TDMS Study 05706-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
NTP Experiment-Test: 05706-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 5 5 6
Moribund 2 2 5
Survivors
Terminal Sacrifice 43 43 38
Missing 1
Animals Examined Microscopically 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (3) (43)
Infiltration Cellular, Lymphocyte 1 (2%)
Intestine Large, Cecum (48) (4) (45)
Peyer's Patch, Hyperplasia, Lymphoid 5 (10%) 5 (11%)
Intestine Small, Jejunum (49) (28) (43)
Hemorrhage 1 (2%)
Peyer's Patch, Angiectasis 1 (4%)
Peyer's Patch, Hyperplasia, Lymphoid 5 (10%) 3 (11%) 4 (9%)
Liver (50) (17) (49)
Basophilic Focus, Multiple 1 (2%)
Cytoplasmic Alteration, Focal 1 (6%) 1 (2%)
Fatty Change, Diffuse 1 (2%) 1 (6%) 2 (4%)
Fatty Change, Focal 1 (2%)
Granuloma 1 (2%) 1 (6%)
Hematocyst 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (6%) 1 (2%)
Infarct 1 (6%)
Infiltration Cellular, Lymphocyte 10 (20%) 2 (12%) 4 (8%)
Mitotic Alteration 1 (2%)
Necrosis, Focal 3 (6%) 2 (12%) 4 (8%)
Pigmentation, Lipofuscin 1 (6%)
Bile Duct, Hyperplasia, Multifocal 1 (2%)
Centrilobular, Fatty Change, Diffuse 1 (2%)
Periportal, Fatty Change, Diffuse 2 (4%)
Mesentery (5) (1) (1)
Amyloid Deposition 1 (20%)
Fat, Necrosis, Focal 2 (40%) 1 (100%)
Pancreas (50) (6) (48)
Amyloid Deposition 1 (17%)
Infiltration Cellular, Multifocal, Lymphocyte 12 (24%) 8 (17%)
Acinus, Atrophy 1 (17%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic 1 (2%)
Duct, Cyst 1 (17%)
Salivary Glands (50) (6) (47)
Infiltration Cellular, Multifocal, Lymphocyte 21 (42%) 1 (17%) 20 (43%)
Stomach, Forestomach (49) (7) (49)
Diverticulum 1 (14%)
Epithelium, Hyperplasia, Focal 2 (4%)
Stomach, Glandular (50) (6) (48)
Hemorrhage 1 (17%)
Infiltration Cellular, Lymphocyte 1 (2%)
Mineralization, Focal 1 (2%)
Necrosis, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Artery, Inflammation, Chronic Active 1 (100%)
Heart (50) (6) (49)
Bacterium 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Aortic Valve, Thrombosis 1 (2%)
Arteriole, Thrombosis, Multifocal 1 (2%)
Artery, Hypertrophy, Multifocal 1 (2%)
Mitral Valve, Inflammation, Acute 1 (2%)
Myocardium, Degeneration 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (7) (48)
Capsule, Ectopic Tissue 4 (8%) 1 (2%)
Capsule, Hyperplasia, Multifocal 50 (100%) 5 (71%) 48 (100%)
Adrenal Gland, Cortex (50) (6) (48)
Atrophy 1 (2%)
Degeneration, Fatty, Multifocal 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (17%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 3 (6%) 3 (6%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Adrenal Gland, Medulla (49) (6) (47)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (50) (5) (48)
Hyperplasia, Multifocal 2 (4%) 1 (2%)
Parathyroid Gland (35) (32)
Hyperplasia 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (3%)
Pituitary Gland (50) (7) (48)
Pars Distalis, Angiectasis 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 3 (6%)
Pars Distalis, Hypertrophy, Focal 1 (2%)
Thyroid Gland (50) (7) (46)
Infiltration Cellular, Lymphocyte 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Follicle, Cyst, Multiple 1 (2%)
Follicular Cell, Hyperplasia, Focal 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (15) (49)
Abscess 1 (2%)
Cyst 16 (32%) 7 (47%) 20 (41%)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 3 (6%) 1 (2%)
Pigmentation, Hemosiderin 1 (7%)
Uterus (50) (45) (48)
Angiectasis 2 (4%)
Dilatation 7 (14%) 5 (11%) 3 (6%)
Hyperplasia, Cystic 44 (88%) 41 (91%) 39 (81%)
Infiltration Cellular, Lymphocyte 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (7) (48)
Atrophy, Focal 2 (4%) 2 (4%)
Hyperplasia, Neutrophil 1 (14%) 2 (4%)
Lymph Node (48) (17) (46)
Hyperplasia, Lymphoid 1 (2%)
Iliac, Hemorrhage 1 (2%)
Iliac, Hyperplasia, Histiocytic 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%) 2 (12%) 1 (2%)
Inguinal, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Lymphoid 2 (4%) 1 (6%) 2 (4%)
Mandibular, Pigmentation, Hemosiderin 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 1 (6%) 2 (4%)
Mediastinal, Mineralization 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Hemorrhage 1 (2%)
Renal, Hyperplasia, Lymphoid 1 (6%) 1 (2%)
Lymph Node, Mesenteric (48) (5) (46)
Abscess 1 (2%)
Amyloid Deposition 1 (2%)
Hemorrhage 2 (40%) 1 (2%)
Hyperplasia, Lymphoid 5 (10%) 1 (2%)
Spleen (50) (29) (49)
Ectopic Tissue 1 (3%)
Hematopoietic Cell Proliferation 4 (8%) 3 (10%) 4 (8%)
Hyperplasia, Lymphoid 4 (8%) 1 (3%) 1 (2%)
Capsule, Inflammation, Chronic 1 (2%)
Thymus (46) (7) (46)
Amyloid Deposition 1 (2%)
Depletion Lymphoid 4 (9%) 3 (43%) 4 (9%)
Ectopic Parathyroid Gland 2 (4%)
Hyperplasia, Lymphoid 4 (9%) 6 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (6) (43)
Hyperplasia 2 (4%) 2 (5%)
Inflammation, Chronic 1 (17%)
Skin (50) (27) (49)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 21 (42%) 13 (48%) 13 (27%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 2 (4%) 2 (7%)
Epithelium, Mitotic Alteration 1 (4%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%)
Subcutaneous Tissue, Mineralization, Focal 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (7) (49)
Fibrous Osteodystrophy 6 (12%) 1 (14%) 9 (18%)
Hyperplasia 1 (2%)
Coccygeal, Fracture 1 (2%)
Skeletal Muscle (2)
Infiltration Cellular, Lymphocyte 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (6) (49)
Hemorrhage 1 (17%)
Mineralization, Multifocal 34 (68%) 1 (17%) 31 (63%)
Arteriole, Meninges, Bacterium 1 (2%)
Arteriole, Meninges, Thrombosis 1 (2%)
Meninges, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (49)
Atelectasis, Focal 1 (2%)
Hemorrhage, Focal 1 (2%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 5 (10%)
Alveolus, Edema 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 1 (2%)
Artery, Hypertrophy, Multifocal 10 (20%) 8 (16%) 21 (43%)
Artery, Mineralization, Multifocal 1 (2%)
Artery, Thrombosis 1 (2%) 1 (2%)
Interstitium, Inflammation, Acute 1 (2%)
Mediastinum, Infiltration Cellular,
Lymphocyte 1 (2%)
Peribronchial, Infiltration Cellular,
Lymphocyte 1 (2%) 2 (4%)
Peribronchiolar, Infiltration Cellular,
Lymphocyte 4 (8%) 1 (2%) 3 (6%)
Perivascular, Infiltration Cellular,
Lymphocyte 16 (32%) 13 (27%) 22 (45%)
Pleura, Infiltration Cellular, Lymphocyte 1 (2%) 1 (2%) 1 (2%)
Nose (50) (6) (48)
Lumen, Foreign Body 4 (8%)
Mucosa, Degeneration, Hyaline 28 (56%) 4 (67%) 27 (56%)
Mucosa, Inflammation, Chronic 2 (4%)
Mucosa, Inflammation, Chronic Active 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic 1 (2%)
Nasolacrimal Duct, Inflammation, Chronic
Active 1 (2%)
Respiratory Epithelium, Hyperplasia 11 (22%) 1 (17%) 9 (19%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Cornea, Inflammation, Chronic 1 (100%)
Cornea, Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (49)
Cyst 1 (2%)
Embolus Bacterial 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 14 (28%) 5 (36%) 9 (18%)
Inflammation, Acute, Multifocal 1 (2%)
Inflammation, Chronic, Multifocal 1 (2%)
Metaplasia, Osseous 1 (7%)
Glomerulus, Amyloid Deposition 3 (6%)
Glomerulus, Inflammation, Chronic 1 (2%)
Renal Tubule, Degeneration, Focal 4 (8%) 1 (7%)
Urinary Bladder (49) (6) (47)
Hemorrhage 1 (2%)
Infiltration Cellular, Lymphocyte 20 (41%) 2 (33%) 21 (45%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 3 3 6
Dead 4 6 2
Survivors
Terminal Sacrifice 43 40 42
Missing 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (4) (48)
Peyer's Patch, Hyperplasia, Lymphoid 7 (15%) 11 (23%)
Intestine Large, Rectum (48) (7) (47)
Serosa, Inflammation, Suppurative 1 (2%)
Intestine Small, Ileum (48) (5) (48)
Peyer's Patch, Hyperplasia, Lymphoid 1 (20%) 1 (2%)
Intestine Small, Jejunum (47) (14) (48)
Hyperplasia, Neutrophil 1 (7%)
Ulcer 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 6 (13%) 3 (21%) 8 (17%)
Serosa, Inflammation, Chronic Active 1 (2%)
Liver (50) (49) (50)
Amyloid Deposition 1 (2%)
Cyst 1 (2%) 1 (2%)
Cytomegaly, Focal 4 (8%) 2 (4%)
Fatty Change, Diffuse 1 (2%)
Fatty Change, Focal 2 (4%) 2 (4%)
Granuloma, Multifocal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Infarct 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Lymphocyte 3 (6%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Mitotic Alteration 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis, Focal 1 (2%) 3 (6%) 1 (2%)
Syncytial Alteration 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Cytomegaly, Diffuse 1 (2%)
Centrilobular, Necrosis, Diffuse 1 (2%)
Hepatocyte, Hyperplasia, Focal 1 (2%)
Portal, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Portal, Inflammation, Chronic 1 (2%)
Serosa, Infiltration Cellular, Histiocyte 1 (2%)
Mesentery (1) (1)
Infiltration Cellular, Lymphocyte 1 (100%)
Pancreas (49) (7) (50)
Infiltration Cellular, Multifocal, Lymphocyte 4 (8%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%)
Salivary Glands (50) (7) (49)
Infiltration Cellular, Multifocal, Lymphocyte 13 (26%) 10 (20%)
Stomach, Forestomach (49) (6) (50)
Abscess 1 (2%)
Serosa, Inflammation, Chronic Active 1 (2%)
Stomach, Glandular (49) (6) (50)
Inflammation, Chronic Active 1 (17%)
Epithelium, Hyperplasia, Focal 1 (17%)
Mucosa, Vacuolization Cytoplasmic 1 (2%)
Tooth (3)
Abscess 1 (33%)
Dysplasia 2 (67%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Inflammation, Chronic Active 1 (100%)
Heart (50) (8) (50)
Atrium, Thrombosis 1 (2%)
Myocardium, Fibrosis 1 (13%)
Myocardium, Mineralization, Multifocal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (7) (50)
Capsule, Ectopic Tissue 1 (2%)
Capsule, Hyperplasia 1 (2%)
Capsule, Hyperplasia, Multifocal 30 (60%) 2 (29%) 38 (76%)
Adrenal Gland, Cortex (50) (7) (50)
Hyperplasia, Focal 2 (4%) 3 (6%)
Hypertrophy, Focal 6 (12%) 12 (24%)
Adrenal Gland, Medulla (50) (6) (48)
Hyperplasia, Focal 1 (2%)
Islets, Pancreatic (49) (7) (50)
Hyperplasia 7 (14%) 1 (14%) 2 (4%)
Pituitary Gland (48) (7) (44)
Pars Distalis, Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia, Focal 1 (14%)
Thyroid Gland (50) (7) (49)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (14%)
Follicle, Cyst, Multiple 1 (2%)
Follicular Cell, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (9) (50)
Granuloma Sperm 1 (2%)
Serosa, Necrosis, Focal 1 (2%)
Penis (3) (1) (4)
Congestion 1 (25%)
Inflammation, Acute 1 (100%) 1 (25%)
Necrosis 2 (67%) 1 (25%)
Preputial Gland (6) (7) (11)
Abscess 4 (36%)
Cyst 1 (14%) 4 (36%)
Dilatation 4 (67%) 3 (43%) 2 (18%)
Hyperplasia 1 (17%)
Inflammation, Chronic 1 (17%) 5 (71%) 3 (27%)
Prostate (50) (7) (48)
Inflammation, Acute 3 (6%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (49) (9) (50)
Fibrosis 3 (6%) 1 (11%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (4%) 1 (11%) 2 (4%)
Testes (50) (9) (50)
Mineralization, Focal 1 (2%)
Spermatocele 1 (2%)
Seminiferous Tubule, Atrophy 1 (11%)
Seminiferous Tubule, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (8) (50)
Hyperplasia 1 (2%)
Hyperplasia, Neutrophil 2 (4%) 2 (25%) 5 (10%)
Erythroid Cell, Depletion Cellular 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node (48) (13) (47)
Hyperplasia, Lymphoid 2 (4%)
Hyperplasia, Plasma Cell 2 (4%)
Axillary, Hemorrhage 1 (2%)
Axillary, Hyperplasia, Lymphoid 1 (2%)
Iliac, Hyperplasia, Lymphoid 1 (2%)
Inguinal, Hyperplasia, Lymphoid 1 (2%) 4 (9%)
Inguinal, Hyperplasia, Plasma Cell 1 (8%) 1 (2%)
Inguinal, Pigmentation, Hemosiderin 2 (4%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%)
Mandibular, Hemorrhage 1 (2%)
Mandibular, Hyperplasia, Lymphoid 3 (6%)
Mandibular, Pigmentation, Hemosiderin 1 (2%)
Renal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (45) (10) (45)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 13 (29%) 3 (30%) 10 (22%)
Hyperplasia, Lymphoid 8 (18%) 2 (20%) 9 (20%)
Spleen (50) (39) (50)
Congestion 1 (2%)
Depletion Lymphoid 2 (4%)
Dysplasia 1 (2%)
Hematopoietic Cell Proliferation 11 (22%) 4 (10%) 12 (24%)
Hyperplasia, Lymphoid 2 (4%) 3 (8%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Thymus (44) (4) (45)
Depletion Lymphoid 3 (7%) 2 (50%) 7 (16%)
Epithelial Cell, Hyperplasia 1 (2%)
Thymocyte, Necrosis 4 (9%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (20) (50)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 6 (12%) 1 (5%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (5%)
Ulcer 5 (10%) 1 (5%) 2 (4%)
Epithelium, Hyperplasia 1 (2%) 1 (5%)
Hair Follicle, Atrophy 1 (2%)
Prepuce, Inflammation, Acute 1 (2%)
Prepuce, Ulcer 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (41) (49)
Hemorrhage 1 (2%)
Mineralization, Multifocal 38 (76%) 37 (90%) 18 (37%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (48) (50)
Giant Cell 2 (4%)
Leukocytosis 2 (4%)
Alveolar Epithelium, Hyperplasia, Focal 3 (6%) 2 (4%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 1 (2%)
Artery, Hypertrophy, Multifocal 1 (2%)
Bronchiole, Inflammation, Chronic 2 (4%)
Interstitium, Fibrosis 1 (2%)
Peribronchial, Infiltration Cellular,
Lymphocyte 2 (4%)
Peribronchiolar, Infiltration Cellular,
Lymphocyte 1 (2%) 1 (2%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (2%) 1 (2%)
Nose (50) (8) (49)
Mucosa, Degeneration, Hyaline 3 (6%) 4 (8%)
Mucosa, Inflammation, Acute 1 (2%)
Mucosa, Inflammation, Chronic Active 3 (6%)
Respiratory Epithelium, Hyperplasia 6 (12%) 1 (13%) 5 (10%)
Trachea (50) (7) (50)
Infiltration Cellular, Lymphocyte 1 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1)
Conjunctiva, Inflammation, Chronic 1 (100%)
Lens, Cataract 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:35
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (50)
Hydronephrosis 1 (2%)
Hyperplasia, Atypical, Focal 1 (2%)
Infarct 1 (7%)
Infiltration Cellular, Lymphocyte 18 (36%) 1 (7%) 13 (26%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Nephropathy, Chronic 8 (16%) 7 (14%)
Cortex, Cyst 1 (2%) 2 (14%) 2 (4%)
Cortex, Mineralization, Multifocal 5 (10%) 2 (14%) 1 (2%)
Glomerulus, Amyloid Deposition 1 (2%)
Pelvis, Fibrosis 1 (2%)
Pelvis, Inflammation, Acute 1 (2%) 3 (6%)
Pelvis, Inflammation, Chronic Active 1 (2%)
Renal Tubule, Degeneration, Focal 2 (4%) 3 (6%)
Renal Tubule, Dilatation 2 (4%)
Ureter (1)
Hyperplasia 1 (100%)
Urethra (2) (2)
Inflammation, Acute 1 (50%) 1 (50%)
Bulbourethral Gland, Ectasia 1 (50%)
Bulbourethral Gland, Inflammation, Acute 1 (50%)
Urinary Bladder (48) (7) (49)
Dilatation 2 (4%)
Infiltration Cellular, Lymphocyte 5 (10%) 1 (14%) 6 (12%)
Inflammation, Acute 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------