TDMS Study 05706-02 Pathology Tables
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
Facility: International Research and Development Corp.
Chemical CAS #: 81-11-8
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X X X X X X X X |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | 3 2 2|
Inflammation, Chronic | 2 1 2 |
Mitotic Alteration | 4 |
Necrosis, Multifocal | 2 |
Bile Duct, Hyperplasia | 1 2 2 1 2 1 2 2 2 2|
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 3 3 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 1 1 1 1 1 1 1|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 1 |
Inflammation, Acute | 1 |
Mineralization | 4 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 1 2 1 1 1 2 1 1|
Mineralization | 3 |
Atrium, Thrombosis | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Necrosis, Focal | 2 2 |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 2 |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 1 2 2 2 3 3 1 2 3 |
Pars Distalis, Cyst | 3 1 3 2 2|
Pars Distalis, Hyperplasia | 1 2 2 |
Pars Nervosa, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 1 2 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + M + + + + + + + + +|
Dilatation | 2 |
Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 1 1 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | 1 |
Endometrium, Hyperplasia, Cystic | 1 1 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | 2 |
Iliac, Cyst | 2 |
Mandibular, Cyst | 1 |
Mandibular, Hemorrhage | 1 2 2 2 |
Mediastinal, Hemorrhage | 1 2 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 |
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Subcutaneous Tissue, Abscess | |
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Thrombosis, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 0| 4| 4| 7| 7| 7| 6| 6| 4| 7|
DAY ON TEST | 3| 3| 8| 5| 3| 3| 2| 8| 3| 3| 3| 3| 6| 8| 3| 9| 5| 5| 1| 3| 3| 5| 0| 5| 3|
| 2| 4| 4| 6| 3| 3| 8| 7| 2| 3| 2| 3| 4| 6| 4| 9| 6| 6| 3| 2| 4| 3| 3| 6| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Hemorrhage | 1 1 1 |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Thrombosis | |
Interstitium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Fungus | |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Foreign Body | 2 |
Sinus, Fungus | 2 |
Sinus, Inflammation, Acute | 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Iris, Inflammation, Chronic | 2 |
Lens Capsule, Cataract | 2 |
Retina, Atrophy | 2 |
Sclera, Metaplasia, Osseous | 1 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 2 3 2 2 2 1 1 1 1 1 4 1 2 2 1 1 1|
Pigmentation | 3 |
Pelvis, Dilatation | 4 |
Pelvis, Inflammation, Acute | 2 |
Pelvis, Inflammation, Subacute | |
Pelvis, Mineralization | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 1 2 |
Cytologic Alterations | X |
Cytologic Alterations, Multiple | X X X X X X X X X X |
Hemorrhage | 1 |
Hepatodiaphragmatic Nodule | X X X X X X X X X X |
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 1 2 1 1 2 1 1 |
Mitotic Alteration | |
Necrosis, Multifocal | |
Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 2 1 |
Centrilobular, Necrosis | 3|
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 1 2 1 1 1 |
__________________________________________________________________________|
Salivary Glands | M + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Acute | |
Mineralization | |
Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 1 1 2|
Mineralization | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + A + + + + + + + +|
Congestion | 2 1 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 1 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | 1 1 1 |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pars Distalis, Angiectasis | 2 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 1 2 3 |
Pars Nervosa, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + +|
Cyst | 2 |
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + +|
Dilatation | |
Inflammation, Acute | 2 2 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 1 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
Endometrium, Hyperplasia, Cystic | 1 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Vagina | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + A + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + +|
Bronchial, Hemorrhage | |
Iliac, Cyst | |
Mandibular, Cyst | 3 1 |
Mandibular, Hemorrhage | 1 |
Mediastinal, Hemorrhage | 2 1 2 1 |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + +|
Congestion | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2|
Necrosis, Focal | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Subcutaneous Tissue, Abscess | 2 |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Thrombosis, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| 4| 7| 5| 7| 7| 7| 4| 7| 4| 7| 7| 5| 6|
DAY ON TEST | 2| 3| 7| 3| 0| 3| 3| 3| 3| 3| 4| 8| 5| 3| 7| 3| 3| 2| 5| 3| 5| 3| 1| 2| 8|
| 9| 2| 8| 3| 0| 8| 2| 3| 3| 2| 4| 2| 6| 2| 8| 4| 3| 9| 6| 4| 6| 3| 3| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 1 1 1 2 1 2 1 1 |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 |
Thrombosis | 2 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + A + + + + + + + +|
Nasolacrimal Duct, Fungus | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Sinus, Foreign Body | |
Sinus, Fungus | |
Sinus, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Iris, Inflammation, Chronic | |
Lens Capsule, Cataract | |
Retina, Atrophy | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 3 1 1 1 1 2 2 2 1 2 1 1 1 1 2 1 2 2 1 1|
Pigmentation | |
Pelvis, Dilatation | |
Pelvis, Inflammation, Acute | |
Pelvis, Inflammation, Subacute | 3 |
Pelvis, Mineralization | 1 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 49 |
Parasite Metazoan | X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 49 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Congestion | | 2 1.5|
Cytologic Alterations | | 1 |
Cytologic Alterations, Multiple | X X X X X | 23 |
Hemorrhage | | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 16 |
Hyperplasia, Focal | 2 | 5 2.2|
Inflammation, Chronic | 1 1 1 | 13 1.3|
Mitotic Alteration | | 1 4.0|
Necrosis, Multifocal | | 1 2.0|
Bile Duct, Hyperplasia | | 19 1.5|
Centrilobular, Necrosis | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 5 2.4|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 49 |
Acinus, Atrophy, Diffuse | | 1 3.0|
Acinus, Atrophy, Focal | 2 | 13 1.2|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 49 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 50 |
Inflammation, Acute | | 2 1.0|
Epithelium, Hyperplasia | 1 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
Erosion | | 1 1.0|
Inflammation, Acute | | 1 1.0|
Mineralization | | 1 4.0|
Pigmentation | | 2 1.0|
__________________________________________________________________________|____________|
Tongue | | 2 |
Epithelium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 50 |
Cardiomyopathy | 1 2 1 1 1 | 25 1.2|
Mineralization | | 1 3.0|
Atrium, Thrombosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + | 49 |
Congestion | | 2 1.5|
Necrosis, Focal | | 2 2.0|
Vacuolization Cytoplasmic, Focal | | 6 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + | 49 |
Hyperplasia | 2 1 | 9 1.3|
Infiltration Cellular, Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Pars Distalis, Angiectasis | 2 2 3 | 15 2.2|
Pars Distalis, Cyst | 2 2 | 7 2.1|
Pars Distalis, Hyperplasia | 3 | 9 2.0|
Pars Nervosa, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 49 |
Cyst | | 1 2.0|
C-Cell, Hyperplasia | 1 | 8 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + | 47 |
Dilatation | | 1 2.0|
Inflammation, Acute | | 6 1.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 50 |
Cyst | 1 1 | 10 1.5|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 50 |
Hemorrhage | | 1 3.0|
Inflammation, Chronic | | 1 1.0|
Endometrium, Hyperplasia, Cystic | 1 | 5 1.2|
__________________________________________________________________________|____________|
Vagina | | 1 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 49 |
Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 50 |
Bronchial, Hemorrhage | | 1 2.0|
Iliac, Cyst | | 1 2.0|
Mandibular, Cyst | 1 | 4 1.5|
Mandibular, Hemorrhage | | 5 1.6|
Mediastinal, Hemorrhage | 2 | 7 1.6|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 50 |
Hemorrhage | | 4 1.3|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 49 |
Congestion | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Necrosis, Focal | | 1 2.0|
Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 48 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 50 |
Dilatation | | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + | 50 |
Cyst | | 1 2.0|
Subcutaneous Tissue, Abscess | | 1 2.0|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Thrombosis, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 50 |
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 33 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + | 50 |
Foreign Body | | 1 1.0|
Hemorrhage | 1 | 12 1.2|
Hyperplasia, Adenomatous | | 2 1.0|
Infiltration Cellular, Histiocyte | | 7 1.0|
Thrombosis | | 1 2.0|
Interstitium, Inflammation, Chronic | 2 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + | 49 |
Nasolacrimal Duct, Fungus | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Sinus, Foreign Body | | 1 2.0|
Sinus, Fungus | | 1 2.0|
Sinus, Inflammation, Acute | | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
Iris, Inflammation, Chronic | | 1 2.0|
Lens Capsule, Cataract | | 1 2.0|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 7| 6| 7| 7| 5| | |
DAY ON TEST | 3| 5| 5| 3| 5| 3| 6| 3| 2| 5| | |
| 4| 6| 6| 4| 6| 4| 4| 4| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
CONTROL | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Sclera, Metaplasia, Osseous | | 1 1.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 50 |
Cyst | 2 | 1 2.0|
Nephropathy | 3 2 2 2 2 3 1 | 46 1.6|
Pigmentation | | 1 3.0|
Pelvis, Dilatation | | 1 4.0|
Pelvis, Inflammation, Acute | | 1 2.0|
Pelvis, Inflammation, Subacute | | 1 3.0|
Pelvis, Mineralization | | 8 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
Mineralization | 2 |
__________________________________________________________________________|
Intestine Small | + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + +|
Angiectasis | 2|
Congestion | |
Cytologic Alterations | X X X |
Cytologic Alterations, Multiple | X X X X X |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | 2 |
Inflammation, Chronic | 1 2 1 1 1 |
Vacuolization Cytoplasmic | 1 |
Bile Duct, Hyperplasia | 1 1 2 2 2|
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + |
Acinus, Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
Inflammation, Chronic | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + |
Erosion | |
Mineralization | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 2 |
__________________________________________________________________________|
Heart | + + + |
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hemorrhage | 2 |
Hypertrophy, Focal | |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Focal | 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 4 3 2|
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 1 2 2 2 |
Pars Distalis, Pigmentation | 1 |
Pars Nervosa, Ectopic Tissue | |
__________________________________________________________________________|
Thyroid Gland | + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + +|
Inflammation, Acute | 2|
__________________________________________________________________________|
Ovary | + + + |
Mineralization | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + +|
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Iliac, Cyst | 2 |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Prefemoral, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + +|
Fibrosis, Focal | 2|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Necrosis, Focal | |
Pigmentation | 1 |
__________________________________________________________________________|
Thymus | + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Osteoporosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + |
Hemorrhage | 1 2 1 |
Hyperplasia, Adenomatous | |
Infiltration Cellular, Histiocyte | 1 |
__________________________________________________________________________|
Nose | + + + |
Metaplasia, Squamous | 2 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Fungus | 2 |
Sinus, Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Cornea, Inflammation, Chronic | |
Lens Capsule, Cataract | 4 2 2 |
Retina, Atrophy | 4 3 2 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 4| 7| 4| 4| 7| 7| 7| 7| 1| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 4| 4| 6| 7|
DAY ON TEST | 0| 4| 5| 3| 5| 5| 3| 3| 3| 2| 1| 1| 3| 5| 3| 3| 3| 0| 3| 3| 2| 5| 5| 2| 3|
| 6| 3| 6| 4| 6| 6| 3| 4| 4| 9| 8| 8| 3| 8| 3| 4| 4| 8| 2| 2| 9| 6| 6| 1| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Nephropathy | 1 4 2 2 2 2 4 1 2 1 2 2 1 1 2 1 2|
Pigmentation | 2 1 |
Artery, Inflammation, Chronic | 2 |
Pelvis, Inflammation, Acute | 2 |
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + |
__________________________________________________________________________|
Intestine Large | + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + |
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + |
Mineralization | |
__________________________________________________________________________|
Intestine Small | + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + |
Angiectasis | |
Congestion | 2 2 |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X X X X |
Fibrosis, Focal | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 3 |
Inflammation, Chronic | 1 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 2 1 2 2 2 1 |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + |
Acinus, Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Inflammation, Chronic | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
Erosion | 2 2 |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + |
Cardiomyopathy | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Hemorrhage | |
Hypertrophy, Focal | |
Necrosis, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + |
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 4 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 |
Pars Distalis, Pigmentation | |
Pars Nervosa, Ectopic Tissue | X |
__________________________________________________________________________|
Thyroid Gland | + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + |
Cervix, Inflammation, Acute | |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Iliac, Cyst | |
Iliac, Hemorrhage | 2 |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hemorrhage | 2 2 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Prefemoral, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 2 |
Hemorrhage | 1 |
Necrosis, Focal | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + |
Dilatation | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + |
Osteoporosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + |
Hemorrhage | 2 1 1 1 2 1 2 |
Hyperplasia, Adenomatous | 1 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + |
Metaplasia, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Acute | 1 |
Sinus, Fungus | |
Sinus, Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
Lens Capsule, Cataract | |
Retina, Atrophy | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 4| 7| 4| 5| 7| 6| 7| 7| 7| 6| 7| 6| 5| 7| 7| 7| 7| 6| 7| 4| 7| 5| 4|
DAY ON TEST | 4| 3| 5| 3| 5| 8| 2| 9| 3| 3| 3| 7| 3| 3| 8| 3| 3| 3| 3| 6| 3| 5| 3| 8| 5|
| 3| 3| 6| 4| 6| 8| 2| 8| 2| 4| 4| 1| 2| 0| 3| 2| 2| 4| 4| 3| 4| 6| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
12500PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
Fibrosis, Focal | |
Nephropathy | 1 2 2 1 1 1 2 2 3 3 2 2 1 2 2 2 2 1 2 2 1 |
Pigmentation | 1 |
Artery, Inflammation, Chronic | |
Pelvis, Inflammation, Acute | |
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pelvis, Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
Hemorrhage | 1 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 8 |
__________________________________________________________________________|____________|
Intestine Large | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 8 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 8 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 42 |
Angiectasis | | 1 2.0|
Congestion | 2 | 3 2.0|
Cytologic Alterations | | 3 |
Cytologic Alterations, Multiple | X X X | 12 |
Fibrosis, Focal | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 10 |
Hyperplasia, Focal | 1 | 4 1.8|
Hyperplasia, Multifocal | | 2 2.5|
Inflammation, Chronic | 2 2 2 2 2 2 | 12 1.6|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Hyperplasia | 1 2 | 14 1.6|
Centrilobular, Necrosis | | 2 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + | 8 |
Acinus, Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 8 |
__________________________________________________________________________|____________|
Stomach | + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 10 |
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + | 10 |
Erosion | | 2 2.0|
Mineralization | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + | 8 |
Cardiomyopathy | 1 | 4 1.0|
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 50 |
Amyloid Deposition | | 1 3.0|
Hemorrhage | | 1 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Necrosis, Focal | | 2 2.0|
Vacuolization Cytoplasmic, Focal | 2 | 8 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
Hyperplasia | 2 | 5 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 7 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 37 |
Pars Distalis, Angiectasis | 3 | 9 2.8|
Pars Distalis, Cyst | 3 | 2 2.5|
Pars Distalis, Hyperplasia | 2 | 6 1.8|
Pars Distalis, Pigmentation | | 1 1.0|
Pars Nervosa, Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 13 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + | 8 |
Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + | 22 |
Cervix, Inflammation, Acute | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 2 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 8 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 27 |
Iliac, Cyst | | 1 2.0|
Iliac, Hemorrhage | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | | 2 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hemorrhage | 2 | 7 2.3|
Prefemoral, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 8 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + | 22 |
Fibrosis, Focal | | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Hemorrhage | | 1 1.0|
Necrosis, Focal | | 1 2.0|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Thymus | + | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 47 |
Dilatation | 2 3 | 4 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + | 8 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 8 |
Osteoporosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 8 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 29 |
Hemorrhage | 1 2 1 | 13 1.4|
Hyperplasia, Adenomatous | 2 | 3 1.7|
Infiltration Cellular, Histiocyte | 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 5| 6| 2| 2| 3| 3| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
12500PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + | 8 |
Metaplasia, Squamous | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 1.0|
Sinus, Fungus | | 1 2.0|
Sinus, Inflammation, Acute | 1 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + | 8 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Cornea, Inflammation, Chronic | 2 | 1 2.0|
Lens Capsule, Cataract | 2 2 | 5 2.4|
Retina, Atrophy | 4 4 | 5 3.4|
Sclera, Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Fibrosis, Focal | | 1 2.0|
Nephropathy | 1 1 2 2 3 1 2 2 2 | 47 1.8|
Pigmentation | | 3 1.3|
Artery, Inflammation, Chronic | | 1 2.0|
Pelvis, Inflammation, Acute | | 1 2.0|
Pelvis, Mineralization | 1 1 1 1 | 30 1.0|
Pelvis, Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 9 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Cytologic Alterations | X X |
Cytologic Alterations, Multiple | X X X X X X |
Hematopoietic Cell Proliferation | |
Hemorrhage | 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 3 4 2|
Inflammation, Chronic | 2 1 1 1 |
Pigmentation | |
Thrombosis | 3 |
Vacuolization Cytoplasmic | |
Bile Duct, Hyperplasia | 1 1 1 2 2 1 1 2|
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 4 3 2 |
__________________________________________________________________________|
Mesentery | + + |
Hyperplasia, Lymphoid | |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy, Focal | 1 1 1 1 2 2 2 1 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | 2 |
Artery, Inflammation, Subacute | |
__________________________________________________________________________|
Pharynx | + |
Palate, Inflammation, Acute | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Ulcer | 4 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 |
Inflammation, Acute | 3 |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 1 1 2 1 1|
Atrium, Thrombosis | 2 3 |
Myocardium, Necrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Hyperplasia, Focal | |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 2 3 2 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 3 3 3 3 2 3 |
Pars Distalis, Cyst | 2 1 2 |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia | 3 2 |
Pars Distalis, Infarct | |
Pars Nervosa, Ectopic Tissue | |
__________________________________________________________________________|
Thyroid Gland | + + M + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + M + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Acute | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 3 |
Endometrium, Hyperplasia, Cystic | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hemorrhage | |
Axillary, Hyperplasia, Lymphoid | 3 |
Lymphocyte, Mandibular, Necrosis | 2|
Mandibular, Cyst | 2 |
Mandibular, Hemorrhage | 1 |
Mediastinal, Hemorrhage | 1 2 2 2 |
Mediastinal, Pigmentation | 2 |
Mediastinal, Lymphocyte, Necrosis | 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Focal, Granulomatous | |
Pigmentation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Hyperplasia | 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 4| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 4| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 9| 5| 3| 1| 3| 2| 3| 3| 8| 0| 1| 3| 5| 0| 5| 3| 7| 3| 3| 3| 3| 1|
| 6| 4| 3| 2| 6| 2| 8| 3| 9| 4| 4| 6| 0| 9| 2| 6| 6| 6| 3| 1| 8| 3| 3| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Adenomatous | |
Infiltration Cellular, Histiocyte | |
Interstitium, Inflammation, Chronic | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Fungus | 2 |
Sinus, Inflammation, Acute | 2 |
Turbinate, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lens Capsule, Cataract | 4 |
Retina, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3|
Nephropathy | 2 2 1 2 1 1 1 2 1 1 1 1 1 1 4 1 1 2 1|
Pigmentation | 2 1 |
Pelvis, Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2|
Cytologic Alterations | |
Cytologic Alterations, Multiple | X X X X X X X X |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X|
Hyperplasia, Focal | |
Inflammation, Chronic | 1 1 1 1|
Pigmentation | 2 |
Thrombosis | |
Vacuolization Cytoplasmic | 1|
Bile Duct, Hyperplasia | 1 1 1 2 2 |
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 |
__________________________________________________________________________|
Mesentery | + |
Hyperplasia, Lymphoid | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Atrophy, Focal | 1 1 2 1 1 1 2 |
Acinus, Hyperplasia, Focal | |
Artery, Inflammation, Chronic | 2 |
Artery, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Pharynx | |
Palate, Inflammation, Acute | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Ulcer | 2 2 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Inflammation, Acute | |
Ulcer | 2 2 |
__________________________________________________________________________|
Tooth | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 2 1 1 1 1 1|
Atrium, Thrombosis | 3 2 |
Myocardium, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + +|
Amyloid Deposition | 3 |
Hyperplasia, Focal | 2 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 2 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Angiectasis | 3 3 3 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Cyst, Multiple | |
Pars Distalis, Hyperplasia | 2 2 2 1 1 1|
Pars Distalis, Infarct | 4 |
Pars Nervosa, Ectopic Tissue | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + M + + +|
Hyperplasia | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 3 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis | |
Endometrium, Hyperplasia, Cystic | 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + M + + +|
Axillary, Hemorrhage | 2 |
Axillary, Hyperplasia, Lymphoid | |
Lymphocyte, Mandibular, Necrosis | |
Mandibular, Cyst | |
Mandibular, Hemorrhage | 1 1 |
Mediastinal, Hemorrhage | 1 2 1 2 1 |
Mediastinal, Pigmentation | |
Mediastinal, Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Focal, Granulomatous | |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 4| 7| 4| 7| 6| 7| 4| 7| 4| 7| 7| 7| 6| 7| 6| 7| 3| 4| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 5| 5| 3| 5| 3| 7| 2| 5| 3| 5| 1| 3| 0| 8| 3| 6| 3| 5| 5| 3| 3| 3|
| 9| 4| 2| 6| 6| 4| 6| 4| 2| 2| 6| 4| 6| 9| 4| 0| 1| 4| 4| 3| 1| 6| 2| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
25000PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Hyperplasia, Adenomatous | 2|
Infiltration Cellular, Histiocyte | 1 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 3 |
Sinus, Fungus | |
Sinus, Inflammation, Acute | |
Turbinate, Inflammation, Chronic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Lens Capsule, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
Nephropathy | 3 1 1 1 2 1 2 1 2 2 1 1 1 1 1 1 1 1 2|
Pigmentation | |
Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | 1 2 | 7 1.9|
Cytologic Alterations | X | 3 |
Cytologic Alterations, Multiple | X X X X X X X X | 22 |
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 8 |
Hyperplasia, Focal | 2 | 4 2.8|
Inflammation, Chronic | 2 1 1 2 1 | 13 1.2|
Pigmentation | | 1 2.0|
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 1 | 16 1.3|
Centrilobular, Necrosis | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 4 3.0|
__________________________________________________________________________|____________|
Mesentery | | 3 |
Hyperplasia, Lymphoid | | 1 2.0|
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Inflammation, Chronic | 1 | 1 1.0|
Acinus, Atrophy, Focal | 2 1 1 1 1 1 1 1 | 23 1.3|
Acinus, Hyperplasia, Focal | 2 | 1 2.0|
Artery, Inflammation, Chronic | | 2 2.0|
Artery, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 50 |
Inflammation, Acute | | 1 2.0|
Ulcer | | 4 2.3|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Erosion | | 1 1.0|
Inflammation, Acute | | 1 3.0|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy | 1 2 1 1 1 1 | 28 1.2|
Atrium, Thrombosis | | 4 2.5|
Myocardium, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 49 |
Amyloid Deposition | | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 9 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 49 |
Hyperplasia | 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 50 |
Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | 2 | 15 2.6|
Pars Distalis, Cyst | | 3 1.7|
Pars Distalis, Cyst, Multiple | X | 1 |
Pars Distalis, Hyperplasia | 2 | 9 1.8|
Pars Distalis, Infarct | | 1 4.0|
Pars Nervosa, Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | | 5 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 46 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Acute | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 50 |
Cyst | | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 50 |
Angiectasis | | 1 2.0|
Fibrosis | | 1 3.0|
Endometrium, Hyperplasia, Cystic | | 4 1.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Fibrosis | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 49 |
Axillary, Hemorrhage | | 1 2.0|
Axillary, Hyperplasia, Lymphoid | 2 | 2 2.5|
Lymphocyte, Mandibular, Necrosis | | 1 2.0|
Mandibular, Cyst | | 1 2.0|
Mandibular, Hemorrhage | 1 | 4 1.0|
Mediastinal, Hemorrhage | 2 1 2 1 2 | 14 1.6|
Mediastinal, Pigmentation | | 1 2.0|
Mediastinal, Lymphocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 49 |
Hemorrhage | 2 | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Fibrosis, Focal | | 2 1.5|
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Focal, Granulomatous | 3 | 1 3.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Cyst | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Dilatation | | 1 2.0|
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
Subcutaneous Tissue, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Hemorrhage | 1 | 4 1.0|
Hyperplasia, Adenomatous | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
Interstitium, Inflammation, Chronic | 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 3.0|
Sinus, Fungus | | 1 2.0|
Sinus, Inflammation, Acute | | 1 2.0|
Turbinate, Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens Capsule, Cataract | 3 | 2 3.5|
Retina, Atrophy | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Inflammation, Acute | 1 | 3 2.0|
Nephropathy | 2 2 2 2 1 1 1 2 2 | 47 1.4|
Pigmentation | 2 | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
| 2| 8| 2| 2| 3| 3| 3| 2| 3| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
25000PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Mineralization | 1 2 1 1 2 1 1 | 37 1.1|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + + + + A A + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A A + + + + + + + + + + + |
Edema | |
Hemorrhage | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A A + + + + + + + + + + + |
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A A + + + + + + + + + + + |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 1 |
Congestion | 2 |
Cyst | 2 |
Cytologic Alterations | X X X |
Cytologic Alterations, Multiple | X X X |
Fibrosis, Focal | 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Nodular | 2 |
Vacuolization Cytoplasmic, Diffuse | 4 |
Bile Duct, Hyperplasia | 1 2 1 1 1 3 2 2 2 2 1 2 2 1 2 |
Centrilobular, Degeneration | 2 |
Centrilobular, Necrosis | 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | |
Periportal, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Fat, Inflammation, Acute | 1 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + |
Acinus, Atrophy, Focal | 1 1 1 |
Artery, Inflammation, Chronic | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + A + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Inflammation, Acute | 2 |
Inflammation, Chronic | 2 |
Mineralization | |
Artery, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + |
Erosion | 1 1 1 2 |
Mineralization | 2 |
Ulcer | |
__________________________________________________________________________|
Tooth | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | 2 |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + |
Cardiomyopathy | 2 2 1 2 1 1 2 2 1 2 2 1 1 1 1 2 1 |
Atrium, Thrombosis | 2 |
Epicardium, Fibrosis, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 |
Thrombosis | 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 1 2 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + |
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + |
Cyst | |
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 3 |
Hyperplasia | |
Inflammation, Acute | 2 1 1 4 2 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia, Focal | 1 1 2 1 |
Inflammation, Acute | 1 1 1 2 2 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + |
Atrophy | 1 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Atrophy | 3 2 2 2 2 2 |
Interstitial Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + |
Fibrosis | |
Hyperplasia | 2 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + |
Inguinal, Cyst | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 2 |
Mandibular, Cyst | 2 2 1 |
Mediastinal, Cyst | |
Mediastinal, Hemorrhage | 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + |
Cyst | |
Edema | |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + |
Congestion | 2 |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Inflammation, Focal, Granulomatous | 2 |
Necrosis | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + |
Edema | |
Inflammation, Acute | 2 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + |
Hyperostosis | |
Osteomalacia | |
Tarsal, Inflammation, Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | |
Thrombosis | 3 |
Thrombosis, Multiple | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + |
Inflammation, Subacute | |
Ulcer | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + |
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Adenomatous | 2 2 |
Infiltration Cellular, Histiocyte | 1 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + A + + + + + + + + + + + + |
Inflammation, Acute | |
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Sinus, Fungus | 2 |
Sinus, Inflammation, Acute | 2 |
Turbinate, Inflammation, Chronic | 2 1 |
Turbinate, Inflammation, Subacute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Lens Capsule, Cataract | |
Retina, Atrophy | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 7| 4| 5| 4| 5| 6| 4| 7| 7| 6| 5| 5| 6| 5| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 6| 5| 3| 5| 4| 4| 6| 4| 5| 3| 2| 2| 8| 7| 2| 7| 2| 2| 5|
| 2| 4| 3| 4| 2| 8| 2| 6| 3| 6| 0| 6| 1| 8| 6| 4| 9| 8| 0| 1| 4| 9| 4| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | 2 |
Hematopoietic Cell Proliferation | 2 |
Nephropathy | 4 3 3 2 3 2 1 3 2 1 1 3 4 3 1 2 3 2 2 2 3 |
Pelvis, Mineralization | |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + |
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + +|
Edema | |
Hemorrhage | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + A + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 2 2 2 1 3 |
Congestion | |
Cyst | |
Cytologic Alterations | X X |
Cytologic Alterations, Multiple | X X X X X X X|
Fibrosis, Focal | 1 |
Hemorrhage | 1 |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Focal | 2 2 3 2 3 |
Hyperplasia, Nodular | 2 3 |
Vacuolization Cytoplasmic, Diffuse | |
Bile Duct, Hyperplasia | 1 1 3 1 1 1 2 1 2 1 2 2 2 1 3 2 2 1 2|
Centrilobular, Degeneration | |
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 |
Periportal, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Acute | 1 |
Inflammation, Chronic | |
Fat, Inflammation, Acute | 2 |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 2 2 2 1 2 1 1 3 2|
Artery, Inflammation, Chronic | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 4 |
Inflammation, Acute | |
Inflammation, Chronic | |
Mineralization | 2 |
Artery, Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | + |
Inflammation, Acute | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Inflammation, Chronic | |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 2 1 2 1 2 3 1 2 2 2 2 1 2|
Atrium, Thrombosis | 4 3 3 3 3|
Epicardium, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
Thrombosis | |
Vacuolization Cytoplasmic, Focal | 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 1 |
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 |
Inflammation, Acute | 2 2 2 2 |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 2 |
Inflammation, Acute | 1 2 2 1 3 2 2 1|
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + A + + + +|
Atrophy | 2 1 2 2 2 2 1 2 2 2 2 2 2|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 3 1 3 2 2 |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Cyst | |
Inguinal, Hyperplasia, Lymphoid | |
Mandibular, Cyst | 2 2 2 2 |
Mediastinal, Cyst | 2 |
Mediastinal, Hemorrhage | 1 1 1 2|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Edema | 2 |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Fibrosis, Focal | 1 2 2 2 3 1 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2|
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Focal, Granulomatous | |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + M +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + +|
Edema | 2 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
Osteomalacia | 2 |
Tarsal, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Thrombosis | 3 |
Thrombosis, Multiple | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 1 |
Hyperplasia, Adenomatous | 1 |
Infiltration Cellular, Histiocyte | 1 3 1 |
Interstitium, Inflammation, Chronic | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
Sinus, Fungus | 2 2 |
Sinus, Inflammation, Acute | 2 1 2 2 3 |
Turbinate, Inflammation, Chronic | 1 2 |
Turbinate, Inflammation, Subacute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens Capsule, Cataract | 3 |
Retina, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 7| 7| 4| 6| 7| 6| 4| 0| 4| 7| 6| 7|
DAY ON TEST | 3| 8| 1| 3| 3| 6| 3| 3| 2| 9| 7| 3| 0| 3| 3| 5| 9| 2| 9| 4| 6| 5| 3| 3| 3|
| 2| 7| 3| 3| 3| 2| 4| 2| 9| 2| 9| 3| 4| 2| 2| 6| 6| 9| 2| 3| 7| 6| 4| 0| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | 2 |
Hematopoietic Cell Proliferation | |
Nephropathy | 4 1 2 3 1 2 3 4 3 2 1 3 2 3 4 2 3 2 3 2 3|
Pelvis, Mineralization | 1 |
Renal Tubule, Degeneration | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 47 |
Edema | 3 | 1 3.0|
Hemorrhage | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 47 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + | 47 |
Parasite Metazoan | X | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 47 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 50 |
Angiectasis | 2 2 2 | 11 1.8|
Congestion | | 1 2.0|
Cyst | | 1 2.0|
Cytologic Alterations | | 5 |
Cytologic Alterations, Multiple | X | 11 |
Fibrosis, Focal | | 2 1.5|
Hemorrhage | | 1 1.0|
Hepatodiaphragmatic Nodule | | 8 |
Hyperplasia, Focal | 2 2 2 | 10 2.2|
Hyperplasia, Nodular | | 3 2.3|
Vacuolization Cytoplasmic, Diffuse | | 1 4.0|
Bile Duct, Hyperplasia | 2 1 2 2 | 38 1.7|
Centrilobular, Degeneration | | 1 2.0|
Centrilobular, Necrosis | | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 2 3.0|
Periportal, Vacuolization Cytoplasmic| 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Inflammation, Acute | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
Fat, Inflammation, Acute | | 2 1.5|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy, Focal | 2 | 14 1.6|
Artery, Inflammation, Chronic | | 3 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + | 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 49 |
Edema | | 1 4.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Mineralization | | 1 2.0|
Artery, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + | 48 |
Erosion | | 4 1.3|
Mineralization | | 2 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Acute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Inflammation, Chronic | | 1 2.0|
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + | 50 |
Cardiomyopathy | 2 1 1 1 | 38 1.5|
Atrium, Thrombosis | | 6 3.0|
Epicardium, Fibrosis, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + | 50 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hyperplasia | | 1 2.0|
Thrombosis | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + | 48 |
Hyperplasia | 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 49 |
Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 50 |
Pars Distalis, Angiectasis | | 3 2.0|
Pars Distalis, Cyst | | 1 2.0|
Pars Distalis, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 49 |
Cyst | | 2 1.0|
C-Cell, Hyperplasia | | 5 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 50 |
Cyst | | 1 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Acute | 2 | 11 1.9|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 50 |
Hyperplasia, Focal | | 6 1.3|
Inflammation, Acute | 1 1 1 | 17 1.5|
Inflammation, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 48 |
Atrophy | 2 2 2 | 25 1.8|
__________________________________________________________________________|____________|
Testes | + + + + + + | 50 |
Atrophy | 2 2 | 15 2.1|
Interstitial Cell, Hyperplasia | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 49 |
Fibrosis | | 1 2.0|
Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 50 |
Inguinal, Cyst | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
Mandibular, Cyst | | 7 1.9|
Mediastinal, Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Hemorrhage | 2 2 | 9 1.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 50 |
Cyst | | 1 2.0|
Edema | | 1 2.0|
Hemorrhage | 2 | 3 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 49 |
Congestion | | 3 2.0|
Fibrosis, Focal | 2 | 8 2.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 48 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + | 49 |
Edema | | 1 2.0|
Inflammation, Acute | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 50 |
Hyperostosis | | 1 2.0|
Osteomalacia | | 1 2.0|
Tarsal, Inflammation, Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Thrombosis | | 2 3.0|
Thrombosis, Multiple | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 26 |
Inflammation, Subacute | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 4| 4| 6| 7| 7| 4| 6| | |
DAY ON TEST | 0| 4| 5| 5| 5| 4| 3| 3| 5| 0| | |
| 4| 0| 6| 6| 6| 1| 2| 3| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | | 1 2.0|
Hemorrhage | | 2 1.5|
Hyperplasia, Adenomatous | 2 | 4 1.8|
Infiltration Cellular, Histiocyte | | 4 1.5|
Interstitium, Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + | 49 |
Inflammation, Acute | | 1 1.0|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 2.0|
Sinus, Fungus | 2 | 4 2.0|
Sinus, Inflammation, Acute | 2 1 | 8 1.9|
Turbinate, Inflammation, Chronic | 1 | 5 1.4|
Turbinate, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 2 |
Lens Capsule, Cataract | 3 | 2 3.0|
Retina, Atrophy | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 50 |
Cyst | 2 | 3 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Nephropathy | 3 2 3 3 4 2 | 48 2.5|
Pelvis, Mineralization | | 1 1.0|
Renal Tubule, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 50 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
Mineralization | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
__________________________________________________________________________|
Intestine Small | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + |
Angiectasis | 2 2 2 2 2 2 2 |
Congestion | 1 2 |
Cytologic Alterations | X X |
Cytologic Alterations, Multiple | X X X X X |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | |
Inflammation, Chronic | 2 |
Thrombosis | 3 |
Bile Duct, Hyperplasia, Cystic | |
Bile Duct, Hyperplasia | 1 2 2 2 2 2 2 4 1 2 3 1 3 1 2 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Accessory Spleen | X |
Acinus, Atrophy, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
Edema | |
Erosion | |
Inflammation, Acute | |
Mineralization | 3 |
Ulcer | 3 |
Epithelium, Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + |
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 2 |
Mineralization | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Aorta, Mineralization | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Cardiomyopathy | 2 2 2 2 2 2 1 |
Mineralization | 3 |
Atrium, Thrombosis | 2 2 3 |
Endocardium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | |
Inflammation, Subacute | 3 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 2 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Pars Distalis, Angiectasis | 3 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
Pars Nervosa, Ectopic Tissue | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + |
Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + |
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + |
Atrophy | 2 2 2 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 4 3 3 4 |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Axillary, Hyperplasia, Lymphoid | |
Iliac, Cyst | |
Inguinal, Hyperplasia, Lymphoid | 3 |
Mandibular, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 2 1 3 2 |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Cyst | |
Hemorrhage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + |
Congestion | 2 |
Fibrosis, Focal | 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 |
Infarct | |
Necrosis | 3 |
Pigmentation | |
Capsule, Fibrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + |
Dilatation | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + |
Cyst | |
Edema | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + |
Osteomalacia | 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 6| 7| 6| 7| 4| 6| 7| 7| 6| 4| 3| 6| 4| 7| 7| 1| 7| 6| 6| 4|
DAY ON TEST | 3| 3| 3| 4| 3| 2| 3| 9| 3| 5| 2| 2| 1| 7| 5| 2| 9| 5| 2| 3| 3| 3| 6| 1| 5|
| 4| 3| 2| 4| 4| 1| 2| 7| 2| 6| 3| 9| 9| 6| 6| 7| 7| 6| 5| 3| 4| 4| 3| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Hemorrhage | 1 |
Hyperplasia, Adenomatous | 2 3 |
Infiltration Cellular, Histiocyte | |
Interstitium, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Nose | + + + + + |
Sinus, Foreign Body | 2 |
Sinus, Fungus | |
Sinus, Inflammation, Acute | 2 |
Turbinate, Thrombosis | |
__________________________________________________________________________|
Trachea | + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + |
Cyst | 1 2 |
Fibrosis, Focal | |
Nephropathy | 3 2 3 2 3 2 3 3 4 2 3 1 3 3 3 3 2 2 |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 2 |
Congestion | 2 3 |
Cytologic Alterations | X X X X X X X |
Cytologic Alterations, Multiple | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | 2 2 2 2|
Hyperplasia, Multifocal | 2 |
Inflammation, Chronic | |
Thrombosis | |
Bile Duct, Hyperplasia, Cystic | 3 |
Bile Duct, Hyperplasia | 1 2 2 1 2 2 2 2 2 2 1 2 2 2 2 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
Accessory Spleen | |
Acinus, Atrophy, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + +|
Edema | 3 |
Erosion | 1 |
Inflammation, Acute | |
Mineralization | |
Ulcer | 2 2 2|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + +|
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 1 2|
Mineralization | |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Aorta, Mineralization | |
__________________________________________________________________________|
Heart | + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 2|
Mineralization | |
Atrium, Thrombosis | 3 |
Endocardium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Subacute | |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 1 1 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 1 2 1 2 2|
Pars Nervosa, Ectopic Tissue | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Prostate | + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + A + + + + + + + + + + + +|
Atrophy | 2 1 3 2 2 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 2 2 3 1 2 |
Interstitial Cell, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + +|
Axillary, Hyperplasia, Lymphoid | |
Iliac, Cyst | 2 |
Inguinal, Hyperplasia, Lymphoid | |
Mandibular, Hyperplasia, Lymphoid | 2 |
Mediastinal, Hemorrhage | 1 1 1 |
Renal, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + +|
Cyst | 2 |
Hemorrhage | 2 2 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis, Focal | 1 2 |
Hematopoietic Cell Proliferation | 2 2 |
Infarct | |
Necrosis | |
Pigmentation | 1 |
Capsule, Fibrosis, Focal | 1 |
__________________________________________________________________________|
Thymus | + + M + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + +|
Dilatation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + +|
Cyst | |
Edema | |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + +|
Osteomalacia | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 6| 6| 7| 7| 5| 5| 4| 5| 5| 7| 4| 5| 7| 7| 4| 4| 6| 6| 7| 7| 4| 6| 6| 5|
DAY ON TEST | 3| 1| 8| 2| 3| 2| 9| 5| 8| 7| 3| 5| 1| 3| 3| 5| 5| 0| 8| 2| 3| 5| 6| 8| 2|
| 2| 8| 3| 9| 3| 1| 5| 6| 0| 1| 3| 6| 0| 2| 3| 6| 6| 9| 7| 9| 3| 6| 3| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
12500PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Adenomatous | |
Infiltration Cellular, Histiocyte | |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + +|
Sinus, Foreign Body | |
Sinus, Fungus | 2 |
Sinus, Inflammation, Acute | 2 1|
Turbinate, Thrombosis | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis, Focal | |
Nephropathy | 3 1 2 3 1 2 1 4 1 3 2 2 4 4 4 2 2 |
Pigmentation | 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 15 |
__________________________________________________________________________|____________|
Intestine Large | + | 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 15 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 14 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 14 |
__________________________________________________________________________|____________|
Intestine Small | + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 12 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 12 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 11 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 49 |
Angiectasis | 2 2 2 | 16 1.9|
Congestion | | 4 2.0|
Cytologic Alterations | X X X X | 13 |
Cytologic Alterations, Multiple | | 5 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 4 |
Hyperplasia, Focal | 2 | 8 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Thrombosis | | 1 3.0|
Bile Duct, Hyperplasia, Cystic | | 1 3.0|
Bile Duct, Hyperplasia | 2 2 3 2 2 1 2 2 | 39 1.9|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + | 16 |
Accessory Spleen | | 1 |
Acinus, Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 14 |
__________________________________________________________________________|____________|
Stomach | + + + | 21 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 21 |
Edema | | 1 3.0|
Erosion | | 1 1.0|
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mineralization | | 1 3.0|
Ulcer | | 4 2.3|
Epithelium, Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 21 |
Amyloid Deposition | | 1 2.0|
Erosion | 2 | 5 1.6|
Mineralization | | 1 3.0|
Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Aorta, Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + | 20 |
Cardiomyopathy | 2 2 1 | 16 1.8|
Mineralization | | 1 3.0|
Atrium, Thrombosis | 3 | 5 2.6|
Endocardium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 49 |
Hyperplasia | | 1 2.0|
Inflammation, Subacute | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 1 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + | 50 |
Hyperplasia | 1 2 4 2 | 21 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 16 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 15 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Pars Distalis, Angiectasis | | 3 2.3|
Pars Distalis, Cyst | 2 2 | 2 2.0|
Pars Distalis, Hyperplasia | 2 2 | 9 1.8|
Pars Nervosa, Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 18 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 13 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 20 |
Inflammation, Acute | | 2 2.0|
__________________________________________________________________________|____________|
Prostate | + | 14 |
Inflammation, Acute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + A + + | 37 |
Atrophy | 2 2 2 | 15 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 50 |
Atrophy | 2 2 2 3 2 | 14 2.5|
Interstitial Cell, Hyperplasia | 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 14 |
Hyperplasia | 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 33 |
Axillary, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Cyst | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mandibular, Hyperplasia, Lymphoid | | 1 2.0|
Mediastinal, Hemorrhage | 2 | 8 1.6|
Renal, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 18 |
Cyst | X | 2 2.0|
Hemorrhage | | 4 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 49 |
Congestion | | 1 2.0|
Fibrosis, Focal | | 5 1.8|
Hematopoietic Cell Proliferation | | 5 2.2|
Infarct | 2 | 1 2.0|
Necrosis | | 1 3.0|
Pigmentation | | 1 1.0|
Capsule, Fibrosis, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + | 14 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 18 |
Dilatation | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 5| 4| 6| 6| 7| 7| | |
DAY ON TEST | 3| 5| 2| 3| 8| 5| 5| 6| 2| 3| | |
| 4| 3| 5| 4| 3| 6| 8| 3| 5| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
12500PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + | 21 |
Cyst | X | 1 |
Edema | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 14 |
Osteomalacia | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 13 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 30 |
Congestion | | 1 2.0|
Hemorrhage | | 1 1.0|
Hyperplasia, Adenomatous | 2 2 | 4 2.3|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Interstitium, Inflammation, Chronic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Nose | + | 14 |
Sinus, Foreign Body | | 1 2.0|
Sinus, Fungus | 2 | 2 2.0|
Sinus, Inflammation, Acute | 3 | 4 2.0|
Turbinate, Thrombosis | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + | 14 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 45 |
Cyst | | 2 1.5|
Fibrosis, Focal | 2 | 1 2.0|
Nephropathy | 3 2 3 3 2 2 2 | 42 2.5|
Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 1 2 2|
Congestion | 2 |
Cytologic Alterations | |
Cytologic Alterations, Multiple | X X X |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Focal | 2 2|
Hyperplasia, Multifocal | |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 1 2 1 2 1 2 2 3 2|
Centrilobular, Necrosis | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 2 |
Acinus, Atrophy, Focal | 1 1 2 1 1 2 1 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + M|
Edema | 3 |
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 1 2 |
Inflammation, Acute | 2 |
Pigmentation | |
Ulcer | |
__________________________________________________________________________|
Tongue | + + |
Inflammation, Chronic | 3 |
Epithelium, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 1 2 2 2 2 1 1 2 1 2 2 2 2 2|
Atrium, Thrombosis | 2 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
Vacuolization Cytoplasmic, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 2 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Cyst | 2 2 2|
Pars Distalis, Hyperplasia | 2 2 1 1 |
Pars Nervosa, Ectopic Tissue | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Acute | 1 2 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + A + + + + + A + +|
Atrophy | 2 2 2 2 2 2 2 2 2|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 2 2 2 2 2 2|
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Cyst | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mandibular, Cyst | 2|
Mandibular, Hemorrhage | 2 |
Mandibular, Hyperplasia, Lymphoid | 1 2 |
Mediastinal, Hemorrhage | 2 2 2 2 1 2 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | |
Renal, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Edema | 2 |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | 2 2 |
Depletion Lymphoid | |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Epithelium, Lip, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Thrombosis | 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 7| 7| 7| 7| 4| 5| 4| 5| 4| 4| 5| 6| 6| 7| 7| 7| 6| 6| 7|
DAY ON TEST | 2| 6| 3| 6| 6| 2| 3| 3| 3| 3| 5| 8| 5| 5| 5| 5| 0| 2| 7| 3| 3| 2| 1| 8| 3|
| 9| 5| 2| 3| 3| 9| 2| 2| 2| 2| 6| 8| 6| 1| 6| 6| 8| 4| 6| 3| 4| 0| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fibrosis | |
Foreign Body | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Adenomatous | 2 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 1 |
Interstitium, Inflammation, Chronic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Sinus, Foreign Body | |
Sinus, Fungus | 3 |
Sinus, Inflammation, Acute | 3 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Developmental Malformation | |
Fibrosis, Focal | |
Nephropathy | 3 1 3 2 3 3 3 3 3 1 1 2 2 3 3 2 3 2|
Pelvis, Dilatation | |
Pelvis, Mineralization | 1 2 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 2 2 2 2 3 |
Congestion | 2 |
Cytologic Alterations | X |
Cytologic Alterations, Multiple | X X X X X |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | 2 2 2 2|
Hyperplasia, Multifocal | |
Necrosis, Focal | 1|
Bile Duct, Hyperplasia | 2 2 1 3 2 2 2 1 3 1 2 2 2 2 2 2 3|
Centrilobular, Necrosis | |
Centrilobular, Vacuolization | |
Cytoplasmic | 3 3 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 1 1 1 2 2 |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 3|
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Acute | |
Pigmentation | 2 |
Ulcer | 2 1 2 3|
__________________________________________________________________________|
Tongue | |
Inflammation, Chronic | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 2 1 1 2 1 2 1 1|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 2 |
Vacuolization Cytoplasmic, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 2 |
Pars Distalis, Hyperplasia | 3 1 2 2 |
Pars Nervosa, Ectopic Tissue | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 2 |
Inflammation, Acute | 2 1 1 1 1 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Acute | 3 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + M + +|
Atrophy | 2 2 2 2 2 2 2 2 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 3 1 2 3 3 |
Interstitial Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + +|
Inguinal, Cyst | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
Mandibular, Cyst | 2 2 |
Mandibular, Hemorrhage | |
Mandibular, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 2 1 1 |
Mediastinal, Pigmentation | 2 |
Pancreatic, Hemorrhage | |
Renal, Inflammation, Chronic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Cyst | |
Edema | |
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | |
Depletion Lymphoid | 2 |
Fibrosis, Focal | 3 2 2 |
Hematopoietic Cell Proliferation | 2 2 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Epithelium, Lip, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Thrombosis | 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 4| 7| 4| 7| 5| 6| 4| 7| 7| 4| 4| 6| 4| 6| 5| 7| 5| 7| 4| 5|
DAY ON TEST | 4| 0| 3| 3| 4| 5| 3| 5| 3| 5| 9| 5| 3| 3| 5| 9| 3| 5| 5| 8| 3| 6| 3| 5| 2|
| 4| 4| 3| 3| 4| 6| 2| 6| 4| 5| 7| 6| 4| 3| 6| 1| 5| 6| 8| 8| 4| 1| 3| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
25000PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Fibrosis | 2 |
Foreign Body | 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Adenomatous | 2 |
Infiltration Cellular, Histiocyte | 2 |
Pigmentation | |
Interstitium, Inflammation, Chronic | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation, | |
Acute | 2 |
Sinus, Foreign Body | 2 2|
Sinus, Fungus | 3 3 |
Sinus, Inflammation, Acute | 2 3 2 3 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Developmental Malformation | X |
Fibrosis, Focal | |
Nephropathy | 1 3 3 2 1 3 2 1 2 3 3 1 1 3 2 3 2 1|
Pelvis, Dilatation | 2 |
Pelvis, Mineralization | 1 |
Renal Tubule, Degeneration | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 50 |
Angiectasis | 1 2 | 17 1.7|
Congestion | | 2 2.0|
Cytologic Alterations | | 1 |
Cytologic Alterations, Multiple | X X X X | 12 |
Hepatodiaphragmatic Nodule | X | 7 |
Hyperplasia, Focal | 2 3 | 8 2.1|
Hyperplasia, Multifocal | 1 | 1 1.0|
Necrosis, Focal | | 2 1.5|
Bile Duct, Hyperplasia | 2 2 2 1 2 3 1 2 2 3 | 44 2.0|
Centrilobular, Necrosis | 4 | 2 3.5|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 | 6 2.7|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | M + + + + + + + + + | 49 |
Acinus, Atrophy, Diffuse | | 2 2.5|
Acinus, Atrophy, Focal | 1 2 2 2 2 | 17 1.5|
Acinus, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 49 |
Edema | | 1 3.0|
Ulcer | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 50 |
Erosion | | 3 1.7|
Inflammation, Acute | | 1 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 4 2.0|
__________________________________________________________________________|____________|
Tongue | + | 3 |
Inflammation, Chronic | | 1 3.0|
Epithelium, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Cardiomyopathy | 2 2 1 2 2 1 1 2 1 | 40 1.6|
Atrium, Thrombosis | 2 4 | 4 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 50 |
Necrosis, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 50 |
Hyperplasia | 1 1 | 13 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | M + + + + + + + + + | 49 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 45 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 50 |
Pars Distalis, Angiectasis | 1 | 2 1.0|
Pars Distalis, Cyst | X 2 3 | 7 2.2|
Pars Distalis, Hyperplasia | | 8 1.8|
Pars Nervosa, Ectopic Tissue | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
C-Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 49 |
Hyperplasia | | 2 2.0|
Inflammation, Acute | 1 | 8 1.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M | 49 |
Hyperplasia, Focal | 2 2 2 | 5 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Acute | | 8 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 47 |
Atrophy | 2 2 2 2 2 2 2 | 25 2.0|
Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 50 |
Atrophy | 2 2 3 3 1 | 24 2.1|
Interstitial Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 50 |
Inguinal, Cyst | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
Mandibular, Cyst | | 3 2.0|
Mandibular, Hemorrhage | | 1 2.0|
Mandibular, Hyperplasia, Lymphoid | | 2 1.5|
Mediastinal, Hemorrhage | 1 | 10 1.6|
Mediastinal, Pigmentation | 2 1 | 3 1.7|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Renal, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 50 |
Cyst | | 1 2.0|
Edema | | 1 2.0|
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
Amyloid Deposition | 4 | 1 4.0|
Congestion | | 2 2.0|
Depletion Lymphoid | | 1 2.0|
Fibrosis, Focal | 2 2 2 | 7 2.1|
Hematopoietic Cell Proliferation | 2 | 5 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 50 |
Dilatation | | 2 1.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | | 1 2.0|
Epithelium, Lip, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Hemorrhage | | 1 1.0|
Thrombosis | 3 | 6 2.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + | 27 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 50 |
Fibrosis | | 1 2.0|
Foreign Body | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Adenomatous | | 2 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Pigmentation | | 1 1.0|
Interstitium, Inflammation, Chronic | 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 50 |
Nasolacrimal Duct, Inflammation, | | |
Acute | | 2 2.0|
Sinus, Foreign Body | | 2 2.0|
Sinus, Fungus | | 3 3.0|
Sinus, Inflammation, Acute | | 9 2.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Sclera, Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Cyst | 3 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05706-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID Date: 04/28/97
Route: DOSED FEED Time: 12:49:48
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 0| 3| 7| 2| 1| 3| 3| 3| 3| 3| | |
| 0| 4| 6| 9| 8| 3| 4| 8| 2| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | A |
25000PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Developmental Malformation | | 1 |
Fibrosis, Focal | 3 | 1 3.0|
Nephropathy | 2 2 2 1 2 3 2 1 2 3 | 46 2.2|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Mineralization | | 3 1.3|
Renal Tubule, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
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