TDMS Study 55301-04 Pathology Tables
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 110-86-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + A + + + A M + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Multiple | |
Histiocytic Sarcoma | |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + M M + M + M + + M + + M + M + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant | |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Lymphoma Malignant | |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | X |
Mediastinal, Sarcoma, Metastatic, | |
Skin | X |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X |
Carcinoma, Metastatic, Harderian | |
Gland | X|
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Mediastinum, Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
Carcinoma | X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + A M + A A + + + + A + + + A + + + + M A A +| 37 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + A + + + + + + + + + A + + + + + M A +| 44 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A A + + + + + + + + A + + + + + + A +| 44 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + A + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + + A + + + + A + + + A + + + + + + A +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A A + + + + + + + + A + + + + + + A +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hepatoblastoma | | 1 |
Hepatocellular Carcinoma | X X X | 10 |
Hepatocellular Carcinoma, Multiple | X X X | 3 |
Hepatocellular Adenoma | X X X X X X X X X| 13 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X | 24 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 4 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Tooth | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Carcinoma, Multiple | X | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M + + + + + + + M M + M M + M M M +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Adenoma | X X X X X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + + + I + + + I + + + + +| 47 |
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + + + + + + + A + + + + + + + +| 47 |
Cystadenoma | X X X| 4 |
Granulosa Cell Tumor Benign | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Adenoma | | 1 |
Lymphoma Malignant | X | 1 |
Polyp Stromal | X | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + +| 10 |
Lymphoma Malignant | X | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | X | 2 |
Inguinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant | X | 2 |
Mediastinal, Sarcoma, Metastatic, | | |
Skin | | 1 |
Renal, Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + M + + + A + + + M + + + +| 45 |
Lymphoma Malignant | X | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | X | 1 |
Subcutaneous Tissue, Sarcoma | X | 2 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 1 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Carcinoma, Metastatic, Harderian | | |
Gland | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X X | 4 |
Mediastinum, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + A + + + + A + + + A + + + + + + + +| 45 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X X X X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Gallbladder | + + + A A A + + + A + + + + M + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lipoma | |
Lymphoma Malignant | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | X |
Schwannoma Malignant, Metastatic, | |
Skin | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Squamous Cell Papilloma | X|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + M + + + + + + + + + + + + + M + + + + + +|
Aorta, Histiocytic Sarcoma | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + M M M M M + + + M + M + + M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + M + + + + + + + + + M + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X X |
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Oviduct | |
Schwannoma Malignant, Metastatic, | |
Skin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Leukemia Granulocytic | |
Bronchial, Lymphoma Malignant | X |
Iliac, Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Leukemia Granulocytic | |
Iliac, Lymphoma Malignant | X |
Iliac, Rhabdomyosarcoma, Metastatic, | |
Skeletal Muscle | |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Leukemia Granulocytic | |
Mediastinal, Lymphoma Malignant | X X |
Mediastinal, Sarcoma, Metastatic, | |
Mesentery | |
Pancreatic, Leukemia Granulocytic | |
Pancreatic, Lymphoma Malignant | X |
Pancreatic, Sarcoma, Metastatic, | |
Mesentery | |
Renal, Leukemia Granulocytic | |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
Schwannoma Malignant, Metastatic, | |
Skin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
Subcutaneous Tissue, Sarcoma | X X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | |
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X |
Rhabdomyosarcoma, Metastatic, | |
Skeletal Muscle | |
Sarcoma, Metastatic, Mesentery | |
Schwannoma Malignant, Metastatic, | |
Skin | |
Mediastinum, Lymphoma Malignant | X |
Mediastinum, Schwannoma Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
Adenoma | X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
Schwannoma Malignant, Metastatic, | |
Skin | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Leukemia Granulocytic | |
Lymphoma Malignant | X X X X X X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Gallbladder | A + + + A + + + + + + + + + A A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | | 2 |
Hepatocellular Carcinoma | X X X X X | 12 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X| 11 |
Hepatocellular Adenoma | X X | 5 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X | 34 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + +| 18 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Granulocytic | X | 1 |
Lipoma | X | 1 |
Lymphoma Malignant | | 1 |
Sarcoma | X | 2 |
__________________________________________________________________________|____________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X X | 2 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 1 |
Schwannoma Malignant, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Aorta, Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M + M M + M + + + + + + + + + + M + M M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + M + M + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Adenoma | X X X X X X| 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Cystadenoma | | 3 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Oviduct | + | 1 |
Schwannoma Malignant, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Leukemia Granulocytic | X | 1 |
Bronchial, Lymphoma Malignant | | 1 |
Iliac, Histiocytic Sarcoma | X | 1 |
Iliac, Leukemia Granulocytic | X | 1 |
Iliac, Lymphoma Malignant | | 1 |
Iliac, Rhabdomyosarcoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Mediastinal, Leukemia Granulocytic | X | 1 |
Mediastinal, Lymphoma Malignant | | 2 |
Mediastinal, Sarcoma, Metastatic, | | |
Mesentery | X | 1 |
Pancreatic, Leukemia Granulocytic | X | 1 |
Pancreatic, Lymphoma Malignant | X | 2 |
Pancreatic, Sarcoma, Metastatic, | | |
Mesentery | X | 1 |
Renal, Leukemia Granulocytic | X | 1 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 2 |
Schwannoma Malignant, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + M + + + + + + + + + + + + + + + +| 47 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + M + M + + + + I + M + + + + + M + + + + + + + +| 44 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Rhabdomyosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 1 |
Rhabdomyosarcoma, Metastatic, | | |
Skeletal Muscle | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
Schwannoma Malignant, Metastatic, | | |
Skin | X | 1 |
Mediastinum, Lymphoma Malignant | | 1 |
Mediastinum, Schwannoma Malignant, | | |
Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | | 2 |
Schwannoma Malignant, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X X | 2 |
Leukemia Granulocytic | X | 1 |
Lymphoma Malignant | X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A M + + + + A + A + + A + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + A + + + + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + A + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A + + A + A + + + + A + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A + + A + A + + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X |
Hepatoblastoma, Multiple | X |
Hepatocellular Carcinoma | X X X X X X X X|
Hepatocellular Carcinoma, Multiple | X X X X X X X X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X|
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | M + + + + + + + + |
Hepatoblastoma, Metastatic, Liver | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + A + + +|
Lymphoma Malignant | X |
Acinus, Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M + + + M + M M + + M + M M M + M|
__________________________________________________________________________|
Pituitary Gland | M + + + I + + + + + + + + + + + + + + + + I + + +|
Pars Distalis, Adenoma | X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Hepatoblastoma, Metastatic, Liver | X |
__________________________________________________________________________|
Tissue NOS | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Hepatoblastoma, Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + M + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Ovary | + M + + + + + + A + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + A + + + + + + + + + + + + A + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + |
Lymphoma Malignant | |
Deep Cervical, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Hepatoblastoma, | |
Metastatic, Liver | X |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + M + + + + + + + A + + +|
Hepatoblastoma, Metastatic, Liver | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
Subcutaneous Tissue, Sarcoma | |
Subcutaneous Tissue, Schwannoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hepatoblastoma, Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X X |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Skin | |
Mediastinum, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
Mediastinum, Lymphoma Malignant | X |
Mediastinum, Sarcoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + A + + + + + + + + + + + + A + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A A A + + + + + + + + A + A M + A + + A + + + + A| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + + + + + + + + + + + + A + + + + + + A A| 40 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + A A + + + + + M + + A + + + + + + + A| 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + A + + A + + + A A| 38 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + A A + + + + + + + + A + + A + + + + A| 37 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | X X X X X | 6 |
Hepatoblastoma, Multiple | X X| 3 |
Hepatocellular Carcinoma | X X X X X X X X X X X| 19 |
Hepatocellular Carcinoma, Multiple | X X X X X | 14 |
Hepatocellular Adenoma | X X X | 6 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X | 37 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Lymphoma Malignant | | 1 |
Acinus, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | M + A + + + + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + M M M + M A + + + + + + M + + + + + +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | M + M + + + + M + + + + + + I + + M + + + + + + +| 42 |
Pars Distalis, Adenoma | X X | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Follicular Cell, Adenoma | X X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
Hepatoblastoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + + + + A + + + + + + + +| 46 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Lymphoma Malignant | X | 1 |
Deep Cervical, Lymphoma Malignant | X | 1 |
Iliac, Lymphoma Malignant | X | 1 |
Inguinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant | X X | 2 |
Pancreatic, Hepatoblastoma, | | |
Metastatic, Liver | | 1 |
Pancreatic, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | X | 2 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + M + + + + + + A + + + + + + M +| 43 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Lymphoma Malignant | X X X | 4 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + + M +| 46 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X X | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | X X X | 3 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hepatoblastoma, Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Carcinoma | | 2 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 6 |
Lymphoma Malignant | X X | 3 |
Sarcoma, Metastatic, Skin | X X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mediastinum, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
Mediastinum, Lymphoma Malignant | X | 2 |
Mediastinum, Sarcoma, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + M + + + + A| 44 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M A + M M + A + M M + + + + + M + + + + A M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + A + + + + + + + + + + + A + + + +|
Leiomyosarcoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + A + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + A + + + +|
Carcinoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatoblastoma | X X X X X X |
Hepatoblastoma, Multiple | X X X |
Hepatocellular Carcinoma | X X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X X X X|
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X|
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Hepatoblastoma, Metastatic, Liver | |
Lymphoma Malignant | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M M + M + + M + + + + + + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Lymphoma Malignant | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Mesothelioma Malignant | X |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatoblastoma, Metastatic, Liver | |
Lymphoma Malignant | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + I + I + + M + M + + M + + + + + + + + M + + M +|
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Schwannoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X|
Lymphoma Malignant | |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + A + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M A + + + + + + + A + A M + + + A + + + + + +| 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + A + + + + A + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + A + +| 45 |
Leiomyosarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + A + A + + + + A + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + A + + + A + + + A + +| 43 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + A + A + + A + + + A + +| 41 |
Carcinoma | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hepatoblastoma | X X X X X X| 12 |
Hepatoblastoma, Multiple | X | 4 |
Hepatocellular Carcinoma | X X X X | 11 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X | 30 |
Hepatocellular Adenoma | X X | 4 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X| 30 |
Lymphoma Malignant | X X X | 4 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Hepatoblastoma, Metastatic, Liver | X | 1 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + + M M M + M + + + M + + + + + +| 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + M + M + + + +| 46 |
Pars Distalis, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + M + + M + + + M + + + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangioma | | 1 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Iliac, Lymphoma Malignant | X X X X X | 5 |
Inguinal, Lymphoma Malignant | X | 1 |
Mediastinal, Lymphoma Malignant | X X | 2 |
Pancreatic, Lymphoma Malignant | X X | 2 |
Pancreatic, Mesothelioma Malignant | | 1 |
Renal, Lymphoma Malignant | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Lymphoma Malignant | X X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + M + + + A + + + M + +| 45 |
Hemangioma | | 1 |
Hepatoblastoma, Metastatic, Liver | X | 1 |
Lymphoma Malignant | X X | 2 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Lymphoma Malignant | X X X X X | 6 |
__________________________________________________________________________|____________|
Thymus | + + A + + + + M + + + M + + + + + + M + + + + + +| 39 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X X | 4 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
Subcutaneous Tissue, Sarcoma | X X X | 4 |
Subcutaneous Tissue, Schwannoma | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | X X | 3 |
Hepatoblastoma, Metastatic, Liver | X X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X | 10 |
Lymphoma Malignant | X | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + A + A + + + + A + + + + + +| 43 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X X X X X | 6 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + M + + A + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + A + M A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + A + + + A + A A +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + A + + + A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatoblastoma | |
Hepatoblastoma, Multiple | |
Hepatocellular Carcinoma | X X X|
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + M + M + + M M M + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + I +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + M + + + + + + + M + + + A + + M +|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M M M M M M M M M M M M M + M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + A + + M + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + A + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + A + + + + + + + + A + + + + + + +| 40 |
Lymphoma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + A + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hepatoblastoma | X | 1 |
Hepatoblastoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X X X X X X X | 12 |
Hepatocellular Carcinoma, Multiple | X | 3 |
Hepatocellular Adenoma | X X X X | 13 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X| 16 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + +| 42 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Adenoma | X | 1 |
Capsule, Adenoma | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + M + A + M + + M M M + + + + + M M + M| 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + A + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Squamous Cell Carcinoma, Metastatic, | | |
Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + + + + + M + + +| 43 |
Lymphoma Malignant | X X X | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + M + + + A + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Alveolar/Bronchiolar Adenoma | X X X| 10 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 7 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + M | 5 |
Adenoma | X X | 3 |
Carcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Transitional Epithelium, Papilloma | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M A + A + A M + + + M + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + A + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma, Multiple | X X |
Hepatoblastoma | X X X X X X X X X |
Hepatoblastoma, Multiple | X X |
Hepatocellular Carcinoma | X X X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X |
Hepatocholangiocarcinoma, Multiple | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X|
__________________________________________________________________________|
Mesentery | + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Sarcoma | X|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | X|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pheochromocytoma Benign | |
Sarcoma, Metastatic, Mesentery | X|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + M M + M + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | +|
Sarcoma, Metastatic, Mesentery | X|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
Sarcoma, Metastatic, Mesentery | X|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | X|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hemangiosarcoma, Metastatic, Liver | X |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + +|
Iliac, Lymphoma Malignant | |
Mediastinal, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
Mediastinal, Lymphoma Malignant | X |
Mediastinal, Sarcoma, Metastatic, | |
Mesentery | X|
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemangiosarcoma, Metastatic, Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + I +|
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | X |
Subcutaneous Tissue, Histiocytic | |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + +|
Hepatoblastoma, Metastatic, Liver | X |
Sarcoma, Metastatic, Mesentery | X|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | |
Hemangiosarcoma, Metastatic, Liver | X |
Hepatoblastoma, Metastatic, Liver | X X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Mediastinum, Hepatocellular | |
Carcinoma, Metastatic, Liver | |
Mediastinum, | |
Hepatocholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + A + A M + + M + M A A + + M + M + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + A + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + A A + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A A + + + + + + + A + + + + + A + + + + + +| 44 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + A + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + A + + A A + + + + A + + + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangioma | | 1 |
Hemangiosarcoma, Multiple | | 2 |
Hepatoblastoma | X X X X X| 14 |
Hepatoblastoma, Multiple | X X | 4 |
Hepatocellular Carcinoma | X X X X X X X X | 16 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X| 19 |
Hepatocellular Adenoma | X X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X| 29 |
Hepatocholangiocarcinoma, Multiple | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X X | 2 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Tooth | + + + + + + +| 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Pheochromocytoma Benign | X | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + M + M + + + + + M M M + M M + + + +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma | X | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Sarcoma, Metastatic, Mesentery | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | | 1 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Iliac, Lymphoma Malignant | X | 1 |
Mediastinal, | | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Sarcoma, Metastatic, | | |
Mesentery | | 1 |
Renal, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M M + + + + +| 47 |
Hemangioma | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemangiosarcoma | X | 3 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + + M + + + + + + + + + + + + +| 46 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M M + M M + M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Hemangioma | | 1 |
Subcutaneous Tissue, Histiocytic | | |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Hepatoblastoma, Metastatic, Liver | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | X X| 2 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Hepatoblastoma, Metastatic, Liver | | 4 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X | 7 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Mediastinum, Hepatocellular | | |
Carcinoma, Metastatic, Liver | X | 1 |
Mediastinum, | | |
Hepatocholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + A + M + + + M + + + + A + M + M + M + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X X X X X X X X |
Hepatoblastoma, Multiple | X X X X |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X|
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X |
Lymphoma Malignant | X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Mesothelioma Malignant | |
Capsule, Sarcoma, Metastatic, | |
Mesentery | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + M + + M + + + + + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
Follicular Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Thoracic, Hemangiosarcoma | X|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + I + + + + + + + + + + + +|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node | + + |
Inguinal, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X |
Mediastinal, Sarcoma, Metastatic, | |
Mesentery | |
Pancreatic, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X X |
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Mesentery | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + +|
Subcutaneous Tissue, Mast Cell Tumor | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | +|
Sarcoma, Metastatic, Mesentery | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | +|
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatoblastoma, Metastatic, Liver | X X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X |
Lymphoma Malignant | X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Tissue | |
NOS | X|
Mast Cell Tumor Malignant, | |
Metastatic, Skin | |
Sarcoma, Metastatic, Mesentery | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | A M M + + M + + M A + A M + + + + + + + + + A + M| 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + M + + + + + A + + + + + + + + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + + + + + + + + + A + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + A + A + + + + + + + + + + A + +| 42 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + + + + + + + A + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hepatoblastoma | X X X X X X X X | 16 |
Hepatoblastoma, Multiple | X X | 6 |
Hepatocellular Carcinoma | X X X X X X X X X| 15 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X X X X | 26 |
Hepatocellular Adenoma | X | 5 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X| 29 |
Lymphoma Malignant | | 1 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | X | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Mesothelioma Malignant | X | 1 |
Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Sarcoma, Metastatic, | | |
Mesentery | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M + + + M +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + I + +| 45 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Adenoma | X | 1 |
Follicular Cell, Adenoma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Thoracic, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Mesothelioma Malignant | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mesothelioma Malignant | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Sarcoma, Metastatic, Mesentery | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Inguinal, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mediastinal, Sarcoma, Metastatic, | | |
Mesentery | X | 1 |
Pancreatic, Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | | 2 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + M + M M + + + + + + + + + + + + A + +| 44 |
Hemangioma | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Hemangiosarcoma | X| 1 |
Lymphoma Malignant | | 2 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M M + M M M + M + + + + + + + + + + + + M + +| 39 |
Lymphoma Malignant | | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Subcutaneous Tissue, Mast Cell Tumor | | |
Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Sarcoma, Metastatic, Mesentery | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatoblastoma, Metastatic, Liver | X X X | 7 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X X X | 11 |
Lymphoma Malignant | | 1 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Hemangiosarcoma, Metastatic, Tissue | | |
NOS | | 1 |
Mast Cell Tumor Malignant, | | |
Metastatic, Skin | X | 1 |
Sarcoma, Metastatic, Mesentery | X | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + A M + + + + + + + + + + + A + +| 44 |
Hemangioma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 3 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + A + + + + + + + + A + + M A + + A A M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + A + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + A A + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A + + + + + + + + + + + + A + + A + A|
Carcinoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + A A + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatoblastoma | X X |
Hepatoblastoma, Multiple | X X |
Hepatocellular Carcinoma | X X X X X X X X X X X X|
Hepatocellular Carcinoma, Multiple | X X X X X X X |
Hepatocellular Adenoma | X X X X X|
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X |
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Mesentery | + + |
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + A + + + A|
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Capsule, Mesothelioma Malignant | X |
Capsule, Squamous Cell Carcinoma, | |
Metastatic, Uncertain Primary | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Site | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + M M + M + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Mediastinal, Squamous Cell Carcinoma,| |
Metastatic, Uncertain Primary | |
Site | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X |
Squamous Cell Carcinoma, Metastatic, | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Uncertain Primary Site | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Basal Cell | |
Adenoma | |
Subcutaneous Tissue, Hemangioma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatoblastoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X X X X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + M M + + M + + M + + + + + + + + + A + +| 36 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatoblastoma | X X X X X X X X X X X | 13 |
Hepatoblastoma, Multiple | | 2 |
Hepatocellular Carcinoma | X X X X X X X X X X | 22 |
Hepatocellular Carcinoma, Multiple | X X X X X X X X X X X | 18 |
Hepatocellular Adenoma | X X X X X X | 11 |
Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X| 28 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Adenoma | | 1 |
Capsule, Mesothelioma Malignant | | 1 |
Capsule, Squamous Cell Carcinoma, | | |
Metastatic, Uncertain Primary | | |
Site | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + M + + M M M + + M + + M M + M + + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Mediastinal, Squamous Cell Carcinoma,| | |
Metastatic, Uncertain Primary | | |
Site | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Mesothelioma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + M + + M + + + + + + + + + + + + + + + +| 47 |
Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Basal Cell | | |
Adenoma | X | 1 |
Subcutaneous Tissue, Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X X| 6 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatoblastoma, Metastatic, Liver | X X | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X X X X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
NTP Experiment-Test: 55301-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:08:29
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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