TDMS Study 93021-06 Pathology Tables
NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:05:09 Final#1/Mice Facility: BIORELIANCE Chemical CAS #: 538-75-0 Lock Date: 02/24/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:05:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0 MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 15 15 Early Deaths Moribund Sacrifice 2 7 Natural Death 1 1 1 Survivors Terminal Sacrifice 15 15 15 12 14 7 Animals Examined Microscopically 15 15 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Mesentery (1) Lymphoma Malignant 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:05:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0 MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (14) (14) (14) (14) Histiocytic Sarcoma 1 (7%) Lymph Node, Mesenteric (14) (15) (15) (15) (14) (14) Histiocytic Sarcoma 1 (7%) Lymph Node, Mediastinal (14) (15) (15) (12) (13) (13) Histiocytic Sarcoma 1 (8%) Lymphoma Malignant 1 (8%) Thymus (15) (15) (15) (15) (14) (13) Histiocytic Sarcoma 1 (7%) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) (14) (15) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:05:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0 MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15) Histiocytic Sarcoma 1 (7%) Lymphoma Malignant 1 (7%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01 Route: SKIN APPLICATION Time: 11:05:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0 MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 1 1 Total Primary Neoplasms 1 1 Total Animals with Benign Neoplasms Total Benign Neoplasms Total Animals with Malignant Neoplasms 1 1 Total Malignant Neoplasms 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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