TDMS Study 50215-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus ACRYLONITRILE DATE: 10/31/00
EXPERIMENT: 50215 TEST: 03 TIME: 12:50:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55388 ROUTE: GAVAGE NTP C#: 50215B
PATHOLOGIST: MISSING CAS: 107-13-1
------------------------------------------------------------------------------------------------------------------------------------
MICE FINAL#1
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus ACRYLONITRILE DATE: 10/31/00
EXPERIMENT: 50215 TEST: 03 TIME: 12:50:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55388 ROUTE: GAVAGE NTP C#: 50215B
PATHOLOGIST: MISSING CAS: 107-13-1
ACRYLONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 464 528 582 607 617 633 636 664 712 714 |
| 723 723 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 2 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 518 535 637 689 689 714 |
| CENSORED DEATHS |
| 3 4 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 211 497 512 515 563 610 626 685 702 709 |
| 714 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ACRYLONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 113 113 114 211 239 274 283 337 410 477 |
| 492 494 502 505 520 525 540 547 553 554 |
| 554 554 569 588 603 642 656 673 679 695 |
| 709 715 716 724 726 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ACRYLONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 94.0 84.0 76.0 |
| | |
| | |
|2.5 | 100.0 100.0 100.0 100.0 100.0 100.0 95.8 95.8 93.7 87.5 |
|MG/KG | |
| | |
|10 MG/KG | 100.0 100.0 98.0 98.0 98.0 98.0 92.0 90.0 86.0 78.0 |
| | |
| | |
|20 MG/KG | 100.0 94.0 90.0 84.0 82.0 80.0 66.0 50.0 46.0 28.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 2.5 10 MG/KG 20 MG/KG |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 76.0% 87.5% 78.0% 28.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.222N P=1.000N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 633.6 630.3 576.7 509.3 |
|NATURAL DEATHS (C) | (23.5) (34.5) (44.3) (30.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 706.9 689.0 696.3 571.1 |
|(STANDARD ERROR) | ( 8.0) (20.9) (13.0) (26.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ACRYLONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 338 562 638 653 659 673 677 701 704 708 |
| 708 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 2.5 MG/KG |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 354 424 468 563 633 640 643 647 648 653 |
| 665 673 683 688 694 696 721 724 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 11 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 190 516 639 645 646 695 708 711 715 716 |
| 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
ACRYLONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 1 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 135 135 185 352 352 352 382 386 429 494 |
| 513 547 555 580 582 640 642 649 649 660 |
| 667 680 704 704 711 722 |
| CENSORED DEATHS |
| 113 |
| |
==================================================================================
ACRYLONITRILE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 96.0 90.0 78.0 |
| | |
| | |
|2.5 | 100.0 100.0 100.0 98.0 96.0 94.0 94.0 92.0 78.0 64.0 |
|MG/KG | |
| | |
|10 MG/KG | 100.0 100.0 98.0 98.0 98.0 98.0 96.0 96.0 90.0 78.0 |
| | |
| | |
|20 MG/KG | 100.0 95.9 93.9 87.8 83.7 81.6 77.6 69.4 59.2 46.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 2.5 10 MG/KG 20 MG/KG |
| MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 78.0% 64.0% 78.0% 46.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.002 P=0.156 P=1.000N P=0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 638.3 623.2 627.5 515.7 |
|NATURAL DEATHS (C) | (32.7) (24.6) (47.4) (35.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 709.0 690.9 706.7 605.7 |
|(STANDARD ERROR) | ( 8.8) (11.3) (11.7) (25.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
ACRYLONITRILE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
2.5 MG/KG = 2
10 MG/KG = 3
20 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 3 1 3 2 12
| 4 4 3 3 12 1 1 2 2
| 4 4 3 3 1 1
90 + 4 4 3 31 1 2 2
| 44 3 3 2 2
| 4 4 4 31 1 3 31
| 4 4 33
P 80 + 4 4 1 1
E | 3 3
R | 444 1 1
C | 4 4
E 70 +
N | 4 4
T | 44
| 44
S 60 +
U |
R | 4 4 4
V | 4 4
I 50 + 4 4
V | 4 4
A | 4 4
L | 4 4
40 + 4 4
| 44
| 44
|
30 +
| 4 4
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
ACRYLONITRILE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
2.5 MG/KG = 2
10 MG/KG = 3
20 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 3 1 2 2 3 1
| 4 4 4 2 2 3 1 131
| 2 2 1 1
P 90 + 223 1 1 3
E | 4 4 3 3
R | 44 22 1 133
C | 4 4 4 22 11
E 80 + 4 4 2 2
N | 4 4 2 2 13 1
T | 44 222
| 4 44 22
S 70 + 4 4
U | 2 2
R | 44 22 2
V |
I 60 + 4 44
V | 4 4
A | 4 4
L |
50 + 44 4
| 4 4
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.