TDMS Study 05706-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05706 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID TIME: 23:59:13
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C60162
CONT: CAS: 81-11-8
PATHOLOGIST: W. HALL S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: IRDC DATE: 09/18/94
EXP: 05706 4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID TIME: 23:59:13
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: C60162
CONT: CAS: 81-11-8
PATHOLOGIST: W. HALL S. EUSTIS
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 67 379 443 446 540 561 562 571 579 580 |
| 606 620 624 624 628 630 640 641 648 662 |
| 687 692 692 696 704 704 708 713 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12500PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 30 CENSORED DEATHS 10 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 134 327 510 521 521 571 580 583 595 609 |
| 615 618 621 623 644 653 658 663 663 663 |
| 676 683 683 687 697 697 719 725 725 725 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25000PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 10 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 491 508 520 538 551 555 561 563 565 588 |
| 588 613 624 635 644 644 658 663 676 676 |
| 683 697 700 704 718 720 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 98.3 98.3 98.3 98.3 96.7 93.3 91.3 81.2 60.9 44.6 |
| | |
| | |
|12500PPM | 100.0 98.3 98.3 96.7 96.7 96.7 90.6 82.6 60.4 40.3 |
| | |
| | |
|25000PPM | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 78.0 64.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 12500PPM 25000PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 44.6% 40.3% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.729N P=0.945 P=0.785N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 594.5 613.0 618.6 |
|NATURAL DEATHS (C) | (25.2) (22.4) (13.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 620.8 625.5 635.7 |
|(STANDARD ERROR) | (17.1) (16.3) (13.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 99 528 559 578 578 603 638 644 653 664 |
| 664 682 684 686 686 687 700 713 713 728 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 12500PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 118 558 565 583 583 588 621 630 643 643 |
| 663 671 698 706 708 718 722 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25000PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 351 638 638 664 671 672 681 686 692 700 |
| 700 706 718 719 719 719 722 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 456 456 456 |
| |
==================================================================================
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 98.3 98.3 98.3 98.3 98.3 96.3 88.3 78.3 60.2 |
| | |
| | |
|12500PPM | 100.0 98.3 98.3 98.3 98.3 98.3 98.3 88.3 78.3 66.2 |
| | |
| | |
|25000PPM | 100.0 100.0 100.0 98.3 98.3 98.3 98.3 98.3 92.3 66.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 12500PPM 25000PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.2% 66.2% 66.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.440N P=0.701N P=0.480N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 624.4 612.8 670.4 |
|NATURAL DEATHS (C) | (30.3) (33.7) (21.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.6 650.6 666.9 |
|(STANDARD ERROR) | (16.2) (16.1) (14.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
12500PPM = 2
25000PPM = 3
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 2 1 1 3 2
| 2 2 3
| 1 313 1
P 90 + 2 33 2
E | 31122
R | 112 2
C | 3 3 2 2
E 80 + 1 121
N | 3 211
T | 3 33
| 2 32
S 70 + 1 1 2
U | 3 2 2
R | 113 3 3
V | 1 1
I 60 + 1 231
V | 22 3
A | 2113
L | 211 3
50 +
| 21122 3
| 1 1
|
40 + 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 30 obs hidden.
4,4-DIAMINO-2,2-STILBENEDISULFONIC ACID
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
12500PPM = 2
25000PPM = 3
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 2 3
| 1 2 3 1 2 3
|
| 1 12
95 +
| 12 12 3 3
| 33
|
P 90 + 1 1
E | 2 1 2 1 3 3
R |
C | 22
E 85 +
N | 2 1 1 33
T | 1 1 33
|
S 80 + 2 2
U | 12 1 33
R |
V | 2 23 3
I 75 +
V | 22
A | 22
L |
70 + 11 22
| 11 22
|
| 1 1 2 2
65 +
|
| 1 1
|
60 + 1 1
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 9 obs hidden.