TDMS Study 93021-05 Pathology Tables
NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 150 DAY SUBCHRONIC Facility: Microbiological Associates Chemical CAS #: 538-75-0 Lock Date: 03/26/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| | | DAY ON TEST | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4| | | | 1| 0| 1| 1| 8| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Gallbladder | + + + + M + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Tooth | + + + + | 4 | Odontoma | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + M + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + M | 8 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 2 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| | | DAY ON TEST | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4| | | | 1| 0| 1| 1| 8| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + M + + + + + + + + | 9 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | Leukemia Erythrocytic | X | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 3 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| | | DAY ON TEST | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4| | | | 4| 1| 1| 1| 1| 1| 1| 1| 1| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | .75 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + | 3 | __________________________________________________________________________|____________| Gallbladder | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Colon | A + + | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | A + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + | 6 | __________________________________________________________________________|____________| Pancreas | + + + | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 4 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + | 3 | __________________________________________________________________________|____________| Tooth | + + + + + | 5 | Odontoma | X X X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + | 3 | __________________________________________________________________________|____________| Heart | + + + | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + | 3 | __________________________________________________________________________|____________| Parathyroid Gland | M M + | 1 | __________________________________________________________________________|____________| Pituitary Gland | M + + | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 4 | C-Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M M | 1 | __________________________________________________________________________|____________| Ovary | + + + | 3 | __________________________________________________________________________|____________| Uterus | + + + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 4 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| | | DAY ON TEST | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4| | | | 4| 1| 1| 1| 1| 1| 1| 1| 1| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | .75 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + | 3 | __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 3 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + | 3 | __________________________________________________________________________|____________| Nose | + + + | 3 | __________________________________________________________________________|____________| Trachea | + + + | 3 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + | 6 | Leukemia Erythrocytic | X X | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + | 2 | Squamous Cell Papilloma | X X | 2 | __________________________________________________________________________|____________| Tooth | + + + + + + | 6 | Odontoma | X X X X X X | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 1 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | Leukemia Erythrocytic | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Squamous Cell Papilloma | X | 1 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | Leukemia Erythrocytic | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | | | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + | 4 | __________________________________________________________________________|____________| Gallbladder | A + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + | 3 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 4 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + | 7 | __________________________________________________________________________|____________| Pancreas | + + + + | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 4 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 4 | __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | + + + + | 4 | Odontoma | X X X | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + | 4 | __________________________________________________________________________|____________| Heart | + + + + | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + | 4 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M | 3 | __________________________________________________________________________|____________| Pituitary Gland | M + + + | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + | 4 | __________________________________________________________________________|____________| Ovary | + + + + | 4 | __________________________________________________________________________|____________| Uterus | + + + + | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | | | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 4 | __________________________________________________________________________|____________| Spleen | + + + + | 4 | __________________________________________________________________________|____________| Thymus | + + M + | 3 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Skin, Site of Application, Squamous | | | Cell Papilloma | X X X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 4 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 4 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + | 4 | __________________________________________________________________________|____________| Nose | + + + + | 4 | __________________________________________________________________________|____________| Trachea | + + + + | 4 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 4 | __________________________________________________________________________|____________| Urinary Bladder | A + + + | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + | 2 | __________________________________________________________________________|____________| Gallbladder | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________|____________| Pancreas | + + | 2 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 4 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + | 2 | __________________________________________________________________________|____________| Tooth | + + + + + | 5 | Odontoma | X X X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + | 2 | __________________________________________________________________________|____________| Heart | + + | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + M | 1 | __________________________________________________________________________|____________| Pituitary Gland | + M | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M | 1 | __________________________________________________________________________|____________| Ovary | + + | 2 | __________________________________________________________________________|____________| Uterus | + + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + | 2 | __________________________________________________________________________|____________| Lymph Node | + | 1 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 2 | __________________________________________________________________________|____________| Spleen | + + + + | 4 | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________|____________| Thymus | + + | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Skin, Site of Application, Squamous | | | Cell Carcinoma | X | 1 | Skin, Site of Application, Squamous | | | Cell Papilloma | X X X | 3 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X X X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Leukemia Erythrocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + M M + | 7 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Tooth | + + + + + | 5 | Odontoma | X X X X X | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M M M + M M M | 2 | __________________________________________________________________________|____________| Pituitary Gland | + I + + + + + + + M | 8 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + | 9 | __________________________________________________________________________|____________| Ovary | + + + + + + + + M + | 9 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 93021-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:27 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + + + | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + | 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Squamous Cell Papilloma | X | 1 | Skin, Site of Application, Squamous | | | Cell Papilloma | X X X | 3 | Skin, Site of Application, Squamous | | | Cell Papilloma, Multiple | X X X X X | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + | 1 | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + M + + + + | 9 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 ------------------------------------------------------------ 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