TDMS Study 05704-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05704 RESORCINOL TIME: 17:09:51
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 05970A
CONT: 05700-04 CAS: 108-46-3
PATHOLOGIST: F. VOELKER S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05704 RESORCINOL TIME: 17:09:51
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 05970A
CONT: 05700-04 CAS: 108-46-3
PATHOLOGIST: F. VOELKER S. EUSTIS
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL M |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 12 CENSORED DEATHS 11 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 331 517 567 612 628 635 692 700 711 717 |
| 721 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 695 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 112MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 7 CENSORED DEATHS 10 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 626 651 664 686 698 715 716 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 225MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 11 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 6 15 133 140 141 209 241 310 429 590 |
| 628 641 653 679 708 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| 574 |
| |
==================================================================================
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL M | 100.0 100.0 100.0 98.3 98.3 98.3 96.3 94.3 88.3 76.0 |
| | |
| | |
|112MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 86.0 |
| | |
| | |
|225MG/KG | 96.7 91.7 88.3 86.7 86.7 85.0 85.0 82.9 76.5 72.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL M 112MG/KG 225MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 86.0% 72.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.381 P=0.280N P=0.462 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 629.6 679.4 368.2 |
|NATURAL DEATHS (C) | (33.3) (12.8) (67.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 663.7 678.4 591.3 |
|(STANDARD ERROR) | (14.6) (13.2) (26.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL F |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 11 CENSORED DEATHS 11 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 127 500 617 620 622 625 639 672 697 715 |
| 727 |
| CENSORED DEATHS |
| 393 456 456 456 456 456 456 456 456 456 |
| 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 112MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 5 7 124 260 484 582 600 601 604 604 |
| 626 639 666 682 699 699 715 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 225MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 43 140 155 313 400 497 621 632 636 676 |
| 680 681 682 685 688 708 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
RESORCINOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL F | 100.0 98.3 98.3 98.3 98.3 98.3 96.3 96.3 86.0 77.8 |
| | |
| | |
|112MG/KG | 96.7 95.0 93.3 93.3 93.3 91.3 91.3 81.2 77.1 67.0 |
| | |
| | |
|225MG/KG | 98.3 95.0 95.0 93.3 91.7 91.7 89.6 89.6 83.5 69.3 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL F 112MG/KG 225MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 77.8% 67.0% 69.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.327 P=0.232 P=0.359 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 596.5 505.7 514.8 |
|NATURAL DEATHS (C) | (50.5) (59.3) (57.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 654.2 620.8 627.0 |
|(STANDARD ERROR) | (16.8) (22.8) (21.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RESORCINOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL M = 1
112MG/KG = 2
225MG/KG = 3
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 13 1 2
| 3 3 1 1
| 2 2
| 3 3 1 1 2 2
P 95 + 33
E | 33 1 1 2 2
R | 1 1 2 2
C | 3 3
E 90 + 3 3 11 2 2
N | 3 3 1 1
T |
| 3 3 11 2 2
S 85 + 3 3
U | 1 1
R | 3 3 11
V | 3 3
I 80 +
V | 3 3
A | 11
L | 3 3 1 1
75 + 3 3
|
| 3 3
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 2 obs hidden.
RESORCINOL
KAPLAN-MEIER SURVIVAL CURVES
CONTROL F = 1
112MG/KG = 2
225MG/KG = 3
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 12 3 1
| 3 13 1
|
| 2 2 3 3 1 1
95 + 2 3 2 3
| 2 3 3 2
P |
E | 3 23 2
R 90 + 3 11
C | 2 2
E | 3131
N | 1 1
T 85 + 22
| 3 13 1
S | 1 1
U | 2 2 33
R 80 + 11
V | 2 2
I | 2 2 1 1
V |
A 75 + 2 2
L | 33
| 2 2
| 3 3
70 +
| 2 32 3
| 2 2
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 3 obs hidden.