TDMS Study 55301-04 Pathology Tables
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
CORE STUDY
Facility: TSI Mason Research
Chemical CAS #: 110-86-1
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + A + + + A M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + A + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + A + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X|
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2|
Mixed Cell Focus | X X |
Necrosis | 2 1 |
Vacuolization Cytoplasmic, Diffuse | |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | 2 |
Fat, Necrosis | 4 4 4 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 2 1 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + A + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Inflammation, Chronic Active | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 3 |
Hemorrhage | 2 |
Hyperplasia | |
Capsule, Hyperplasia | 2 1 1 2 1 3 1 1 1 1 1 1 1 2 2 1 1 1 2 2 3|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + M M + M + M + + M + + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + I + + + + + + + + + + + + M + + + + + + + + + +|
Pars Distalis, Hyperplasia | 3 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 |
Follicle, Cyst | 2 2 1 |
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 4 3 3 4 3 3 3 3 4 3 3 3 2 3 3 3 3 3 3 4 3|
Cyst | 1 2 2 |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + M + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 3 2 2 3 2 2 2 3 |
__________________________________________________________________________|
Uterus | + A + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Cyst | 4 4 4 |
Hyperplasia, Cystic | 4 4 4 2 4 3 2 2 3 3 4 4 3 4 4 3 3 1 4 4 3 2 4|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Pigmentation | |
Mediastinal, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Inflammation, Chronic | |
Active | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 1 1 1 1 4 2 2 1 1|
Hyperplasia, Lymphoid | |
Inflammation, Chronic Active | 2 |
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Atrophy | 2 1 4 1 |
Ectopic Parathyroid Gland | 2 |
Hyperplasia, Lymphoid | 4 |
Inflammation, Acute | 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Mineralization | 2 2 2 1 1 2 2 2 1 1 1 2 1 1 2 2|
Meninges, Inflammation, Chronic | |
Active | |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 1| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 6| 2| 2| 2| 2| 2| 2| 1| 2| 2| 5| 7| 2| 5| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2|
| 9| 2| 9| 9| 9| 9| 9| 9| 1| 9| 5| 1| 0| 9| 4| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 1 2 1 2 2 1 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 2 2 1 2 2 1 1 1 2 1 1 2 |
Respiratory Epithelium, Hyperplasia | 2 2 2 2 2 1 2 |
Respiratory Epithelium, Inflammation,| |
Chronic Active | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphocyte | 2 1 1 1 |
Nephropathy | 2 2 1|
__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + A M + A A + + + + A + + + A + + + + M A A +| 37 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + A + + + + + + + + + A + + + + + M A +| 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A A + + + + + + + + A + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + A + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A A + + A + + + + A + + + A + + + + + + A +| 42 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A A + + + + + + + + A + + + + + + A +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Basophilic Focus | | 1 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X X X X X X X | 17 |
Hematopoietic Cell Proliferation | 2 3 | 2 2.5|
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 | 4 1.8|
Mixed Cell Focus | X X X | 5 |
Necrosis | 2 4 3 | 5 2.4|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 17 |
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Fat, Necrosis | 4 4 3 4 4 4 | 12 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 2 1 1 1 1 1 1 2| 33 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Ulcer | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + A + + + + + + + +| 48 |
Necrosis | 1 2 | 3 1.3|
__________________________________________________________________________|____________|
Tooth | + + | 2 |
Developmental Malformation | 1 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Aorta, Inflammation, Chronic Active | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Cytoplasmic Alteration | | 2 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia | 1 | 1 1.0|
Capsule, Hyperplasia | 2 1 2 2 2 2 1 2 2 3 2 1 2 1 1 2 1 1 1 2| 41 1.6|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M + + + + + + + M M + M M + M M M +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 |
Pars Distalis, Hyperplasia | 1 2 3 | 5 2.2|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | | 1 4.0|
Follicle, Cyst | 3 | 4 2.0|
Follicular Cell, Hyperplasia | 2 1 1 4 2 1| 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + M + + + + I + + + I + + + + +| 47 |
Atrophy | 3 3 3 3 3 3 4 4 3 3 3 3 2 3 3 3 3 4 3 3| 45 3.1|
Cyst | | 3 1.7|
Inflammation, Chronic | | 2 1.0|
Inflammation, Chronic Active | 2 1 | 2 1.5|
Pigmentation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + M + + + + + + + + + + + + A + + + + + + + +| 47 |
Cyst | 2 3 4 3 3 | 14 2.7|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Congestion | | 1 2.0|
Cyst | | 3 4.0|
Hyperplasia, Cystic | 2 2 3 1 3 1 1 4 3 2 3 2 3 2 3 3 4 4 2 2 4| 44 2.9|
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Atrophy | 3 | 1 3.0|
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + +| 10 |
Iliac, Hemorrhage | 2 | 1 2.0|
Iliac, Hyperplasia, Lymphoid | 3 4 1| 3 2.7|
Iliac, Pigmentation | 2 | 1 2.0|
Mediastinal, Hemorrhage | | 1 2.0|
Mediastinal, Inflammation, Chronic | | |
Active | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Hemorrhage | 2 1 | 3 2.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hemorrhage | 1 2 2 | 4 1.8|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 1 2 4 2 1 4 2 4 4 3 2 2 1 2 3 1| 29 2.1|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Inflammation, Chronic Active | | 1 2.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + M + + + A + + + M + + + +| 45 |
Atrophy | 2 4 2 3 3 3 2 | 11 2.5|
Ectopic Parathyroid Gland | | 1 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Acute | | 1 2.0|
Necrosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 6| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 0| 7| |
DAY ON TEST | 2| 2| 2| 6| 8| 2| 9| 6| 2| 4| 2| 2| 4| 2| 2| 9| 1| 7| 2| 2| 2| 2| 1| 6| 2| |
| 9| 9| 9| 8| 7| 9| 1| 5| 9| 4| 9| 9| 4| 9| 9| 7| 4| 5| 9| 9| 9| 9| 9| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Mineralization | 1 2 1 2 1 2 1 2 2| 25 1.6|
Meninges, Inflammation, Chronic | | |
Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | | 4 1.3|
Inflammation, Chronic Active | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 | 5 1.6|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 2 1 2 1 2| 19 1.4|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 1 1 1 1 1 1 2 1 | 27 1.3|
Respiratory Epithelium, Hyperplasia | 2 2 1 2 1| 12 1.8|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 1 1 | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Infarct | 4 | 1 4.0|
Infiltration Cellular, Lymphocyte | | 4 1.3|
Nephropathy | 1 2 | 5 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + A + + + + A + + + A + + + + + + + +| 45 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 | 16 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A A A + + + A + + + + M + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + A + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X|
Eosinophilic Focus | X X X X X X X|
Hematopoietic Cell Proliferation | 2 |
Mixed Cell Focus | X X X|
Necrosis | 4 4 |
Periportal, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Fat, Necrosis | 3 2 4 4 4|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Acinus, Atrophy | 4 3 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 2 2 1 1 1 1 3 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + M + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Capsule, Hyperplasia | 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 3 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + + + M M M M M + + + M + M + + M + + + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + M + + + + + + + + + M + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 1 1 2 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
Follicular Cell, Hyperplasia | 3 1 2 1 3 4 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 3 3 2 4 3 3 4 3 3 3 3 3 3 3 3 3 3 3 3 2|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 2 4 2 4 1 2 |
Periovarian Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Cystic | 2 3 2 1 4 4 2 4 3 3 3 4 2 1 1 2 2 3 4 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 2 2 3 3 2 2 3 2 4 2 2 3 1|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 2 2 1 1 2 |
Necrosis | 3 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 0| 6| 7| 7| 7| 7| 7| 6| 7| 0| 7| 3| 6| 7| 0| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 2| 2| 9| 9| 0| 4| 2| 2| 2| 1| 2| 0| 2| 2| 2| 7| 8| 2| 1| 2| 2| 2| 2| 7| 2|
| 9| 9| 6| 9| 4| 9| 9| 9| 9| 3| 9| 5| 9| 0| 9| 2| 0| 9| 6| 9| 9| 9| 9| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
125 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Mineralization | 2 2 2 2 2 2 2 1 1 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Lymphocyte | 1 1 |
Alveolar Epithelium, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 1 2 1 1 2 2 1 1 2 |
Olfactory Epithelium, Necrosis | 1 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 1 2 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 |
Respiratory Epithelium, Necrosis | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 1 |
Infiltration Cellular, Lymphocyte | 2|
Nephropathy | 1 1 1 3 1 2 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A + + + A + + + + + + + + + A A + + + + + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X X X | 5 |
Eosinophilic Focus | X X X X X | 12 |
Hematopoietic Cell Proliferation | | 1 2.0|
Mixed Cell Focus | X | 4 |
Necrosis | | 2 4.0|
Periportal, Vacuolization Cytoplasmic| 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + +| 18 |
Fat, Necrosis | 4 4 4 4 4 3 2 3| 13 3.5|
__________________________________________________________________________|____________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Acinus, Atrophy | | 2 3.5|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 35 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | 1 2 | 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | | 1 2.0|
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 2| 35 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M + M M + M + + + + + + + + + + M + M M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + M + M + + + + + + + + + + + + + + + +| 44 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | | 4 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1| 3 1.0|
Follicular Cell, Hyperplasia | 1 4 1 2 1 1 4 1 1 1 1 2| 21 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 2 3 3 3 3 2 3 2 2 3 3 2 3 3 3 3 3 2 3 3 3 3| 43 2.9|
Inflammation, Chronic | 1 | 2 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Cyst | 1 2 | 9 2.3|
Periovarian Tissue, Hyperplasia, | | |
Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 4 3 | 3 3.3|
Hyperplasia, Cystic | 1 2 4 4 3 3 1 3 1 1 2 4 1 3 3 2 2 2 4 1 2 3| 43 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + M + + + + + + + + + + + + + + + +| 47 |
Ectasia | | 1 3.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 3 4 3 1 1 3 2 2 1 3 3 3 2 2| 27 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 1 2 3 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M + + + + I + M + + + + + M + + + + + + + +| 44 |
Atrophy | 3 4 | 11 2.3|
Necrosis | 2 2 | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 | 1 3.0|
Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 3 4 | 5 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Mineralization | 1 2 2 2 2 2 1 2 2 1 2 2 1| 27 1.7|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 2 2.0|
Infiltration Cellular, Lymphocyte | | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 3 2.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 3 1 2 2 1 2 1 2 2 2 2 2| 27 1.6|
Olfactory Epithelium, Necrosis | | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 2 1 1 1 1| 16 1.3|
Respiratory Epithelium, Hyperplasia | 1 1 2 | 8 1.1|
Respiratory Epithelium, Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 6| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| |
DAY ON TEST | 0| 2| 2| 7| 5| 2| 7| 2| 2| 2| 4| 2| 2| 2| 7| 1| 2| 2| 2| 2| 1| 2| 2| 2| 2| |
| 8| 9| 9| 4| 5| 9| 7| 9| 9| 9| 2| 9| 9| 9| 2| 1| 4| 9| 9| 9| 9| 9| 9| 9| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
125 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 2 1.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Nephropathy | 1 3 1 1| 10 1.5|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 1 1 1 1| 16 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A M + + + + A + A + + A + A + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + A + + + + A + + + + + + A A + + +|
Edema | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + A + + A + A + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + A + + A + A + + + + A + A A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + A + + A + A + + + + + + A A + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cyst | |
Eosinophilic Focus | X X X X X X|
Hematopoietic Cell Proliferation | |
Mixed Cell Focus | |
Necrosis | 3 2 4 |
Centrilobular, Degeneration | 2 |
Midzonal, Vacuolization Cytoplasmic | |
Periportal, Vacuolization Cytoplasmic| 1 |
__________________________________________________________________________|
Mesentery | M + + + + + + + + |
Fat, Necrosis | 3 3 2 4 4 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + A + + +|
Acinus, Atrophy | 3 |
Artery, Inflammation, Chronic | 2 |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Infiltration Cellular, Lymphocyte | 3 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + M + + + + + + + M + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Capsule, Hyperplasia | 2 2 2 1 1 2 1 1 1 1 1 1 1 1 2 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + A + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + M + + + M + M M + + M + M M M + M|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | M + + + I + + + + + + + + + + + + + + + + I + + +|
Pars Distalis, Hyperplasia | 3 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 3 3 2 1 2 2 2 2 3 2 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + M + + +|
Atrophy | 3 3 3 3 2 4 3 4 3 4 3 3 3 3 3 3 2 3 4 3|
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Ovary | + M + + + + + + A + + + + + + + + + + + + + + + +|
Cyst | 4 2 3 2 4|
__________________________________________________________________________|
Uterus | + + + + + + + + A + + + + + + + + + + + + A + + +|
Cyst | 4 4 3 4 |
Hyperplasia, Cystic | 4 2 3 2 3 4 2 3 1 3 1 2 1 1 2 1 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 4 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + M + + + + + + + A + + +|
Angiectasis | 2 |
Hemorrhage | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 2 1 3 1 3 2 4 3|
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +|
Atrophy | 3 2 2 4 3 4 2 2 |
Ectopic Parathyroid Gland | 2 |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 0| 7| 1| 7| 6| 7| 6| 7| 6| 7| 7| 6| 7| 0| 7| 7| 7| 7| 6| 7| 6| 0| 7| 7| 7|
DAY ON TEST | 4| 2| 7| 2| 3| 2| 9| 2| 9| 2| 0| 8| 2| 0| 2| 2| 2| 2| 4| 2| 9| 3| 2| 2| 2|
| 0| 9| 5| 9| 3| 9| 6| 7| 7| 9| 0| 4| 9| 3| 9| 9| 9| 9| 2| 9| 9| 3| 3| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
250 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 3 1 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 2 3 2 2 2 1 1 2 2 2 2 2 1 2 2|
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 2 2 1|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 4|
Nephropathy | 1 1 1 1 1 |
Glomerulus, Amyloid Deposition | |
Renal Tubule, Dilatation | 2 2 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + A + + + + + + + + + + + + A + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | A A A + + + + + + + + A + A M + A + + A + + + + A| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + + + + + + + + + + + + + A + + + + + + A A| 40 |
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + A A + + + + + M + + A + + + + + + + A| 39 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + A + + A + + + A A| 38 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + A A + + + + + + + + A + + A + + + + A| 37 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Cyst | 4 | 1 4.0|
Eosinophilic Focus | X X X X X X X X | 14 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Mixed Cell Focus | X X X | 3 |
Necrosis | 1 2 | 5 2.4|
Centrilobular, Degeneration | | 1 2.0|
Midzonal, Vacuolization Cytoplasmic | 2 | 1 2.0|
Periportal, Vacuolization Cytoplasmic| | 1 1.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 13 |
Fat, Necrosis | 3 2 3 3 | 11 3.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Acinus, Atrophy | | 1 3.0|
Artery, Inflammation, Chronic | | 1 2.0|
Duct, Cyst | 1 | 2 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 2 2 1 1 1 2 1 1 1 2 2 1 1| 36 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Necrosis | 2 2 1| 4 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 1 1 1 2 1 2 1 2 1 1 1 2 1 1 1 1 2 1 1 1 | 39 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | M + A + + + + + + + + + + + + + A + + + + + + + +| 45 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M + + M + M M M + M A + + + + + + M + + + + + +| 30 |
__________________________________________________________________________|____________|
Pituitary Gland | M + M + + + + M + + + + + + I + + M + + + + + + +| 42 |
Pars Distalis, Hyperplasia | 2 2 1 1 | 6 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 3 4 2 2 2 4 2 1 1 | 22 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 2 |
Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 3 4 3 3 2 4 3 3 2 4 3 3 3 3 3 3 3 3 2 3 3 3 4 3| 45 3.1|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | 1 | 3 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + + + + + + + + A + + + + + + + +| 46 |
Cyst | 1 2 3 1 4 1 | 11 2.5|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Cyst | 4 | 5 3.8|
Hyperplasia, Cystic | 3 1 3 3 2 2 2 4 1 4 2 2 1 2 3 4 1 1 4 1 1| 38 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Iliac, Hyperplasia, Lymphoid | 1 4 | 2 2.5|
Inguinal, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + M + + + + + + A + + + + + + M +| 43 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 1 2.0|
Hemorrhage | 4 3 2 | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 4 2 2 2 1 2 2 4 3 2 3 1 4 4 4 2 2 | 32 2.5|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 1 1 | 4 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + + M +| 46 |
Atrophy | 2 2 3 3 2 | 13 2.6|
Ectopic Parathyroid Gland | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Necrosis | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 2 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 2 2 2 1 2 2 2 2 2| 18 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 4 2.3|
Alveolar Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + A + + + + + + + A| 47 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 2 2 2 1 1 1 2 2 1 2 1 2 2 | 35 1.8|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 1 1 2 1 1 | 12 1.3|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 12 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 6| 7| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 4| 7| 7| 7| 6| 5| |
DAY ON TEST | 0| 5| 0| 2| 9| 2| 5| 3| 2| 2| 2| 8| 2| 0| 2| 2| 4| 2| 1| 1| 2| 2| 2| 7| 6| |
| 8| 6| 0| 9| 2| 9| 9| 2| 9| 9| 9| 3| 9| 9| 4| 9| 8| 9| 2| 7| 2| 9| 9| 8| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
250 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 1 | 5 1.6|
Nephropathy | 1 1 | 7 1.0|
Glomerulus, Amyloid Deposition | 4 | 1 4.0|
Renal Tubule, Dilatation | | 2 2.0|
Renal Tubule, Pigmentation | 2 3 | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + M + + + + A| 44 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 | 17 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M A + M M + A + M M + + + + + M + + + + A M + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + A + + + + + + + + + + + + + + + +|
Artery, Necrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + M + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + A + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X |
Hematopoietic Cell Proliferation | |
Necrosis | 3 2 2 4 |
Vacuolization Cytoplasmic, Diffuse | |
Centrilobular, Congestion | |
Centrilobular, Degeneration | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis | 4 4 4 3 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic Active | 3 4 |
Acinus, Atrophy | 2 4 |
Duct, Cyst | 3 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 1 1 2 1 2 2 1 1 2 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Hemorrhage | 2 2 |
Capsule, Hyperplasia | 2 1 2 3 2 1 1 1 1 2 1 3 2 1 1 1 2 1 1 1 1 1 1 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + M M + M + + M + + + + + + + + M M|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 2 1 1|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
Follicular Cell, Hyperplasia | 1 2 1 2 4 2 3 1 2 2 1 2 1 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
Atrophy | 4 4 3 3 3 3 3 4 3 2 2 3 3 3 4 3 3 3 3 3 3 3 3|
Inflammation, Chronic | 2 1 1 1 |
Pigmentation | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 1 3 4 4 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia, Cystic | 2 2 3 3 1 3 1 3 2 3 2 1 3 2 2 2 2 1 2|
Inflammation, Chronic Active | 3 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M M + + + + + + + + M + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 3 |
Artery, Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 2 3 3 2 3 2 2 2 1 2 2 3 3 3 3 3 3 3 1 3|
Hyperplasia, Lymphoid | 1 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + I + I + + M + M + + M + + + + + + + + M + + M +|
Atrophy | 2 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Mineralization | 1 2 2 1 2 1 2 1 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 2 2 1 2 2 1 2 2 1 1 1 2 1 2 1 2 2 2 2 1 2|
Olfactory Epithelium, Inflammation, | |
Chronic Active | |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 1 2 1|
Respiratory Epithelium, Hyperplasia | 1 2 |
Respiratory Epithelium, Inflammation,| |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Lymphocyte | 1 |
Nephropathy | 2 1 2 1 1 1 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 2| 6| 8| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 9| 2| 9| 2| 2|
| 9| 9| 9| 9| 9| 6| 6| 9| 0| 9| 9| 6| 9| 9| 9| 9| 9| 9| 5| 9| 0| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
500 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + A + A + + + + + + + + + + + A + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + M A + + + + + + + A + A M + + + A + + + + + +| 34 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + A + A + + + + A + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 |
Artery, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + A + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + A + A + + + + A + + + A + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + A + + + A + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + A + A + + A + + + A + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X X X | 9 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Necrosis | 1 4 4 | 7 2.9|
Vacuolization Cytoplasmic, Diffuse | 1 | 1 1.0|
Centrilobular, Congestion | 1 | 1 1.0|
Centrilobular, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Fat, Necrosis | 3 3 4 | 9 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
Inflammation, Chronic Active | | 2 3.5|
Acinus, Atrophy | | 2 3.0|
Duct, Cyst | | 2 3.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 29 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Necrosis | 1 1| 3 1.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration | 3 1 | 2 2.0|
Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Capsule, Hyperplasia | 1 1 1 1 1 1 2 2 1 1 1 1 1| 37 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Hyperplasia | 1 | 3 1.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + M + + + M M M + M + + + M + + + + + +| 36 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + M + M + + + +| 46 |
Hemorrhage | 2 | 1 2.0|
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 1 1 3 1 2 | 8 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | | 3 1.0|
Follicular Cell, Hyperplasia | 2 1 1 2 1 1 1 1 | 23 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + M + + M + + M + + + M + + + + + + + + + +| 45 |
Atrophy | 3 3 4 2 3 3 4 3 4 3 4 3 2 4 4 3 3 3 4 4| 43 3.2|
Inflammation, Chronic | | 4 1.3|
Pigmentation | 2 | 3 2.0|
__________________________________________________________________________|____________|
Ovary | + + I + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 1 2 2 | 11 2.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 4 | 2 4.0|
Hyperplasia, Cystic | 1 3 2 1 2 1 1 2 1 2 1 1 2 3 2 1 3 2 3 4| 39 2.0|
Inflammation, Chronic Active | | 1 3.0|
Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Iliac, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + A + + M + + + A + + + M + +| 45 |
Angiectasis | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 1.0|
Hemorrhage | 3 | 2 3.0|
Artery, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 |
Hematopoietic Cell Proliferation | 2 3 3 2 3 1 4 4 2 3 1 2 2 2 2 3 2| 39 2.4|
Hyperplasia, Lymphoid | | 2 1.5|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + A + + + + M + + + M + + + + + + M + + + + + +| 39 |
Atrophy | 2 2 2 4 3 2 4 2 | 10 2.6|
Necrosis | 2 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 2 | 1 2.0|
Mineralization | 1 2 2 2 1 2 1 1 2| 19 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 2 | 3 2.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 1 1 1 1 1 1 2 1 1 1 2 2 | 36 1.5|
Olfactory Epithelium, Inflammation, | | |
Chronic Active | 1 | 1 1.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 1 | 13 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 2| 7| 6| 5| 0| 7| 7| 6| 4| 7| 7| 6| 7| 6| 0| 1| 7| 7| 7| 7| 7| 7| 0| 4| 5| |
DAY ON TEST | 9| 2| 9| 1| 1| 2| 2| 2| 7| 2| 2| 7| 2| 8| 1| 8| 2| 2| 0| 2| 2| 2| 1| 3| 7| |
| 9| 9| 0| 0| 5| 9| 9| 6| 9| 9| 9| 7| 9| 0| 4| 8| 9| 9| 3| 9| 9| 9| 2| 0| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
500 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Hyperplasia | 1 1 | 4 1.3|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Nephropathy | 1 3 | 8 1.5|
Renal Tubule, Dilatation | 2 2 | 2 2.0|
Renal Tubule, Pigmentation | 3 | 2 3.0|
Renal Tubule, Regeneration | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + + + + + + + A + A + + + + A + + + + + +| 43 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 1 2 1| 22 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + + + + + + + + + + + + + + + M + + A + A + +|
Infiltration Cellular, Lymphocyte | 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + A + M A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + A + + + + A + + + A + A A +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + A + + + + A + + + A + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | |
Clear Cell Focus | |
Eosinophilic Focus | X X X X X X X X X X X |
Hemorrhage | |
Infiltration Cellular, Mixed Cell | |
Mixed Cell Focus | X X |
Necrosis | 1|
Vacuolization Cytoplasmic, Diffuse | 2 2 |
Centrilobular, Congestion | 3 |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 |
Periportal, Vacuolization Cytoplasmic| |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | |
Ulcer | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 2 1 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2|
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 3 4 4 2 3 3 3 4 4 4 4 3 4 3 2 2 3 4 3 3 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
Myocardium, Hypertrophy | 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 2 1 1 2 1 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 1 |
Capsule, Hyperplasia | 1 1 2 1 3 1 4 2 2 2 2 1 2 2 1 3 2 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + M + M + + M M M + + + + + M + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + I +|
Cyst | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 3 2 4 2 2 2 3 3 4 4 4 4 4 3 4 2|
Cyst | 3 3 3 3 4 3 4 4 3 3 2 |
Inflammation, Chronic | 2 2 3 2 2 2 1 |
Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia | |
Inflammation, Chronic | 1 1 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Mineralization | |
Interstitial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 2 2 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + M + + + + + + + M + + + A + + M +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 1 2 3 2 2 1 2 |
Hyperplasia, Histiocytic | 1 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 1 4 1|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M M + + + +|
Atrophy | 2 2 1 2 1 2 2 2 3 1 3 2 3 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + M M M M M M M M M M M M M + M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 1|
Subcutaneous Tissue, Edema | 3 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Mineralization | 1 2 2 3 1 3 2 2 2 3 2 2 2 2 1 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia | 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 6| 7| 5|
DAY ON TEST | 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 3| 2| 2| 2| 7| 2| 7| 0| 7|
| 9| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 8| 2| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Foreign Body | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 3 2 2|
Olfactory Epithelium, Glands, | |
Hyperplasia | 3 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 1 2 1 1 1|
Respiratory Epithelium, Hyperplasia | 1 2 1 2 3 2 3 2 3 2|
Respiratory Epithelium, Inflammation,| |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hydronephrosis | |
Infarct | 1 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Chronic Active | 4 3 |
Mineralization | 1 |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 3 1|
Artery, Inflammation, Chronic | |
Artery, Inflammation, Chronic Active | |
Renal Tubule, Hyperplasia | 1 3 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + A + + M + + + + + + + + + + + + +| 43 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + A + A + + + + + + + + + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + A + A + + + + + + + + A + + + + + + +| 40 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + A + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Basophilic Focus | X X X | 3 |
Clear Cell Focus | X| 1 |
Eosinophilic Focus | X X X X X X X X| 19 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
Mixed Cell Focus | X X | 4 |
Necrosis | 1 4 | 3 2.0|
Vacuolization Cytoplasmic, Diffuse | | 2 2.0|
Centrilobular, Congestion | | 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | | 1 2.0|
Periportal, Vacuolization Cytoplasmic| 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 2 |
Fat, Necrosis | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy | | 3 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 1 1 1 1 2 1 1 1 1 1 2 1 1 1 | 31 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + + + + + + + + + + + + + + + + + +| 42 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Developmental Malformation | 4 3 2 4 4 2 3 4 3 2 4 2 4 2 4 4 2 3 2 4 2| 42 3.1|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Aorta, Thrombosis | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | 2 | 2 2.5|
Myocardium, Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration | 2 1 1 2 1 1 3 1 2 1 1 1| 18 1.4|
Hyperplasia | 1 | 2 1.0|
Vacuolization Cytoplasmic | 1 | 2 1.0|
Capsule, Hyperplasia | 1 1 2 1 1 2 4 1 1 2 2 1 3 1 1 3 2 1 2 1 1 1| 42 1.7|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + M + A + M + + M M M + + + + + M M + M| 31 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + A + + + + + + + + + + + + + + + +| 46 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Follicle, Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 2 1 1 | 8 1.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 3 4 4 3 4 3 3 4 2 2 3 3 3 2 2 3 4 2 2 2 2 4 3| 48 3.0|
Cyst | 2 2 3 4 3 4 4 4 2 3 4 4 4 4 2 4 2 3| 29 3.2|
Inflammation, Chronic | 2 1 1 1 2 1 1 1 2 2 2| 18 1.7|
Inflammation, Chronic Active | 4 2 | 4 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic | 1 1 1 1 1 | 7 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 3 | 2 2.5|
Mineralization | 1 | 1 1.0|
Interstitial Cell, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 1 | 2 2.0|
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Congestion | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 3 2.0|
Hyperplasia, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + A + + + + + + + + + + + + M + + +| 43 |
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | 4 1 3 2 1 2| 13 2.0|
Hyperplasia, Histiocytic | 3 | 2 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 4 3 1 1 3 3 1 | 13 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + A + + + + + + + + + + + + + + + +| 46 |
Atrophy | 4 2 2 2 2 3 2 3 1 2 3 | 26 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic Active | 2 | 1 2.0|
Ulcer | | 1 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 2 1 1 2 3 1 2 2 1 1 3 2 2 1 2 2 1 2 2 2| 41 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Congestion | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 4 | 4 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 1 2 1 2 2 2 2 | 15 1.8|
Olfactory Epithelium, Glands, | | |
Hyperplasia | | 1 3.0|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 2 1 2 1 1 1 1 1 | 20 1.2|
Respiratory Epithelium, Hyperplasia | 2 1 2 1 1 2 1 2 2 2 | 20 1.9|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 4 | 1 4.0|
Cornea, Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + + + M | 5 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 2 | 4 2.0|
Hydronephrosis | 1 | 1 1.0|
Infarct | 1 | 2 1.0|
Infiltration Cellular, Lymphocyte | 2 3 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 7| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 2| 6| 2| 2| 5| 2| 9| 2| 1| 2| 2| 2| 2| 2| 4| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| |
| 2| 3| 2| 2| 3| 3| 8| 3| 4| 3| 3| 0| 3| 3| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Chronic Active | | 2 3.5|
Mineralization | 1 | 2 1.0|
Nephropathy | 2 2 1 1 1 1 1 1 2 2 1 2 1 3 1 1 2 1| 34 1.4|
Artery, Inflammation, Chronic | 2 | 1 2.0|
Artery, Inflammation, Chronic Active | 3 | 1 3.0|
Renal Tubule, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M A + A + A M + + + M + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | X X X X X X X X X X X|
Hematopoietic Cell Proliferation | |
Infiltration Cellular, Mixed Cell | 2 |
Mixed Cell Focus | X |
Necrosis | 2 2 |
Vacuolization Cytoplasmic, Diffuse | |
Centrilobular, Vacuolization | |
Cytoplasmic | |
__________________________________________________________________________|
Mesentery | + + + +|
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Tooth | + + + |
Developmental Malformation | 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 3 1 1 |
Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + M M + M + + + M + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Follicular Cell, Hyperplasia | 2 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | +|
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Infiltration Cellular, Lymphocyte | 1 1 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 3 3 4 2 3 4 4 3 3 4 3 3 3 4 3 3 3 4 4|
Cyst | 3 2 2 3 4 4 4 4 4 3 2|
Inflammation, Chronic | 2 2 2 2 1 1 2 |
Inflammation, Chronic Active | 4 4 4 1|
__________________________________________________________________________|
Prostate | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + +|
Pancreatic, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | 2 1 |
Hematopoietic Cell Proliferation | 2 2|
Hemorrhage | 2 3 2 2 1 3 1|
Hyperplasia, Lymphoid | 2 2 3 1 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 1 3 2 3 3 2 4 3 4 1 2 4 4 2 4 4|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + I +|
Atrophy | 2 2 2 3 3 3 3 1 3 3 4 2 2 3|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Edema | 3|
Subcutaneous Tissue, Inflammation, | |
Acute | 2 |
Subcutaneous Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Mineralization | 3 1 2 2 2 1 2 2 3 2 2 2 1 1 |
__________________________________________________________________________|
Peripheral Nerve | + |
Sciatic, Degeneration | 2 |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 2 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + A + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 2 2 2 2 1 3 1 2 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 2 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 1 2 1 |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 6| 6| 5| 2| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 0| 2| 2| 2| 2| 7| 2| 3| 2| 9| 0| 2| 2| 2| 2| 8| 7| 3| 3| 2| 2| 2| 5| 6|
| 2| 8| 2| 2| 2| 2| 6| 2| 8| 2| 2| 2| 2| 2| 2| 2| 0| 7| 2| 7| 2| 2| 2| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Inflammation,| |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fibrosis | |
Infarct | |
Infiltration Cellular, Lymphocyte | 2 |
Mineralization | 1 |
Nephropathy | 1 2 1 3 1 1 1 2 1 1 1 1 1 1 2 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Pigmentation | 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + A + A + A M + + M + M A A + + M + M + + + + + +| 33 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + A + + + + + + + A + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + A A + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A A + + + + + + + A + + + + + A + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + A + + + + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + A + + + A + + A A + + + + A + + + + + +| 41 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | | 1 |
Clear Cell Focus | X X | 3 |
Eosinophilic Focus | X X X X X X X X X X X | 22 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Mixed Cell Focus | X | 2 |
Necrosis | 4 2 4 | 5 2.8|
Vacuolization Cytoplasmic, Diffuse | 2 | 1 2.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 7 |
Fat, Necrosis | 4 2 | 3 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1| 33 1.1|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 1 | 1 1.0|
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + +| 10 |
Developmental Malformation | 3 2 1 4 4 3 3| 10 2.6|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 3 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration | 1 1 1 3 1 1 2 2 1| 13 1.5|
Hyperplasia | | 1 1.0|
Capsule, Hyperplasia | 4 1 1 1 1 2 1 1 2 1 1 1 2 1| 29 1.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 5 2.2|
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + + M + M + + + + + M M M + M M + + + +| 35 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 1 2 1 1 2 1 2| 14 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | 1 1 | 4 1.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 2 3 3 4 3 4 3 3 3 3 3 4 4 3 3 3 2 4 2 3 2 3| 45 3.2|
Cyst | 4 4 4 4 3 4 4 3 4 3 3 3 2 2| 25 3.3|
Inflammation, Chronic | 2 2 1 1 1 1 2 1 2 3 2| 18 1.7|
Inflammation, Chronic Active | 2 4 | 6 3.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Erythroid Cell, Hyperplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 4 |
Pancreatic, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M M + + + + +| 47 |
Angiectasis | | 2 1.5|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Hemorrhage | 1 2 1 | 10 1.8|
Hyperplasia, Lymphoid | | 5 1.8|
Hyperplasia, Plasma Cell | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 2.0|
Hematopoietic Cell Proliferation | 2 2 4 1 2 3 3 3 2 2 2 2 1 1| 30 2.5|
Hyperplasia, Lymphoid | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + I + + + + + + + M + + + + + + + + + + + + +| 46 |
Atrophy | 3 2 2 4 2 2 2 | 21 2.5|
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M + M M M M M M + M M + M M M M M M M M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Edema | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Acute | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Mineralization | 1 1 2 3 2 1 2 3 2 2 1 2 1| 27 1.8|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Sciatic, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 5| 0| 6| 6| 5| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 2| 8| 0| 9| 7| 9| 2| 2| 2| 1| 2| 2| 4| 4| 2| 2| 2| 2| 4| 2| 2| 9| 2| 2| 2| |
| 2| 7| 8| 6| 4| 5| 2| 2| 2| 5| 2| 3| 5| 9| 2| 2| 2| 2| 6| 3| 3| 1| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 2 3| 4 1.8|
Alveolar Epithelium, Hyperplasia | 2 2| 8 1.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2| 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 2 2 2 2 1 2 2 2 1 1 2 2 2| 31 1.7|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 1 2 1 2 | 10 1.3|
Respiratory Epithelium, Hyperplasia | 2 1 1 2 2 1 1 2 2 1 1 2 1| 22 1.3|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 3 | 2 2.0|
Fibrosis | 2 | 1 2.0|
Infarct | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Mineralization | 1 1 | 3 1.0|
Nephropathy | 1 2 1 2 2 1 1 1 2 1 2| 27 1.4|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 2.0|
Renal Tubule, Dilatation | 3 | 1 3.0|
Renal Tubule, Pigmentation | 2 3 2 | 5 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 | 7 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + A + M + + + M + + + + A + M + M + M + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + A A + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia | 2 2 |
Lymphoid Tissue, Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 2 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Cyst | |
Eosinophilic Focus | X X X X X X X X|
Hematopoietic Cell Proliferation | 1 |
Mixed Cell Focus | |
Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
Acinus, Cytoplasmic Alteration | 3 |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 1 2 2 1 1 2 1 1|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 2 2 |
Glands, Dysplasia | 2 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 1 1 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Capsule, Hyperplasia | 1 3 1 1 2 1 3 1 1 1 1 1 1 1 1 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + M + + M + + + + + + M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 4 1 2 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 2 4 4 3 4 4 4 3 4 4 4 2 4 4 2 2 3 3 3|
Cyst | 2 4 3 3 2 2 1 4 4 4 4 2 2|
Inflammation, Chronic | 2 2 2 2 3 1 |
Inflammation, Chronic Active | 4 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + I + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Renal, Hemorrhage | 4 |
Renal, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | 2 2 3 1 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 2 |
Necrosis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 3 1 1 2 2 2 4 2 2 3 4 2 4 3|
Hyperplasia, Lymphoid | 4 |
Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + M + M + + + + + + + + + + + + + + M + + + +|
Atrophy | 1 1 3 2 3 1 2 2 2 2|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 1 2 1 2 2 3 1 1 2 1 2 2|
__________________________________________________________________________|
Peripheral Nerve | +|
__________________________________________________________________________|
Spinal Cord | +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 2 2 2 3 2 2 2 3 1 2 2 1 2 2 1 1|
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 1 1 1 1 2 2 1 2 1 |
Respiratory Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 2| 7| 7| 7| 0| 6|
DAY ON TEST | 1| 2| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5| 1| 2| 2| 2| 2| 2| 2| 2| 0| 3|
| 3| 2| 3| 8| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 4| 2| 2| 2| 6| 2| 2| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
Nephropathy | 1 1 2 1 2 1 2 1 3 1 2 2|
Renal Tubule, Dilatation | 3 2 |
Renal Tubule, Hyperplasia | 2 |
Renal Tubule, Pigmentation | 4 3 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | A M M + + M + + M A + A M + + + + + + + + + A + M| 30 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + + + + + + + + + + + + + + + + + + + A + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + M + + + + + A + + + + + + + + + + A + +| 42 |
Lymphoid Tissue, Hyperplasia | | 2 2.0|
Lymphoid Tissue, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A A + + + + + + + + + A + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + A + + + A + A + + + + + + + + + + A + +| 42 |
Peyer's Patch, Hyperplasia, Lymphoid | 4 | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + + + + + + + + A + + + + + + + + + + A + +| 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | X | 1 |
Cyst | 2 | 1 2.0|
Eosinophilic Focus | X X X X X X X X X X | 18 |
Hematopoietic Cell Proliferation | | 1 1.0|
Mixed Cell Focus | X | 1 |
Necrosis | 3 4 2 4 4 | 7 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 6 |
Fat, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Acinus, Atrophy | | 1 4.0|
Acinus, Cytoplasmic Alteration | | 1 3.0|
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 3 2 1 1 2 1 2 1 | 26 1.3|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Inflammation, Chronic Active | 2 | 2 2.0|
Epithelium, Hyperplasia | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Necrosis | 1 | 4 1.8|
Glands, Dysplasia | | 2 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cytoplasmic Alteration | 1 2 1 1 1 1 | 9 1.1|
Hyperplasia | 1 1 | 2 1.0|
Capsule, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 3 1 | 30 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M + + + M +| 40 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + I + +| 45 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Follicular Cell, Hyperplasia | 3 2 2 1 1 1 1 1 1 2 2 | 20 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infiltration Cellular, Lymphocyte | 1 | 4 1.0|
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 4 4 3 4 4 3 3 3 3 3 4 4 3 4 2 3 4 3 3 4 3 2 4| 47 3.3|
Cyst | 3 3 4 3 2 4 4 3 4 2 2 4 4 4 4 4 4 4 4| 32 3.2|
Inflammation, Chronic | 2 2 2 2 1 2 2 | 13 1.9|
Inflammation, Chronic Active | 2 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 1 1 1 1 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
Renal, Hemorrhage | 2 | 2 3.0|
Renal, Necrosis | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + + + + + M + M M + + + + + + + + + + + + A + +| 44 |
Hematopoietic Cell Proliferation | 2 1 2 2 | 6 1.8|
Hemorrhage | 2 1 1 2 2 | 10 1.9|
Hyperplasia, Histiocytic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + A + +| 47 |
Atrophy | 3 3 | 3 3.0|
Hematopoietic Cell Proliferation | 3 3 4 2 3 4 2 1 1 1 2| 26 2.4|
Hyperplasia, Lymphoid | | 1 4.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M M + M M M + M + + + + + + + + + + + + M + +| 39 |
Atrophy | 3 2 1 3 3 2 | 16 2.1|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mineralization | 1 2 1 1 3 2 2 1 2 2 1 1 2 2 2 2 | 30 1.7|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 2.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 8| 2| 2| 2| 4| 2| 2| 2| 2| 3| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 2| |
| 6| 6| 2| 2| 2| 2| 2| 2| 2| 2| 7| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 2 2 2 2 2 2 2 3 1 1 3 2 1 2| 35 1.9|
Respiratory Epithelium, Degeneration,| | |
Hyaline | 2 2 2 1 1 | 15 1.4|
Respiratory Epithelium, Hyperplasia | 2 1 1 1 2 1 1 1 1 | 11 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
Cyst | 2 1 2 2 | 4 1.8|
Infarct | 1 1 | 2 1.0|
Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0|
Nephropathy | 2 1 1 3 1 1 1 1 1 1 1 1 2| 25 1.4|
Renal Tubule, Dilatation | | 2 2.5|
Renal Tubule, Hyperplasia | | 1 2.0|
Renal Tubule, Pigmentation | 3 | 3 3.3|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + A M + + + + + + + + + + + A + +| 44 |
Infiltration Cellular, Lymphocyte | 1 1 1 2 | 9 1.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + A + + + + + + + + A + + M A + + A A M|
Hyperplasia | 4 |
Ulcer | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + A + + + A|
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + A A + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + A + + + + + + + + + + + + A + + A + A|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + A A + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X X |
Eosinophilic Focus | X X X X X X |
Infiltration Cellular, Mixed Cell | 2 |
Mixed Cell Focus | X |
Necrosis | 4 4 4 4 2|
Centrilobular, Hypertrophy | |
Centrilobular, Vacuolization | |
Cytoplasmic | 2 1 4 |
Periportal, Vacuolization Cytoplasmic| 2 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Cytoplasmic Alteration | 2 |
Duct, Cyst | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Chronic | |
Inflammation, Chronic Active | 1 |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + A + + + A|
Necrosis | 1 |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | 1 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 1 1 1 1 2 |
Vacuolization Cytoplasmic | |
Capsule, Hyperplasia | 2 1 1 1 2 2 1 1 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + M M + M + + M + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 2 2 2 3 3 4 3 2 3 3 3 2 3 1|
Cyst | 2 2 4 2 3 2 4 4 2 4 3 3 4 |
Inflammation, Chronic | 3 2 2 1 2 2 2 |
Inflammation, Chronic Active | 4 2 1 |
__________________________________________________________________________|
Prostate | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic | 1 1 1 1 1 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | |
Renal, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 3 1 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 2 2 4 4 1 1 2 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 2 3 4 3 2 2 2 2 1 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 1 2 1 2 2 1 2 2 2 2 1 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 2 2 |
Respiratory Epithelium, Degeneration,| |
Hyaline | 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 2 |
Respiratory Epithelium, Inflammation,| |
Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic Active | 4 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 0| 7| 0| 5| 7| 4| 6| 4|
DAY ON TEST | 2| 2| 9| 8| 2| 0| 6| 2| 2| 2| 2| 2| 2| 2| 2| 3| 2| 5| 2| 0| 9| 2| 0| 4| 3|
| 2| 2| 9| 6| 2| 3| 5| 2| 2| 2| 2| 3| 2| 2| 2| 9| 3| 9| 3| 9| 4| 2| 6| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infarct | 4 1 1 |
Infiltration Cellular, Lymphocyte | 2 1 1 1 |
Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 1 1 1 |
Renal Tubule, Dilatation | 1 1 1 1 2 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + M M + + M + + M + + + + + + + + + A + +| 36 |
Hyperplasia | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + A + +| 45 |
Lymphoid Tissue, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
Peyer's Patch, Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 2 |
Eosinophilic Focus | X X X X X X X X X | 15 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis | 3 | 6 3.5|
Centrilobular, Hypertrophy | 3| 1 3.0|
Centrilobular, Vacuolization | | |
Cytoplasmic | 3 2 2| 6 2.3|
Periportal, Vacuolization Cytoplasmic| | 2 1.5|
__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Fat, Necrosis | 3 | 2 3.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Cytoplasmic Alteration | | 1 2.0|
Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1 2 | 34 1.2|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic Active | 1 | 2 1.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 3 |
Developmental Malformation | 4 | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cytoplasmic Alteration | 1 1 1 2 1 | 11 1.2|
Vacuolization Cytoplasmic | 2 | 1 2.0|
Capsule, Hyperplasia | 2 2 1 1 2 1 1 1 2 1 2 1 2 1 1 1| 29 1.3|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + M + + M M M + + M + + M M + M + + M + +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicular Cell, Hyperplasia | 2 1 1 1 2 1 | 12 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 | 4 1.3|
Inflammation, Granulomatous | 3 4 | 3 3.3|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 3 2 4 3 3 3 3 4 4 3 4 2 2 4 3 3 4 4 4 3 3 4 4 3| 42 3.0|
Cyst | 4 3 4 4 4 4 2 4 1 2 4 3 3 3 2| 28 3.1|
Inflammation, Chronic | 2 1 1 2 1 | 12 1.8|
Inflammation, Chronic Active | 2 3 3 | 6 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic | 1 1 1 | 8 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Myeloid Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Renal, Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hemorrhage | 2 2 2 3 1 2| 12 1.9|
Hyperplasia, Lymphoid | 2 3 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 3 1 1 4 2 2 3 3 2 1 3 2 1 | 23 2.2|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + M + + + + + + + + + + + + + + + +| 47 |
Atrophy | 1 1 2 3 2 3 3 | 16 2.3|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 2 2 2 1 2 2 2 2 2 1 2 2 2 2 2 1 2 | 35 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 2 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 1 1 | 7 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 55301-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PYRIDINE Date: 11/19/96
Route: DOSED WATER Time: 15:53:54
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 8| 2| 2| |
| 2| 2| 2| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2| 2| 2| 3| 4| 2| 3| 2| 0| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Respiratory Epithelium, Degeneration,| | |
Hyaline | 1 | 2 1.0|
Respiratory Epithelium, Hyperplasia | 2 2 1 2 1 1 1 1 1 | 15 1.3|
Respiratory Epithelium, Inflammation,| | |
Chronic Active | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic Active | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Infarct | 1 1 2 | 6 1.7|
Infiltration Cellular, Lymphocyte | 4 1 | 6 1.7|
Nephropathy | 2 1 1 1 2 1 2 1 1 3 2 1 1 2 1 1 3 3| 32 1.4|
Renal Tubule, Dilatation | | 5 1.2|
Renal Tubule, Hyperplasia | 2 | 1 2.0|
Renal Tubule, Pigmentation | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphocyte | 1 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
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---------- END OF REPORT ----------
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