TDMS Study 05706-02 Pathology Tables
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X |
Pars Distalis, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + M + + + + + + + + +|
Adenoma | |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Cervix, Carcinoma | X |
Cervix, Leiomyosarcoma | |
Endometrium, Polyp Stromal | X X X X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X X |
Mandibular, Leukemia Mononuclear | X X X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Axillary, Mediastinal, | |
Adenocarcinoma, Metastatic, Skin | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + +|
Leukemia Mononuclear | X X |
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | X |
Fibroadenoma | X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Adenocarcinoma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Schwannoma | |
Benign | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Glioma Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Skin | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + +|
Leiomyosarcoma | X|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + +|
Adenoma | X X X |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Cervix, Carcinoma | |
Cervix, Leiomyosarcoma | |
Endometrium, Polyp Stromal | X X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Axillary, Mediastinal, | |
Adenocarcinoma, Metastatic, Skin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X |
Fibroadenoma | X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Sebaceous Gland, Adenocarcinoma | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Schwannoma | |
Benign | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Glioma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Skin | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Zymbal's Gland | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Leukemia Mononuclear | X | 16 |
Neoplastic Nodule | X | 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 49 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 49 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 49 |
Leukemia Mononuclear | | 7 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X | 15 |
Pars Distalis, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
C-Cell, Adenoma | | 2 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 47 |
Adenoma | | 3 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Cervix, Carcinoma | | 1 |
Cervix, Leiomyosarcoma | X | 1 |
Endometrium, Polyp Stromal | | 9 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 1 |
Deep Cervical, Carcinoma, Metastatic,| | |
Thyroid Gland | | 1 |
Iliac, Leukemia Mononuclear | | 3 |
Inguinal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mandibular, Leukemia Mononuclear | | 4 |
Mediastinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
Axillary, Mediastinal, | | |
Adenocarcinoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 49 |
Leukemia Mononuclear | X | 16 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 48 |
Leukemia Mononuclear | | 3 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 50 |
Adenocarcinoma | | 1 |
Adenoma | | 2 |
Fibroadenoma | X | 9 |
Fibroadenoma, Multiple | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
Sebaceous Gland, Adenocarcinoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Benign | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Glioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 33 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Adenocarcinoma, Metastatic, Skin | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Squamous Cell Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 50 |
Leukemia Mononuclear | X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + +|
C-Cell, Carcinoma | X|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + |
__________________________________________________________________________|
Uterus | + + + + + + + +|
Leiomyosarcoma | X |
Leukemia Mononuclear | |
Cervix, Squamous Cell Carcinoma | |
Endometrium, Polyp Stromal | X X |
Endometrium, Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X|
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Thymus | + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Astrocytoma Benign | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Nose | + + + |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Carcinoma | |
__________________________________________________________________________|
Urinary Bladder | + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X X X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + |
Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ovary | + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + |
Leiomyosarcoma | |
Leukemia Mononuclear | X |
Cervix, Squamous Cell Carcinoma | X |
Endometrium, Polyp Stromal | X X X X X X |
Endometrium, Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Adenocarcinoma | |
Adenoma | X |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
Astrocytoma Benign | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Renal Tubule, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 8 |
__________________________________________________________________________|____________|
Intestine Large | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 42 |
Leukemia Mononuclear | X | 13 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
__________________________________________________________________________|____________|
Pancreas | + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + | 8 |
__________________________________________________________________________|____________|
Stomach | + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 7 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 37 |
Pars Distalis, Adenoma | X X X X | 20 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 10 |
C-Cell, Carcinoma | X | 2 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 13 |
Adenoma | X | 5 |
__________________________________________________________________________|____________|
Ovary | + | 8 |
__________________________________________________________________________|____________|
Uterus | + + + | 22 |
Leiomyosarcoma | | 1 |
Leukemia Mononuclear | | 1 |
Cervix, Squamous Cell Carcinoma | | 1 |
Endometrium, Polyp Stromal | | 8 |
Endometrium, Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 8 |
__________________________________________________________________________|____________|
Lymph Node | + + | 27 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 2 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 8 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 22 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Thymus | + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 47 |
Adenocarcinoma | X X | 2 |
Adenoma | | 1 |
Fibroadenoma | X X X X | 17 |
Fibroadenoma, Multiple | | 4 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 8 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 8 |
Astrocytoma Benign | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 29 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Nose | + | 8 |
__________________________________________________________________________|____________|
Trachea | + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Renal Tubule, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 9 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + M + + + + + + + + + + + + + + +|
Adenoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Polyp Stromal | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Thymoma Benign | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenoma | |
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lipoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Glioma Benign | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + M + + +|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Endometrium, Polyp Stromal | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + + +|
Axillary, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + +|
Thymoma Benign | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X |
Adenoma | X|
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Glioma Benign | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 12 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Adenoma | X | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 5 |
Pheochromocytoma Benign | X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X X X | 13 |
Pars Distalis, Adenoma, Multiple | X | 1 |
Pars Distalis, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
C-Cell, Adenoma | X | 3 |
C-Cell, Carcinoma | | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 46 |
Adenoma | X X | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Granulosa Cell Tumor Benign | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Endometrium, Polyp Stromal | | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Axillary, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Thymoma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Adenocarcinoma | | 3 |
Adenoma | X | 2 |
Fibroadenoma | X X X X | 19 |
Fibroadenoma, Multiple | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
Subcutaneous Tissue, Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Glioma Benign | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + |
Adenoma, Papillary | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Pheochromocytoma Benign, Multiple | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + |
Adenoma | X X X X |
Carcinoma | X |
Leukemia Mononuclear | X |
Bilateral, Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Iliac, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Fibroadenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Keratoacanthoma | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Schwannoma | |
Benign | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Sarcoma | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
External Ear, Squamous Cell Carcinoma| X |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + +|
Adenoma, Papillary | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Neoplastic Nodule | X|
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X X X X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | |
Leukemia Mononuclear | X |
Bilateral, Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
Interstitial Cell, Adenoma | X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Deep Cervical, Carcinoma, Metastatic,| |
Thyroid Gland | |
Iliac, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + M +|
Fibroadenoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + +|
Keratoacanthoma | X X |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Benign | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
External Ear, Squamous Cell Carcinoma| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 48 |
Adenoma, Papillary | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 47 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 22 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + | 48 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 48 |
Leukemia Mononuclear | X | 4 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X X | 12 |
Pheochromocytoma Benign, Multiple | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 40
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 49 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Pars Distalis, Adenoma | X X | 16 |
Pars Distalis, Adenoma, Multiple | X | 1 |
Pars Distalis, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 49 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 50 |
Adenoma | X | 8 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 2 |
Bilateral, Carcinoma | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 48 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | X | 3 |
Interstitial Cell, Adenoma | | 4 |
Interstitial Cell, Adenoma, Multiple | X X X X | 38 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 49 |
Leukemia Mononuclear | X X X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 50 |
Axillary, Leukemia Mononuclear | X | 1 |
Deep Cervical, Carcinoma, Metastatic,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thyroid Gland | X | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | X X | 4 |
Mediastinal, Leukemia Mononuclear | X | 4 |
Pancreatic, Leukemia Mononuclear | X | 4 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
Leukemia Mononuclear | X X | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 49 |
Leukemia Mononuclear | X X X X | 23 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 48 |
Fibroadenoma | | 3 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 49 |
Keratoacanthoma | | 2 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Schwannoma | | |
Benign | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Leukemia Mononuclear | | 4 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 26 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X X X | 19 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
Carcinoma, Metastatic, Thyroid Gland | X | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
External Ear, Squamous Cell Carcinoma| | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 23 |
Mesothelioma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
Neoplastic Nodule | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Leukemia Mononuclear | |
Sarcoma, Metastatic, Tissue NOS | X |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Sarcoma, Metastatic, Tissue NOS | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Leukemia Mononuclear | X |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Malignant, Multiple | |
Pheochromocytoma Benign | X X X X X X X |
Pheochromocytoma Benign, Multiple | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Leukemia Mononuclear | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Adenoma | X |
Carcinoma | X X |
Bilateral, Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Mesothelioma Benign | |
Interstitial Cell, Adenoma | X X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + |
Keratoacanthoma | |
Squamous Cell Carcinoma | |
Sebaceous Gland, Adenoma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
Diaphragm, Sarcoma, Metastatic, | |
Tissue NOS | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma, Metastatic, Preputial | |
Gland | X |
Leukemia Mononuclear | X X |
Sarcoma, Metastatic, Skin | X |
Squamous Cell Carcinoma, Metastatic, | |
Zymbal's Gland | |
Mediastinum, Hemangiosarcoma | X |
__________________________________________________________________________|
Nose | + + + + + |
__________________________________________________________________________|
Trachea | + + + + + |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | |
Leukemia Mononuclear | X X X X X X X X X |
Mesothelioma Benign | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Neoplastic Nodule | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Leukemia Mononuclear | X|
Sarcoma, Metastatic, Tissue NOS | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Sarcoma, Metastatic, Tissue NOS | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Malignant, Multiple | X |
Pheochromocytoma Benign | X X |
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Distalis, Leukemia Mononuclear | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Adenoma | X X |
Carcinoma | |
Bilateral, Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Benign | X |
Interstitial Cell, Adenoma | X X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X |
Mediastinal, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Mediastinal, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X X|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + M + + + + M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Adenocarcinoma | |
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Keratoacanthoma | X |
Squamous Cell Carcinoma | X |
Sebaceous Gland, Adenoma | |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Sarcoma, Metastatic, | |
Tissue NOS | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Carcinoma, Metastatic, Preputial | |
Gland | |
Leukemia Mononuclear | X X X X X X X|
Sarcoma, Metastatic, Skin | |
Squamous Cell Carcinoma, Metastatic, | |
Zymbal's Gland | X |
Mediastinum, Hemangiosarcoma | |
__________________________________________________________________________|
Nose | + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + +|
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X|
Mesothelioma Benign | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 15 |
__________________________________________________________________________|____________|
Intestine Large | + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 14 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 49 |
Leukemia Mononuclear | X X X X X X X | 27 |
Neoplastic Nodule | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + | 16 |
Leukemia Mononuclear | | 1 |
Sarcoma, Metastatic, Tissue NOS | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 21 |
Sarcoma, Metastatic, Tissue NOS | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 21 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + | 20 |
Leukemia Mononuclear | X | 2 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X | 11 |
Pheochromocytoma Malignant | | 3 |
Pheochromocytoma Malignant, Multiple | | 1 |
Pheochromocytoma Benign | X X X X X | 14 |
Pheochromocytoma Benign, Multiple | X | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 15 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Adenoma | | 8 |
Pars Distalis, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 18 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 13 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 20 |
Adenoma | X | 4 |
Carcinoma | | 2 |
Bilateral, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + | 14 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + A + + | 37 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Mesothelioma Benign | | 1 |
Interstitial Cell, Adenoma | X X X | 9 |
Interstitial Cell, Adenoma, Multiple | X X X X X X | 31 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 14 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 33 |
Leukemia Mononuclear | | 1 |
Axillary, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 2 |
Mandibular, Leukemia Mononuclear | X | 2 |
Mediastinal, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinal, Leukemia Mononuclear | X X X | 7 |
Pancreatic, Leukemia Mononuclear | | 4 |
Renal, Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 18 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 29 |
__________________________________________________________________________|____________|
Thymus | + + + | 14 |
Leukemia Mononuclear | X X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 18 |
Adenocarcinoma | X | 1 |
Fibroadenoma | | 2 |
__________________________________________________________________________|____________|
Skin | + + + | 21 |
Keratoacanthoma | X | 2 |
Squamous Cell Carcinoma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 14 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Diaphragm, Sarcoma, Metastatic, | | |
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 30 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma, Metastatic, Preputial | | |
Gland | | 1 |
Leukemia Mononuclear | X X X | 12 |
Sarcoma, Metastatic, Skin | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Zymbal's Gland | | 1 |
Mediastinum, Hemangiosarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + | 14 |
__________________________________________________________________________|____________|
Trachea | + | 14 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 45 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 14 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 50 |
Histiocytic Sarcoma | | 1 |
Leukemia Mononuclear | X X X X X X X | 29 |
Mesothelioma Benign | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + A + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
Neoplastic Nodule | X |
Neoplastic Nodule, Multiple | X |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | |
__________________________________________________________________________|
Mesentery | + + |
Fibrous Histiocytoma | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Tongue | + + |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Malignant, Multiple | X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X X X X X X |
Pheochromocytoma Benign, Multiple | X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Fibrosarcoma | X|
Leukemia Mononuclear | |
Squamous Cell Papilloma | |
Bilateral, Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + A + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | |
Inguinal, Renal, Iliac, Bronchial, | |
Mediastinal, Sarcoma, | |
Metastatic, Skin | |
Lumbar, Leukemia Mononuclear | |
Mandibular, Leukemia Mononuclear | X X |
Mediastinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M M + + + +|
Leukemia Mononuclear | X X X X X |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Leukemia Mononuclear | |
Squamous Cell Papilloma | X |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Leukemia Mononuclear | X X X X X X X X X X |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | |
Sarcoma, Metastatic, Skin | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Mesothelioma Malignant | |
Neoplastic Nodule | X X X |
Neoplastic Nodule, Multiple | |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | X |
__________________________________________________________________________|
Mesentery | + |
Fibrous Histiocytoma | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Tongue | |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Malignant, Multiple | X X X |
Pheochromocytoma Complex | X|
Pheochromocytoma Benign | X X X X X|
Pheochromocytoma Benign, Multiple | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Distalis, Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + +|
Adenoma | X |
Carcinoma | |
Fibrosarcoma | |
Leukemia Mononuclear | X X |
Squamous Cell Papilloma | X |
Bilateral, Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Interstitial Cell, Adenoma | X X|
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Axillary, Leukemia Mononuclear | X X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X |
Inguinal, Renal, Iliac, Bronchial, | |
Mediastinal, Sarcoma, | |
Metastatic, Skin | X |
Lumbar, Leukemia Mononuclear | X |
Mandibular, Leukemia Mononuclear | X X X X X |
Mediastinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X|
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Mesothelioma Malignant | |
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Fibroadenoma | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Leukemia Mononuclear | |
Squamous Cell Papilloma | |
Trichoepithelioma | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lipoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Diaphragm, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Leukemia Mononuclear | X X X X X X X X X|
Neuroblastoma Malignant, Metastatic, | |
Adrenal Gland | X |
Sarcoma, Metastatic, Skin | X |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Mesothelioma Malignant | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 48 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 27 |
Mesothelioma Malignant | | 1 |
Neoplastic Nodule | | 4 |
Neoplastic Nodule, Multiple | | 1 |
Neuroblastoma Malignant, Metastatic, | | |
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fibrous Histiocytoma | | 1 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Pancreas | M + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 2 |
Mesothelioma Malignant | X | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 4 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Tongue | + | 3 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 8 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
Pheochromocytoma Malignant | X | 4 |
Pheochromocytoma Malignant, Multiple | | 4 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | X X | 14 |
Pheochromocytoma Benign, Multiple | X X | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + + + + | 49 |
Adenoma | X X | 2 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Adenoma | X X | 10 |
Pars Distalis, Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 49 |
Adenoma | X X | 4 |
Carcinoma | | 1 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | | 1 |
Bilateral, Carcinoma | | 3 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M | 49 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 47 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Mesothelioma Malignant | X X | 3 |
Interstitial Cell, Adenoma | | 3 |
Interstitial Cell, Adenoma, Multiple | X X X X X X X X X | 43 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 6 |
Neuroblastoma Malignant, Metastatic, | | |
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Axillary, Leukemia Mononuclear | | 2 |
Iliac, Leukemia Mononuclear | | 2 |
Inguinal, Leukemia Mononuclear | | 1 |
Inguinal, Renal, Iliac, Bronchial, | | |
Mediastinal, Sarcoma, | | |
Metastatic, Skin | | 1 |
Lumbar, Leukemia Mononuclear | | 1 |
Mandibular, Leukemia Mononuclear | | 7 |
Mediastinal, Leukemia Mononuclear | | 3 |
Pancreatic, Leukemia Mononuclear | | 2 |
Renal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 28 |
Mesothelioma Malignant | X X | 3 |
Neuroblastoma Malignant, Metastatic, | | |
Adrenal Gland | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 46 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Fibroadenoma | X | 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Keratoacanthoma | X | 2 |
Leukemia Mononuclear | X | 1 |
Squamous Cell Papilloma | | 1 |
Trichoepithelioma | | 2 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
Subcutaneous Tissue, Lipoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Diaphragm, Mesothelioma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Astrocytoma Malignant | | 1 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + | 27 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Leukemia Mononuclear | X X X X | 23 |
Neuroblastoma Malignant, Metastatic, | | |
Adrenal Gland | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05706-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/09/97
Route: DOSED FEED Time: 07:53:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 1 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X | 11 |
Mesothelioma Malignant | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
Leukemia Mononuclear | X | 3 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 50 |
Leukemia Mononuclear | X X X X | 28 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
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---------- END OF REPORT ----------
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