TDMS Study 93021-06 Pathology Tables
NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:05:09
Final#1/Mice
Facility: BIORELIANCE
Chemical CAS #: 538-75-0
Lock Date: 02/24/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:05:09
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MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Moribund Sacrifice 2 7
Natural Death 1 1 1
Survivors
Terminal Sacrifice 15 15 15 12 14 7
Animals Examined Microscopically 15 15 15 15 15 15
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ALIMENTARY SYSTEM
Mesentery (1)
Lymphoma Malignant 1 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:05:09
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (14) (14) (14) (14)
Histiocytic Sarcoma 1 (7%)
Lymph Node, Mesenteric (14) (15) (15) (15) (14) (14)
Histiocytic Sarcoma 1 (7%)
Lymph Node, Mediastinal (14) (15) (15) (12) (13) (13)
Histiocytic Sarcoma 1 (8%)
Lymphoma Malignant 1 (8%)
Thymus (15) (15) (15) (15) (14) (13)
Histiocytic Sarcoma 1 (7%)
Lymphoma Malignant 1 (7%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (14) (15)
Lymphoma Malignant 1 (7%)
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SPECIAL SENSES SYSTEM
None
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NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:05:09
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Histiocytic Sarcoma 1 (7%)
Lymphoma Malignant 1 (7%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 93021-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK DICYCLOHEXYLCARBODIIMIDE (DCC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:05:09
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 1
Total Primary Neoplasms 1 1
Total Animals with Benign Neoplasms
Total Benign Neoplasms
Total Animals with Malignant Neoplasms 1 1
Total Malignant Neoplasms 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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