TDMS Study 93021-05 Pathology Tables
NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 150 DAY SUBCHRONIC Facility: Microbiological Associates Chemical CAS #: 538-75-0 Lock Date: 03/26/96 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| | | DAY ON TEST | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4| | | | 1| 0| 1| 1| 8| 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + | 9 | __________________________________________________________________________|____________| Gallbladder | + + + + M + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Inflammation, Focal | 2 2 1 | 3 1.7| Necrosis, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Thyroid Gland | + M + + + + + + + + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + M | 8 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 0| 1| 1| | | DAY ON TEST | 4| 0| 4| 4| 5| 4| 4| 8| 4| 4| | | | 1| 0| 1| 1| 8| 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Hyperplasia | 2 2 2 | 3 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Infiltration Cellular, Histiocyte | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + M | 9 | Infiltration Cellular, Histiocyte | 2 | 1 2.0| Necrosis, Focal | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 3 2 3 3 2 2 2 2 | 8 2.4| __________________________________________________________________________|____________| Thymus | + M + + + + + + + + | 9 | Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | Synovial Tissue, Inflammation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Cortex, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| | | DAY ON TEST | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4| | | | 4| 1| 1| 1| 1| 1| 1| 1| 1| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | .75 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + | 3 | __________________________________________________________________________|____________| Gallbladder | + + + | 3 | Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | A + + | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | A + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + | 6 | Fibrosis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Inflammation, Chronic Active, Focal | 1 4 1 | 3 2.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + | 3 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 4 | Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + | 3 | __________________________________________________________________________|____________| Tooth | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + | 3 | __________________________________________________________________________|____________| Heart | + + + | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + | 3 | __________________________________________________________________________|____________| Adrenal Medulla | + + + | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + | 3 | __________________________________________________________________________|____________| Parathyroid Gland | M M + | 1 | __________________________________________________________________________|____________| Pituitary Gland | M + + | 2 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M M | 1 | __________________________________________________________________________|____________| Ovary | + + + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 0| 1| 1| 1| 1| 1| 1| 1| 1| 0| | | DAY ON TEST | 8| 4| 4| 4| 4| 3| 4| 4| 4| 4| | | | 4| 1| 1| 1| 1| 1| 1| 1| 1| 7| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | .75 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Uterus | + + + | 3 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + | 3 | Myeloid Cell, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + | 1 | Bronchial, Infiltration Cellular, | | | Plasma Cell | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 3 | Hematopoietic Cell Proliferation | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + | 3 | Hematopoietic Cell Proliferation | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + | 5 | Hematopoietic Cell Proliferation | 1 4 1 3 | 4 2.3| __________________________________________________________________________|____________| Thymus | + + + | 3 | Atrophy | 3 3 | 2 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + | 3 | __________________________________________________________________________|____________| Nose | + + + | 3 | __________________________________________________________________________|____________| Trachea | + + + | 3 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 3 | Inflammation, Chronic Active | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + | 6 | Inflammation, Chronic Active, Focal | 1 1 1 | 3 1.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + | 2 | __________________________________________________________________________|____________| Tooth | + + + + + + | 6 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 1 | Infiltration Cellular, Plasma Cell | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + | 5 | Hematopoietic Cell Proliferation | 4 2 1 1 | 4 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 2 2 1 | 3 1.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1.5 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | | | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + | 4 | __________________________________________________________________________|____________| Gallbladder | A + + + | 3 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 4 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | A + + + | 3 | __________________________________________________________________________|____________| Intestine Small, Duodenum | A + + + | 3 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + | 4 | __________________________________________________________________________|____________| Intestine Small, Ileum | A + + + | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + | 7 | Inflammation, Chronic Active, Focal | 1 2 2 1 | 4 1.5| Necrosis | 1 1 | 2 1.0| __________________________________________________________________________|____________| Pancreas | + + + + | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + | 4 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + | 4 | __________________________________________________________________________|____________| Tongue | + | 1 | __________________________________________________________________________|____________| Tooth | + + + + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + | 4 | __________________________________________________________________________|____________| Heart | + + + + | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + | 4 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + | 4 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M | 3 | __________________________________________________________________________|____________| Pituitary Gland | M + + + | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + | 4 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + | 4 | __________________________________________________________________________|____________| Ovary | + + + + | 4 | __________________________________________________________________________|____________| Uterus | + + + + | 4 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | | | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + | 4 | Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + | 4 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + | 4 | Necrosis, Focal | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + | 4 | Hematopoietic Cell Proliferation | 1 3 1 | 3 1.7| __________________________________________________________________________|____________| Thymus | + + M + | 3 | Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Dermis, Inflammation, Chronic Active | 2 | 1 2.0| Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 2 2 2 2 1 | 5 1.8| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 1 2 2 2 2 | 6 1.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 4 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 4 | Hemorrhage, Acute | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + | 4 | Hemorrhage, Acute | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + | 4 | __________________________________________________________________________|____________| Trachea | + + + + | 4 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 0| 0| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 1| 7| 9| 5| 4| 4| 4| | | | 1| 1| 1| 3| 9| 2| 4| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | A + + + | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + | 2 | __________________________________________________________________________|____________| Gallbladder | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Colon | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + | 2 | Anus, Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 1 2 | 2 1.5| Inflammation, Chronic Active, Focal | 1 1 1 1 1 1 | 6 1.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + | 2 | __________________________________________________________________________|____________| Salivary Glands | + + | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + | 2 | __________________________________________________________________________|____________| Tooth | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + | 2 | __________________________________________________________________________|____________| Heart | + + | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + | 2 | __________________________________________________________________________|____________| Adrenal Medulla | + + | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + M | 1 | __________________________________________________________________________|____________| Pituitary Gland | + M | 1 | Pars Distalis, Necrosis, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M | 1 | __________________________________________________________________________|____________| Ovary | + + | 2 | __________________________________________________________________________|____________| Uterus | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | | DAY ON TEST | 4| 4| 4| 4| 7| 2| 4| 4| 4| 4| | | | 1| 1| 1| 1| 1| 6| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 6 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + | 2 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + | 3 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 2 | __________________________________________________________________________|____________| Spleen | + + + + | 4 | Hematopoietic Cell Proliferation | 2 3 3 | 3 2.7| __________________________________________________________________________|____________| Thymus | + + | 2 | Atrophy | 4 4 | 2 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Dermis, Inflammation | 2 | 1 2.0| Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 2 2 2 2 3 3 1 1 | 8 2.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 3 1 2 2 3 1 | 7 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + | 2 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | Inflammation | 1 1 1 | 3 1.0| __________________________________________________________________________|____________| Trachea | + + | 2 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Gallbladder | M + + + + + + M M + | 7 | Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + | 9 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Fibrosis | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Inflammation, Chronic Active, Focal | 1 2 | 2 1.5| Inflammation, Focal | 3 1 3 2 2 | 5 2.2| Necrosis, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 10 | Inflammation | 1 | 1 1.0| Serosa, Fibrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Tooth | + + + + + | 5 | Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 10 | Inflammation, Acute | 2 | 1 2.0| Mineralization, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 10 | __________________________________________________________________________|____________| Parathyroid Gland | + M M M M M + M M M | 2 | __________________________________________________________________________|____________| Pituitary Gland | + I + + + + + + + M | 8 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + + + + + + + + | 9 | Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + M + | 9 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| Bilateral, Cyst | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 10 | Hyperplasia | 3 2 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Infiltration Cellular, Plasma Cell | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + M + + + | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Fibrosis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 2 3 1 2 2 2 2 2 2 | 9 2.0| Lymphoid Follicle, Depletion Cellular| 1 | 1 1.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 4 | 1 4.0| Hemorrhage | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + | 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 10 | Hyperplasia | 1 | 1 1.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Larynx | + | 1 | Inflammation | 1 | 1 1.0| __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 93021-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 150-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:20:51 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 1| 1| 1| 1| 0| 1| | | DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| | | | 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 12 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Inflammation, Chronic Active | 1 2 1 1 | 4 1.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 10 | Inflammation | 3 | 1 3.0| Respiratory Epithelium, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + M + + + + | 9 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Bilateral, Inflammation | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------