INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
NTP Experiment-Test: 05706-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Dead 5 5 6
Moribund 2 2 5
Survivors
Terminal Sacrifice 43 43 38
Missing 1
Animals Examined Microscopically 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (47) (6) (46)
Gallbladder (45) (3) (43)
Intestine Large, Cecum (48) (4) (45)
Intestine Large, Rectum (46) (4) (47)
Intestine Small, Duodenum (47) (2) (38)
Intestine Small, Ileum (46) (2) (44)
Intestine Small, Jejunum (49) (28) (43)
Liver (50) (17) (49)
Hepatocellular Carcinoma 2 (4%)
Hepatocellular Adenoma 3 (6%) 2 (4%)
Mesentery (5) (1) (1)
Pancreas (50) (6) (48)
Salivary Glands (50) (6) (47)
Stomach, Forestomach (49) (7) (49)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (6) (48)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (6) (49)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (6) (48)
Adrenal Gland, Medulla (49) (6) (47)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (5) (48)
Adenoma 1 (20%)
Page 2
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pituitary Gland (50) (7) (48)
Pars Distalis, Adenoma 7 (14%) 2 (29%) 6 (13%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (50) (7) (46)
Follicular Cell, Adenoma 1 (14%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (15) (49)
Cystadenoma 1 (7%) 1 (2%)
Uterus (50) (45) (48)
Hemangioma 1 (2%)
Mixed Tumor Malignant 1 (2%)
Endometrium, Polyp Stromal 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (7) (48)
Lymph Node (48) (17) (46)
Lymph Node, Mesenteric (48) (5) (46)
Spleen (50) (29) (49)
Hemangiosarcoma 1 (3%) 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
Thymus (46) (7) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (6) (43)
Adenocarcinoma 1 (2%) 1 (2%)
Skin (50) (27) (49)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (4%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (6) (49)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (36) (39)
Lung (50) (49) (49)
Alveolar/Bronchiolar Adenoma 10 (20%) 3 (6%) 4 (8%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 2 (4%)
Nose (50) (6) (48)
Trachea (50) (6) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2)
Adenoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (49)
Renal Tubule, Carcinoma 1 (2%)
Renal Tubule, Carcinoma, Metastatic, Kidney 1 (2%)
Urinary Bladder (49) (6) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49)
Leukemia 1 (2%)
Lymphoma Malignant Histiocytic 2 (4%) 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 8 (16%) 4 (8%) 5 (10%)
Lymphoma Malignant Mixed 7 (14%) 5 (10%) 4 (8%)
Lymphoma Malignant Undifferentiated Cell 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 6250PPM 12500PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 34 17 24
Total Primary Neoplasms 53 21 37
Total Animals with Benign Neoplasms 21 9 12
Total Benign Neoplasms 26 9 18
Total Animals with Malignant Neoplasms 24 12 15
Total Malignant Neoplasms 27 12 19
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 3 3 6
Dead 4 6 2
Survivors
Terminal Sacrifice 43 40 42
Missing 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (48) (4) (48)
Intestine Small, Duodenum (47) (4) (46)
Intestine Small, Ileum (48) (5) (48)
Intestine Small, Jejunum (47) (14) (48)
Liver (50) (49) (50)
Hemangiosarcoma 1 (2%) 1 (2%)
Hepatocellular Carcinoma 2 (4%) 3 (6%) 3 (6%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Adenoma 2 (4%) 9 (18%) 5 (10%)
Hepatocellular Adenoma, Multiple 1 (2%)
Hepatocholangiocarcinoma 1 (2%)
Pancreas (49) (7) (50)
Hemangioma 1 (2%)
Stomach, Forestomach (49) (6) (50)
Stomach, Glandular (49) (6) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (8) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (7) (50)
Capsule, Adenoma 1 (2%)
Adrenal Gland, Cortex (50) (7) (50)
Adrenal Gland, Medulla (50) (6) (48)
Pheochromocytoma Benign 2 (4%)
Thyroid Gland (50) (7) (49)
Page 6
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (9) (50)
Prostate (50) (7) (48)
Seminal Vesicle (49) (9) (50)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (8) (50)
Lymph Node (48) (13) (47)
Sarcoma, Metastatic, Skin 1 (8%)
Lymph Node, Mesenteric (45) (10) (45)
Spleen (50) (39) (50)
Hemangiosarcoma 1 (3%)
Hemangiosarcoma, Metastatic, Liver 1 (3%)
Sarcoma 1 (2%)
Thymus (44) (4) (45)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (20) (50)
Carcinoma 2 (10%)
Subcutaneous Tissue, Fibroma 2 (4%) 1 (5%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (5%) 2 (4%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (5%) 2 (4%)
Subcutaneous Tissue, Schwannoma NOS 1 (2%)
Sweat Gland, Adenocarcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (1)
Fibrosarcoma, Metastatic 1 (50%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (41) (49)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (48) (50)
Alveolar/Bronchiolar Adenoma 10 (20%) 3 (6%) 7 (14%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (4%)
Alveolar/Bronchiolar Carcinoma 3 (6%) 1 (2%) 4 (8%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Nose (50) (8) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (1)
Adenoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (14) (50)
Urinary Bladder (48) (7) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%) 3 (6%) 1 (2%)
Lymphoma Malignant Mixed 2 (4%) 2 (4%)
Lymphoma Malignant Undifferentiated Cell 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 05706-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 22:48:38
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 6250PPM 12500PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 23 24 25
Total Primary Neoplasms 34 30 36
Total Animals with Benign Neoplasms 15 10 15
Total Benign Neoplasms 19 14 18
Total Animals with Malignant Neoplasms 11 15 16
Total Malignant Neoplasms 15 16 17
Total Animals with Metastatic Neoplasms 1 4
Total Metastatic Neoplasm 1 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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