TDMS Study 50215-03 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Battelle Columbus ACRYLONITRILE DATE: 10/31/00
EXPERIMENT: 50215 TEST: 03 TIME: 12:32:57
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP: C50215B
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: BATTELLE COLUMBUS ACRYLONITRILE DATE: 10/31/00
EXPERIMENT: 50215 TEST: 03 TIME: 12:41:44
SPECIES: MICE, B6C3F1
TEST TYPE: TWO YEAR ROUTE: ORAL GAVAGE NTP: 50215B
CONT: N01-ES-55388 CAS: 107-13-1
MEAN BODY WEIGHTS AND SURVIVAL OF MALE MICE IN THE
TWO YEAR ORAL GAVAGE STUDY OF ACRYLONITRILE
==========================================================================================================
WEEK 0 MG/KG 2.5 MG/KG 10 MG/KG 20 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 22.3 50 22.2 99.6 50 22.5 100.9 50 22.3 100.0 50
1 22.3 50 22.2 99.6 50 22.5 100.9 50 22.3 100.0 50
5 27.0 50 26.8 99.3 48 26.6 98.5 50 26.1 96.7 50
9 31.1 50 30.7 98.7 48 30.7 98.7 50 29.6 95.2 50
13 35.1 50 35.0 99.7 48 35.0 99.7 50 32.8 93.4 50
17 38.7 50 38.3 99.0 48 38.3 99.0 50 35.1 90.7 50
21 41.4 50 41.2 99.5 48 41.2 99.5 50 38.0 91.8 47
25 43.8 50 43.4 99.1 48 43.5 99.3 50 40.4 92.2 47
29 45.4 50 45.0 99.1 48 45.0 99.1 50 41.2 90.7 47
33 46.7 50 46.4 99.4 48 45.9 98.3 49 42.7 91.4 46
37 48.1 50 47.5 98.8 48 47.4 98.5 49 44.3 92.1 45
41 49.9 50 49.2 98.6 48 49.4 99.0 49 46.4 93.0 44
45 51.2 50 50.4 98.4 48 50.8 99.2 49 48.1 93.9 43
49 50.6 50 50.7 100.2 48 50.8 100.4 49 48.0 94.9 43
53 51.5 50 51.2 99.4 48 51.4 99.8 49 49.4 95.9 42
57 52.0 50 50.9 97.9 48 51.9 99.8 49 50.1 96.3 42
61 51.8 50 51.6 99.6 48 51.6 99.6 49 50.3 97.1 41
64 52.4 50 52.4 100.0 48 52.4 100.0 49 51.5 98.3 41
69 52.6 49 52.5 99.8 48 52.0 98.9 49 51.4 97.7 40
73 52.5 49 52.8 100.6 48 52.4 99.8 48 53.0 101.0 36
77 52.5 48 52.2 99.4 47 51.7 98.5 46 52.0 99.0 34
81 53.0 48 53.3 100.6 46 52.4 98.9 46 53.3 100.6 28
85 52.2 47 53.2 101.9 46 51.9 99.4 45 52.5 100.6 26
89 53.4 45 53.5 100.2 46 52.4 98.1 44 52.5 98.3 25
93 52.5 43 53.4 101.7 45 50.5 96.2 43 50.7 96.6 24
97 51.9 42 52.6 101.3 45 49.5 95.4 43 48.6 93.6 22
101 50.5 42 52.2 103.4 43 48.4 95.8 42 47.0 93.1 20
TERM. SAC. 38 42 39 14
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE
TWO YEAR ORAL GAVAGE STUDY OF ACRYLONITRILE
==========================================================================================================
WEEK 0 MG/KG 2.5 MG/KG 10 MG/KG 20 MG/KG
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 18.6 50 18.4 98.9 50 18.2 97.8 50 18.4 98.9 50
1 18.6 50 18.4 98.9 50 18.2 97.8 50 18.4 98.9 50
5 22.2 50 21.9 98.6 50 21.9 98.6 50 21.8 98.2 50
9 25.1 50 25.5 101.6 50 25.3 100.8 50 24.9 99.2 50
13 28.8 50 29.4 102.1 50 28.8 100.0 50 27.9 96.9 50
17 32.1 50 33.5 104.4 50 32.3 100.6 50 30.2 94.1 49
21 35.5 50 37.2 104.8 50 35.0 98.6 50 34.5 97.2 47
25 40.1 50 41.1 102.5 50 39.4 98.3 50 37.4 93.3 47
29 42.7 50 44.0 103.0 50 42.1 98.6 49 39.1 91.6 46
33 46.0 50 47.0 102.2 50 44.4 96.5 49 41.1 89.3 46
37 49.0 50 50.8 103.7 50 48.3 98.6 49 45.5 92.9 46
41 51.6 50 53.5 103.7 50 50.9 98.6 49 47.3 91.7 46
45 53.3 50 55.0 103.2 50 53.3 100.0 49 49.5 92.9 46
49 56.7 50 57.6 101.6 50 56.4 99.5 49 51.7 91.2 46
53 58.2 49 58.8 101.0 49 57.8 99.3 49 52.8 90.7 43
57 58.5 49 58.8 100.5 49 58.3 99.7 49 53.7 91.8 41
61 59.3 49 59.6 100.5 49 60.0 101.2 49 54.5 91.9 41
64 60.8 49 61.6 101.3 48 61.9 101.8 49 56.7 93.3 40
69 60.9 49 62.1 102.0 47 62.0 101.8 49 57.6 94.6 40
73 61.1 49 62.6 102.5 47 61.5 100.7 49 58.7 96.1 39
77 60.4 49 62.4 103.3 47 62.5 103.5 48 58.4 96.7 38
81 61.0 49 62.6 102.6 47 62.8 103.0 48 60.6 99.3 36
85 61.8 48 62.9 101.8 46 62.9 101.8 48 60.7 98.2 34
89 62.7 48 62.2 99.2 46 62.7 100.0 48 60.5 96.5 34
93 59.8 47 60.2 100.7 43 60.6 101.3 47 60.0 100.3 32
97 57.8 44 58.2 100.7 38 58.0 100.3 45 58.9 101.9 28
101 55.3 42 57.4 103.8 34 54.4 98.4 44 55.4 100.2 27
TERM. SAC. 39 32 39 23
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.