TDMS Study 05706-01 Pathology Tables
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|
| 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + M + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + A + + A + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + A + |
Peyer's Patch, Hyperplasia, Lymphoid | 3 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + M + M + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + |
Peyer's Patch, Hyperplasia, Lymphoid | 2 1 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + |
Basophilic Focus, Multiple | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | |
Granuloma | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 |
Mitotic Alteration | |
Necrosis, Focal | 1 1 4 |
Bile Duct, Hyperplasia, Multifocal | |
Centrilobular, Fatty Change, Diffuse | 2 |
Periportal, Fatty Change, Diffuse | 2 |
__________________________________________________________________________|
Mesentery | + |
Amyloid Deposition | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 4 1 1 2 2 1 1 |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 3 2 1 1 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M + |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + |
Mineralization, Focal | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|
| 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + |
Arteriole, Thrombosis, Multifocal | 3 |
Myocardium, Degeneration | 2 |
Ventricle, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + |
Capsule, Ectopic Tissue | 2 2 |
Capsule, Hyperplasia, Multifocal | 2 2 2 4 2 4 3 3 2 2 2 2 3 3 2 3 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + |
Atrophy | |
Degeneration, Fatty, Multifocal | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + |
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M M + + + + + + M + + + M |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + |
Cyst | 2 1 4 1 4 2 4 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Dilatation | 2 3 |
Hyperplasia, Cystic | 3 4 2 3 2 1 2 2 2 3 2 3 1 1 2 2 4 2 |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|
| 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + A + |
Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | 4 |
Mandibular, Pigmentation, Hemosiderin| 2 |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + A + |
Amyloid Deposition | |
Hyperplasia, Lymphoid | 3 3 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Depletion Lymphoid | 3 |
Hyperplasia, Lymphoid | 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + M |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 2 1 2 1 1 1 |
Ulcer | |
Epithelium, Hyperplasia | |
Subcutaneous Tissue, Inflammation, | |
Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + |
Fibrous Osteodystrophy | 3 1 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + |
Mineralization, Multifocal | 2 1 2 1 2 2 1 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + M + + + + + + + M + M M |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + |
Atelectasis, Focal | 3 |
Hemorrhage, Focal | 1 |
Infiltration Cellular, Lymphocyte | 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 4| 4| 7| 5| 7| 4|
DAY ON TEST | 3| 5| 3| 5| 3| 3| 2| 2| 3| 3| 2| 5| 3| 3| 3| 3| 3| 1| 3| 5| 5| 3| 8| 3| 5|
| 0| 6| 0| 6| 1| 0| 9| 9| 2| 1| 9| 6| 2| 1| 1| 2| 0| 4| 0| 6| 6| 0| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Hypertrophy, Multifocal | 3 2 1 |
Artery, Thrombosis | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | 2 |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | 3 2 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 4 3 2 1 2 1 |
Pleura, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + |
Lumen, Foreign Body | 1 1 1 1 |
Mucosa, Degeneration, Hyaline | 1 1 2 1 3 2 1 2 |
Mucosa, Inflammation, Chronic | 1 |
Mucosa, Inflammation, Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Cyst | |
Hydronephrosis | 3 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 2 2 |
Inflammation, Chronic, Multifocal | 2 |
Glomerulus, Amyloid Deposition | 1 |
Renal Tubule, Degeneration, Focal | 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 2 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|
| 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus, Multiple | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 |
Granuloma | 2 |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 |
Mitotic Alteration | 1 |
Necrosis, Focal | |
Bile Duct, Hyperplasia, Multifocal | 3 |
Centrilobular, Fatty Change, Diffuse | |
Periportal, Fatty Change, Diffuse | 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Amyloid Deposition | 3 |
Fat, Necrosis, Focal | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 3 1 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 1 2 1 3 1 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|
| 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Thrombosis, Multifocal | |
Myocardium, Degeneration | |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Ectopic Tissue | |
Capsule, Hyperplasia, Multifocal | 2 2 2 1 2 3 3 2 2 3 2 2 2 2 4 2 3 2 2 3 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Degeneration, Fatty, Multifocal | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Focal | 1 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + M + + + + M + M + + + + M + M +|
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 1|
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Follicular Cell, Hyperplasia, Focal | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 1 2 3 2 2|
Infiltration Cellular, Lymphocyte | 2 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Dilatation | 2 4 4 3 2|
Hyperplasia, Cystic | 1 1 1 4 2 3 3 2 1 3 2 3 1 2 1 4 3 2|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|
| 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy, Focal | 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mandibular, Hyperplasia, Lymphoid | 4 |
Mandibular, Pigmentation, Hemosiderin| |
Mediastinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + +|
Amyloid Deposition | 4 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 |
Hyperplasia, Lymphoid | 3 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M M + + + + +|
Amyloid Deposition | 4 |
Depletion Lymphoid | 4 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + M +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 2 2 1 1 1 1 |
Ulcer | |
Epithelium, Hyperplasia | 2 |
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 2 1 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 2 1 1 1 1 1 3 1 2 1 1 1 1 1 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + M + + + M + + + M + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis, Focal | |
Hemorrhage, Focal | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 3| 5| 3| 3| 3| 2| 2| 3| 3| 2| 3| 5| 2| 3| 3| 5| 3| 3| 2| 2| 3| 1| 3|
| 0| 0| 0| 6| 1| 2| 1| 9| 9| 2| 2| 9| 2| 6| 9| 1| 0| 6| 1| 2| 9| 9| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1|
Artery, Hypertrophy, Multifocal | 3 4 3 4 4|
Artery, Thrombosis | 1 |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 3 2 2 2 2 3|
Pleura, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Lumen, Foreign Body | |
Mucosa, Degeneration, Hyaline | 2 2 2 2 2 2 1 2 3 1 1 2 1 2 1 |
Mucosa, Inflammation, Chronic | 2 |
Mucosa, Inflammation, Chronic Active | 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Hyperplasia | 2 1 2 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 1 1 2 2 1 4 1 |
Inflammation, Chronic, Multifocal | |
Glomerulus, Amyloid Deposition | 3 |
Renal Tubule, Degeneration, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 2 1 1 2|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2| | |
| 1| 9| 2| 6| 4| 5| 2| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M | 45 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 48 |
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 5 1.8|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 49 |
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 5 1.4|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Basophilic Focus, Multiple | X | 1 |
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | | 1 2.0|
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 10 1.2|
Mitotic Alteration | | 1 1.0|
Necrosis, Focal | | 3 2.0|
Bile Duct, Hyperplasia, Multifocal | | 1 3.0|
Centrilobular, Fatty Change, Diffuse | | 1 2.0|
Periportal, Fatty Change, Diffuse | | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Amyloid Deposition | | 1 3.0|
Fat, Necrosis, Focal | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 12 1.7|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 | 21 1.6|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
Epithelium, Hyperplasia, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2| | |
| 1| 9| 2| 6| 4| 5| 2| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Artery, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Arteriole, Thrombosis, Multifocal | | 1 3.0|
Myocardium, Degeneration | | 1 2.0|
Ventricle, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
Capsule, Ectopic Tissue | 1 2 | 4 1.8|
Capsule, Hyperplasia, Multifocal | 2 3 2 1 3 2 2 3 3 | 50 2.4|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Atrophy | | 1 2.0|
Degeneration, Fatty, Multifocal | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Focal | | 3 2.0|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 49 |
Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Hyperplasia, Multifocal | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + M + | 35 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 2 | 3 1.7|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Follicular Cell, Hyperplasia, Focal | | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2| | |
| 1| 9| 2| 6| 4| 5| 2| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | 2 4 2 | 16 2.4|
Infiltration Cellular, Lymphocyte | | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Angiectasis | | 2 2.0|
Dilatation | | 7 2.9|
Hyperplasia, Cystic | 3 4 2 1 2 2 1 1 | 44 2.2|
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Atrophy, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | | 2 4.0|
Mandibular, Pigmentation, Hemosiderin| | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 48 |
Amyloid Deposition | | 1 4.0|
Hyperplasia, Lymphoid | | 5 2.6|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Hematopoietic Cell Proliferation | 2 | 4 2.5|
Hyperplasia, Lymphoid | | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + | 46 |
Amyloid Deposition | | 1 4.0|
Depletion Lymphoid | 3 2 | 4 3.0|
Hyperplasia, Lymphoid | | 4 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + | 45 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Inflammation, Chronic | 1 1 4 | 21 1.4|
Ulcer | 4 | 1 4.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2| | |
| 1| 9| 2| 6| 4| 5| 2| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
Fibrous Osteodystrophy | 2 | 6 1.8|
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Mineralization, Multifocal | 1 1 1 1 | 34 1.4|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + | 36 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Atelectasis, Focal | | 1 3.0|
Hemorrhage, Focal | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 1.7|
Artery, Hypertrophy, Multifocal | 3 3 | 10 3.0|
Artery, Thrombosis | | 1 1.0|
Peribronchial, Infiltration Cellular,| | |
Lymphocyte | | 1 2.0|
Peribronchiolar, Infiltration | | |
Cellular, Lymphocyte | 3 | 4 2.5|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 3 2 | 16 2.3|
Pleura, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 50 |
Lumen, Foreign Body | | 4 1.0|
Mucosa, Degeneration, Hyaline | 1 1 1 2 3 | 28 1.7|
Mucosa, Inflammation, Chronic | | 2 1.5|
Mucosa, Inflammation, Chronic Active | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 11 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| | |
DAY ON TEST | 3| 2| 3| 5| 1| 9| 0| 3| 3| 2| | |
| 1| 9| 2| 6| 4| 5| 2| 0| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Cyst | | 1 4.0|
Hydronephrosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 14 1.6|
Inflammation, Chronic, Multifocal | | 1 2.0|
Glomerulus, Amyloid Deposition | 2 | 3 2.0|
Renal Tubule, Degeneration, Focal | 1 | 4 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + | 49 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 | 20 1.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|
| 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | + |
__________________________________________________________________________|
Intestine Large, Cecum | + |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + |
Peyer's Patch, Angiectasis | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 1 2 |
__________________________________________________________________________|
Liver | + + + + + + + |
Cytoplasmic Alteration, Focal | |
Fatty Change, Diffuse | |
Granuloma | |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | 2 2 |
Necrosis, Focal | |
Pigmentation, Lipofuscin | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + |
Amyloid Deposition | |
Acinus, Atrophy | 4 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Stomach | +|
__________________________________________________________________________|
Stomach, Forestomach | +|
Diverticulum | 2|
__________________________________________________________________________|
Stomach, Glandular | |
Hemorrhage | |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
Capsule, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|
| 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | + |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
__________________________________________________________________________|
Thyroid Gland | + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + +|
Cyst | 3 3 3 4|
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 2 |
Hyperplasia, Cystic | 3 4 4 3 4 4 3 2 2 1 2 4 2 1 1 4 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 1 |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Mineralization | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
Ectopic Tissue | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + |
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Inflammation, Chronic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + |
Inflammation, Chronic | 2 1 2 1 1 2 1 1 2 |
Epithelium, Hyperplasia | 2 1 |
Epithelium, Mitotic Alteration | 1 |
Subcutaneous Tissue, Mineralization, | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 5| 2| 3| 3| 3| 3| 3| 2| 3| 2| 3| 3| 3| 2| 2| 3| 3| 2|
| 9| 1| 2| 2| 2| 6| 2| 6| 9| 1| 0| 2| 1| 2| 9| 1| 9| 0| 0| 1| 9| 9| 1| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Hemorrhage | |
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 1 2 4 |
Artery, Hypertrophy, Multifocal | 4 2 2 4 4 |
Artery, Mineralization, Multifocal | |
Artery, Thrombosis | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 2 2 2 2 |
Pleura, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | |
Mucosa, Degeneration, Hyaline | |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Infiltration Cellular, Lymphocyte | 4 4 3 2 |
Metaplasia, Osseous | 2 |
Renal Tubule, Degeneration, Focal | |
__________________________________________________________________________|
Urinary Bladder | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|
| 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6250PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + A A |
__________________________________________________________________________|
Intestine Large | + A + A + + |
__________________________________________________________________________|
Intestine Large, Cecum | A A + A + + |
__________________________________________________________________________|
Intestine Large, Colon | + A + A + + |
__________________________________________________________________________|
Intestine Large, Rectum | + A M A + + |
__________________________________________________________________________|
Intestine Small | A + A + + + + + + A + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + A + A |
__________________________________________________________________________|
Intestine Small, Ileum | A A + A + A |
__________________________________________________________________________|
Intestine Small, Jejunum | A + A + + + + + + A + + + A +|
Peyer's Patch, Angiectasis | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + |
Cytoplasmic Alteration, Focal | 2 |
Fatty Change, Diffuse | 3 |
Granuloma | 2 |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | |
Necrosis, Focal | 1 3 |
Pigmentation, Lipofuscin | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + A + A + + |
Amyloid Deposition | 2 |
Acinus, Atrophy | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Stomach | + + + A + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + |
Diverticulum | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + |
Hemorrhage | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + |
Capsule, Hyperplasia, Multifocal | 2 1 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + A + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|
| 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6250PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + A + + |
__________________________________________________________________________|
Islets, Pancreatic | + A + A + + |
__________________________________________________________________________|
Parathyroid Gland | M M M M M M |
__________________________________________________________________________|
Pituitary Gland | A + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + A + + + + |
Cyst | 2 2 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + A + + + + + +|
Dilatation | 4 3 |
Hyperplasia, Cystic | 4 2 2 2 3 1 2 2 4 2 1 3 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + A + + + |
Iliac, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Mineralization | 4 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M A + + |
Hemorrhage | 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + A + + + +|
Ectopic Tissue | X |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + M + + |
Depletion Lymphoid | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Skin | M + + + + + + + + + |
Inflammation, Chronic | 2 1 1 |
Epithelium, Hyperplasia | |
Epithelium, Mitotic Alteration | |
Subcutaneous Tissue, Mineralization, | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 6| 7| 7| 4| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 4| 4| 6| 4| 7|
DAY ON TEST | 7| 3| 2| 5| 3| 2| 2| 0| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 6| 5| 3|
| 6| 1| 9| 6| 0| 9| 9| 1| 1| 8| 0| 1| 0| 1| 0| 8| 2| 9| 0| 0| 6| 6| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
6250PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Focal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
Fibrous Osteodystrophy | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Hemorrhage | 3 |
Mineralization, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Artery, Hypertrophy, Multifocal | 3 |
Artery, Mineralization, Multifocal | 4 |
Artery, Thrombosis | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | 2 2 |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 2 2 2 |
Pleura, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + |
Mucosa, Degeneration, Hyaline | 1 2 3 2 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + A + + |
Infiltration Cellular, Lymphocyte | 2 |
Metaplasia, Osseous | |
Renal Tubule, Degeneration, Focal | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + |
Infiltration Cellular, Lymphocyte | 2 1 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3| | |
| 3| 6| 0| 6| 6| 6| 9| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M | 6 |
__________________________________________________________________________|____________|
Gallbladder | M | 3 |
__________________________________________________________________________|____________|
Intestine Large | + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 4 |
__________________________________________________________________________|____________|
Intestine Small | A + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | M | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + | 28 |
Peyer's Patch, Angiectasis | 3 | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 3 2.0|
__________________________________________________________________________|____________|
Liver | A + + | 17 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Fatty Change, Diffuse | | 1 3.0|
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
Necrosis, Focal | | 2 2.0|
Pigmentation, Lipofuscin | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis, Focal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | A | 6 |
Amyloid Deposition | | 1 2.0|
Acinus, Atrophy | | 1 4.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | M | 6 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 7 |
Diverticulum | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 6 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | M | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3| | |
| 3| 6| 0| 6| 6| 6| 9| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 7 |
Capsule, Hyperplasia, Multifocal | | 5 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 6 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | |
__________________________________________________________________________|____________|
Pituitary Gland | M | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | M | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + | 15 |
Cyst | | 7 3.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 45 |
Dilatation | | 5 3.0|
Hyperplasia, Cystic | 1 1 2 4 3 | 41 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 7 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | M + | 17 |
Iliac, Hyperplasia, Lymphoid | 4 | 2 2.5|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Mineralization | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | 5 |
Hemorrhage | | 2 1.5|
__________________________________________________________________________|____________|
Spleen | M + + + | 29 |
Ectopic Tissue | | 1 |
Hematopoietic Cell Proliferation | 1 | 3 2.3|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3| | |
| 3| 6| 0| 6| 6| 6| 9| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 6 |
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + | 27 |
Inflammation, Chronic | 1 | 13 1.4|
Epithelium, Hyperplasia | | 2 1.5|
Epithelium, Mitotic Alteration | | 1 1.0|
Subcutaneous Tissue, Mineralization, | | |
Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 7 |
Fibrous Osteodystrophy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | M | 6 |
Hemorrhage | | 1 3.0|
Mineralization, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | M + + + + + | 49 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 5 2.2|
Artery, Hypertrophy, Multifocal | 1 3 | 8 2.9|
Artery, Mineralization, Multifocal | | 1 4.0|
Artery, Thrombosis | 1 | 1 1.0|
Peribronchial, Infiltration Cellular,| | |
Lymphocyte | | 2 2.0|
Peribronchiolar, Infiltration | | |
Cellular, Lymphocyte | | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 1 1 | 13 1.7|
Pleura, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | M | 6 |
Mucosa, Degeneration, Hyaline | | 4 2.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 1| 4| 7| 4| 4| 4| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 5| 5| 5| 2| 3| 3| 3| | |
| 3| 6| 0| 6| 6| 6| 9| 2| 1| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
6250PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | M | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 14 |
Infiltration Cellular, Lymphocyte | | 5 3.0|
Metaplasia, Osseous | | 1 2.0|
Renal Tubule, Degeneration, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 6 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|
| 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + A + + + + + M +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + M + + + + + + +|
Hemorrhage | 1 |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Fatty Change, Diffuse | 2 |
Hematocyst | 3 |
Hematopoietic Cell Proliferation | 1 |
Infiltration Cellular, Lymphocyte | 2 1|
Necrosis, Focal | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Necrosis, Multifocal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Infiltration Cellular, Lymphocyte | 1 |
Aortic Valve, Thrombosis | 4 |
Artery, Hypertrophy, Multifocal | 2 |
Mitral Valve, Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|
| 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Ectopic Tissue | 2 |
Capsule, Hyperplasia, Multifocal | 2 3 2 2 3 2 2 3 3 2 2 2 2 3 3 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
Hyperplasia, Focal | 2 3 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + M M M + M + + M M + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 1 2 |
Pars Distalis, Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | |
Follicle, Cyst, Multiple | |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | 2 3 2 3 2 2 3|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia, Cystic | 3 2 2 2 2 1 1 1 3 1 3 3 4 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Hyperplasia, Neutrophil | 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + M + +|
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Histiocytic | |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 4 |
Mandibular, Hyperplasia, Lymphoid | 3|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|
| 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + M + +|
Abscess | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 |
Hyperplasia, Lymphoid | 2 |
Capsule, Inflammation, Chronic | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 3 3 3 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 2 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + M M + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Inflammation, Chronic | 1 1 1 2 1 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 2 3 4 1|
Coccygeal, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 2 1 2 1 2 1 1 2 2 1 2 |
Arteriole, Meninges, Bacterium | X |
Arteriole, Meninges, Thrombosis | 1 |
Meninges, Inflammation, Acute | 1 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Alveolus, Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 7| 6| 7| 7| 7| 3| 7| 6| 5| 7| 7| 4| 4| 7| 6| 7| 6| 7| 7| 4| 7|
DAY ON TEST | 2| 5| 6| 3| 3| 3| 3| 3| 2| 8| 3| 4| 2| 3| 2| 5| 5| 2| 8| 2| 8| 3| 3| 5| 2|
| 9| 6| 0| 0| 2| 9| 0| 2| 9| 7| 1| 0| 9| 0| 1| 6| 6| 9| 4| 9| 0| 0| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Hypertrophy, Multifocal | 3 3 1 2 4 3 |
Interstitium, Inflammation, Acute | 2 |
Mediastinum, Infiltration Cellular, | |
Lymphocyte | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 2 2 1 2 2 |
Pleura, Infiltration Cellular, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Degeneration, Hyaline | 2 1 2 2 1 2 2 1 2 1 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | X |
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 1 2 2 4 2 |
Inflammation, Acute, Multifocal | 2 |
Glomerulus, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | 1 3 1 1 2 1 1 2 1|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|
| 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
12500PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + A +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + A A|
Peyer's Patch, Hyperplasia, Lymphoid | 2 2 1 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + A + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + A A M + + + + + A A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + A A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M A + + + + + + A A|
Hemorrhage | |
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 4 |
Fatty Change, Diffuse | 3|
Hematocyst | |
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Lymphocyte | |
Necrosis, Focal | 4 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M + + + + + + + + M|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 2 1 1 2 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A +|
Infiltration Cellular, Lymphocyte | |
Necrosis, Multifocal | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Lymphocyte | |
Aortic Valve, Thrombosis | |
Artery, Hypertrophy, Multifocal | |
Mitral Valve, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|
| 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
12500PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Ectopic Tissue | |
Capsule, Hyperplasia, Multifocal | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Parathyroid Gland | + M + M M + + + + M M + + + + + + + M M|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hypertrophy, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + M|
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 2 |
Follicle, Cyst, Multiple | 2 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | 2 2 3 2 3 2 4 4 3 |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + A +|
Dilatation | 3 4 |
Hyperplasia, Cystic | 2 1 2 3 1 2 2 2 1 2 2 2 2 3 2 1 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A +|
Atrophy, Focal | |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + M + + + + + + + + +|
Iliac, Hemorrhage | 2 |
Iliac, Hyperplasia, Histiocytic | |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|
| 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
12500PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Hyperplasia, Lymphoid | |
Renal, Hemorrhage | 4 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + +|
Abscess | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Capsule, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + A +|
Depletion Lymphoid | 2 |
Ectopic Parathyroid Gland | X |
Hyperplasia, Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + M + + + + M +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 1 1 1 1 1 1 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
Coccygeal, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 1 1 2 1 1 1 1 2 1 1 1 2 |
Arteriole, Meninges, Bacterium | |
Arteriole, Meninges, Thrombosis | |
Meninges, Inflammation, Acute | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 3 2 |
Alveolus, Edema | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 4| 4| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 5| 3| 3| 5| 2| 3| 3| 3| 2| 0| 1| 2| 5| 3| 5| 5| 3| 3| 3| 3| 7| 6|
| 9| 1| 0| 6| 2| 0| 6| 9| 0| 2| 2| 9| 2| 8| 9| 6| 1| 6| 6| 0| 2| 1| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
12500PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
Artery, Hypertrophy, Multifocal | 3 4 4 3 2 3 2 2 2 2 2 |
Interstitium, Inflammation, Acute | |
Mediastinum, Infiltration Cellular, | |
Lymphocyte | 3 |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | 2 |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 3 4 3 2 2 2 2 2 2 2 1 |
Pleura, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M +|
Mucosa, Degeneration, Hyaline | 3 1 1 1 2 1 1 1 2 3 1 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Respiratory Epithelium, Hyperplasia | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic Active | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Embolus Bacterial | |
Hydronephrosis | 1 |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Acute, Multifocal | |
Glomerulus, Inflammation, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + M + + + + + + + + + + + + + + A +|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3| | |
| 2| 2| 1| 2| 1| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + | 46 |
__________________________________________________________________________|____________|
Gallbladder | + + M + + + + M + | 43 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 45 |
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 5 1.4|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + M M + | 38 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 43 |
Hemorrhage | | 1 1.0|
Peyer's Patch, Hyperplasia, Lymphoid | 2 1 1 | 4 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 49 |
Cytoplasmic Alteration, Focal | | 1 4.0|
Fatty Change, Diffuse | | 2 2.5|
Hematocyst | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 2 | 4 1.5|
Necrosis, Focal | 1 4 | 4 2.8|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 48 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 1 | 8 1.4|
Acinus, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 47 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 2 1 2 1 | 20 1.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Necrosis, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 49 |
Bacterium | | 1 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Aortic Valve, Thrombosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3| | |
| 2| 2| 1| 2| 1| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Artery, Hypertrophy, Multifocal | | 1 2.0|
Mitral Valve, Inflammation, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 48 |
Capsule, Ectopic Tissue | | 1 2.0|
Capsule, Hyperplasia, Multifocal | 2 2 1 2 2 3 2 2 2 | 48 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 48 |
Hemorrhage | | 1 2.0|
Hyperplasia, Focal | | 3 2.3|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 48 |
Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + M + | 32 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 48 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 1 | 3 1.3|
Pars Distalis, Hypertrophy, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 46 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
Follicle, Cyst, Multiple | | 1 2.0|
Follicular Cell, Hyperplasia, Focal | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 49 |
Abscess | | 1 4.0|
Cyst | 4 2 1 2 | 20 2.6|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 48 |
Dilatation | | 3 3.3|
Hyperplasia, Cystic | 2 2 1 1 2 2 2 2 | 39 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3| | |
| 2| 2| 1| 2| 1| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 48 |
Atrophy, Focal | 2 2 | 2 2.0|
Hyperplasia, Neutrophil | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 46 |
Iliac, Hemorrhage | | 1 2.0|
Iliac, Hyperplasia, Histiocytic | 2 | 1 2.0|
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 4.0|
Mandibular, Hyperplasia, Lymphoid | 4 | 2 3.5|
Mediastinal, Hyperplasia, Lymphoid | 1 | 2 1.5|
Renal, Hemorrhage | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 46 |
Abscess | | 1 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
Hematopoietic Cell Proliferation | | 4 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Capsule, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + M + | 46 |
Depletion Lymphoid | | 4 2.8|
Ectopic Parathyroid Gland | | 2 |
Hyperplasia, Lymphoid | 3 2 | 6 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M + + | 43 |
Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 49 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | 1 1 | 13 1.1|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 49 |
Fibrous Osteodystrophy | 2 2 | 9 2.1|
Coccygeal, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3| | |
| 2| 2| 1| 2| 1| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Mineralization, Multifocal | 1 1 1 1 2 1 2 | 31 1.4|
Arteriole, Meninges, Bacterium | | 1 |
Arteriole, Meninges, Thrombosis | | 1 1.0|
Meninges, Inflammation, Acute | | 1 1.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + | 39 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 49 |
Hemorrhage, Focal | | 2 2.5|
Alveolus, Edema | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Artery, Hypertrophy, Multifocal | 1 1 2 3 | 21 2.5|
Interstitium, Inflammation, Acute | | 1 2.0|
Mediastinum, Infiltration Cellular, | | |
Lymphocyte | | 1 3.0|
Peribronchiolar, Infiltration | | |
Cellular, Lymphocyte | 2 3 | 3 2.3|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 2 2 2 2 4 | 22 2.1|
Pleura, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 48 |
Mucosa, Degeneration, Hyaline | 2 1 2 | 27 1.6|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 3 | 1 3.0|
Respiratory Epithelium, Hyperplasia | 1 | 9 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 3| 5| 3| | |
| 2| 2| 1| 2| 1| 9| 1| 1| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
12500PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 49 |
Embolus Bacterial | | 1 |
Hydronephrosis | | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 2 | 9 1.9|
Inflammation, Acute, Multifocal | | 1 2.0|
Glomerulus, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 47 |
Hemorrhage | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 2 1 | 21 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|
| 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 2 3 2|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytomegaly, Focal | 2 2 |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Granuloma, Multifocal | 1 |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | 2 |
Mitotic Alteration | |
Mixed Cell Focus | X |
Necrosis, Focal | 2 |
Syncytial Alteration | 1 |
Centrilobular, Cytomegaly, Diffuse | |
Centrilobular, Necrosis, Diffuse | 2 |
Portal, Inflammation, Chronic | |
__________________________________________________________________________|
Mesentery | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|
| 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 |
Capsule, Hyperplasia, Multifocal | 2 1 2 2 1 2 2 3 2 3 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M M M + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Follicle, Cyst, Multiple | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
__________________________________________________________________________|
Penis | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + + + + + |
Dilatation | 4 2 3 |
Hyperplasia | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Acute | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | 3 |
Seminiferous Tubule, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|
| 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Axillary, Hemorrhage | 3 |
Axillary, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Pigmentation, Hemosiderin | 2 |
Mandibular, Hyperplasia, Lymphoid | |
Mandibular, Pigmentation, Hemosiderin| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M M|
Hemorrhage | 2 1 1 1 2 |
Hyperplasia, Lymphoid | 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 3 2 |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + +|
Depletion Lymphoid | 3 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
Inflammation, Chronic Active | |
Ulcer | 3 |
Epithelium, Hyperplasia | |
Hair Follicle, Atrophy | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 2 2 2 1 1 1 1 2 2 3 1 2 2 3 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Giant Cell | |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 2| 5| 2| 5| 3| 3| 2| 3| 3| 2| 5| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 5| 3| 3|
| 9| 6| 9| 6| 2| 2| 9| 0| 1| 9| 6| 1| 1| 2| 0| 0| 9| 0| 1| 0| 2| 2| 6| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Bronchiole, Inflammation, Chronic | |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Degeneration, Hyaline | 2 |
Mucosa, Inflammation, Chronic Active | 1|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Conjunctiva, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 |
Infiltration Cellular, Mixed Cell | |
Nephropathy, Chronic | 1 1 |
Cortex, Cyst | |
Cortex, Mineralization, Multifocal | 1 1 1|
Glomerulus, Amyloid Deposition | 3 |
Pelvis, Inflammation, Acute | |
Pelvis, Inflammation, Chronic Active | |
Renal Tubule, Degeneration, Focal | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | |
Bulbourethral Gland, Ectasia | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|
| 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + M + + M + M + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + A + +|
Peyer's Patch, Hyperplasia, Lymphoid | 1 3 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4|
Cytomegaly, Focal | 2 2|
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 3 |
Granuloma, Multifocal | |
Infarct | |
Infiltration Cellular, Lymphocyte | 1 |
Mitotic Alteration | 3|
Mixed Cell Focus | |
Necrosis, Focal | |
Syncytial Alteration | |
Centrilobular, Cytomegaly, Diffuse | 3 |
Centrilobular, Necrosis, Diffuse | |
Portal, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Mesentery | |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Pancreas | + + + + + A + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 1 1 2 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + + + + + + + + + + + + +|
Abscess | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + + +|
Mucosa, Vacuolization Cytoplasmic | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|
| 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | |
Capsule, Hyperplasia, Multifocal | 3 2 2 1 1 3 1 1 3 2 3 2 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + A + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + M + + + + M + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Follicle, Cyst, Multiple | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________________________________________|
Penis | + + + |
Necrosis | 4 4 |
__________________________________________________________________________|
Preputial Gland | + |
Dilatation | 2 |
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 4 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Acute | 4 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
Seminiferous Tubule, Dilatation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 4 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|
| 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
Axillary, Hemorrhage | |
Axillary, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Lymphoid | 4|
Inguinal, Hyperplasia, Lymphoid | 2|
Inguinal, Pigmentation, Hemosiderin | 2 |
Mandibular, Hyperplasia, Lymphoid | 3 3 |
Mandibular, Pigmentation, Hemosiderin| 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + M + + + + + + + + + + + + + +|
Hemorrhage | 2 2 1 2 1 3|
Hyperplasia, Lymphoid | 2 1 1 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 3 1 2 4 4 3 1|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + M + + + M + M + + + + + M + + + + M +|
Depletion Lymphoid | 1 2 |
Thymocyte, Necrosis | 3 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 3 1 |
Inflammation, Chronic Active | 4 4 |
Ulcer | 4 4 3 3 |
Epithelium, Hyperplasia | 3 |
Hair Follicle, Atrophy | 3 |
Subcutaneous Tissue, Abscess | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Multifocal | 2 1 2 1 2 1 2 1 4 2 1 3 2 3 3 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Giant Cell | 2 2 |
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 3| 7| 1| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 0| 0| 4| 7| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 2| 5| 3| 6| 2| 2| 3| 2| 5| 3| 4| 5| 5| 3| 2|
| 1| 2| 9| 7| 0| 1| 1| 0| 1| 1| 9| 6| 1| 8| 9| 9| 0| 9| 6| 0| 5| 3| 6| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
Bronchiole, Inflammation, Chronic | 3 4 |
Peribronchial, Infiltration Cellular,| |
Lymphocyte | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Degeneration, Hyaline | 2 |
Mucosa, Inflammation, Chronic Active | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
Conjunctiva, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 2|
Infiltration Cellular, Mixed Cell | 3 |
Nephropathy, Chronic | 1 2 2 1 |
Cortex, Cyst | 1 |
Cortex, Mineralization, Multifocal | 1 |
Glomerulus, Amyloid Deposition | |
Pelvis, Inflammation, Acute | 4 |
Pelvis, Inflammation, Chronic Active | 2 |
Renal Tubule, Degeneration, Focal | 1 |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | 4 |
Bulbourethral Gland, Ectasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Acute | 4 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 4| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3| | |
| 0| 2| 0| 6| 6| 2| 1| 2| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 46 |
__________________________________________________________________________|____________|
Gallbladder | A + + M + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large | A + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + | 48 |
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 7 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + M + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + | 48 |
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | A + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + | 47 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 6 2.2|
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Cyst | | 1 4.0|
Cytomegaly, Focal | | 4 2.0|
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | 2 | 2 2.5|
Granuloma, Multifocal | | 1 1.0|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | 1 | 3 1.3|
Mitotic Alteration | | 1 3.0|
Mixed Cell Focus | | 1 |
Necrosis, Focal | | 1 2.0|
Syncytial Alteration | | 1 1.0|
Centrilobular, Cytomegaly, Diffuse | | 1 3.0|
Centrilobular, Necrosis, Diffuse | | 1 2.0|
Portal, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 4 1.8|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 13 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 49 |
Abscess | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 4| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3| | |
| 0| 2| 0| 6| 6| 2| 1| 2| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 49 |
Mucosa, Vacuolization Cytoplasmic | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 50 |
Capsule, Hyperplasia | | 1 2.0|
Capsule, Hyperplasia, Multifocal | 3 2 1 2 | 30 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 50 |
Hyperplasia, Focal | 2 | 2 2.0|
Hypertrophy, Focal | 3 | 6 2.3|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
Hyperplasia | 2 3 | 7 2.1|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + | 48 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Follicle, Cyst, Multiple | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 50 |
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 3 |
Necrosis | | 2 4.0|
__________________________________________________________________________|____________|
Preputial Gland | | 6 |
Dilatation | | 4 2.8|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 50 |
Inflammation, Acute | | 3 3.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 49 |
Fibrosis | 4 3 | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 4| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3| | |
| 0| 2| 0| 6| 6| 2| 1| 2| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 1 4.0|
Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + | 50 |
Spermatocele | | 1 3.0|
Seminiferous Tubule, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | A + + + + + + | 48 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
Axillary, Hemorrhage | | 1 3.0|
Axillary, Hyperplasia, Lymphoid | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Pigmentation, Hemosiderin | | 2 2.0|
Mandibular, Hyperplasia, Lymphoid | 3 | 3 3.0|
Mandibular, Pigmentation, Hemosiderin| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + + | 45 |
Hemorrhage | 3 1 | 13 1.7|
Hyperplasia, Lymphoid | | 8 1.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 50 |
Congestion | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 4 1 | 11 2.6|
Hyperplasia, Lymphoid | | 2 2.5|
Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 44 |
Depletion Lymphoid | | 3 2.0|
Thymocyte, Necrosis | 2 | 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
Inflammation, Chronic | 2 | 7 1.6|
Inflammation, Chronic Active | | 2 4.0|
Ulcer | | 5 3.4|
Epithelium, Hyperplasia | | 1 3.0|
Hair Follicle, Atrophy | | 1 3.0|
Subcutaneous Tissue, Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 4| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3| | |
| 0| 2| 0| 6| 6| 2| 1| 2| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Mineralization, Multifocal | 3 2 2 2 2 | 38 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 41 |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Giant Cell | | 2 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 2 | 3 2.7|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.5|
Bronchiole, Inflammation, Chronic | | 2 3.5|
Peribronchial, Infiltration Cellular,| | |
Lymphocyte | 2 2 | 2 2.0|
Peribronchiolar, Infiltration | | |
Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 50 |
Mucosa, Degeneration, Hyaline | 1 | 3 1.7|
Mucosa, Inflammation, Chronic Active | | 3 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Conjunctiva, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 3 | 18 1.2|
Infiltration Cellular, Mixed Cell | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 0| 7| 7| 4| 4| 7| 7| 7| 4| 7| | |
DAY ON TEST | 7| 3| 3| 5| 5| 3| 3| 3| 5| 3| | |
| 0| 2| 0| 6| 6| 2| 1| 2| 6| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Nephropathy, Chronic | 1 4 | 8 1.6|
Cortex, Cyst | | 1 1.0|
Cortex, Mineralization, Multifocal | 2 | 5 1.2|
Glomerulus, Amyloid Deposition | | 1 3.0|
Pelvis, Inflammation, Acute | | 1 4.0|
Pelvis, Inflammation, Chronic Active | | 1 2.0|
Renal Tubule, Degeneration, Focal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Urethra | | 2 |
Inflammation, Acute | | 1 4.0|
Bulbourethral Gland, Ectasia | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + | 48 |
Infiltration Cellular, Lymphocyte | 1 1 | 5 1.2|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|
| 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Gallbladder | + + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + |
Hyperplasia, Neutrophil | 3 |
Peyer's Patch, Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 4 |
Hematopoietic Cell Proliferation | 2 |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Mixed Cell | 2 |
Necrosis, Focal | 3 2 |
Hepatocyte, Hyperplasia, Focal | |
Serosa, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Myocardium, Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
Capsule, Hyperplasia, Multifocal | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | M + M |
__________________________________________________________________________|
Pituitary Gland | M + + |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|
| 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + |
__________________________________________________________________________|
Penis | |
Inflammation, Acute | |
__________________________________________________________________________|
Preputial Gland | + + + |
Cyst | 4 |
Dilatation | 3 |
Inflammation, Chronic | 4 4 |
__________________________________________________________________________|
Prostate | + + + |
__________________________________________________________________________|
Seminal Vesicle | M + + + + |
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
Hyperplasia, Neutrophil | 4 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + M |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | |
Ulcer | |
Epithelium, Hyperplasia | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 2| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 7| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 2| 3| 2| 3| 0| 3| 2| 5| 2| 3| 3| 3| 1| 5| 0| 5| 5| 3| 2| 1| 3| 3| 5| 5|
| 0| 9| 1| 8| 2| 1| 1| 9| 6| 9| 0| 2| 1| 1| 6| 7| 6| 6| 0| 9| 4| 1| 1| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + |
Hemorrhage | |
Mineralization, Multifocal | 1 1 2 2 2 1 1 2 2 3 2 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + |
Leukocytosis | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
Artery, Hypertrophy, Multifocal | |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Infarct | |
Infiltration Cellular, Lymphocyte | 1 |
Cortex, Cyst | |
Cortex, Mineralization, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|
| 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6250PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Gallbladder | A + A |
__________________________________________________________________________|
Intestine Large | + + A |
__________________________________________________________________________|
Intestine Large, Cecum | A + A |
__________________________________________________________________________|
Intestine Large, Colon | + + A |
__________________________________________________________________________|
Intestine Large, Rectum | + + A |
__________________________________________________________________________|
Intestine Small | + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + A |
__________________________________________________________________________|
Intestine Small, Ileum | + A + A |
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + A + + +|
Hyperplasia, Neutrophil | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | |
Infarct | |
Infiltration Cellular, Lymphocyte | 1|
Infiltration Cellular, Mixed Cell | |
Necrosis, Focal | 1 |
Hepatocyte, Hyperplasia, Focal | 3 |
Serosa, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
Inflammation, Chronic Active | |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Myocardium, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
Capsule, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + |
__________________________________________________________________________|
Pituitary Gland | + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|
| 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6250PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + |
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + |
__________________________________________________________________________|
Penis | + |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Preputial Gland | + + |
Cyst | |
Dilatation | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Prostate | A + + |
__________________________________________________________________________|
Seminal Vesicle | + + |
Fibrosis | |
Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Inguinal, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | M + M |
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M |
__________________________________________________________________________|
Skin | + + + + + + + + |
Inflammation, Chronic | |
Inflammation, Chronic Active | 4 |
Ulcer | 4 |
Epithelium, Hyperplasia | |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 2| 7| 6| 7| 7| 4| 4| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 5| 3| 3| 2| 7| 3| 9| 3| 3| 5| 5| 3| 3| 2| 3| 3| 0| 3| 3| 3| 2| 3| 3|
| 2| 9| 6| 0| 0| 9| 9| 0| 6| 2| 1| 6| 6| 0| 0| 9| 2| 0| 5| 2| 0| 1| 9| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
6250PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Mineralization, Multifocal | 1 3 2 3 1 1 1 3 3 2 1 2 3 1 2 2 1 2 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Artery, Hypertrophy, Multifocal | 2 |
Peribronchiolar, Infiltration | |
Cellular, Lymphocyte | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | 1 |
__________________________________________________________________________|
Nose | + + + |
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + |
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | |
Cortex, Cyst | 3 |
Cortex, Mineralization, Multifocal | 1 |
__________________________________________________________________________|
Urinary Bladder | A + + |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3| | |
| 9| 1| 9| 9| 2| 9| 2| 2| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + A | 7 |
__________________________________________________________________________|____________|
Gallbladder | A A | 4 |
__________________________________________________________________________|____________|
Intestine Large | + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 7 |
__________________________________________________________________________|____________|
Intestine Small | A A + | 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A | 5 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + | 14 |
Hyperplasia, Neutrophil | | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 49 |
Amyloid Deposition | | 1 4.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Necrosis, Focal | | 3 2.0|
Hepatocyte, Hyperplasia, Focal | | 1 3.0|
Serosa, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + A | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + A | 7 |
__________________________________________________________________________|____________|
Stomach | A A | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A A | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | A A | 6 |
Inflammation, Chronic Active | | 1 2.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 8 |
Myocardium, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + A | 7 |
Capsule, Hyperplasia, Multifocal | | 2 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + A | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3| | |
| 9| 1| 9| 9| 2| 9| 2| 2| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + A | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A | 7 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M A | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 7 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + A | 7 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 9 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 7 |
Cyst | | 1 4.0|
Dilatation | 3 | 3 2.7|
Inflammation, Chronic | 4 2 | 5 3.4|
__________________________________________________________________________|____________|
Prostate | + + | 7 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 9 |
Fibrosis | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + | 9 |
Seminiferous Tubule, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 8 |
Hyperplasia, Neutrophil | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node | + A + + | 13 |
Inguinal, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + | 10 |
Hemorrhage | | 3 2.7|
Hyperplasia, Lymphoid | 1 | 2 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + A + + + | 39 |
Hematopoietic Cell Proliferation | | 4 4.0|
Hyperplasia, Lymphoid | | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + M | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3| | |
| 9| 1| 9| 9| 2| 9| 2| 2| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Lymphoid | | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M | 1 |
__________________________________________________________________________|____________|
Skin | + + | 20 |
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Ulcer | | 1 4.0|
Epithelium, Hyperplasia | | 1 4.0|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 9 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 41 |
Hemorrhage | | 1 1.0|
Mineralization, Multifocal | 1 2 2 1 1 | 37 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + A + + + | 48 |
Leukocytosis | | 2 2.5|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Artery, Hypertrophy, Multifocal | | 1 2.0|
Peribronchiolar, Infiltration | | |
Cellular, Lymphocyte | 2 | 1 2.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + | 8 |
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + A | 7 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 7| 4| 7| 7| 4| 7| | |
DAY ON TEST | 0| 3| 2| 2| 3| 3| 3| 3| 5| 3| | |
| 9| 1| 9| 9| 2| 9| 2| 2| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
6250PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + | 14 |
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Cortex, Cyst | 2 | 2 2.5|
Cortex, Mineralization, Multifocal | 2 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 7 |
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|
| 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + M + + + M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 2 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + M + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + +|
Ulcer | |
Peyer's Patch, Hyperplasia, Lymphoid | 1 1 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Cytomegaly, Focal | 2 |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | |
Infarct | |
Infiltration Cellular, Mixed Cell | 3 |
Mitotic Alteration | 2 |
Necrosis, Focal | |
Bile Duct, Hyperplasia | |
Portal, Fibrosis | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic Active | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
Abscess | |
Dysplasia | 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|
| 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization, | |
Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
Capsule, Ectopic Tissue | |
Capsule, Hyperplasia, Multifocal | 1 3 1 3 2 2 2 3 2 2 2 3 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1 2 2 4 3 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M M M + + + M M + + M + M M M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + M + + + +|
Pars Distalis, Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Serosa, Necrosis, Focal | |
__________________________________________________________________________|
Penis | + + + |
Congestion | 4 |
Inflammation, Acute | |
Necrosis | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Abscess | 4 4 |
Cyst | 4 4 3 |
Dilatation | 1 4|
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|
| 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Neutrophil | 2 |
Erythroid Cell, Depletion Cellular | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 2 |
Inguinal, Hyperplasia, Lymphoid | 3 3 |
Inguinal, Hyperplasia, Plasma Cell | 2|
Lumbar, Hyperplasia, Plasma Cell | |
Mandibular, Hemorrhage | 2 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + M +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 1 1 1 |
Hyperplasia, Lymphoid | 1 3 1 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Dysplasia | 3 |
Hematopoietic Cell Proliferation | 4 4 1 3|
Hyperplasia, Lymphoid | 1 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + +|
Depletion Lymphoid | 2 3 4 4 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | |
Ulcer | 4 |
Prepuce, Inflammation, Acute | |
Prepuce, Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 7| 7| 4| 4| 7| 0| 0| 7| 6| 4| 7| 7| 7| 7| 7| 1| 1| 7| 7| 7|
DAY ON TEST | 3| 5| 2| 2| 3| 2| 3| 5| 5| 3| 2| 2| 2| 4| 5| 2| 3| 3| 2| 3| 3| 3| 3| 3| 2|
| 0| 6| 9| 9| 0| 9| 1| 6| 6| 2| 2| 2| 9| 5| 6| 9| 1| 1| 9| 0| 0| 1| 2| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization, Multifocal | 1 2 1 3 2 2 3 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 |
Interstitium, Fibrosis | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + M + + + + + + + + + + + + +|
Mucosa, Degeneration, Hyaline | |
Mucosa, Inflammation, Acute | 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hyperplasia, Atypical, Focal | |
Infiltration Cellular, Lymphocyte | 1 1 1 |
Infiltration Cellular, Mixed Cell | |
Nephropathy, Chronic | 1 1 |
Cortex, Cyst | 3 |
Cortex, Mineralization, Multifocal | |
Pelvis, Fibrosis | |
Pelvis, Inflammation, Acute | 2 |
Renal Tubule, Degeneration, Focal | |
Renal Tubule, Dilatation | 2 |
__________________________________________________________________________|
Ureter | |
Hyperplasia | |
__________________________________________________________________________|
Urethra | + |
Inflammation, Acute | |
Bulbourethral Gland, Inflammation, | |
Acute | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 |
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|
| 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 2 4 2 2 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Peyer's Patch, Hyperplasia, Lymphoid | 1 2 2 |
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Cytomegaly, Focal | 2 |
Fatty Change, Focal | 2 2 |
Hematopoietic Cell Proliferation | 1 |
Infarct | 3 |
Infiltration Cellular, Mixed Cell | |
Mitotic Alteration | |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 |
Portal, Fibrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Chronic Active | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Abscess | 2 |
Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|
| 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Myocardium, Mineralization, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
Capsule, Ectopic Tissue | 2 |
Capsule, Hyperplasia, Multifocal | 1 1 2 3 2 1 4 2 1 1 2 1 1 2 1 1|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
Hypertrophy, Focal | 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + M M + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + M M M + + M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + M + + + + + + + + + + + + M|
Pars Distalis, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + +|
Serosa, Necrosis, Focal | |
__________________________________________________________________________|
Penis | |
Congestion | |
Inflammation, Acute | |
Necrosis | |
__________________________________________________________________________|
Preputial Gland | + +|
Abscess | |
Cyst | 3|
Dilatation | |
Inflammation, Chronic | 4 3|
__________________________________________________________________________|
Prostate | + M + + + M + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|
| 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Hyperplasia, Neutrophil | 4 2 |
Erythroid Cell, Depletion Cellular | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | |
Lumbar, Hyperplasia, Plasma Cell | 4 |
Mandibular, Hemorrhage | |
Renal, Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + M + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 1 2 3 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Dysplasia | |
Hematopoietic Cell Proliferation | 4 3 1 3 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Thymus | + M M + + + + + + + + + + + + + + M + +|
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Inflammation, Chronic | 3 3 |
Ulcer | 4 |
Prepuce, Inflammation, Acute | |
Prepuce, Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 5| 3| 3| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3|
| 0| 6| 8| 0| 0| 1| 6| 9| 0| 0| 6| 1| 2| 2| 0| 2| 1| 9| 6| 2| 9| 6| 2| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
12500PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization, Multifocal | 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Fibrosis | |
Perivascular, Infiltration Cellular, | |
Lymphocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Mucosa, Degeneration, Hyaline | 1 1 |
Mucosa, Inflammation, Acute | |
Respiratory Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Hyperplasia, Atypical, Focal | |
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 |
Infiltration Cellular, Mixed Cell | 1 |
Nephropathy, Chronic | 1 1 1 1 |
Cortex, Cyst | 3 |
Cortex, Mineralization, Multifocal | 2 |
Pelvis, Fibrosis | 2 |
Pelvis, Inflammation, Acute | 4 |
Renal Tubule, Degeneration, Focal | 1 1 |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Ureter | + |
Hyperplasia | 2 |
__________________________________________________________________________|
Urethra | |
Inflammation, Acute | |
Bulbourethral Gland, Inflammation, | |
Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Lymphocyte | 1 1|
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5| | |
| 0| 0| 9| 1| 1| 5| 2| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A | 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + | 48 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 3 | 11 2.7|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + A + + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + | 48 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + | 48 |
Ulcer | 3 | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | 1 1 4 | 8 1.6|
Serosa, Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 50 |
Cyst | | 1 4.0|
Cytomegaly, Focal | | 2 2.0|
Fatty Change, Focal | | 2 2.0|
Hematopoietic Cell Proliferation | 3 | 2 2.0|
Infarct | | 1 3.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Mitotic Alteration | | 1 2.0|
Necrosis, Focal | | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
Portal, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic Active | 3 | 1 3.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 49 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 50 |
Serosa, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5| | |
| 0| 0| 9| 1| 1| 5| 2| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Abscess | | 1 2.0|
Dysplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Aorta, Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
Myocardium, Mineralization, | | |
Multifocal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
Capsule, Ectopic Tissue | | 1 2.0|
Capsule, Hyperplasia, Multifocal | 1 1 1 2 1 1 | 38 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Hyperplasia, Focal | | 3 2.0|
Hypertrophy, Focal | 1 2 3 | 12 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 48 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M + M + + | 27 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + | 44 |
Pars Distalis, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 49 |
Follicular Cell, Hyperplasia, Focal | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 50 |
Serosa, Necrosis, Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Penis | + | 4 |
Congestion | | 1 4.0|
Inflammation, Acute | 4 | 1 4.0|
Necrosis | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5| | |
| 0| 0| 9| 1| 1| 5| 2| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 11 |
Abscess | 4 4 | 4 4.0|
Cyst | | 4 3.5|
Dilatation | | 2 2.5|
Inflammation, Chronic | 3 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 48 |
Inflammation, Acute | 4 | 1 4.0|
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 50 |
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Hyperplasia | 3 | 1 3.0|
Hyperplasia, Neutrophil | 2 2 | 5 2.4|
Erythroid Cell, Depletion Cellular | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + A + + + | 47 |
Hyperplasia, Plasma Cell | | 2 2.5|
Inguinal, Hyperplasia, Lymphoid | 3 4 | 4 3.3|
Inguinal, Hyperplasia, Plasma Cell | | 1 2.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 4.0|
Mandibular, Hemorrhage | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + A + + + | 45 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | 2 3 1 | 10 1.7|
Hyperplasia, Lymphoid | 3 | 9 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
Depletion Lymphoid | | 2 2.0|
Dysplasia | | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 4 1 | 12 2.8|
Hyperplasia, Lymphoid | | 1 1.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 45 |
Depletion Lymphoid | 1 2 2 | 7 2.6|
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5| | |
| 0| 0| 9| 1| 1| 5| 2| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic | 1 | 3 2.3|
Ulcer | | 2 4.0|
Prepuce, Inflammation, Acute | 4 | 1 4.0|
Prepuce, Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 49 |
Mineralization, Multifocal | 1 2 1 1 2 | 18 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + | 39 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 3.0|
Interstitium, Fibrosis | 3 | 1 3.0|
Perivascular, Infiltration Cellular, | | |
Lymphocyte | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 49 |
Mucosa, Degeneration, Hyaline | 1 1 | 4 1.0|
Mucosa, Inflammation, Acute | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 2 | 5 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Hydronephrosis | | 1 3.0|
Hyperplasia, Atypical, Focal | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 13 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05706-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 13:29:12
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 2| 3| 3| 6| 3| 3| 7| 5| | |
| 0| 0| 9| 1| 1| 5| 2| 1| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
12500PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Mixed Cell | | 1 1.0|
Nephropathy, Chronic | 1 | 7 1.0|
Cortex, Cyst | | 2 3.0|
Cortex, Mineralization, Multifocal | | 1 2.0|
Pelvis, Fibrosis | | 1 2.0|
Pelvis, Inflammation, Acute | 2 | 3 2.7|
Renal Tubule, Degeneration, Focal | 2 | 3 1.3|
Renal Tubule, Dilatation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ureter | | 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 2 |
Inflammation, Acute | 4 | 1 4.0|
Bulbourethral Gland, Inflammation, | | |
Acute | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 49 |
Dilatation | | 2 3.5|
Infiltration Cellular, Lymphocyte | 1 1 | 6 1.2|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
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---------- END OF REPORT ----------
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