
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A | 44 |
Hyperplasia, Focal, Lymphoid | | 1 3.0|
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 47 |
Hyperplasia, Focal, Lymphoid | | 1 3.0|
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 2 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 3 1 1 4 | 13 1.6|
Necrosis, Acute, Focal | 3 | 1 3.0|
Necrosis, Focal, Subacute | | 1 1.0|
Vacuolization Cytoplasmic, Focal | | 1 1.0|
Centrilobular, Fatty Change | 2 | 2 2.5|
Periportal, Fatty Change | | 1 2.0|
Serosa, Inflammation, Subacute | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 48 |
Atrophy, Diffuse | 4 | 1 4.0|
Cyst | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 4| 6| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 2| 3| 5| 2| 3| 3| 9| | |
| 6| 5| 0| 5| 5| 6| 2| 0| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Focal, Glandular | 1 | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 2.0|
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + M + + + | 48 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | 1 1 | 4 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 | 13 1.8|
Infiltration Cellular, Multifocal, | | |
Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Hyperplasia, Focal, Squamous | | 1 2.0|
Hyperplasia, Multifocal | | 1 3.0|
Hyperplasia, Multifocal, Squamous | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 50 |
Cyst | | 1 |
Erosion, Multifocal | | 1 2.0|
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Coronary Artery, Hyperplasia, | | |
Chronic, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 48 |
Congestion, Focal | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 2 2.0|
Spindle Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 4| 6| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 2| 3| 5| 2| 3| 3| 9| | |
| 6| 5| 0| 5| 5| 6| 2| 0| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | I M + M M + + M | 24 |
Infiltration Cellular, Focal, Plasma | | |
Cell | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + | 48 |
Pars Distalis, Ectasia, Focal | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | | 9 2.2|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Depletion Secretory | | 1 4.0|
Follicular Cell, Hyperplasia | | 5 2.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 49 |
Abscess | | 2 4.0|
Cyst | | 3 |
Cyst Multilocular | | 6 |
Hemorrhage | | 3 3.3|
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 3 | 2 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Abscess | | 1 4.0|
Dilatation | | 2 3.0|
Hyperplasia, Chronic, Cystic, Diffuse| 3 4 2 4 3 2 4 2 | 41 3.2|
Hyperplasia, Diffuse, Lymphoid | | 1 3.0|
Serosa, Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Myelofibrosis | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
Axillary, Infiltration Cellular, | | |
Diffuse, Plasma Cell | 2 | 1 2.0|
Iliac, Hematopoietic Cell | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 4| 6| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 2| 3| 5| 2| 3| 3| 9| | |
| 6| 5| 0| 5| 5| 6| 2| 0| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Proliferation, Diffuse | | 1 3.0|
Iliac, Hyperplasia, Diffuse, Lymphoid| | 2 3.0|
Mediastinal, Infiltration Cellular, | | |
Diffuse, Plasma Cell | | 1 3.0|
Renal, Hyperplasia, Diffuse, Lymphoid| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 47 |
Giant Cell, Diffuse | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 4 | 5 3.6|
Hyperplasia, Diffuse, Lymphoid | | 1 4.0|
Hyperplasia, Lymphoid | | 1 3.0|
Capsule, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 43 |
Medulla, Hyperplasia, Focal, Lymphoid| | 6 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skin | + + + I + + + + | 49 |
Inflammation, Chronic | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Hyperostosis | | 2 3.0|
Osteoporosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 49 |
Hemorrhage, Multifocal | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 2.0|
Mineralization, Multifocal | 1 2 1 1 | 21 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 4| 6| 7| 7| 6| | |
DAY ON TEST | 5| 3| 3| 2| 3| 5| 2| 3| 3| 9| | |
| 6| 5| 0| 5| 5| 6| 2| 0| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyperplasia, Focal, Adenomatous | | 1 2.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 3 2 3 1 1 1 2 | 35 1.8|
Mediastinum, Bacterium | | 1 |
Mediastinum, Inflammation, Chronic, | | |
Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Foreign Body | | 2 1.0|
Inflammation, Acute | | 3 1.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Degeneration, Chronic, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 3 3 2 3 | 34 1.8|
Glomerulus, Amyloid Deposition, | | |
Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + | 48 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 3 | 6 2.2|
Serosa, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 6| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 0| 3| 6| 5| 5| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 2| 9| 3| 0| 3| 3| 3| 3|
| 6| 2| 4| 0| 6| 6| 6| 5| 4| 0| 4| 4| 0| 3| 4| 6| 5| 6| 9| 5| 5| 3| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
112MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Intestine Large, Colon | |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
Hyperplasia, Atypical, Focal | 3 |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Diverticulum | 3 |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Liver | + |
Hematopoietic Cell Proliferation, | |
Diffuse | |
Serosa, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Mesentery | |
Cyst | |
Fat, Necrosis | |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
Hyperplasia, Focal, Squamous | 2 |
Hyperplasia, Multifocal, Squamous | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Epicardium, Inflammation, Diffuse, | |
Subacute | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Pituitary Gland | + + + + + +|
Pars Distalis, Congestion, Diffuse | |
Pars Distalis, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 6| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 0| 3| 6| 5| 5| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 2| 9| 3| 0| 3| 3| 3| 3|
| 6| 2| 4| 0| 6| 6| 6| 5| 4| 0| 4| 4| 0| 3| 4| 6| 5| 6| 9| 5| 5| 3| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
112MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ovary | + + + + |
Cyst | X X X |
Cyst Multilocular | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + +|
Hemorrhage, Chronic | 3|
Hyperplasia, Chronic, Cystic, Diffuse| 4 4 2 3 3 3 2 3 3 3 3 3 2 2|
Serosa, Inflammation, Chronic, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Spleen | + + + |
Hematopoietic Cell Proliferation, | |
Diffuse | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + |
__________________________________________________________________________|
Skin | + |
Inflammation, Chronic | 2 |
Subcutaneous Tissue, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Abscess | 4 |
Atelectasis, Diffuse | |
Congestion, Diffuse | 2 |
Foreign Body | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 6| 7| 6| 4| 4| 7| 7| 7| 1| 7| 7| 7| 7| 4| 7| 6| 6| 7| 0| 7| 7| 7| 7|
DAY ON TEST | 5| 8| 0| 3| 6| 5| 5| 3| 3| 3| 2| 3| 3| 3| 3| 5| 3| 2| 9| 3| 0| 3| 3| 3| 3|
| 6| 2| 4| 0| 6| 6| 6| 5| 4| 0| 4| 4| 0| 3| 4| 6| 5| 6| 9| 5| 5| 3| 4| 4| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
112MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + |
Nephropathy, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 4| 4| 7| 7| 7| 7| 5| 7| 6| 0| 4| 4| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 5| 5| 3| 3| 1| 3| 8| 3| 0| 0| 5| 5| 8| 3| 5| 3| 3| 3| 3|
| 0| 0| 5| 3| 3| 0| 6| 6| 4| 4| 5| 3| 2| 0| 4| 7| 6| 6| 4| 3| 6| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
112MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Intestine Large, Colon | |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Duodenum | |
Hyperplasia, Atypical, Focal | |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
Diverticulum | |
Serosa, Inflammation, Chronic, | |
Diffuse | |
__________________________________________________________________________|
Liver | + + |
Hematopoietic Cell Proliferation, | |
Diffuse | |
Serosa, Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Mesentery | + |
Cyst | X |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
Hyperplasia, Focal, Squamous | |
Hyperplasia, Multifocal, Squamous | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Epicardium, Inflammation, Diffuse, | |
Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Congestion, Diffuse | 3 |
Pars Distalis, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 4| 4| 7| 7| 7| 7| 5| 7| 6| 0| 4| 4| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 5| 5| 3| 3| 1| 3| 8| 3| 0| 0| 5| 5| 8| 3| 5| 3| 3| 3| 3|
| 0| 0| 5| 3| 3| 0| 6| 6| 4| 4| 5| 3| 2| 0| 4| 7| 6| 6| 4| 3| 6| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
112MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ovary | + + + + + |
Cyst | X X X X |
Cyst Multilocular | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + +|
Hemorrhage, Chronic | |
Hyperplasia, Chronic, Cystic, Diffuse| 3 2 4 2 4 2 3 4 2 4 4 4 2 2|
Serosa, Inflammation, Chronic, | |
Diffuse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + + |
Hematopoietic Cell Proliferation, | |
Diffuse | 3 |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
__________________________________________________________________________|
Skin | + + |
Inflammation, Chronic | |
Subcutaneous Tissue, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage, Acute | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + |
Abscess | |
Atelectasis, Diffuse | 4 |
Congestion, Diffuse | |
Foreign Body | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Bronchiole, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 2| 4| 4| 7| 7| 7| 7| 5| 7| 6| 0| 4| 4| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 0| 3| 3| 3| 3| 6| 5| 5| 3| 3| 1| 3| 8| 3| 0| 0| 5| 5| 8| 3| 5| 3| 3| 3| 3|
| 0| 0| 5| 3| 3| 0| 6| 6| 4| 4| 5| 3| 2| 0| 4| 7| 6| 6| 4| 3| 6| 5| 5| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
112MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + |
Nephropathy, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 9| 3| 3| 0| 5| 3| 3| 3| 3| | |
| 3| 9| 5| 3| 1| 6| 4| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
112MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
Serosa, Inflammation, Chronic, | | |
Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
Serosa, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 2 |
Hyperplasia, Atypical, Focal | | 1 3.0|
Serosa, Inflammation, Chronic, | | |
Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 2 |
Diverticulum | | 1 3.0|
Serosa, Inflammation, Chronic, | | |
Diffuse | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + | 5 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 4 | 1 4.0|
Serosa, Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Cyst | | 1 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 3 |
Hyperplasia, Focal, Squamous | | 1 2.0|
Hyperplasia, Multifocal, Squamous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 1 |
Epicardium, Inflammation, Diffuse, | | |
Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | |
__________________________________________________________________________|____________|
Pituitary Gland | | 7 |
Pars Distalis, Congestion, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 9| 3| 3| 0| 5| 3| 3| 3| 3| | |
| 3| 9| 5| 3| 1| 6| 4| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
112MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + | 11 |
Cyst | X | 8 |
Cyst Multilocular | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 36 |
Hemorrhage, Chronic | | 1 3.0|
Hyperplasia, Chronic, Cystic, Diffuse| 3 2 3 4 4 4 4 | 35 3.0|
Serosa, Inflammation, Chronic, | | |
Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 6 |
__________________________________________________________________________|____________|
Spleen | + + + | 12 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 4 | 2 3.5|
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 6 |
Inflammation, Chronic | 2 1 | 3 1.7|
Subcutaneous Tissue, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 7 |
Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 6| 7| | |
DAY ON TEST | 3| 9| 3| 3| 0| 5| 3| 3| 3| 3| | |
| 3| 9| 5| 3| 1| 6| 4| 0| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
112MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Atelectasis, Diffuse | | 1 4.0|
Congestion, Diffuse | 3 | 2 2.5|
Foreign Body | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Bronchiole, Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 3 |
Nephropathy, Diffuse | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 0| 7| 6| 7| 7| 1| 3| 4| 7| 6| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 3| 3| 3| 4| 1| 5| 3| 3| 0| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 3| 4| 2| 0| 4| 0| 3| 6| 3| 6| 0| 6| 4| 3| 5| 6| 3| 3| 5| 4| 5| 0| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
__________________________________________________________________________|
Gallbladder | A + + + + A + + + A + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Inflammation, | |
Chronic, Focal | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + A + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + A + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + A + + + + + + + + + + + + + + + A|
Diverticulum | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis, Diffuse | |
Fatty Change, Diffuse | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 |
Inflammation, Focal, Subacute | 1 |
Necrosis, Acute, Focal | |
Pigmentation, Diffuse, Hemosiderin | |
Centrilobular, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + M|
Hyperplasia, Glandular, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + M|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 2 3 1 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal, Squamous | 2 2 2 |
Hyperplasia, Multifocal, Squamous | 2 |
Inflammation, Subacute | |
Ulcer, Acute, Multifocal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + M|
Erosion, Focal | 3 |
Ulcer, Acute, Focal | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 0| 7| 6| 7| 7| 1| 3| 4| 7| 6| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 3| 3| 3| 4| 1| 5| 3| 3| 0| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 3| 4| 2| 0| 4| 0| 3| 6| 3| 6| 0| 6| 4| 3| 5| 6| 3| 3| 5| 4| 5| 0| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + M + + + + + M|
__________________________________________________________________________|
Parathyroid Gland | M + + M M M + M M + M M + M + M M M + + M M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 3 3 3 3 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M|
Depletion Secretory | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + I + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Cyst | X X |
Cyst Multilocular | X X X |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Diffuse | |
Dilatation | |
Hemorrhage, Chronic | |
Hyperplasia, Chronic, Cystic, Diffuse| 3 3 3 3 4 4 3 3 4 4 4 4 4 3 4 4 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Diffuse, Hemosiderin | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + M|
Congestion, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 0| 7| 6| 7| 7| 1| 3| 4| 7| 6| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 3| 3| 3| 4| 1| 5| 3| 3| 0| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 3| 4| 2| 0| 4| 0| 3| 6| 3| 6| 0| 6| 4| 3| 5| 6| 3| 3| 5| 4| 5| 0| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Erythrophagocytosis, Diffuse | |
Hematopoietic Cell Proliferation, | |
Diffuse | 2 |
Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Thymus | + + + + M + + + M M + + + M + M M + + M + M|
Atrophy, Diffuse | |
Medulla, Hyperplasia, Focal, Lymphoid| 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 2 1 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Osteoporosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 2 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + M|
Congestion, Diffuse | 4 |
Hyperplasia, Focal, Adenomatous | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 2 1 1 1 1 1 2 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Degeneration, Chronic, Diffuse | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Casts | |
Cyst | X |
Hydronephrosis | 4 |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 0| 7| 6| 7| 7| 1| 3| 4| 7| 6| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 3| 3| 3| 3| 4| 1| 5| 3| 3| 0| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8|
| 3| 4| 2| 0| 4| 0| 3| 6| 3| 6| 0| 6| 4| 3| 5| 6| 3| 3| 5| 4| 5| 0| 4| 5| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell, Multifocal | 1 3 2 1 1 1 1 1 1 1 3 1 1 1 4 1|
Nephropathy, Diffuse | |
Glomerulus, Amyloid Deposition, | |
Diffuse | |
Papilla, Mineralization, Multifocal | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urinary Bladder | A + + + + A + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 3 |
Inflammation, Diffuse, Subacute | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 1| 4| 6| 6| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 8| 7| 8| 5| 5| 3| 3| 3| 5| 9| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3|
| 5| 6| 2| 6| 1| 6| 6| 0| 3| 5| 6| 7| 0| 3| 8| 3| 4| 4| 5| 3| 6| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
225MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Gallbladder | A + A + + + + + + + A M + + + + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
Anorectal Junction, Inflammation, | |
Chronic, Focal | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + A + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + A + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + A + + A + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis, Diffuse | 2 2 |
Fatty Change, Diffuse | 3 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 2 1 2 1 |
Inflammation, Focal, Subacute | |
Necrosis, Acute, Focal | 1 |
Pigmentation, Diffuse, Hemosiderin | 2 2 |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Glandular, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 1 1 1 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + I + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | 3 1 |
Hyperplasia, Multifocal, Squamous | |
Inflammation, Subacute | 2 |
Ulcer, Acute, Multifocal | 2 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + I + + + + + + + + + + + +|
Erosion, Focal | 1 |
Ulcer, Acute, Focal | 3 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 1| 4| 6| 6| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 8| 7| 8| 5| 5| 3| 3| 3| 5| 9| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3|
| 5| 6| 2| 6| 1| 6| 6| 0| 3| 5| 6| 7| 0| 3| 8| 3| 4| 4| 5| 3| 6| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
225MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M + M M + + + M M + M + + M M M M +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 1 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Depletion Secretory | |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Cyst | X X |
Cyst Multilocular | X |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Diffuse | 3 |
Dilatation | 4 |
Hemorrhage, Chronic | 4 |
Hyperplasia, Chronic, Cystic, Diffuse| 2 2 3 3 4 4 4 3 3 4 2 3 4 3 3 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Diffuse, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 3 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 4 4 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 1| 4| 6| 6| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 8| 7| 8| 5| 5| 3| 3| 3| 5| 9| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3|
| 5| 6| 2| 6| 1| 6| 6| 0| 3| 5| 6| 7| 0| 3| 8| 3| 4| 4| 5| 3| 6| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
225MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Erythrophagocytosis, Diffuse | 4 3 |
Hematopoietic Cell Proliferation, | |
Diffuse | 3 4 3 3|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + I + M + + + + + + M + + + + + + + + +|
Atrophy, Diffuse | 4 4 |
Medulla, Hyperplasia, Focal, Lymphoid| 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Osteoporosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 4 |
Hyperplasia, Focal, Adenomatous | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 3 2 2 2 2 2 1 2 1 2 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Degeneration, Chronic, Diffuse | 4 |
__________________________________________________________________________|
Harderian Gland | + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Casts | X X |
Cyst | X |
Hydronephrosis | 4 |
Infiltration Cellular, Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 1| 4| 6| 6| 6| 4| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7|
DAY ON TEST | 5| 5| 8| 7| 8| 5| 5| 3| 3| 3| 5| 9| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 2| 3|
| 5| 6| 2| 6| 1| 6| 6| 0| 3| 5| 6| 7| 0| 3| 8| 3| 4| 4| 5| 3| 6| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
225MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cell, Multifocal | 2 2 1 2 2 2 1 2 1 1 2 1|
Nephropathy, Diffuse | 4 3 |
Glomerulus, Amyloid Deposition, | |
Diffuse | 2 |
Papilla, Mineralization, Multifocal | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urinary Bladder | A + M + + + + I + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 3 2 2 |
Inflammation, Diffuse, Subacute | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 8| 3| 8| 5| 3| 3| 3| 3| | |
| 6| 4| 8| 5| 5| 6| 0| 0| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 49 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
__________________________________________________________________________|____________|
Gallbladder | + A + A + + + + | 39 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
Anorectal Junction, Inflammation, | | |
Chronic, Focal | | 2 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + | 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A + + + + | 41 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A + + + + | 42 |
Diverticulum | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Erythrophagocytosis, Diffuse | 2 | 3 2.0|
Fatty Change, Diffuse | 2 | 2 2.5|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 | 9 1.2|
Inflammation, Focal, Subacute | | 1 1.0|
Necrosis, Acute, Focal | | 1 1.0|
Pigmentation, Diffuse, Hemosiderin | | 2 2.0|
Centrilobular, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 48 |
Hyperplasia, Glandular, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 47 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 3 1 1 2 1 | 22 1.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 46 |
Hyperplasia, Focal, Squamous | | 5 2.0|
Hyperplasia, Multifocal, Squamous | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Ulcer, Acute, Multifocal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 46 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 8| 3| 8| 5| 3| 3| 3| 3| | |
| 6| 4| 8| 5| 5| 6| 0| 0| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion, Focal | | 2 2.0|
Ulcer, Acute, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + | 49 |
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + M M + | 20 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 50 |
Pars Distalis, Hyperplasia, Focal | 1 | 10 2.4|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Depletion Secretory | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 49 |
Angiectasis, Focal | 3 | 1 3.0|
Cyst | X X X | 7 |
Cyst Multilocular | | 4 |
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 3 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 50 |
Amyloid Deposition, Diffuse | | 1 3.0|
Dilatation | | 1 4.0|
Hemorrhage, Chronic | | 1 4.0|
Hyperplasia, Chronic, Cystic, Diffuse| 4 3 2 4 3 4 4 | 41 3.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 8| 3| 8| 5| 3| 3| 3| 3| | |
| 6| 4| 8| 5| 5| 6| 0| 0| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
Pigmentation, Diffuse, Hemosiderin | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 48 |
Hematopoietic Cell Proliferation, | | |
Diffuse | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 49 |
Congestion, Diffuse | | 2 4.0|
Erythrophagocytosis, Diffuse | 4 | 3 3.7|
Hematopoietic Cell Proliferation, | | |
Diffuse | 2 3 | 7 2.9|
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 39 |
Atrophy, Diffuse | 3 | 3 3.7|
Medulla, Hyperplasia, Focal, Lymphoid| 3 | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + | 48 |
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 50 |
Inflammation, Chronic | | 7 1.9|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Osteoporosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Mineralization, Multifocal | 2 1 | 19 1.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 49 |
Congestion, Diffuse | 3 | 3 3.7|
Hyperplasia, Focal, Adenomatous | 2 | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 2 1 3 2 1 | 35 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 5| 3| 8| 3| 8| 5| 3| 3| 3| 3| | |
| 6| 4| 8| 5| 5| 6| 0| 0| 3| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
225MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Foreign Body | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Degeneration, Chronic, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Casts | X | 3 |
Cyst | | 2 |
Hydronephrosis | 4 | 3 4.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 2 1 2 1 | 32 1.5|
Nephropathy, Diffuse | 4 | 3 3.7|
Glomerulus, Amyloid Deposition, | | |
Diffuse | | 1 2.0|
Papilla, Mineralization, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 45 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 5 2.4|
Inflammation, Diffuse, Subacute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 5| 9| 3| 3| 3| 2| 3| 3| 3| 3| 6| 1| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 3| 6| 4| 5| 6| 2| 3| 5| 3| 8| 4| 4| 5| 3| 7| 1| 4| 5| 3| 6| 5| 3| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + I + + A M + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + I + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 4 |
Hyperplasia, Focal, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Inclusion Body Intranuclear, Diffuse | |
Infarct | |
Karyomegaly, Diffuse | |
Necrosis, Acute, Focal | 2 2 |
Centrilobular, Fatty Change | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 2 2 2 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Diverticulum, Focal | |
Hyperplasia, Focal, Squamous | 2 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | 1 |
Cyst Epithelial Inclusion, Focal | 1 |
Degeneration, Cystic, Focal | |
Erosion, Focal | |
__________________________________________________________________________|
Tooth | + + + + + |
Inflammation, Chronic | 4 2 2 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 5| 9| 3| 3| 3| 2| 3| 3| 3| 3| 6| 1| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 3| 6| 4| 5| 6| 2| 3| 5| 3| 8| 4| 4| 5| 3| 7| 1| 4| 5| 3| 6| 5| 3| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1 1 |
Hypertrophy, Multifocal | |
Spindle Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + M|
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 2 3|
__________________________________________________________________________|
Parathyroid Gland | + + + I + M M + M M I + + I + M M M + I M I|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + M + + + + +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + +|
Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
__________________________________________________________________________|
Penis | + |
Congestion | 3 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 4 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Granuloma Sperm, Focal | |
Mineralization, Focal | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 5| 9| 3| 3| 3| 2| 3| 3| 3| 3| 6| 1| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 3| 6| 4| 5| 6| 2| 3| 5| 3| 8| 4| 4| 5| 3| 7| 1| 4| 5| 3| 6| 5| 3| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 4 |
Giant Cell, Diffuse | 1 1|
Hematopoietic Cell Proliferation, | |
Diffuse | 3 2 |
Hemorrhage, Diffuse | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 4 2 3 2 4 3 |
__________________________________________________________________________|
Thymus | + M I M M I M I M M M M I + M + I + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M I M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | |
Inflammation, Chronic | 3 1 |
Hair Follicle, Atrophy, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Coccygeal, Hyperostosis | |
Cranium, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Demyelination, Multifocal | |
Hemorrhage, Focal | 1 |
Mineralization, Multifocal | 1 2 2 1 1 2 1 2 2 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | |
Hyperplasia, Focal, Adenomatous | 2 |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 1 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 5| 9| 3| 3| 3| 2| 3| 3| 3| 3| 6| 1| 3| 3| 3| 5| 3| 3| 3| 3|
| 3| 3| 6| 4| 5| 6| 2| 3| 5| 3| 8| 4| 4| 5| 3| 7| 1| 4| 5| 3| 6| 5| 3| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal, Tubular | 1 |
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 2 1 1 1 2 2 1 1 1 1 1 1 1 2|
Nephropathy, Diffuse | |
Cortex, Degeneration, Diffuse, | |
Hyaline | 2 |
Glomerulus, Inflammation, Diffuse, | |
Subacute, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 4 |
Inflammation, Acute, Diffuse | |
Inflammation, Chronic, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 5| 3| 0| 9| 3|
| 1| 7| 0| 5| 0| 6| 2| 4| 7| 0| 6| 0| 4| 5| 0| 6| 1| 0| 5| 6| 6| 0| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A A + + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + I + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A M + + + + + + + + + + + + + + + A + +|
Diverticulum | |
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Inclusion Body Intranuclear, Diffuse | |
Infarct | 2 |
Karyomegaly, Diffuse | |
Necrosis, Acute, Focal | |
Centrilobular, Fatty Change | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 1 1 1 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Diverticulum, Focal | 2 |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + +|
Cyst, Focal | |
Cyst Epithelial Inclusion, Focal | |
Degeneration, Cystic, Focal | |
Erosion, Focal | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 5| 3| 0| 9| 3|
| 1| 7| 0| 5| 0| 6| 2| 4| 7| 0| 6| 0| 4| 5| 0| 6| 1| 0| 5| 6| 6| 0| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | 2 1 |
Hypertrophy, Multifocal | 2 |
Spindle Cell, Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | M M M + M M + + + + + M M + M M M M I M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + I +|
Pars Distalis, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
__________________________________________________________________________|
Penis | |
Congestion | |
Inflammation, Chronic | |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Granuloma Sperm, Focal | 4 |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 5| 3| 0| 9| 3|
| 1| 7| 0| 5| 0| 6| 2| 4| 7| 0| 6| 0| 4| 5| 0| 6| 1| 0| 5| 6| 6| 0| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + +|
Congestion, Diffuse | 3 2 |
Giant Cell, Diffuse | 1 2 |
Hematopoietic Cell Proliferation, | |
Diffuse | |
Hemorrhage, Diffuse | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 4 3 |
__________________________________________________________________________|
Thymus | + + + + M M + M + + + + M M M + + M + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | |
Inflammation, Chronic | 3 |
Hair Follicle, Atrophy, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Coccygeal, Hyperostosis | |
Cranium, Inflammation, Chronic | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Demyelination, Multifocal | 2 |
Hemorrhage, Focal | |
Mineralization, Multifocal | 1 1 1 1 1 2 1 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion, Diffuse | 4 |
Hyperplasia, Focal, Adenomatous | 2 |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 2 2 1 1 2 1 1 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 4| 7| 7| 6| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 1| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 5| 3| 0| 9| 3|
| 1| 7| 0| 5| 0| 6| 2| 4| 7| 0| 6| 0| 4| 5| 0| 6| 1| 0| 5| 6| 6| 0| 0| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 2 3 1 2 |
Inflammation, Acute | 1 2 1 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Trachea | + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal, Tubular | |
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 2 2 2 2 1 1 3 1 2 1 1 2 2 2 2|
Nephropathy, Diffuse | 3 |
Cortex, Degeneration, Diffuse, | |
Hyaline | |
Glomerulus, Inflammation, Diffuse, | |
Subacute, Suppurative | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + +|
Concretion | 2 2 3 |
Inflammation, Acute, Diffuse | 4 |
Inflammation, Chronic, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 7| 6| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 2| 5| 3| 1| 3| 3| | |
| 0| 6| 0| 3| 4| 6| 4| 2| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + M | 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 48 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + | 46 |
Diverticulum | | 1 4.0|
Hyperplasia, Focal, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 50 |
Basophilic Focus | X | 3 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Inclusion Body Intranuclear, Diffuse | 3 | 1 3.0|
Infarct | | 1 2.0|
Karyomegaly, Diffuse | 3 | 1 3.0|
Necrosis, Acute, Focal | | 2 2.0|
Centrilobular, Fatty Change | 1 | 2 1.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 50 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 50 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 2 1.5|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 2 1 | 17 1.3|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 49 |
Cyst | | 1 |
Diverticulum, Focal | | 1 2.0|
Hyperplasia, Focal, Squamous | 2 | 2 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 47 |
Cyst, Focal | | 1 1.0|
Cyst Epithelial Inclusion, Focal | | 1 1.0|
Degeneration, Cystic, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 7| 6| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 2| 5| 3| 1| 3| 3| | |
| 0| 6| 0| 3| 4| 6| 4| 2| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Erosion, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 6 |
Inflammation, Chronic | | 6 3.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 50 |
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 49 |
Hyperplasia, Focal | 2 | 3 2.3|
Hypertrophy, Focal | 3 | 5 1.6|
Hypertrophy, Multifocal | | 1 2.0|
Spindle Cell, Hyperplasia, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 47 |
Hyperplasia, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 50 |
Hyperplasia, Focal | | 3 2.7|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M M + | 20 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + | 45 |
Pars Distalis, Cyst | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 49 |
Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 50 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Congestion | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
Abscess | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 7| 6| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 2| 5| 3| 1| 3| 3| | |
| 0| 6| 0| 3| 4| 6| 4| 2| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 50 |
Atrophy, Diffuse | | 1 4.0|
Granuloma Sperm, Focal | | 1 4.0|
Mineralization, Focal | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 49 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 48 |
Congestion, Diffuse | 2 3 | 5 2.8|
Giant Cell, Diffuse | 2 2 | 6 1.5|
Hematopoietic Cell Proliferation, | | |
Diffuse | | 2 2.5|
Hemorrhage, Diffuse | | 2 4.0|
Hyperplasia, Lymphoid | 4 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + M + + + + + | 49 |
Hematopoietic Cell Proliferation, | | |
Diffuse | 3 4 | 10 3.2|
__________________________________________________________________________|____________|
Thymus | + + M M + M M M | 24 |
Cyst | X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M I M M | 1 |
__________________________________________________________________________|____________|
Skin | + M + + + + + + | 49 |
Abscess | | 1 4.0|
Cyst | X | 1 |
Inflammation, Chronic | 3 4 3 | 6 2.8|
Hair Follicle, Atrophy, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 50 |
Coccygeal, Hyperostosis | 2 | 1 2.0|
Cranium, Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 7| 6| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 2| 5| 3| 1| 3| 3| | |
| 0| 6| 0| 3| 4| 6| 4| 2| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 50 |
Demyelination, Multifocal | | 1 2.0|
Hemorrhage, Focal | | 1 1.0|
Mineralization, Multifocal | 1 2 1 | 24 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 50 |
Congestion, Diffuse | 3 | 2 3.5|
Hyperplasia, Focal, Adenomatous | 2 1 | 4 1.8|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 1 1 2 1 | 25 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 50 |
Foreign Body | 1 | 8 1.8|
Inflammation, Acute | 2 | 6 1.7|
Inflammation, Chronic | | 2 3.5|
__________________________________________________________________________|____________|
Trachea | + M + + M + + M | 46 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 50 |
Cyst | X | 2 |
Hyperplasia, Focal, Tubular | | 1 1.0|
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 1 3 3 1 1 3 | 39 1.6|
Nephropathy, Diffuse | | 1 3.0|
Cortex, Degeneration, Diffuse, | | |
Hyaline | | 1 2.0|
Glomerulus, Inflammation, Diffuse, | | |
Subacute, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 49 |
Concretion | 2 3 | 6 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 4| 7| 6| 7| 7| | |
DAY ON TEST | 3| 5| 3| 3| 2| 5| 3| 1| 3| 3| | |
| 0| 6| 0| 3| 4| 6| 4| 2| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute, Diffuse | | 1 4.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 5| 3| 3| 2|
| 6| 4| 4| 3| 3| 0| 0| 0| 5| 4| 6| 0| 3| 4| 3| 6| 5| 3| 0| 3| 6| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + + |
Diverticulum | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
Diverticulum | 4 4 |
__________________________________________________________________________|
Liver | + + + + + |
Infarct | 2 |
Mixed Cell Focus | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + |
__________________________________________________________________________|
Islets, Pancreatic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
__________________________________________________________________________|
Testes | |
Atrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + |
Congestion | |
Pigmentation | |
Thoracic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
__________________________________________________________________________|
Spleen | + + |
Hematopoietic Cell Proliferation, | |
Diffuse | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 3| 1| 3| 3| 3| 3| 5| 5| 3| 3| 2|
| 6| 4| 4| 3| 3| 0| 0| 0| 5| 4| 6| 0| 3| 4| 3| 6| 5| 3| 0| 3| 6| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + |
Hyperplasia, Focal, Adenomatous | 2 |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Proximal Convoluted Renal Tubule, | |
Dilatation, Diffuse | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 9| 1| 5| 5| 3| 3| 3|
| 5| 5| 4| 3| 4| 6| 5| 4| 0| 5| 4| 0| 5| 6| 0| 1| 0| 4| 8| 5| 6| 6| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + + |
Diverticulum | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Diverticulum | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + |
Infarct | |
Mixed Cell Focus | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Islets, Pancreatic | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 3 |
__________________________________________________________________________|
Testes | |
Atrophy, Diffuse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + |
Congestion | 2 |
Pigmentation | |
Thoracic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + |
__________________________________________________________________________|
Spleen | + + |
Hematopoietic Cell Proliferation, | |
Diffuse | 4 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 4| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 8| 3| 5| 3| 3| 9| 1| 5| 5| 3| 3| 3|
| 5| 5| 4| 3| 4| 6| 5| 4| 0| 5| 4| 0| 5| 6| 0| 1| 0| 4| 8| 5| 6| 6| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
112MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + |
Hyperplasia, Focal, Adenomatous | |
__________________________________________________________________________|
Trachea | + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Proximal Convoluted Renal Tubule, | |
Dilatation, Diffuse | 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 3| 3| | |
| 3| 4| 5| 4| 3| 6| 6| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 5 |
Diverticulum | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 4 |
Diverticulum | | 3 4.0|
__________________________________________________________________________|____________|
Liver | + + | 16 |
Infarct | | 1 2.0|
Mixed Cell Focus | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + | 3 |
Abscess | 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Testes | + | 1 |
Atrophy, Diffuse | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Congestion | | 1 2.0|
Pigmentation | 2 | 1 2.0|
Thoracic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 5 |
__________________________________________________________________________|____________|
Spleen | | 4 |
Hematopoietic Cell Proliferation, | | |
Diffuse | | 3 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 5| 5| 5| 3| 3| | |
| 3| 4| 5| 4| 3| 6| 6| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
112MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + | 7 |
Hyperplasia, Focal, Adenomatous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 3 |
Proximal Convoluted Renal Tubule, | | |
Dilatation, Diffuse | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 5| 7| 1| 2| 4| 7| 7| 1| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 3| 3| 5| 3| 3| 7| 3| 3| 0| 5| 3| 3| 4| 5| 3| 2| 3| 5| 3| 3| 3| 3|
| 9| 6| 1| 0| 4| 6| 4| 0| 4| 0| 3| 9| 6| 5| 4| 0| 6| 4| 8| 5| 6| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Subacute | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + A + A + + I I +|
Cyst | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + +|
Inflammation, Acute, Focal | 2 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + A + + + + + + +|
Amyloid Deposition, Chronic, Diffuse | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
Mixed Cell Focus | |
Necrosis, Acute, Multifocal | 2 |
Centrilobular, Fatty Change | |
Centrilobular, Necrosis, Acute, | |
Diffuse | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Edema, Acute, Diffuse | |
Hyperplasia, Focal, Glandular | |
Inflammation, Chronic, Multifocal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | 1 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 2 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + +|
Cyst Epithelial Inclusion | X |
Hyperplasia, Focal, Squamous | |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + +|
Edema, Diffuse | |
Hyperplasia, Focal | 3 |
Hyperplasia, Adenomatous | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 5| 7| 1| 2| 4| 7| 7| 1| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 3| 3| 5| 3| 3| 7| 3| 3| 0| 5| 3| 3| 4| 5| 3| 2| 3| 5| 3| 3| 3| 3|
| 9| 6| 1| 0| 4| 6| 4| 0| 4| 0| 3| 9| 6| 5| 4| 0| 6| 4| 8| 5| 6| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M M + M + M + + M M + + + + M M +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Depletion Secretory | |
Hemorrhage, Acute, Focal | |
Inflammation, Subacute | |
C-Cell, Hyperplasia, Chronic, Focal | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Congestion | |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Seminal Vesicle | |
Dilatation | |
Inflammation, Chronic, Diffuse | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 5| 7| 1| 2| 4| 7| 7| 1| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 3| 3| 5| 3| 3| 7| 3| 3| 0| 5| 3| 3| 4| 5| 3| 2| 3| 5| 3| 3| 3| 3|
| 9| 6| 1| 0| 4| 6| 4| 0| 4| 0| 3| 9| 6| 5| 4| 0| 6| 4| 8| 5| 6| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy, Diffuse | |
Degeneration, Diffuse | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | |
Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Ectasia, Diffuse | |
Giant Cell, Diffuse | 3 |
Hyperplasia, Diffuse, Re Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 4 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + M + M M M + + + M +|
Atrophy, Diffuse | 4 |
Cyst | X |
Mediastinum, Inflammation, Acute | |
Medulla, Hyperplasia, Focal, Lymphoid| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + I + + + + + + +|
Edema, Acute, Diffuse | |
Inflammation, Chronic | 1 3 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cartilage, Proliferation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
Mineralization, Multifocal | 1 2 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 4| 6| 7| 7| 4| 7| 7| 5| 7| 1| 2| 4| 7| 7| 1| 4| 7| 6| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 2| 5| 4| 3| 3| 5| 3| 3| 7| 3| 3| 0| 5| 3| 3| 4| 5| 3| 2| 3| 5| 3| 3| 3| 3|
| 9| 6| 1| 0| 4| 6| 4| 0| 4| 0| 3| 9| 6| 5| 4| 0| 6| 4| 8| 5| 6| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion, Diffuse | 3 |
Hemorrhage, Focal | 1 |
Hemorrhage, Multifocal | |
Hyperplasia, Focal, Adenomatous | 1 |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 1 1 2 1 2 2 1|
Infiltration Cellular, Multifocal, | |
Histiocyte | |
Inflammation, Chronic | |
Pleura, Inflammation, Subacute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Hyperplasia, Focal, Glandular | 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Ectopic Tissue | |
Hyperplasia, Focal, Tubular | 1 |
Hyperplasia, Multifocal, Tubular | 3 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Inflammation, Chronic | |
Nephropathy, Diffuse | 3 |
Vacuolization Cytoplasmic, Multifocal| 1 |
Cortex, Degeneration, Diffuse, | |
Hyaline | |
Cortex, Vacuolization Cytoplasmic, | |
Multifocal | |
Glomerulus, Amyloid Deposition, | |
Diffuse | |
Proximal Convoluted Renal Tubule, | |
Degeneration, Focal | 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + A + + + + + + +|
Concretion | 2 |
Edema, Acute, Diffuse | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 6| 7| 7| 7| 4| 4| 7| 7| 7| 3| 5| 4| 7| 7| 0| 2| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 4| 7| 0| 3| 3| 5| 5| 3| 3| 3| 1| 9| 5| 3| 3| 0| 4| 5| 3| 3|
| 6| 3| 3| 3| 3| 1| 9| 8| 3| 4| 6| 6| 5| 4| 0| 0| 0| 6| 0| 0| 6| 1| 6| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + I + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Gallbladder | + + + M A A + + + + + + + A + + + A + +|
Cyst | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A M A + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + A + + + A + +|
Amyloid Deposition, Chronic, Diffuse | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + A + + + M + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + A + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 |
Mixed Cell Focus | X |
Necrosis, Acute, Multifocal | |
Centrilobular, Fatty Change | 1 2 |
Centrilobular, Necrosis, Acute, | |
Diffuse | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + M + + + + + +|
Edema, Acute, Diffuse | 3 |
Hyperplasia, Focal, Glandular | 2 |
Inflammation, Chronic, Multifocal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 1 2 2 1 1 1 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + +|
Cyst Epithelial Inclusion | X|
Hyperplasia, Focal, Squamous | 3 2 |
Inflammation, Chronic, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + M + + + + + + +|
Edema, Diffuse | 3 |
Hyperplasia, Focal | |
Hyperplasia, Adenomatous | 3 |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 6| 7| 7| 7| 4| 4| 7| 7| 7| 3| 5| 4| 7| 7| 0| 2| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 4| 7| 0| 3| 3| 5| 5| 3| 3| 3| 1| 9| 5| 3| 3| 0| 4| 5| 3| 3|
| 6| 3| 3| 3| 3| 1| 9| 8| 3| 4| 6| 6| 5| 4| 0| 0| 0| 6| 0| 0| 6| 1| 6| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Mononuclear Cell | |
Inflammation, Chronic, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + M + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + M M M + M M M M|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Depletion Secretory | X |
Hemorrhage, Acute, Focal | 2 |
Inflammation, Subacute | 3 |
C-Cell, Hyperplasia, Chronic, Focal | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Congestion | 3 |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 4 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + M + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 4 4 |
Inflammation, Chronic, Diffuse | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 6| 7| 7| 7| 4| 4| 7| 7| 7| 3| 5| 4| 7| 7| 0| 2| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 4| 7| 0| 3| 3| 5| 5| 3| 3| 3| 1| 9| 5| 3| 3| 0| 4| 5| 3| 3|
| 6| 3| 3| 3| 3| 1| 9| 8| 3| 4| 6| 6| 5| 4| 0| 0| 0| 6| 0| 0| 6| 1| 6| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy, Diffuse | 4 |
Degeneration, Diffuse | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 3 |
Thrombosis | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +|
Ectasia, Diffuse | 2 |
Giant Cell, Diffuse | 3 |
Hyperplasia, Diffuse, Re Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation, | |
Diffuse | 4 3 |
Hyperplasia, Lymphoid | 3 3 3 |
__________________________________________________________________________|
Thymus | M + + M I M I M + + + + + + M + + + + +|
Atrophy, Diffuse | |
Cyst | |
Mediastinum, Inflammation, Acute | 3 |
Medulla, Hyperplasia, Focal, Lymphoid| 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Edema, Acute, Diffuse | 4 |
Inflammation, Chronic | 3 |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Cartilage, Proliferation, Chronic, | |
Focal | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 |
Mineralization, Multifocal | 2 2 1 2 2 2 1 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 1| 6| 7| 7| 7| 4| 4| 7| 7| 7| 3| 5| 4| 7| 7| 0| 2| 4| 7| 7|
DAY ON TEST | 5| 5| 3| 3| 3| 4| 7| 0| 3| 3| 5| 5| 3| 3| 3| 1| 9| 5| 3| 3| 0| 4| 5| 3| 3|
| 6| 3| 3| 3| 3| 1| 9| 8| 3| 4| 6| 6| 5| 4| 0| 0| 0| 6| 0| 0| 6| 1| 6| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
225MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion, Diffuse | 3 4 3 |
Hemorrhage, Focal | |
Hemorrhage, Multifocal | 2 |
Hyperplasia, Focal, Adenomatous | |
Infiltration Cellular, Diffuse, | |
Histiocyte | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 2 1 2 2 1 2 1 2|
Infiltration Cellular, Multifocal, | |
Histiocyte | 2 |
Inflammation, Chronic | 1 |
Pleura, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hyperplasia, Focal, Glandular | |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Ectopic Tissue | X |
Hyperplasia, Focal, Tubular | |
Hyperplasia, Multifocal, Tubular | |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | 2 1 1 2 2 2 3 1 1 1 2 1 2|
Inflammation, Chronic | 4 |
Nephropathy, Diffuse | 3 3 |
Vacuolization Cytoplasmic, Multifocal| |
Cortex, Degeneration, Diffuse, | |
Hyaline | 3 |
Cortex, Vacuolization Cytoplasmic, | |
Multifocal | 2 |
Glomerulus, Amyloid Deposition, | |
Diffuse | 2 |
Proximal Convoluted Renal Tubule, | |
Degeneration, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Edema, Acute, Diffuse | 4 |
Infiltration Cellular, Mononuclear | |
Cell, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| | |
| 5| 0| 4| 0| 5| 5| 3| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
Serosa, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + | 39 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + | 45 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 49 |
Inflammation, Acute, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + | 43 |
Amyloid Deposition, Chronic, Diffuse | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + | 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Basophilic Focus | | 1 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 1.0|
Mixed Cell Focus | X | 2 |
Necrosis, Acute, Multifocal | | 1 2.0|
Centrilobular, Fatty Change | | 2 1.5|
Centrilobular, Necrosis, Acute, | | |
Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 48 |
Edema, Acute, Diffuse | | 1 3.0|
Hyperplasia, Focal, Glandular | | 1 2.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | | 1 1.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 1 1 3 1 | 16 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 46 |
Cyst Epithelial Inclusion | | 2 |
Hyperplasia, Focal, Squamous | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| | |
| 5| 0| 4| 0| 5| 5| 3| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Chronic, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 47 |
Edema, Diffuse | | 1 3.0|
Hyperplasia, Focal | | 1 3.0|
Hyperplasia, Adenomatous | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Infiltration Cellular, Focal, | | |
Mononuclear Cell | 1 | 1 1.0|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Hyperplasia, Focal | 1 | 1 1.0|
Hypertrophy, Focal | 2 2 1 | 8 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + + | 31 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Cyst | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Depletion Secretory | | 1 |
Hemorrhage, Acute, Focal | | 1 2.0|
Inflammation, Subacute | | 1 3.0|
C-Cell, Hyperplasia, Chronic, Focal | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| | |
| 5| 0| 4| 0| 5| 5| 3| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Congestion | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Abscess | | 1 4.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 48 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | | 2 |
Dilatation | | 2 4.0|
Inflammation, Chronic, Diffuse | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Atrophy, Diffuse | | 1 4.0|
Degeneration, Diffuse | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | | 1 3.0|
Thrombosis | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Ectasia, Diffuse | 3 2 | 3 2.3|
Giant Cell, Diffuse | | 2 3.0|
Hyperplasia, Diffuse, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation, | | |
Diffuse | | 4 3.8|
Hyperplasia, Lymphoid | 4 | 4 3.3|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + I + | 35 |
Atrophy, Diffuse | 3 | 2 3.5|
Cyst | | 1 |
Mediastinum, Inflammation, Acute | | 1 3.0|
Medulla, Hyperplasia, Focal, Lymphoid| | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Edema, Acute, Diffuse | | 1 4.0|
Inflammation, Chronic | 4 | 4 2.8|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| | |
| 5| 0| 4| 0| 5| 5| 3| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Cartilage, Proliferation, Chronic, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Hydrocephalus | | 1 2.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | | 1 2.0|
Mineralization, Multifocal | 1 1 2 1 2 1 | 24 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Congestion, Diffuse | 4 | 5 3.4|
Hemorrhage, Focal | | 1 1.0|
Hemorrhage, Multifocal | | 1 2.0|
Hyperplasia, Focal, Adenomatous | | 1 1.0|
Infiltration Cellular, Diffuse, | | |
Histiocyte | 3 | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 2 1 2 1 2 1 | 26 1.5|
Infiltration Cellular, Multifocal, | | |
Histiocyte | | 1 2.0|
Inflammation, Chronic | | 1 1.0|
Pleura, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Foreign Body | | 1 1.0|
Hyperplasia, Focal, Glandular | | 1 2.0|
Inflammation, Acute | 1 | 3 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Cyst | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05704-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC RESORCINOL Date: 04/29/97
Route: GAVAGE Time: 08:24:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| | |
| 5| 0| 4| 0| 5| 5| 3| 0| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
225MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Ectopic Tissue | | 1 |
Hyperplasia, Focal, Tubular | | 1 1.0|
Hyperplasia, Multifocal, Tubular | | 1 3.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 2 1 1 2 1 1 3 2 2 | 36 1.4|
Inflammation, Chronic | | 1 4.0|
Nephropathy, Diffuse | | 3 3.0|
Vacuolization Cytoplasmic, Multifocal| | 1 1.0|
Cortex, Degeneration, Diffuse, | | |
Hyaline | | 1 3.0|
Cortex, Vacuolization Cytoplasmic, | | |
Multifocal | | 1 2.0|
Glomerulus, Amyloid Deposition, | | |
Diffuse | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Degeneration, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 48 |
Concretion | | 2 2.0|
Edema, Acute, Diffuse | | 1 4.0|
Infiltration Cellular, Mononuclear | | |
Cell, Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
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