TDMS Study 05706-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
NTP Experiment-Test: 05706-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 15 14 16
Dead 5 3 1
Survivors
Terminal Sacrifice 30 32 33
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (8) (50)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (49) (8) (50)
Mineralization 1 (13%)
Parasite Metazoan 4 (8%)
Intestine Large, Rectum (49) (8) (50)
Mineralization 1 (13%)
Parasite Metazoan 1 (2%)
Liver (50) (42) (50)
Angiectasis 1 (2%) 1 (2%) 7 (14%)
Congestion 2 (4%) 3 (7%)
Cytologic Alterations 1 (2%) 3 (7%) 3 (6%)
Cytologic Alterations, Multiple 23 (46%) 12 (29%) 22 (44%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 16 (32%) 10 (24%) 8 (16%)
Hyperplasia, Focal 5 (10%) 4 (10%) 4 (8%)
Hyperplasia, Multifocal 2 (5%)
Inflammation, Chronic 13 (26%) 12 (29%) 13 (26%)
Mitotic Alteration 1 (2%)
Necrosis, Multifocal 1 (2%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 19 (38%) 14 (33%) 16 (32%)
Centrilobular, Necrosis 1 (2%) 2 (5%) 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 5 (10%) 1 (2%) 4 (8%)
Mesentery (2) (2) (3)
Hyperplasia, Lymphoid 1 (33%)
Fat, Necrosis 2 (100%) 2 (100%) 2 (67%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (49) (8) (50)
Inflammation, Chronic 1 (2%)
Acinus, Atrophy, Diffuse 1 (2%)
Acinus, Atrophy, Focal 13 (27%) 1 (13%) 23 (46%)
Acinus, Hyperplasia, Focal 1 (2%)
Artery, Inflammation, Chronic 2 (4%)
Artery, Inflammation, Subacute 1 (2%)
Pharynx (1)
Palate, Inflammation, Acute 1 (100%)
Salivary Glands (49) (8) (50)
Atrophy, Focal 1 (2%)
Cyst 1 (2%)
Stomach, Forestomach (50) (10) (50)
Inflammation, Acute 2 (4%) 1 (2%)
Inflammation, Chronic 1 (10%)
Ulcer 1 (10%) 4 (8%)
Epithelium, Hyperplasia 2 (4%) 1 (2%)
Stomach, Glandular (49) (10) (50)
Edema 1 (2%)
Erosion 1 (2%) 2 (20%) 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Mineralization 1 (2%) 1 (10%)
Pigmentation 2 (4%)
Ulcer 2 (4%)
Tongue (2)
Epithelium, Hyperplasia 2 (100%)
Tooth (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Aorta, Mineralization 1 (100%)
Artery, Inflammation, Chronic 1 (100%)
Heart (50) (8) (50)
Cardiomyopathy 25 (50%) 4 (50%) 28 (56%)
Mineralization 1 (2%) 1 (13%)
Atrium, Thrombosis 2 (4%) 4 (8%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (49)
Amyloid Deposition 1 (2%) 1 (2%)
Congestion 2 (4%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 1 (2%)
Hypertrophy, Focal 1 (2%)
Necrosis, Focal 2 (4%) 2 (4%) 1 (2%)
Vacuolization Cytoplasmic, Focal 6 (12%) 8 (16%) 9 (18%)
Adrenal Gland, Medulla (49) (50) (49)
Hyperplasia 9 (18%) 5 (10%) 7 (14%)
Infiltration Cellular, Lymphocyte 1 (2%)
Islets, Pancreatic (49) (8) (50)
Hyperplasia 2 (4%)
Parathyroid Gland (47) (7) (48)
Hyperplasia 1 (14%)
Pituitary Gland (50) (37) (49)
Hemorrhage 1 (2%)
Pars Distalis, Angiectasis 15 (30%) 9 (24%) 15 (31%)
Pars Distalis, Cyst 7 (14%) 2 (5%) 3 (6%)
Pars Distalis, Cyst, Multiple 1 (2%)
Pars Distalis, Hyperplasia 9 (18%) 6 (16%) 9 (18%)
Pars Distalis, Infarct 1 (2%)
Pars Distalis, Pigmentation 1 (3%)
Pars Nervosa, Cyst 1 (2%)
Pars Nervosa, Ectopic Tissue 1 (3%) 1 (2%)
Thyroid Gland (49) (10) (49)
Cyst 1 (2%)
C-Cell, Hyperplasia 8 (16%) 5 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (13) (46)
Dilatation 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Acute 6 (13%) 1 (8%) 2 (4%)
Ovary (50) (8) (50)
Cyst 10 (20%) 3 (6%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (13%)
Uterus (50) (22) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Angiectasis 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Cervix, Inflammation, Acute 1 (5%)
Endometrium, Hyperplasia, Cystic 5 (10%) 3 (14%) 4 (8%)
Vagina (1)
Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (8) (50)
Fibrosis 1 (2%) 1 (2%)
Hyperplasia 2 (25%) 1 (2%)
Lymph Node (50) (27) (49)
Axillary, Hemorrhage 1 (2%)
Axillary, Hyperplasia, Lymphoid 2 (4%)
Bronchial, Hemorrhage 1 (2%)
Iliac, Cyst 1 (2%) 1 (4%)
Iliac, Hemorrhage 1 (4%)
Iliac, Hyperplasia, Lymphoid 2 (7%)
Inguinal, Hyperplasia, Lymphoid 1 (4%)
Lymphocyte, Mandibular, Necrosis 1 (2%)
Mandibular, Cyst 4 (8%) 1 (2%)
Mandibular, Hemorrhage 5 (10%) 4 (8%)
Mediastinal, Hemorrhage 7 (14%) 7 (26%) 14 (29%)
Mediastinal, Pigmentation 1 (2%) 1 (2%)
Mediastinal, Lymphocyte, Necrosis 1 (2%)
Prefemoral, Hyperplasia, Lymphoid 1 (4%)
Lymph Node, Mesenteric (50) (8) (49)
Hemorrhage 4 (8%) 1 (13%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (49) (22) (50)
Congestion 1 (2%)
Fibrosis, Focal 1 (2%) 1 (5%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 3 (14%) 2 (4%)
Hemorrhage 1 (5%)
Inflammation, Focal, Granulomatous 1 (2%)
Necrosis, Focal 1 (2%) 1 (5%)
Pigmentation 2 (4%) 2 (9%) 1 (2%)
Thymus (48) (8) (49)
Cyst 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (47) (50)
Dilatation 6 (12%) 4 (9%) 1 (2%)
Hyperplasia 4 (8%) 1 (2%) 3 (6%)
Skin (50) (8) (50)
Cyst 1 (2%)
Subcutaneous Tissue, Abscess 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Thrombosis, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (8) (50)
Osteoporosis 1 (13%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (8) (50)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (33) (38)
Inflammation, Chronic 1 (3%)
Lung (50) (29) (50)
Foreign Body 1 (2%)
Hemorrhage 12 (24%) 13 (45%) 4 (8%)
Hyperplasia, Adenomatous 2 (4%) 3 (10%) 1 (2%)
Infiltration Cellular, Histiocyte 7 (14%) 2 (7%) 1 (2%)
Thrombosis 1 (2%)
Interstitium, Inflammation, Chronic 3 (6%) 10 (20%)
Nose (49) (8) (50)
Metaplasia, Squamous 1 (13%)
Nasolacrimal Duct, Fungus 1 (2%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%) 1 (13%) 1 (2%)
Sinus, Foreign Body 1 (2%)
Sinus, Fungus 1 (2%) 1 (13%) 1 (2%)
Sinus, Inflammation, Acute 3 (6%) 2 (25%) 1 (2%)
Turbinate, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (5) (2)
Cornea, Inflammation, Chronic 1 (20%)
Iris, Inflammation, Chronic 1 (33%)
Lens Capsule, Cataract 1 (33%) 5 (100%) 2 (100%)
Retina, Atrophy 1 (33%) 5 (100%) 2 (100%)
Sclera, Metaplasia, Osseous 1 (33%) 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Cyst 1 (2%)
Fibrosis, Focal 1 (2%)
Inflammation, Acute 3 (6%)
Nephropathy 46 (92%) 47 (94%) 47 (94%)
Pigmentation 1 (2%) 3 (6%) 3 (6%)
Artery, Inflammation, Chronic 1 (2%)
Pelvis, Dilatation 1 (2%)
Pelvis, Inflammation, Acute 1 (2%) 1 (2%)
Pelvis, Inflammation, Subacute 1 (2%)
Pelvis, Mineralization 8 (16%) 30 (60%) 37 (74%)
Pelvis, Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (9) (50)
Hemorrhage 1 (11%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 21 24 20
Dead 7 6 6
Survivors
Terminal Sacrifice 22 20 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (47) (15) (48)
Edema 1 (2%)
Hemorrhage 1 (2%) 1 (7%)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (47) (14) (49)
Mineralization 1 (7%)
Parasite Metazoan 4 (9%)
Intestine Large, Rectum (47) (14) (48)
Parasite Metazoan 2 (4%)
Intestine Small, Duodenum (48) (12) (49)
Inflammation, Acute 1 (8%)
Intestine Small, Jejunum (47) (11) (48)
Hyperplasia, Lymphoid 1 (2%)
Liver (50) (49) (50)
Angiectasis 11 (22%) 16 (33%) 17 (34%)
Congestion 1 (2%) 4 (8%) 2 (4%)
Cyst 1 (2%)
Cytologic Alterations 5 (10%) 13 (27%) 1 (2%)
Cytologic Alterations, Multiple 11 (22%) 5 (10%) 12 (24%)
Fibrosis 1 (2%)
Fibrosis, Focal 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 8 (16%) 4 (8%) 7 (14%)
Hyperplasia, Focal 10 (20%) 8 (16%) 8 (16%)
Hyperplasia, Multifocal 1 (2%) 1 (2%)
Hyperplasia, Nodular 3 (6%)
Inflammation, Chronic 1 (2%)
Necrosis, Focal 2 (4%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Diffuse 1 (2%)
Bile Duct, Hyperplasia 38 (76%) 39 (80%) 44 (88%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia, Cystic 1 (2%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (4%)
Centrilobular, Vacuolization Cytoplasmic 2 (4%) 3 (6%) 6 (12%)
Periportal, Vacuolization Cytoplasmic 1 (2%)
Mesentery (5) (2) (5)
Inflammation, Acute 1 (20%)
Inflammation, Chronic 1 (20%)
Fat, Inflammation, Acute 2 (40%)
Fat, Necrosis 1 (20%) 2 (100%) 1 (20%)
Pancreas (49) (16) (49)
Accessory Spleen 1 (6%)
Acinus, Atrophy, Diffuse 2 (4%)
Acinus, Atrophy, Focal 14 (29%) 1 (6%) 17 (35%)
Acinus, Hyperplasia, Focal 1 (2%)
Artery, Inflammation, Chronic 3 (6%)
Salivary Glands (50) (14) (50)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (49) (21) (49)
Edema 1 (2%) 1 (5%) 1 (2%)
Erosion 1 (5%)
Inflammation, Acute 1 (2%) 1 (5%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%) 1 (5%)
Ulcer 4 (19%) 1 (2%)
Artery, Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 3 (14%) 1 (2%)
Stomach, Glandular (48) (21) (50)
Amyloid Deposition 1 (5%)
Erosion 4 (8%) 5 (24%) 3 (6%)
Inflammation, Acute 1 (2%)
Mineralization 2 (4%) 1 (5%)
Pigmentation 1 (2%)
Ulcer 1 (2%) 1 (5%) 4 (8%)
Tongue (3)
Inflammation, Chronic 1 (33%)
Epithelium, Hyperplasia 2 (67%)
Tooth (1)
Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (1)
Aorta, Inflammation, Chronic 1 (50%)
Aorta, Mineralization 1 (50%) 1 (100%)
Heart (50) (20) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Cardiomyopathy 38 (76%) 16 (80%) 40 (80%)
Mineralization 1 (5%)
Atrium, Thrombosis 6 (12%) 5 (25%) 4 (8%)
Endocardium, Thrombosis 1 (5%)
Epicardium, Fibrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%)
Necrosis, Focal 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic, Focal 2 (4%) 2 (4%) 1 (2%)
Adrenal Gland, Medulla (48) (50) (50)
Hyperplasia 17 (35%) 21 (42%) 13 (26%)
Islets, Pancreatic (49) (16) (49)
Hyperplasia 4 (8%) 1 (6%) 3 (6%)
Parathyroid Gland (49) (15) (45)
Hyperplasia 3 (6%) 1 (7%) 1 (2%)
Pituitary Gland (50) (49) (50)
Pars Distalis, Angiectasis 3 (6%) 3 (6%) 2 (4%)
Pars Distalis, Cyst 1 (2%) 2 (4%) 7 (14%)
Pars Distalis, Hyperplasia 3 (6%) 9 (18%) 8 (16%)
Pars Nervosa, Ectopic Tissue 1 (2%) 1 (2%)
Thyroid Gland (49) (18) (50)
Cyst 2 (4%)
C-Cell, Hyperplasia 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (50) (20) (49)
Cyst 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Acute 11 (22%) 2 (10%) 8 (16%)
Inflammation, Chronic 1 (2%)
Prostate (50) (14) (49)
Hyperplasia, Focal 6 (12%) 5 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Acute 17 (34%) 1 (7%) 8 (16%)
Inflammation, Chronic 2 (4%)
Seminal Vesicle (48) (37) (47)
Atrophy 25 (52%) 15 (41%) 25 (53%)
Inflammation, Acute 1 (2%)
Testes (50) (50) (50)
Atrophy 15 (30%) 14 (28%) 24 (48%)
Interstitial Cell, Hyperplasia 2 (4%) 5 (10%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (14) (50)
Fibrosis 1 (2%)
Hyperplasia 2 (4%) 5 (36%) 2 (4%)
Lymph Node (50) (33) (50)
Axillary, Hyperplasia, Lymphoid 1 (3%)
Iliac, Cyst 1 (3%)
Inguinal, Cyst 1 (2%) 1 (2%)
Inguinal, Hyperplasia, Lymphoid 2 (4%) 1 (3%) 2 (4%)
Mandibular, Cyst 7 (14%) 3 (6%)
Mandibular, Hemorrhage 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (3%) 2 (4%)
Mediastinal, Cyst 1 (2%)
Mediastinal, Hemorrhage 9 (18%) 8 (24%) 10 (20%)
Mediastinal, Pigmentation 3 (6%)
Pancreatic, Hemorrhage 1 (2%)
Renal, Hemorrhage 1 (3%)
Renal, Inflammation, Chronic 1 (2%)
Lymph Node, Mesenteric (50) (18) (50)
Cyst 1 (2%) 2 (11%) 1 (2%)
Edema 1 (2%) 1 (2%)
Hemorrhage 3 (6%) 4 (22%) 1 (2%)
Spleen (49) (49) (50)
Amyloid Deposition 1 (2%)
Congestion 3 (6%) 1 (2%) 2 (4%)
Depletion Lymphoid 1 (2%)
Fibrosis, Focal 8 (16%) 5 (10%) 7 (14%)
Hematopoietic Cell Proliferation 2 (4%) 5 (10%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Inflammation, Focal, Granulomatous 1 (2%)
Necrosis 2 (4%) 1 (2%)
Pigmentation 1 (2%)
Capsule, Fibrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (18) (50)
Dilatation 1 (2%) 2 (11%) 2 (4%)
Hyperplasia 1 (2%)
Skin (49) (21) (50)
Cyst 1 (5%)
Edema 1 (2%) 1 (5%)
Hyperkeratosis 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic 1 (5%)
Epithelium, Lip, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (14) (50)
Hyperostosis 1 (2%)
Osteomalacia 1 (2%) 1 (7%)
Tarsal, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (13) (50)
Hemorrhage 1 (2%) 1 (2%)
Thrombosis 2 (4%) 6 (12%)
Thrombosis, Multiple 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (26) (27)
Inflammation, Subacute 1 (4%)
Ulcer 1 (4%)
Lung (50) (30) (50)
Congestion 1 (2%) 1 (3%)
Fibrosis 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 2 (4%) 1 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Adenomatous 4 (8%) 4 (13%) 2 (4%)
Infiltration Cellular, Histiocyte 4 (8%) 1 (3%) 1 (2%)
Pigmentation 1 (2%)
Interstitium, Inflammation, Chronic 1 (2%) 2 (7%) 5 (10%)
Nose (49) (14) (50)
Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:55
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Acute 1 (2%) 2 (4%)
Sinus, Foreign Body 1 (7%) 2 (4%)
Sinus, Fungus 4 (8%) 2 (14%) 3 (6%)
Sinus, Inflammation, Acute 8 (16%) 4 (29%) 9 (18%)
Turbinate, Inflammation, Chronic 5 (10%)
Turbinate, Inflammation, Subacute 1 (2%)
Turbinate, Thrombosis 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Lens Capsule, Cataract 2 (100%)
Retina, Atrophy 2 (100%)
Sclera, Metaplasia, Osseous 1 (50%)
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URINARY SYSTEM
Kidney (50) (45) (50)
Cyst 3 (6%) 2 (4%) 3 (6%)
Developmental Malformation 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Nephropathy 48 (96%) 42 (93%) 46 (92%)
Pigmentation 1 (2%)
Pelvis, Dilatation 1 (2%)
Pelvis, Mineralization 1 (2%) 3 (6%)
Renal Tubule, Degeneration 1 (2%) 1 (2%)
Urinary Bladder (50) (14) (49)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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