TDMS Study 05706-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
NTP Experiment-Test: 05706-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 15 14 16
Dead 5 3 1
Survivors
Terminal Sacrifice 30 32 33
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (8) (50)
Intestine Large, Colon (49) (8) (50)
Intestine Large, Rectum (49) (8) (50)
Intestine Small, Ileum (49) (8) (50)
Intestine Small, Jejunum (49) (8) (50)
Liver (50) (42) (50)
Neoplastic Nodule 3 (6%) 1 (2%)
Mesentery (2) (2) (3)
Pancreas (49) (8) (50)
Salivary Glands (49) (8) (50)
Stomach, Forestomach (50) (10) (50)
Stomach, Glandular (49) (10) (50)
Leiomyosarcoma 1 (2%)
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CARDIOVASCULAR SYSTEM
Heart (50) (8) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (49)
Adenoma 2 (4%)
Adrenal Gland, Medulla (49) (50) (49)
Pheochromocytoma Malignant 2 (4%)
Pheochromocytoma Benign 2 (4%) 4 (8%) 5 (10%)
Islets, Pancreatic (49) (8) (50)
Adenoma 1 (2%)
Pituitary Gland (50) (37) (49)
Page 2
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma 15 (30%) 20 (54%) 13 (27%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (49) (10) (49)
C-Cell, Adenoma 2 (4%) 3 (6%)
C-Cell, Carcinoma 2 (4%) 2 (20%) 5 (10%)
Follicular Cell, Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (13) (46)
Adenoma 3 (6%) 5 (38%) 4 (9%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (8) (50)
Granulosa Cell Tumor Benign 2 (4%)
Uterus (50) (22) (50)
Leiomyosarcoma 1 (5%)
Cervix, Carcinoma 1 (2%)
Cervix, Leiomyosarcoma 1 (2%)
Cervix, Squamous Cell Carcinoma 1 (5%)
Endometrium, Polyp Stromal 9 (18%) 8 (36%) 11 (22%)
Endometrium, Sarcoma Stromal 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (8) (50)
Lymph Node (50) (27) (49)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (50) (8) (49)
Axillary, Mediastinal, Adenocarcinoma,
Metastatic, Skin 1 (2%)
Spleen (49) (22) (50)
Thymus (48) (8) (49)
Thymoma Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (47) (50)
Adenocarcinoma 1 (2%) 2 (4%) 3 (6%)
Adenoma 2 (4%) 1 (2%) 2 (4%)
Fibroadenoma 9 (18%) 17 (36%) 19 (38%)
Fibroadenoma, Multiple 2 (4%) 4 (9%) 2 (4%)
Skin (50) (8) (50)
Sebaceous Gland, Adenocarcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (8) (50)
Astrocytoma Benign 1 (13%)
Glioma Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (33) (38)
Lung (50) (29) (50)
Adenocarcinoma, Metastatic, Skin 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (3%) 1 (2%)
Nose (49) (8) (50)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (5) (2)
Zymbal's Gland (2) (1)
Squamous Cell Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (50) (9) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 16 (32%) 14 (28%) 15 (30%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 12500PPM 25000PPM
FEMALE FEMALE FEMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 44 50
Total Primary Neoplasms 77 86 97
Total Animals with Benign Neoplasms 32 36 44
Total Benign Neoplasms 52 62 72
Total Animals with Malignant Neoplasms 23 21 22
Total Malignant Neoplasms 25 24 25
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund 21 24 20
Dead 7 6 6
Survivors
Terminal Sacrifice 22 20 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (14) (49)
Intestine Large, Rectum (47) (14) (48)
Intestine Small, Duodenum (48) (12) (49)
Intestine Small, Ileum (48) (12) (48)
Adenoma, Papillary 1 (2%)
Intestine Small, Jejunum (47) (11) (48)
Liver (50) (49) (50)
Neoplastic Nodule 1 (2%) 1 (2%) 4 (8%)
Neoplastic Nodule, Multiple 1 (2%)
Neuroblastoma Malignant, Metastatic, Adrenal
Gland 1 (2%)
Mesentery (5) (2) (5)
Fibrous Histiocytoma 1 (20%)
Pancreas (49) (16) (49)
Sarcoma, Metastatic, Tissue NOS 1 (6%)
Salivary Glands (50) (14) (50)
Stomach, Forestomach (49) (21) (49)
Sarcoma, Metastatic, Tissue NOS 1 (5%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (48) (21) (50)
Tongue (3)
Squamous Cell Papilloma 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (20) (50)
Sarcoma, Metastatic, Skin 1 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49) (50)
Adrenal Gland, Medulla (48) (50) (50)
Pheochromocytoma Malignant 2 (4%) 3 (6%) 4 (8%)
Pheochromocytoma Malignant, Multiple 1 (2%) 4 (8%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 12 (25%) 14 (28%) 14 (28%)
Pheochromocytoma Benign, Multiple 4 (8%) 4 (8%) 5 (10%)
Islets, Pancreatic (49) (16) (49)
Adenoma 2 (4%)
Carcinoma 1 (2%) 2 (4%)
Parathyroid Gland (49) (15) (45)
Adenoma 1 (2%)
Pituitary Gland (50) (49) (50)
Pars Distalis, Adenoma 16 (32%) 8 (16%) 10 (20%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Thyroid Gland (49) (18) (50)
C-Cell, Adenoma 2 (4%) 1 (6%)
C-Cell, Carcinoma 2 (4%) 1 (6%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (13) (50)
Preputial Gland (50) (20) (49)
Adenoma 8 (16%) 4 (20%) 4 (8%)
Carcinoma 1 (2%) 2 (10%) 1 (2%)
Fibrosarcoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Bilateral, Carcinoma 2 (4%) 1 (5%) 3 (6%)
Prostate (50) (14) (49)
Seminal Vesicle (48) (37) (47)
Testes (50) (50) (50)
Interstitial Cell, Adenoma 4 (8%) 9 (18%) 3 (6%)
Interstitial Cell, Adenoma, Multiple 38 (76%) 31 (62%) 43 (86%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (14) (50)
Neuroblastoma Malignant, Metastatic, Adrenal
Gland 1 (2%)
Lymph Node (50) (33) (50)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (2%)
Inguinal, Renal, Iliac, Bronchial,
Mediastinal, Sarcoma, Metastatic, Skin 1 (2%)
Mediastinal, Alveolar/Bronchiolar Carcinoma,
Metastatic, Lung 1 (3%)
Lymph Node, Mesenteric (50) (18) (50)
Spleen (49) (49) (50)
Histiocytic Sarcoma 1 (2%)
Neuroblastoma Malignant, Metastatic, Adrenal
Gland 1 (2%)
Thymus (50) (14) (46)
Sarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (18) (50)
Adenocarcinoma 1 (6%)
Fibroadenoma 3 (6%) 2 (11%) 4 (8%)
Skin (49) (21) (50)
Keratoacanthoma 2 (4%) 2 (10%) 2 (4%)
Squamous Cell Carcinoma 1 (2%) 1 (5%)
Squamous Cell Papilloma 1 (2%) 1 (2%)
Trichoepithelioma 2 (4%)
Sebaceous Gland, Adenoma 1 (5%)
Subcutaneous Tissue, Fibroma 1 (5%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 2 (4%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Sarcoma 2 (10%) 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Diaphragm, Sarcoma, Metastatic, Tissue NOS 1 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (13) (50)
Astrocytoma Malignant 1 (2%)
Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (26) (27)
Carcinoma, Metastatic, Thyroid Gland 1 (4%)
Lung (50) (30) (50)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (3%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (3%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Carcinoma, Metastatic, Preputial Gland 1 (3%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Neuroblastoma Malignant, Metastatic, Adrenal
Gland 1 (2%)
Sarcoma, Metastatic, Skin 1 (3%) 1 (2%)
Squamous Cell Carcinoma, Metastatic,
Zymbal's Gland 1 (3%)
Mediastinum, Alveolar/Bronchiolar Carcinoma 1 (2%)
Mediastinum, Hemangiosarcoma 1 (3%)
Nose (49) (14) (50)
Trachea (50) (14) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Sarcoma, Metastatic, Skin 1 (7%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1)
External Ear, Squamous Cell Carcinoma 1 (100%)
Zymbal's Gland (1) (1)
Adenoma 1 (100%)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (45) (50)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (50) (14) (49)
Page 10
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 23 (46%) 29 (58%) 28 (56%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 3 (6%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05706-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 09/18/94
Route: DOSED FEED Time: 23:48:57
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 12500PPM 25000PPM
MALE MALE MALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50
Total Primary Neoplasms 136 127 161
Total Animals with Benign Neoplasms 47 44 48
Total Benign Neoplasms 97 80 104
Total Animals with Malignant Neoplasms 32 38 42
Total Malignant Neoplasms 39 47 57
Total Animals with Metastatic Neoplasms 1 4 2
Total Metastatic Neoplasm 4 9 9
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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