TDMS Study 96003-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: BIORELIANCE ALLYL BROMIDE DATE: 11/14/03
EXPERIMENT: 96003 TEST: 06 TIME: 14:46:34
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-25408 ROUTE: GAVAGE NTP C#: C96003
PATHOLOGIST: LANNING, LYNDA CAS: 106-95-6
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: BIORELIANCE ALLYL BROMIDE DATE: 11/14/03
EXPERIMENT: 96003 TEST: 06 TIME: 14:46:34
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-25408 ROUTE: GAVAGE NTP C#: C96003
PATHOLOGIST: LANNING, LYNDA CAS: 106-95-6
ALLYL BROMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 280 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 264 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALLYL BROMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 280 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 28 56 84 112 140 168 196 224 252 280 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 |
|CONTROL | |
| | |
|8 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 8 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 93.3% 100.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 264.0 . |
|NATURAL DEATHS (C) | ( . ) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 278.9 280.0 |
|(STANDARD ERROR) | ( 1.1) ( 0.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALLYL BROMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 279 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 0 CENSORED DEATHS 0 TERMINAL 15 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 8 MG/KG |
| --------------------- |
| |
| TOTAL 15 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 221 266 266 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ALLYL BROMIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 279 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 28 56 84 112 140 168 196 224 252 279 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 |
|CONTROL | |
| | |
|8 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.3 93.3 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 8 MG/KG |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 100.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.226 P=0.226 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | . 251.0 |
|NATURAL DEATHS (C) | ( . ) (15.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 279.0 273.4 |
|(STANDARD ERROR) | ( 0.0) ( 3.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ALLYL BROMIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
8 MG/KG = 2
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 1 obs hidden.)
P |
E |
R 100.00 +1 1 2
C |
E |
N |
T 93.33 + 1 1
|
S -+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-
U 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40
R
WEEK
ALLYL BROMIDE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
8 MG/KG = 2
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
P |
E |
R 100.00 +1 2 1
C |
E |
N |
T 93.33 + 2 2
|
S |
U |
R 86.67 +
V |
I |
V |
A 80.00 + 2 2
L |
-+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-----+-
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40
WEEK
NOTE: 1 obs hidden.